Clinical trials: Pain, Post Surgical
Postoperative Pain
Oral Gabapentin Versus Placebo for Treatment of Postoperative Pain Following Photorefractive Keratectomy
The purpose of this study is to determine the effectiveness of an oral medication called gabapentin in reducing pain after Photorefractive Keratectomy (PRK) eye surgery and to assess the frequency of use of rescue medication…
- Trial name
- NCT00793910
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Total Knee Replacement Surgery, Post-operative Pain
Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN
This is a prospective, randomized study. The purpose of this study is to evaluate if the addition of Suzetrigine, a new pain medication, to well established peri-operative pain regimen used for total knee replacement surgery will…
- Trial name
- STRIDE-PAIN (NCT07548385)
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pain, Postoperative, Anesthesia
Oral Methadone in Cardiac Surgery
The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac…
- Conditions
- Pain, Postoperative, Anesthesia, Cardiac Surgery
- Trial name
- OMICS (NCT07221617)
- Testing
- Methadone, oral, Methadone, intravenously
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Perianal Fistula
This Study Compares the Conventional Cutting Seton Technique and a GLUBRAN®-Coated Seton in High Perianal Fistula Treatment. The Study Aims to Determine Whether the GLUBRAN®-Coated Seton Improves Healing, Reduces Postoperative Pain and Recurrence, and Better Preserves Anal Continence.
High anal fistula is a complex anorectal condition that can cause persistent pain, purulent discharge, recurrent infection, and a significant reduction in quality of life.
- Trial name
- NCT07676825
- Testing
- Glubran-coated Seton, Seton
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Kasr El Aini Hospital
Breast Cancer
Selective Intraoperative Administration of Local Anesthesia in Breast Reconstruction
Subjects are being asked to participate in this study because they will be undergoing unilateral (one) or bilateral (two) mastectomy surgery with immediate reconstruction involving insertion of a tissue expander.
- Trial name
- NCT02525718
- Testing
- Saline, 0.25 % bupivacaine (2.5 mg/ml) w/ 1:100,000 epinephrine & 4 mg dexamethasone
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Northwestern University
Postoperative Pain, Knee Surgery
Comparison of Nerve Blocks for Pain Relief After Knee Surgery
This retrospective observational study compares the postoperative analgesic effectiveness of ultrasound-guided fascia iliaca compartment block (FICB) with combined IPACK and genicular nerve block (GNB) in patients undergoing knee…
- Trial name
- NCT07845591
- Testing
- Ultrasound-Guided Fascia Iliaca Compartment Block, Ultrasound-Guided Combined IPACK and Genicular Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- University of Gaziantep
Thyroid Nodule
Mini-flap BABA (Bilateral Axillo-breast Approach) Robotic Thyroidectomy is Safe
In this study, a randomized controlled study was conducted between two groups of 40 recipients of conventional flap during BABA robotic-thyroidectomy and 40 recipients of Mini-flap method during BABA robotic-thyroidectomy.
- Trial name
- NCT05216718
- Testing
- Mini-flap, Conventional flap
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Inje University
Postoperative Pain, Total Knee Arthroplasty
US Guided GNB vs Saline Injection for TKA
Do ultrasound-guided genicular nerve blocks with 0.5% bupivacaine provide improved knee analgesia for patients recovering from total knee replacement surgery compared to saline injection? Hypotheses: The investigators hypothesize…
- Conditions
- Postoperative Pain, Total Knee Arthroplasty, Nerve Block
- Trial name
- NCT03316118
- Testing
- bupivacaine, saline
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Northwestern University
Thyroidectomy, Pain
Combination Effect of Nefopam With Propacetamol for Postoperative Pain After Thyroidectomy
Patients undergoing thyroidectomy are suffering not only surgical wound pain but posterior neck pain because of neck extension position during the surgery. However, there has been little attention of posterior neck pain.
- Trial name
- NCT02577068
- Testing
- Nefopam, Propacetamol
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Yonsei University
Thyroidectomy, Postoperative Neck Pain
Neck Exercises After Thyroid Surgery
Postoperative neck pain is common after thyroidectomy and may impair early recovery. This prospective randomized controlled study aimed to evaluate the effects of postoperative neck range-of-motion (ROM) and isometric…
- Conditions
- Thyroidectomy, Postoperative Neck Pain, Quality of Life (QOL), Cervical Range of Motion
- Trial name
- NCT07415174
- Testing
- Postoperative Neck Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Istanbul University - Cerrahpasa
Tibial Fractures, Fibula Fracture
Effect of Palmitoylethanolamide on Reducing Opioid Consumption for Below Knee Fracture Fixation
Palmitoylethanolamide (PEA), a non-psychoactive cannabis compound derived from peanuts, egg yolks, and soybeans, is an Endogenous FA Amide produced in the body as a biological response and a repair mechanism in chronic…
- Conditions
- Tibial Fractures, Fibula Fracture, Knee Fracture
- Trial name
- NCT05317676
- Testing
- Palmitoylethanolamide
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Pain
Femoral Nerve Block Versus Adductor Canal Nerve Block for Peri-Operative Analgesia Following Anterior Cruciate Ligament (ACL) Reconstruction: Evaluation of Post-operative Pain and Strength
All patients over the age of 16 undergoing primary or revision anterior cruciate ligament reconstruction with the use of bone-patellar-bone autograft are eligible for the study.
- Trial name
- NCT03033589
- Testing
- Marcaine 0.25 % Injectable Solution
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Pain, Postoperative, Agitation States as Acute Reaction to Exceptional Stress
Gabapentin as Preanesthetic Medication to Fast Procedures in Pediatric´s Oncology
This study is a clinical trial, prospective, randomized and double-blinded. Placebo, Gabapentin syrup at 15 mg/kg, and Gabapentin syrup at 30 mg/kg were administered to reduce agitation before and after in children submitted…
- Conditions
- Pain, Postoperative, Agitation States as Acute Reaction to Exceptional Stress, Anesthesia, Vomiting
- Trial name
- NCT03681574
- Testing
- GABA 15mg/kg Group, GABA 30mg/kg Group
- Where
- Brazil
- Volunteers
- 135 people
- Sponsor
- Hospital Infantil Albert Sabin
Hernia, Umbilical, Clonidine
Clonidine in Ultrasound-guided Rectus Sheath Block for Outpatient Umbilical Hernioplasty
This clinical trial aims to evaluate the effectiveness of an ultrasound-guided nerve block technique as the sole anesthetic method for patients undergoing outpatient umbilical hernia surgery.
- Conditions
- Hernia, Umbilical, Clonidine, Pain, Postoperative, Ambulatory Surgical Procedures
- Trial name
- NCT07062497
- Testing
- Rectus Sheath Block, Rectus Sheath Block with Clonidine
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Pain, Postoperative, Shoulder Pain
Analgesic Efficacy of Serratus Posterior Superior Intercostal Plane (SPSIP) Block in Shoulder Arthroscopies
Patients in the block group will be placed in a lateral position with the operated shoulder on top before awakening from surgery.
- Conditions
- Pain, Postoperative, Shoulder Pain, Block
- Trial name
- NCT06423677
- Testing
- Serratus Posterior Superior Intercostal Plane Block, patient controlled analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Molar, Third, Third Molar Surgery
3D Evaluation of Postoperative Edema After Third Molar Surgery
Surgical removal of third molars is recognized as one of the most frequent procedures performed in oral surgery. Literature is rich in studies attempting to demonstrate the benefit of corticosteroids in third molar surgery…
- Conditions
- Molar, Third, Third Molar Surgery, Soft Tissue Swelling, Pain, Postoperative
- Trial name
- NCT05941130
- Testing
- Combination of corticosteroid (methylprednisolone - Medrol, 16mg Pfizer Laboratories) therapy and non-steroidal anti-inflammatory (Ibuprofen 600mg Mylan) therapy, Non-steroidal anti-inflammatory therapy (Ibuprofen 600mg Mylan)
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Implantology Institute
Lung Cancer
Postoperative Pain After Single Port, Two Ports and Three Ports VATS Lobectomy
This single-center, prospective, randomized controlled trial was designed to assess and compare the postoperative pain after VATS lobectomy performed though one, two and three incisions.
- Trial name
- NCT03228056
- Testing
- pain intensity measured in VAS scale
- Where
- 2 sites in Poland
- Volunteers
- 90 people
- Sponsor
- Pulmonary Hospital Zakopane
Coronary Artery Disease, Pain, Postoperative
Parasternal Nerve Block in Cardiac Patients
Exparel is a new local analgesic (numbing medication) that is intended to be longer acting than currently available local analgesics.
- Trial name
- NCT01826851
- Testing
- Exparel
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Peter A Knight
Lumbar Spinal Stenosis, Lumbar Spondylolisthesis
Cognitive Behavioral Therapy (CBT) After Lumbar Spinal Fusion in Patients With High Pain Catastrophizing
Catastrophizing has emerged as the strongest independent predictor for persistent postsurgical pain. Although behavioral interventions, including Cognitive Behavioral Therapy (CBT), have been shown to reduce the impact of…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Lumbar Instability, Spinal Disease
- Trial name
- TRIBECA (NCT03969602)
- Testing
- Cognitive-behavioral Therapy, Biomedical and surgery-specific education
- Where
- Switzerland
- Volunteers
- 126 people
- Sponsor
- Neurocenter of Southern Switzerland
Postoperative Pain
New Truncal Nerve Blocks for Thoracoscopic Surgery and Open Heart Surgery.
This study is divided to two sub-studies. First sub-study evaluates if Serratus Anterior Plane block (SAPB) reduces opioid consumption after thoracoscopic surgery.
- Trial name
- NCT03704753
- Testing
- Ropivacaine, Sodium chloride 0.9%
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Tampere University Hospital
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