Clinical trials: Pain, Experimental
Chronic Neck Pain
Effects of Minimally Invasive Techniques in Healthy and Chronic Cervical Pain Individuals
Brief Summary: This project consists of two sequential experimental phases designed to analyze the immediate and 24-hour effects of three invasive physiotherapy techniques -dry needling (DN), percutaneous neuromodulation (PENS)…
- Trial name
- NCT07345793
- Testing
- Dry needling, Percutaneous nerve stimulation, Percutaneous electrolysis
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Basic Physiology, Brain Stimulation
Transcranial Direct Current Stimulation (tDCS) in the Primary Motor Cortex in Healthy Individuals
The main aim of this study is to assess the short-term effects of active-tDCS (a-tDCS) on the M1 regarding sensorimotor variables such as discriminative sensation, pressure pain threshold and electromyographic activity compared…
- Trial name
- NCT04148547
- Testing
- Sooma transcranial direct current stimulation device
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Pain, Acute, Pain, Chronic
Noninvasive Brain Stimulation for Pain Relief
Non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial focused ultrasound (FUS), is be applied to healthy human subjects, acute pain patients, and chronic pain patients to investigate…
- Conditions
- Pain, Acute, Pain, Chronic, Pain, Experimental
- Trial name
- NCT04283643
- Testing
- Transcranial Focused Ultrasound, Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Pain, Acute Pain
Pain Induced by m-Cresol as Preservative
Preservatives such as m-Cresol are essential components in many subcutaneously injected medications, including insulin or human growth hormone, to prevent bacterial growth.
- Conditions
- Pain, Acute Pain, Healthy Volunteer Study
- Trial name
- NCT07600814
- Testing
- m-Cresol 0.1%, m-Cresol 0.25%, Control Solution
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Muscle Strength
The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain
The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps.
- Trial name
- NCT01346995
- Testing
- Experimental knee pain, Non-painful control injections
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Frederiksberg University Hospital
Interstitial Cystitis
The Efficacy of Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome
The purpose of this study is to evaluate efficacy of biomarker in patient with interstitial cystitis/painful bladder syndrome
- Trial name
- NCT01985880
- Where
- 2 sites in South Korea
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Pain, Parkinson Disease
Experimental Pain in Parkinsons
Study comparing pain intensity and discomfort in patients with Parkinson´s disease and healthy controls during inducement of mechanical, thermal, and chemical experimental pain
- Trial name
- ExPainPD (NCT05981261)
- Testing
- inducement of experimental pain
- Where
- Denmark
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Acute Pain
Assessment of PF614 Effects on Experimental Pain in the Cold Pressure Test (PF614-201)
The primary objective of the study is to evaluate the onset of analgesia following administration of a single oral dose of PF614 (50 mg or 100 mg) or placebo in healthy male subjects in an experimental pain model (cold pressor…
- Trial name
- CPT (NCT06629402)
- Testing
- PF614
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ensysce Biosciences
Pain
Experimental Study of Detection an Intentional Performance Degradation in Grip Strength
In this study, the detection of the feigning weakness in grip strength is measured using different grip strength testing instruments.
- Trial name
- NCT02260999
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Christoph Maier, Prof. Dr.
Pain
Reduction of Pain in Childhood Vaccination in the Primary Care Nurse Vaccination Consultation
Non-randomized study with control group (CG) with the objective of analyzing the non-pharmacological analgesic efficacy of the "Painless Vaccine" protocol for the reduction of pain during vaccination in the population aged 2…
- Trial name
- NoVacPain (NCT06004258)
- Testing
- Painless Vaccination
- Where
- Spain
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Virgen Macarena
Pain, Dentin Sensitivity
Effect of an Experimental Gel Containing Copaiba Oil-resin in the Control of Dentin Hypersensitivity
This randomized, single-blind, placebo-controlled clinical trial aims to clinically evaluate the effect of an experimental gel containing copaiba oleo-resin in the control of dentin hypersensitivity (DH) in non-carious cervical…
- Conditions
- Pain, Dentin Sensitivity, Dentin Desensitizing Agents
- Trial name
- NCT06872749
- Testing
- KF2 (Potassium nitrate gel), experimental Copaiba gel
- Where
- Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Para
Experimental Pain in Healthy Human Subjects
How do Alpha Oscillations Shape the Perception of Pain? - An EEG-based Neurofeedback Study
Pain is closely linked to alpha oscillations (8 -13 Hz) which are thought to represent a supra-modal, top-down mediated gating mechanism that shapes sensory processing.
- Trial name
- NCT05570695
- Testing
- attention right training, ARTNF, attention left training, ALTNF
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Pain
Evaluation of Pain Measurement Device
This longitudinal observational study will attempt to objectively measure pain with an experimental, non-invasive device. Patients and volunteers will receive a baseline screening with psychophysical tests and questionnaires.
- Trial name
- NCT02036567
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Stanford University
Headache
Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow
To investigate headache score and accompanying symptoms during and after infusion of carbachol.
- Trial name
- NCT00357864
- Testing
- carbachol
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Pain
An Exploratory Study to Assess the Effects of JNJ-39439335 on the Relief of Pain Using a Thermal-Grill Experimental Model
This exploratory study will use a thermal-grill experimental model to assess the effects of JNJ-39439335 (50 mg, single oral dose) on the relief of pain.
- Trial name
- NCT01006304
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Pain Perception
The Impact of an Immersive Digital Therapeutic Tool on Pain Perception
The goal of this experimental study is to examine the impact of a virtual reality paradigm on heat pain perception in healthy volunteers.
- Trial name
- NCT06130267
- Testing
- Endocare
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Stéphane Potvin
Experimental Pain in Healthy Human Participants
Sensory Evidence and Expectations in Pain Processing
Pain is a highly complex and subjective phenomenon which is not only rooted in sensory information but also shaped by cognitive processes such as expectation.
- Trial name
- NCT04296968
- Testing
- Painful stimulation using a laser device (DEKA Stimul 1340, Calenzano, Italy), Visual cueing
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Musculoskeletal Pain, Musculoskeletal Injury
A New Experimental Model of Transient and Short-lasting Muscle Pain in Humans Based on Diathermy
This study evaluates the use of short-wave diathermy (SWD) as an novel experimental model to induce transient and intensity-controlled muscle pain by heating muscle tissue.
- Trial name
- NCT03573219
- Testing
- Short-wave diathermy
- Where
- Argentina
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Mechanisms and Modulators of Placebo Analgesia in Healthy Volunteers
The Effect of Oxytocin on Placebo Analgesia: an Experimental Study in Healthy Volunteers
Placebo responses contribute to medical treatment outcome. The purpose of this study is to determine whether a single intranasal application of oxytocin can increase the placebo response in an experimental model of placebo…
- Trial name
- NCT01886014
- Testing
- Oxytocin
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Pain Management, Nurse
The Effect of Pain Management Education Program on Pain Management Self-Efficacy Among Nurses Caring for Palliative Care Patients: A Quasi-Experimental Study
The goal of this quasi-experimental research designed as a single-group pre-test post-test model is to evaluate the effect of an educational intervention aimed at improving the pain management self-efficacy of nurses providing…
- Conditions
- Pain Management, Nurse, Self Efficacy, Palliative Care
- Trial name
- P-EASE (NCT07685665)
- Testing
- Education
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University