Clinical trials: Pain Acute
Neuropathic Pain
Vitamin C as add-on Therapy in Patients With Acute Herpes Zoster
To compare the efficacy and tolerability of three different doses of Pascorbin® besides standard medication with placebo and the reduction of herpes zoster-associated clinical symptoms as an add-on therapy for patients suffering…
- Trial name
- NCT05561257
- Testing
- Vitamin C
- Where
- 3 sites in Germany
- Volunteers
- 12 people
- Sponsor
- Pascoe Pharmazeutische Praeparate GmbH
Acute Traumatic Pain
Morphine-Midazolam in Pre-hospital Traumatic Patients With Severe Acute Pain
Administration of midazolam with morphine in patients with severe acute pain is a routine practice in the management of pre- and post-operative patients but has not been evaluated in pre-hospital setting.
- Trial name
- Morphine-Mida (NCT01731184)
- Testing
- Midazolam
- Where
- 4 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier de Cornouaille
Acute Pain, Ambulances
A Comparison of Three Regimens of Acute Pain Management: Methoxyflurane; Intranasal Fentanyl; Intravenous Morphine
The study rationale is to provide evidence for early, safe and effective pain management in the ambulance service with non-invasive and fast acting analgesics.
- Trial name
- PreMeFen (NCT05137184)
- Testing
- Methoxyflurane, Fentanyl, Morphine hydrochloride
- Where
- Norway
- Volunteers
- 338 people
- Sponsor
- Oslo University Hospital
Postoperative Pain
Open-Label Safety and Tolerability Study of Oxymorphone for Acute Postoperative Pain in Pediatric Subjects.
When post-operative parenteral analgesia is discontinued, oral dosing with study medication may begin once the subject has developed a moderate level of pain as defined by a 100 mm VAS (pain intensity score greater than or equal…
- Trial name
- NCT00801398
- Testing
- Oxymorphone IR
- Where
- 11 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Cancer
Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation
RATIONALE: Acupuncture may be effective in relieving mucositis-related pain caused by chemotherapy in patients undergoing stem cell transplantation.
- Trial name
- NCT00060021
- Testing
- acupuncture therapy, management of therapy complications, pain therapy
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Pain, Postoperative
Preoperative Methadone Single Dose Reduces Postoperative Morphine Consumption.
The aim of this study was to evaluate the effect of intraoperative methadone on postoperative analgesic requirements, pain scores and patient satisfaction in comparison to standard intraoperative pain control with fentanyl.
- Trial name
- NCT03529032
- Testing
- Methadone
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- Kantonsspital Baden
Pain, Acute
A Novel Electronic Method of Collecting Pain Scores in the Emergency Department
Can a novel electronic display of pain be successfully used in the emergency department and does it (1) change analgesic prescription and (2) change amount of pain experienced? Pain is a common symptom in emergency care.
- Trial name
- PIMPERNEL (NCT03881982)
- Testing
- PIMPERNEL Novel Electronic Log: Pain display can be seen, PIMPERNEL Novel Electronic Log: Pain display is hidden
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- University of Leicester
Non-ST Elevation Myocardial Infarction, Acute Coronary Syndrome
One-hour Troponin in a Low-prevalence Population of Acute Coronary Syndrome
This study aims to evaluate if the 1-hour rule-in/rule-out algorithm for a high-sensitivity cardiac troponin T (hs-cTnT) is safe and effective for use in the primary care where the patients have a lower pretest probability of an…
- Conditions
- Non-ST Elevation Myocardial Infarction, Acute Coronary Syndrome, Angina, Unstable, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- OUT-ACS (NCT02983123)
- Testing
- 1-hour hs-cTnT
- Where
- Norway
- Volunteers
- 1,750 people
- Sponsor
- Oslo University Hospital
Hip Arthroplasty Replacement, Post Operative Analgesia
Comparison of Pericapsular Nerve Group (PENG) Block With a Combined Femoral, Sciatic, Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia in Secondary Total Hip Arthroplasty; (REVPET)
The aim of this clinical trial is to compare the analgesic effect of a pericapsular nerve group (PENG) block with a combined femoral, sciatic, lateral femoral cutaneous nerve block for postoperative analgesia in patients…
- Conditions
- Hip Arthroplasty Replacement, Post Operative Analgesia, Post Operative Pain, Acute
- Trial name
- REVPET (NCT07109388)
- Testing
- Pericapsular nerve group (PENG) block with 0.75% ropivacaine guided by ultrasound, Femoral, sciatic and lateral femoral cutaneous nerve block with 0.375% ropivacaine
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
ACS - Acute Coronary Syndrome, Angor Pectoris
National Tunisian Registry of Percutaneous Coronary Intervention
The National Tunisian Registry of Percutaneous Coronary Intervention is an observational, prospective and multicenter study aiming to assess coronary intervention strategies in tunisian departments of cardiology.
- Conditions
- ACS - Acute Coronary Syndrome, Angor Pectoris, Myocardial Infarction, Myocardial Ischemia
- Trial name
- NATURE-PCI (NCT04219761)
- Where
- Tunisia
- Volunteers
- 2,698 people
- Sponsor
- Dacima Consulting
Microbial Substitution, Tryptophan Metabolism Alterations
Impact of Gut Microbiota and Tryptophan Metabolites on Acute Pain in Lumbar Disc Herniation Surgery Patients
It is well-established that the gut microbiota plays a crucial role in various pain mechanisms, including visceral pain, inflammatory pain, headache, neuropathic pain, and opioid tolerance.
- Conditions
- Microbial Substitution, Tryptophan Metabolism Alterations, Postoperative Pain, Acute
- Trial name
- NCT06502223
- Testing
- Pain Perception in Patients Undergoing Lumbar Disc Herniation Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Dokuz Eylul University
Pain Perception, Pain Acute
Effect of Hypnosis Combined to Transcranial Direct Stimulation in Pain
Pain is a public health condition, which causes great functional disability. Its consequences pervade the personal and social life of the patient, leading to significant changes in their interpersonal relationships, including…
- Trial name
- NCT03744897
- Testing
- Hypnotic analgesia, a-tDCS, Hypnotic analgesia + a-tDCS
- Where
- 2 sites in Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Pain, Acute, Postoperative Pain
Bupivacaine Versus Bupivacaine Plus Lidocaine in Infraclavicular Block
In this study, the investigators will compare two different anesthetic solutions in the infraclavicular block in patients having forearm, wrist, and hand surgery.
- Conditions
- Pain, Acute, Postoperative Pain, Analgesia
- Trial name
- NCT05834023
- Testing
- Bupivacaine-Lidocaine, Bupivacaine
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Hospital de San Carlos Dr. Benicio Arzola Medina
Radiculopathy, Lumbosacral Region, Back Pain With Radiation
Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.
This will be a placebo controlled, randomized, double-blind, comparative effectiveness study, in which we patients are enrolled during an emergency department (ED) visit for acute radicular low back pain (LBP) and followed by…
- Conditions
- Radiculopathy, Lumbosacral Region, Back Pain With Radiation, Low Back Pain
- Trial name
- NCT05721027
- Testing
- Ibuprofen 400 mg, Dexamethasone Oral, Educational Intervention
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Coronary Artery Disease
Pre-hOspital Evaluation of Chest Pain Patients With sUspected Non ST-segment eLevation myocARdial Infarction Using the HEART-score With a Troponin Point-of-care Test
Overcrowding in the emergency department is an increasing problem in hospitals worldwide. Point-of-care Troponin (POC cTn) testing combined with a well investigated risk stratification tool (HEART-score) used in the ambulance may…
- Trial name
- POPular HEART (NCT04851418)
- Testing
- Possible NSTE-ACS
- Where
- 2 sites in Netherlands
- Volunteers
- 650 people
- Sponsor
- St. Antonius Hospital
Acute Pain
Acupuncture for Acute and Chronic Pain in Air Force Personnel
The purpose of this project is to conduct a scientifically rigorous investigation of the clinical outcomes, quality of life, and cost associated with the delivery of acupuncture in the treatment of acute and chronic pain in…
- Trial name
- NCT00286390
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Samueli Institute for Information Biology
Myocardial Ischemia
MCG for Non-Obstructive Myocardial Ischemia
The aim of this prospective study is to identify Non-Obstructive Myocardial Ischemia of patients who have acute chest pain using Magnetocardiography.
- Trial name
- NCT07657546
- Testing
- Magnetocardiography
- Where
- China
- Volunteers
- 3,786 people
- Sponsor
- Qilu Hospital of Shandong University
Coronary Disease, Acute Coronary Syndrome
European Survey of Cardiovascular Disease Prevention, Diabetes and Chronic Kidney Disease (EUROASPIRE VI)
The goal of this observational study is to provide a unique European picture of preventive action by cardiologists, other specialists and primary care physicians looking after patients with coronary heart disease (CHD)…
- Conditions
- Coronary Disease, Acute Coronary Syndrome, Unstable Angina, ST Elevation Myocardial Infarction
- Trial name
- EUROASPIRE VI (NCT06495177)
- Where
- Turkey (Türkiye)
- Volunteers
- 8,000 people
- Sponsor
- European Society of Cardiology
Oncology, Pain, Acute
Utility of an APP for the Monitoring of Irruptive Oncological Pain
The present investigation aims at exploring the effect of including a pain app called Pain Monitor irruptive oncological pain for chronic pain patients' daily monitoring. Two conditions will be set: 1.
- Conditions
- Oncology, Pain, Acute, Pain, Chronic
- Trial name
- NCT03597737
- Testing
- Pain APP
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- Universitat Jaume I
Emergency Service, Hospital, Child/Adolescent Problem
A RCT of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture
MSK-I is the most common cause for ED visits for children with pain, with a child's risk of sustaining a fracture ranging from 27-42% by the age of 16 years.
- Conditions
- Emergency Service, Hospital, Child/Adolescent Problem, Acute Pain, Fentanyl
- Trial name
- CAST (NCT02985177)
- Testing
- INF2.0 + IBU, INF1.0 + IBU
- Where
- 3 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Justine's Hospital