Clinical trials: Pain, Chronic Disease
Musculoskeletal Pain, Chronic Pain
N-of-1 Trials Using mHealth in Chronic Pain
Chronic musculoskeletal pain is an important problem, and treatments are often prescribed in a "trial and error" fashion. Clinicians prescribe a treatment to a patient and then wait and see if the treatment is successful.
- Trial name
- PREEMPT (NCT02116621)
- Testing
- Trialist Intervention, smartphone
- Where
- 2 sites in United States
- Volunteers
- 215 people
- Sponsor
- University of California, Davis
Osteoarthritis
A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 In Participants With Osteoarthritis Pain
The main purpose of this study is to evaluate the efficacy and safety of LY3857210 in participants with Osteoarthritic Pain. This trial is part of the chronic pain master protocol, H0P-MC-CPMP (NCT05986292), which is a protocol…
- Trial name
- OA05 (NCT05620563)
- Testing
- LY3857210
- Where
- 30 sites in United States, Puerto Rico
- Volunteers
- 147 people
- Sponsor
- Eli Lilly and Company
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer
RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00726830
- Testing
- methadone hydrochloride, morphine sulfate, oxycodone hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Opioid-use Disorder, Chronic Pain Syndrome
The Effect of Chronic Pain on Delay Discounting in Methadone Patients
The epidemic of opioid overdose deaths continues to rise, killing more persons in 2017 than HIV/AIDS at the height of that epidemic.
- Trial name
- NCT04473950
- Testing
- Naloxone Hydrochloride
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Chronic Pain, Opioid Use Disorder
Virtual Reality for Chronic Pain and Opioid Use Disorder Pilot
This is a pilot feasibility study of a virtual reality device for patients with co-morbid chronic pain and opioid use disorder.
- Trial name
- NCT05546749
- Testing
- RelieVRx
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Albert Einstein College of Medicine
Traumatic Brain Injury, Chronic Pain
One-day Life Skills Workshop for Veterans With TBI, Pain, and Psychopathology: Evaluating Efficacy and Mechanism of Change
Mild traumatic brain injury (mTBI) is the signature wound of Veterans returning from the operations in Iraq and Afghanistan (i.e., OIF/OEF/OND), with up to 20 percent experiencing persistent post-concussive symptoms.
- Conditions
- Traumatic Brain Injury, Chronic Pain, Post Traumatic Stress Disorder, Depression
- Trial name
- NCT04143243
- Testing
- ACT on Life, Education, Resources, and Support
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- VA Office of Research and Development
Chronic Migraine, Chronic Migraine, Headache
A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine
This is a phase 2, double-blind, randomized, multicenter, placebo-controlled, three arm parallel study to evaluate the efficacy and safety of two different dosages (30 IU daily and 60 IU daily) of TNX-1900 in patients with…
- Conditions
- Chronic Migraine, Chronic Migraine, Headache, Chronic Migraine Without Aura, Aura Migraine
- Trial name
- PREVENTION (NCT05679908)
- Testing
- TNX-1900
- Where
- 26 sites in United States
- Volunteers
- 88 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Clinical Decision Making, Nonarthritic Hip Disease
Nonarthritic Hip Disease Evaluation And Treatment
The investigators aim to understand how interdisciplinary care influences decisions, expectations, and outcomes for patients with non-arthritic hip disease (NAHD).
- Trial name
- NEAT (NCT03519087)
- Testing
- Interdisciplinary Evaluation for Nonarthritic Hip Disease, Posture and Movement Training, Treatment-of-choice
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Ohio State University
Neurologically Impaired, Irritable Mood
Effectiveness of Gabapentin on Chronic Irritability in Neurologically Impaired Children
This study is a prospective, randomized, double blind, placebo controlled, crossover clinical trial looking at whether gabapentin can provide symptom relief for chronic irritability in neurologically impaired children.
- Conditions
- Neurologically Impaired, Irritable Mood, Signs and Symptoms, Digestive, Sleeplessness
- Trial name
- NCT01675960
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gillette Children's Specialty Healthcare
Prostatitis, Chronic Pain Syndrome
Botox for Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
The objective of this study is to evaluate the safety and efficacy of intraprostatic injection of Botox for the treatment of men diagnosed with chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CP/CPPS).
- Trial name
- NCT00529386
- Testing
- Botox
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Queen's University
Musculoskeletal Pain, Chronic Pain
Living in Full Even With Pain Study
This project will increase our understanding of the mechanisms underlying changes in opioid medication use associated with three psychosocial chronic pain (CP) treatments.
- Trial name
- LIFE (NCT03916276)
- Testing
- Cognitive Therapy (CT), Mindfulness Meditation (MM), Behavioral Activation (BA)
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- University of Washington
Anxiety Disorders, Anxiety Disorders and Symptoms
Anxiety Level Among Patients With Chronic Low Back Pain
The goal of this observational cross-sectional study is to learn about the intensity of anxiety symptoms among Polish people suffering from chronic lower back pain.
- Conditions
- Anxiety Disorders, Anxiety Disorders and Symptoms, Lower Back Pain, Chronic Pain
- Trial name
- NCT06404788
- Where
- Poland
- Volunteers
- 202 people
- Sponsor
- Medical University of Silesia
Medication Overuse Headache
Medication-overuse Headache: 4 Years Follow up
From 1 January 2004 to 31 December 2006 64 individuals with probable medication overuse headache were included in a randomized, 1-year open-labeled, multicentre study to evaluate the effect of early introduction of prophylactic…
- Trial name
- MOHfollowup (NCT00918671)
- Testing
- No new specific intervention
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
Post Herpetic Neuralgia (PHN)
Transcutaneous Auricular Vagus Nerve Stimulation on Post-Herpetic Neuralgia
The purpose of this study is to evaluate the therapeutic efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) in the treatment of patients with post-herpetic neuralgia (PHN).
- Trial name
- NCT07123987
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS), traditional medical treatment for PHN
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Mohamed Hosny Ismail Easa
Back Pain, Chronic Low Back Pain
Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System
The purpose of this investigation is to establish the safety and efficacy of the Biostat System when used for treatment of chronic low back (lumbar) pain due to symptomatic internal disc disruptions (IDD) by comparing safety and…
- Conditions
- Back Pain, Chronic Low Back Pain, Internal Disc Disruption, Degenerative Disc Disease
- Trial name
- NCT01011816
- Testing
- BIOSTAT BIOLOGX, Saline
- Where
- 20 sites in United States
- Volunteers
- 220 people
- Sponsor
- Spinal Restoration, Inc.
Chronic Pain
Study to Evaluate the Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) for Relief of Moderate to Severe Pain in Patients With Osteoarthritis or Low Back Pain Who Require Opioid Treatment for an Extended Period of Time
The primary objective of this study is to evaluate efficacy of hydrocodone extended-release (ER) tablets compared with placebo in alleviating moderate to severe pain in patients with osteoarthritis or low back pain as assessed by…
- Trial name
- NCT01240863
- Testing
- Hydrocodone ER
- Where
- 73 sites in United States
- Volunteers
- 391 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Coronary Artery Disease, Asthma
Comparison of Dobutamine and Regadenoson Stress Cardiac Magnetic Resonance (MR)
The goal of this research is to determine the utility of Regadenoson (Lexiscan)for use as an imaging agent with cardiac MR. If found useful, it will help us establish a protocol for regadenoson stress MR perfusion (Regadenoson…
- Conditions
- Coronary Artery Disease, Asthma, Chronic Obstructive Pulmonary Disease (COPD), Angina
- Trial name
- NCT00763035
- Testing
- Regadenoson, Dobutamine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Wake Forest University Health Sciences
Fatigue, Lupus Erythematosus, Systemic
Acupressure for Fatigue in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by involvement of multiple organs with a female to male ratio of 12:1 with the highest incidence reported in women of child bearing age (15-44…
- Conditions
- Fatigue, Lupus Erythematosus, Systemic, Pain, Chronic, Quality of Life
- Trial name
- AcuSLE (NCT03200548)
- Testing
- Relaxing acupressure plus usual care, Usual care, Stimulating acupressure plus usual care
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Suzanna Zick
Stress Disorders, Post-traumatic
Trauma-Sensitive Yoga for Female Veterans With PTSD Who Experienced Military Sexual Trauma
In this study, we are evaluating the effectiveness of a yoga intervention to treat posttraumatic stress disorder (PTSD), its associated symptoms of chronic pain and insomnia, and biological and physiological responses to trauma…
- Trial name
- PSLII (NCT02640690)
- Testing
- Trauma Center Trauma Sensitive Yoga Intervention (TCTSY), Cognitive Processing Therapy
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- VA Office of Research and Development
Chronic Pancreatitis
Viokase 16, Viokase16 Plus Nexium and Nexium Alone
Our primary hypothesis is that the addition of Nexium to Viokase 16 will decrease the chronic abdominal pain in patients with small duct chronic pancreatitis in a superior fashion compared to Viokase 16 plus placebo or to Nexium…
- Trial name
- AZ (NCT01142128)
- Testing
- Nexium (esomeprazole magnesium), Viokase 16 (pancrelipase) + Nexium
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Florida