Clinical trials: PYY
Eating Disorder, Bulimia Nervosa
Co-Feedback Action of Growth Hormone, PP and PYY on Ghrelin in Bulimia
This study evaluates the addition of Acipimox or placebo to exercise on growth hormone release and ghrelin secretion in bulimic patients and in healthy women.
- Trial name
- NCT03338387
- Testing
- Acipimox
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Obesity
The Role of Peptide YY (PYY)Infusions in Inhibiting Food Intake.
The aim of the study is to compare fasting and postprandial PYY levels between overweight/obese and lean subjects during and after an infusion of saline, PYY1-36 or PYY3-36 and to evaluate the efects on appetite, energy intake…
- Trial name
- NCT00259246
- Testing
- Peptide YY infusion
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Lack of Satiety
Fibersol-2 Clinical Trials Related to Appetite
Emerging research suggests fiber, particularly digestion-resistant maltodextrins such as Fibersol-2, may impact satiety, by decreasing hunger, prolonging satiation, and/or increasing satiety signals from the gut.
- Trial name
- NCT01305291
- Testing
- digestion-resistant maltodextrin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Obesity
The Role of Peptide YY (PYY)in Inhibiting Food Intake.
12 obese subjects will receive peripheral administration of placebo and 4 escalating doses of PYY1-36 and another 12 obese subjects will receive peripheral administration of placebo and 4 escalating doses PYY3-36 on 5 different…
- Trial name
- NCT00259233
- Testing
- peripheral Peptide YY administration
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Metabolic Health, Gut Hormones
Breaking Sitting and Metabolic Health in Sedentary Overweight and Obese Adults
The purpose of this project is to investigate the effects of breaking up prolonged sitting on postprandial metabolic responses, gut hormones secretion and energy balance in sedentary overweight and obese adults.
- Conditions
- Metabolic Health, Gut Hormones, Energy Balance
- Trial name
- NCT05306678
- Testing
- Prolonged sitting, Breaking sitting
- Where
- Taiwan
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Obesity
Safety, Toleration and Pharmacokinetics of Single Intravenous Doses of Peptide YY in Overweight Adults
The purpose of this trial is to evaluate the safety and tolerability of single escalating doses of Peptide YY3-36 and to determine effects on food intake and serum hormones when administered by intravenous infusion to otherwise…
- Trial name
- NCT00331175
- Testing
- Peptide YY3-36
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Pfizer
Taste Disorder, Primary, Sweet
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY
The purpose of this study is to determine the functional significance of sweet taste receptors in the secretion of GI satiation peptides by using a specific sweet taste receptor antagonist to block sweet taste perception in the…
- Trial name
- NCT01304823
- Testing
- lactisole, mixed liquid meal
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Esophageal Neoplasms, Stomach Neoplasms
The Effect of Satiety Gut Hormone Modulation on Appetitive Drive After Upper Gastrointestinal Surgery
Improvements to treatment strategies for patients with cancers of the upper gastrointestinal tract have produced a large population of people who remain free from cancer recurrence in the long term following treatment.
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02381249
- Testing
- Octreotide
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Appetitive Behavior, Obesity
Individual Variability of Appetite Responses to a Standardised Meal
The aim of this study is to examine the interindividual variability of subjective and hormonal appetite responses to a standardised meal in healthy men and explore any moderating influence of the fat mass and obesity associated…
- Conditions
- Appetitive Behavior, Obesity, Genetic Predisposition to Disease
- Trial name
- NCT03771690
- Testing
- Standardised meal
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Appetite and General Nutritional Disorders, Hormone Replacement
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY
The purpose of this study is to determine the functional significance of sweet taste receptors in the secretion of GI satiety peptides by using a specific sweet taste receptor antagonist to block sweet taste perception in the gut.
- Trial name
- NCT01088841
- Testing
- lactisole
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
Carbohydrate Intake and Gut Hormone Release During Exercise
It is well known that following a single session of moderate-to-high intensity exercise individuals experience a temporary suppression of hunger and a delay in the commencement of eating.
- Trial name
- NCT04019418
- Testing
- Maltodextrin (carbohydrate), Exercise, Rest
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Healthy Male Adults
Testing the Potential Metabolic Effect of the Human Gut Bacterial Peptide, RUCILP, in Healthy Men
The goal of this randomized, double-blinded and placebo-controlled clinical cross-over trial is in healthy men to explore the potential metabolic effects of the naturally occurring gut bacterial polypeptide, RUCILP.
- Trial name
- NCT06923839
- Testing
- Test bacterial peptide: RUCILP
- Where
- Denmark
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Oluf Pedersen
Healthy
Degradation of the Anorexic Hormone Peptide YY
Peptide YY (PYY) is a gastrointestinal hormone released from the enteroendocrine cell upon food intake. The N-terminal truncated form, PYY3-36, exerts anorexic effects.
- Trial name
- NCT02493959
- Testing
- PYY1-36 infusion, PYY1-36 + sitagliptin, PYY3-36 infusion
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Healthy
Brain Natriuretic Peptide Effects on Appetite Regulating Hormones and Endothelial Derived Peptides
Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic peptide (BNP) from the ventricular myocytes.
- Trial name
- BNP/Appetite (NCT01375153)
- Testing
- BNP, 0.9% NaCl
- Where
- 2 sites in Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Breastfeeding
Effects of Breastfeeding on Maternal Plasma Ghrelin and Peptide Tyrosine Tyrosine (PYY) Levels
Weight retention after pregnancy contributes to increasing rates of obesity. There is evidence that breastfeeding is accompanied from changes in fat mobilisation and fat mass, nevertheless there are no data on the effects of…
- Trial name
- NCT00831818
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Insulin Resistance, Type2 Diabetes Mellitus
High-fat Overfeeding, Hepatokines and Appetite Regulation
The present study will investigate the effect of high-fat overfeeding on a group of liver-secreted proteins linked to worsened blood sugar control, as well as proteins involved in appetite control.
- Conditions
- Insulin Resistance, Type2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, Obesity
- Trial name
- OVEREAT (NCT03369145)
- Testing
- High-fat diet
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Bariatric Surgery (Gastric Bypass)
Can Postprandial Reactive Hypoglycaemia be Reduced in Patients After Roux-en-Y Gastric Bypass With a Low Carbohydrate Diet?
Roux-en-Y gastric bypass (RYGB) accelerates nutrient delivery to the small intestine causing higher peak blood glucose concentration early after meal intake.
- Trial name
- NCT02665715
- Testing
- Low carbohydrate meals, Standard carbohydrate meals
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Amirsalar Samkani
Neuroendocrine Reproductive Status
Impacts of Metabolic Variation on Neuroendocrine Control of Reproduction
This study will evaluate the potential effects of a changing metabolic environment on GnRH hypothalamic neurons, by performing studies of LH pulsatility (basal and during clamp studies) in different groups of male subjects fed…
- Trial name
- NCT01058681
- Testing
- effect of metabolic variations on LH pulsatility
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Obesity
Effect of Coffee and Agave Inulin-based Beverage on Appetite in Adults With Obesity.
Nutritional treatment is key in managing obesity; however, the lack of fullness or satiety signals may affect adherence to this treatment.
- Trial name
- NCT06527209
- Testing
- Coffee and agave inulin-based beverage (A), Control beverage (B)
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Metabolic Health, Gut Hormones
Breaking Sitting and Metabolic Health in Sedentary Lean Adults
The purpose of this project is to investigate the effects of breaking up prolonged sitting on postprandial metabolic responses, gut hormones secretion and energy balance in sedentary lean adults.
- Conditions
- Metabolic Health, Gut Hormones, Energy Balance
- Trial name
- NCT05306613
- Testing
- Prolonged sitting, Breaking sitting
- Where
- Taiwan
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University