Clinical trials: Pain, Acute
Migraine, Headaches
Efficacy and Safety of 20 mg Sumatriptan Powder Delivered Intranasally With the Bi-directional Device Compared With 100 mg Sumatriptan Tablets in Adults With Acute Migraine With or Without Aura
This study is being conducted to determine if OPTINOSE SUMATRIPTAN delivered nasally (through the nose) using the OPTINOSE SUMATRIPTAN DEVICE can reduce the pain associated with migraine headaches in 30 minutes after use.
- Trial name
- COMPASS (NCT01667679)
- Where
- 13 sites in United States
- Volunteers
- 275 people
- Sponsor
- Avanir Pharmaceuticals
Acute Renal Colic
Atomized Intranasal Vs Intravenous Ketorolac in Acute Renal Colic Pain Management.
Introduction: Pain is a common reason for individuals to seek health care, especially emergency care. Ketorolac has numerous advantages over other pain medications, especially the opioids.
- Trial name
- Ink-Arc (NCT04441762)
- Testing
- Intravenous Ketorolac Tromethamine, Intranasal Ketorolac Tromethamine
- Where
- Oman
- Volunteers
- 171 people
- Sponsor
- Oman Medical Speciality Board
Acute Coronary Syndrome, Non ST Elevation Myocardial Infarction
Assessment of Coronary Flow Reserve by Doppler Flow WIre in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Differences Between the Loading Dose of Prasugrel and Ticagrelor .
Study design Investigators aim to perform a prospective, single-center, investigator-initiated, randomized study to compare the Adenosine-induced coronary vasodilatation after the loading dose of Ticagrelor either Prasugrel…
- Conditions
- Acute Coronary Syndrome, Non ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- NCT02032303
- Testing
- Assessment of coronary flow reserve, Percutaneous Coronary Intervention, Ticagrelor loading
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Azienda Policlinico Umberto I
Pain, Acute
Dose Finding Study of STR-324
This study aims to evaluate the analgesic effect and the safety of 4 doses of STR-324 administered as an infusion, with or without initial bolus, to patients suffering from post-operative pain.
- Trial name
- NCT04582786
- Testing
- Morphine, Morphine HCl, STR-324
- Where
- Netherlands
- Volunteers
- 118 people
- Sponsor
- Alaxia SAS
Neoplasm Related Pain (Acute) (Chronic)
Bicarbonate for Tumor Related Pain
The purpose of this study is to: Determine how well people tolerated sodium bicarbonate taken by mouth in higher doses than those usually given for heartburn. Determine if sodium bicarbonate can reduce cancer-related pain.
- Trial name
- NCT01350583
- Testing
- Sodium Bicarbonate (NaHCO3)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Surgery, Acute Pain
IPACK and Adductor Canal Catheter Patient Outcomes for TKAs?
This study evaluates the addition of the IPACK block to the adductor canal block and catheter in the pain management of total knee arthroplasty.
- Trial name
- NCT03774966
- Testing
- Adductor Canal Block + Catheter & IPACK block, Adductor canal block + catheter
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Migraine, Headache
Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine
The purpose of this study is to determine whether a fixed-dose combination of naratriptan + naproxen is effective compared each monotherapy for the acute treatment of migraine.
- Trial name
- Atenéia (NCT01390324)
- Testing
- Fixed-dose combination of naratriptan+naproxen, Naratriptan, Naproxen
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Acute Pain Due to Trauma, Analgesia
Fentanyl OR Esketamine for Traumatic PAIN (FORE-PAIN) Trial
Fentanyl and esketamine are both standard of care for treatment of acute severe traumatic pain in the prehospital setting in the Netherlands. However, it is not known whether they are equally effective and safe.
- Conditions
- Acute Pain Due to Trauma, Analgesia, Fentanyl, Esketamine
- Trial name
- FORE-PAIN (NCT06051227)
- Testing
- Fentanyl Citrate, Esketamine
- Where
- Netherlands
- Volunteers
- 235 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Breast Cancer Female
Efficacy of Transdermal Fentanyl Patches in Relief of Acute Postoperative Pain After Mastectomy
to determine the safety, efficacy and tolerability of transdermal fentanyl in patients undergoing mastectomy, as well as the postoperative consumption of analgesic.
- Trial name
- NCT03051503
- Testing
- The Transdermal Therapeutic System-Fentanyl (TTS-F), Intravenous patient-controlled analgesia (PCA) morphine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- South Egypt Cancer Institute
Healthy Volunteers
A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Intravenous Doses of NH302 Injection in Healthy Participants
This is a first-in-human study of NH302 injection in healthy participants. The study will test single intravenous doses of NH302 to evaluate its safety and tolerability, how the body processes NH302, and its effects on selected…
- Trial name
- NCT07892469
- Testing
- NH302 injection
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Low Back Pain
TENS Treatment Plus Ibuprofen for the Treatment of Acute Back Pain in the ED
Patients presenting to the ED with a chief complaint of acute low back pain and whom the providing physician feels symptomatic treatment is appropriate in the ED will be screened for inclusion in the study.
- Trial name
- NCT02611583
- Testing
- TENS
- Where
- United States
- Sponsor
- Albert Einstein Healthcare Network
Acute Pain, Procedural Anxiety
VR for Steroid Joint Injections - Feasibility
The goal of the project is to implement virtual reality for pain and anxiety management for patients undergoing intra-articular glucocorticoid injections in the outpatient pediatric rheumatology clinic.
- Conditions
- Acute Pain, Procedural Anxiety, Juvenile Idiopahtic Arthritis
- Trial name
- NCT07778069
- Testing
- VR-PAT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nationwide Children's Hospital
Acute Renal Colic
Nasal Fentanyl And Renal Colic
The purpose of this study is to determine whether nasal fentanyl is effective in the treatment of renal colic in adults in emergency department.
- Trial name
- NCT01339624
- Testing
- FENTANYL, Ketorolac Tromethamine AND morphine
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Valduce Hospital
Hip Arthroplasty Replacement, Post Operative Analgesia
Comparison of Pericapsular Nerve Group (PENG) Block With a Combined Femoral, Sciatic, Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia in Secondary Total Hip Arthroplasty; (REVPET)
The aim of this clinical trial is to compare the analgesic effect of a pericapsular nerve group (PENG) block with a combined femoral, sciatic, lateral femoral cutaneous nerve block for postoperative analgesia in patients…
- Conditions
- Hip Arthroplasty Replacement, Post Operative Analgesia, Post Operative Pain, Acute
- Trial name
- REVPET (NCT07109388)
- Testing
- Pericapsular nerve group (PENG) block with 0.75% ropivacaine guided by ultrasound, Femoral, sciatic and lateral femoral cutaneous nerve block with 0.375% ropivacaine
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Pain, Acute, Opioid Use
Postoperative Pain Scores and Opioid Consumption in Video Assisted Thoracic Surgery
Video assisted thoracoscopic surgery (VATS) is a type of minimally invasive thoracic surgery (MITS) procedure used for diagnosis or treatment of chest pathologies (pulmonary, mediastinal, chest wall).
- Trial name
- EsPITHX (NCT04459923)
- Testing
- ultrasound-guided erector spinae plane block catheter, thoracic epidural catheter
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ataturk University
Acute Low Back Pain
Study to Evaluate a Pharmacokinetic Drug Interaction Between Eperisone Hydrochloride and Aceclofenac in Healthy Male Subjects
A randomized, open label, single-dose, 6-sequence, 3-period, crossover study to evaluate a pharmacokinetic drug interaction between eperisone hydrochloride and aceclofenac in healthy male subjects.
- Trial name
- NCT01638286
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Acute Post Operative Pain
Various Strategies to Reduce Acute Post Hemorrhoidectomy Pain: A Comparative Study
Since post hemorrhoidectomy pain is a severe and common post operative symptom so there is a need to find a suitable method for reducing this pain, up to our knowledge, this the first study in ZUH to compare between ketrolac…
- Trial name
- NCT06307106
- Testing
- ketorolac and light marcaine, light marcaine, Corticosteroids injection
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Zagazig University
Disc Prolapse, Pain
ADALISKIAS: Adalimumab for Acute Disc Prolapse
Aims: To study the efficacy and safety of adalimumab versus placebo in the treatment of acute disc prolapse will be will be compared up to 12 months after the start of study drug treatment.
- Trial name
- NCT01510548
- Testing
- Adalimumab injections for acute disc prolapse patients
- Where
- Finland
- Volunteers
- 90 people
- Sponsor
- Kuopio University Hospital
Pain, Acute, Surgery
ESP Block in VATS: Programmed Intermittent Bolus Versus Continuous Infusion on Quality of Recovery
Fascial plane blocks, such as ESP, rely on the spread of local anaesthetic on an interfacial plane, automated boluses may be particularly useful for this group of blocks.
- Trial name
- NCT05181371
- Testing
- Ultrasound Guided ESP Block with Programmed Intermittent Bolus (PIB) for VATS, Ultrasound Guided ESP Block with Continuous Infusion (CI) for VATS
- Where
- 2 sites in Ireland
- Volunteers
- 60 people
- Sponsor
- Mater Misericordiae University Hospital
Acute Pain, Molar
A Study of LY4515100 in Participants With Pain Following Third Molar Removal
The purpose of this study is to evaluate the safety and efficacy of LY4515100 and see how a single oral dose compares with placebo in acute postsurgical pain after removing impacted third molars.
- Conditions
- Acute Pain, Molar, Molar, Third, Surgery, Oral
- Trial name
- NCT07511816
- Testing
- LY4515100
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- Eli Lilly and Company