Clinical trials: Pain Trajectories
Failed Back Surgery Syndrome, Spinal Cord Stimulation
Return to Work for Persistent Spinal Pain Syndrome Type II Patients
A multicenter randomized controlled trial will be conducted to evaluate whether the ability to work in Persistent Spinal Pain Syndrome Type II (PSPS-T2) patients after SCS implantation is different after a personalized…
- Trial name
- OPERA (NCT05269212)
- Testing
- Usual Care trajectory, A biopsychosocial rehabilitation program
- Where
- 5 sites in Belgium
- Volunteers
- 112 people
- Sponsor
- Moens Maarten
Acute Postoperative Pain, Trajectory
Pain Trajectories and Predictors After Noncardiac Surgery in Elderly Patients
This study will use group-based trajectory modeling to identify the different postoperative pain trajectory groups that exist in a mixed surgical population (non-cardiac surgery) of elderly patients during the first seven days…
- Trial name
- NCT05865366
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Feng Gao
Endometriosis, Postoperative Pain
Postoperative Pain Trajectories After Endometriosis Surgery
The pain associated with endometriosis reflects a multifactorial pathophysiology combining peripheral nociception, central sensitisation and psychosocial factors.
- Conditions
- Endometriosis, Postoperative Pain, Pain Trajectories, Chronic Postsurgical Pain
- Trial name
- TRACK-ENDO (NCT07882498)
- Testing
- Perioperative quantitative sensory testing, questionnaire
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chronic Pain
Pain Trajectories in Severe Persistent Inguinal Post-herniorrhaphy Pain
Severe persistent postsurgical pain (PPP) remains a major healthcare challenge. In the third most common surgical procedure in the UK, inguinal herniorrhaphy, including 85,000 surgeries in 2015, an estimated 1,500 to 3,000…
- Trial name
- NCT03881124
- Volunteers
- 95 people
- Sponsor
- University of Copenhagen
Postoperative Pain
Prospective External Validation of an Early Prediction Model for Adverse Postoperative Pain Trajectories After Orthopedic Surgery
This prospective observational study will externally validate a previously developed and locked prediction model for identifying adult patients at risk of adverse postoperative pain trajectories after elective orthopedic surgery.
- Trial name
- NCT07846878
- Testing
- Elective Orthopedic Surgery
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Breast Neoplasms
Acute Pain Trajectories and Persistent Pain After Breast Cancer Surgery
Persistent pain after breast cancer surgery (PPBCS) is a significant clinical problem, affecting between 25 and 50% of patients. Several factors are associated with the development of PPBCS, including acute postoperative pain.
- Trial name
- NCT02823015
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Intracerebral Hemorrhage, Hemorrhagic Stroke
Outcome Prediction and Recovery After Spontaneous Intracerebral Haemorrhage
Spontaneous intracerebral haemorrhage (ICH) is a severe form of stroke with high mortality and frequent long-term disability. Current tools to predict how an individual patient will recover are limited.
- Trial name
- CR-4-Health (NCT07882784)
- Where
- 3 sites in Austria, Slovenia
- Volunteers
- 300 people
- Sponsor
- University Medical Centre Maribor
Surgery-Complications, Anesthesia Complication
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major…
- Conditions
- Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia
- Trial name
- THRIVE (NCT05991453)
- Testing
- Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent
- Where
- 24 sites in United States
- Volunteers
- 13,000 people
- Sponsor
- Washington University School of Medicine
Surgical Procedures, Operative, Pain
Characterization of Post-operative Pain Trajectories Over Seven Days and Links With Chronicity
The main objective of this study is to establish the postoperative "pain pathways" observed from D1 to D7 in the context of the current management after orthopedic, digestive, obstetrics and gynecology, urology, neurosurgery…
- Conditions
- Surgical Procedures, Operative, Pain, Chronic Pain
- Trial name
- PATCH (NCT02599233)
- Testing
- Telephone conctact at 3 months, In hospital pain evaluation, In hospital questionnaires
- Where
- France
- Volunteers
- 392 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Surgery--Complications, Anesthesia Complication
THRIVE Feasibility Trial
To evaluate the feasibility of a pragmatic, large scale, comparative effectiveness, randomized evaluation of patient experience of intravenous propofol versus inhaled volatile anesthesia.
- Conditions
- Surgery--Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia Emergence Delirium
- Trial name
- THRIVE (NCT05346588)
- Testing
- Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Chronic Postsurgical Pain, Acute Postoperative Pain
Persistent Pain and Its Impact on Daily Life After Lung Surgery
This study will examine how pain changes over the first six months after lung surgery and how it affects daily life. It will include adults scheduled for surgery to remove part or all of a lung.
- Conditions
- Chronic Postsurgical Pain, Acute Postoperative Pain, Pain-Related Functional Interference
- Trial name
- NCT07853456
- Testing
- Longitudinal Assessment of Pain and Pain-Related Functional Interference
- Volunteers
- 350 people
- Sponsor
- Aerospace Center Hospital
Acute Low Back Pain, Chronic Low Back Pain (CLBP)
Exploring Multidimensional Trajectories in People With Low Back Pain
Low back pain (LBP) is a major health problem in Switzerland and worldwide. Globally, LBP remains the leading cause of years lived with disability and its incidence and associated socioeconomic consequences are predicted to…
- Trial name
- NCT07176845
- Testing
- Observational
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Bern University of Applied Sciences
Postoperative Cognitive Dysfunction, Depressive Symptoms
Perioperative Cognitive Trajectories in Deferred Surgery (CoTELE-SURGE)
Cognition is the way people use their brains to think, understand, remember and make decisions. Cognitive changes are often seen even up to 1 year after surgery.
- Conditions
- Postoperative Cognitive Dysfunction, Depressive Symptoms, Postoperative Pain
- Trial name
- CoTELE-SURGE (NCT04787536)
- Testing
- Non-cardiac surgery
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- McMaster University
Low Back Pain, Triage
The Effect of Chiropractor-informed Triage on Low Back Pain Patient Outcomes and Trajectories
Almost everyone will have low back pain (LBP) at some point in their lives. LBP is a complex multifactorial condition for which diagnosis and clinical management remains a challenge.
- Trial name
- NCT04923308
- Testing
- Triage results disclosed, Triage results undisclosed
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- Université du Québec à Trois-Rivières
Hand Osteoarthritis
Hand Osteoarthritis: Investigating Pain Trajectories and Association With Biomarkers Including Estrogen Cohort
Adults with painful hand osteoarthritis are invited to take part in this observational cohort study. The course of hand pain can vary and is not well understood - some people seem to have short episodes of worsening pain…
- Trial name
- HOPE-c (NCT05105854)
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Oxford
Surgical Procedures, Operative, Pain
Evaluation of Pain Trajectories After Surgery and Their Potential Relationship With Chronicity at 3 Months
The effective management of acute postoperative pain remains a daily challenge despite the organizational efforts made and the techniques put in place.
- Conditions
- Surgical Procedures, Operative, Pain, Chronic Pain
- Trial name
- ETADOL (NCT05326737)
- Testing
- In hospital pain evaluation, In hospital questionnaires, Telephone contact at 3 months
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Low Back Pain, Neck Pain
Applying Artificial Intelligence in Developing Personalized and Sustainable Healthcare for Spinal Disorders
The primary objective is to use machine learning methods on large survey and health register data to identify participants with different treatment trajectories and health outcomes after surgical and/or conservative treatment for…
- Conditions
- Low Back Pain, Neck Pain, Disc Herniation, Disc Degeneration
- Trial name
- AID-Spine (NCT05745129)
- Where
- Norway
- Volunteers
- 165,000 people
- Sponsor
- Oslo Metropolitan University
PTSD, Depression
Impact of Modifiable Psychosocial Factors on Veterans' Long-term Trajectories of Functioning and Quality of Life
This study is Phase 3 of Project SERVE (Study Evaluating Returning Veterans' Experiences). Through two prior phases, SERVE has followed a cohort of post-9/11 Veterans since 2010 and has identified numerous risk and protective…
- Conditions
- PTSD, Depression, Chronic Pain, Alcohol Use Disorder
- Trial name
- SERVE:IMPACT (NCT03615222)
- Where
- 2 sites in United States
- Volunteers
- 377 people
- Sponsor
- VA Office of Research and Development