Clinical trials: Palliative Radiotherapy
Bone Metastases
Dexamethasone for Pain Flare After Radiotherapy of Painful Bone metastasesZonMW 11510009
Cancer patients with pain due to bone metastases are often treated with external irradiation in order to reduce pain. However, patients may experience a temporary increase of pain shortly after irradiation, a so-called pain…
- Trial name
- NCT01669499
- Testing
- Dexamethasone acetate
- Where
- 2 sites in Netherlands
- Volunteers
- 411 people
- Sponsor
- UMC Utrecht
Sarcoma
Radiation Therapy as Palliative Treatment of GIST
Gastrointestinal stromal tumors (GISTs) are generally considered resistant to radiation, but no prospective trials addressing efficacy and tolerability of radiation therapy have been carried out.
- Trial name
- GIST-RT (NCT00515931)
- Testing
- Radiation therapy (external beam photons)
- Where
- Finland
- Volunteers
- 25 people
- Sponsor
- Heikki Joensuu
Head and Neck Neoplasms
Comparing Two Palliative Schemes of Radiotherapy for Head and Neck Cancer
RCT to compare two radiation schemes for palliative HeadNeck cancer
- Trial name
- COOPERATION (NCT02421458)
- Testing
- 6 x 6 Gy, 16 x 3.125 Gy
- Where
- 11 sites in Netherlands
- Volunteers
- 36 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer, Advanced Breast Cancer
Hypo-Fractionated Radiotherapy in Breast Cancer
This is a prospective interventional phase I/II study which will be done at Tata Medical Centre, Kolkata. Total 30 eligible female patients, ≥18 years of age, with locally advance invasive carcinoma of breast, not amenable to…
- Conditions
- Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer
- Trial name
- HYPORT-B (NCT03669497)
- Testing
- Hypo fractionated whole breast radiotherapy
- Where
- India
- Volunteers
- 33 people
- Sponsor
- Tata Medical Center
Bone Cancer Metastatic
A Multi-Center Observational Trial of Symptomatic, High-Risk Bone Metastases Treated With Percutaneous Ablation and Palliative Radiation Therapy
The objective of this study is to evaluate real-world outcomes (e.g., pain, patient reported outcomes, skeletal related events, healthcare utilization, etc.) in patients treated with both percutaneous ablation and palliative…
- Trial name
- TRIBUTE (NCT06859801)
- Testing
- Percutaneous Ablation, Radiation Therapy
- Where
- 8 sites in United States
- Volunteers
- 120 people
- Sponsor
- Society of Interventional Oncology
Bone Metastases, Radiotherapy
Short Course Radiation Therapy in Palliative Treatment of Complicated Bone Metastases
Aim of the study is to assess efficacy of a short course radiation treatment in patients with complicated bone metastases
- Conditions
- Bone Metastases, Radiotherapy, Palliative Care
- Trial name
- NCT03503682
- Testing
- standard treatment, short course treatment
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cancer Metastatic
Access to Single-Fraction Palliative Radiation Therapy in Cancer Patients Enrolled in Hospice
Feasibility study to report on the impact of ACCESS of single-fraction radiation therapy on cancer patients with bone metastases enrolled in hospice care.
- Trial name
- SFPRT (NCT04049188)
- Testing
- Single-Fraction Palliative Radiation Therapy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Care Partners
Digestive System Neoplasms
IP rmhTNF-NC + Tislelizumab + Palliat RT for GIT Tumor Malignant Ascites After Failed Std Tx
This study is a prospective, non-randomized, dual-cohort Phase II clinical trial designed to explore the efficacy and safety of radiotherapy combined with intraperitoneal injection of Recombinant Mutant Human Tumor Necrosis…
- Trial name
- NCT07196540
- Testing
- Radiotherapy for large-volume abdominal lesions + whole peritoneal cavity low-dose radiotherapy + rmhTNF-NC + tislelizumab
- Volunteers
- 78 people
- Sponsor
- Sun Yat-sen University
Recurrent Follicular Lymphoma
Efficacy of Palliative Low-Dose Involved-Field Radiation Therapy for Recurrent Advanced Follicular Lymphoma
Many trials that patients with advanced or recurrent indolent lymphoma managed with very low-dose (4Gy) limited-field RT (LD-IFRT) have shown that high response rates and durable remission can be achieved.
- Trial name
- WUCC-NHL02 (NCT02438501)
- Testing
- Low-dose involved-field radiotherapy, Involved-field radiotherapy
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Di Deng
Radiation Toxicity, Chemotherapeutic Toxicity
Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2022 and 2025
The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms, who have been referred to the HUGCDN Chronic Pain Unit for adjuvant palliative treatment with…
- Conditions
- Radiation Toxicity, Chemotherapeutic Toxicity, Chemotherapy-induced Peripheral Neuropathy, Delayed Wound Healing
- Trial name
- EPOOzo (NCT05417737)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Bernardino Clavo, MD, PhD
Palliative Care
2D-radiotherapy in Palliation of Advanced Esophageal Cancer
The study wants to define the efficacy of a short course 2D-radiation therapy in patients with symptomatic advanced esophageal cancer.
- Trial name
- SHARON-2D (NCT03922152)
- Testing
- Short course radiotherapy
- Volunteers
- 17 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Rectal Neoplasms
Palliative Short-Course Radiotherapy in Rectal Cancer
Radiotherapy (RT) is a potentially effective method in the treatment of symptoms of rectal carcinomas. Nevertheless, almost all the evidences about palliative RT in rectal cancer have been published more than two decades ago and…
- Trial name
- NCT02639403
- Testing
- Conformal three-dimensional Radiotherapy
- Volunteers
- 18 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Radiodermatitis; Acute, Radiotherapy Side Effect
The Use of Photobiomodulation in the Management of Radiodermatitis in Patients in Palliative Care. A Prospective Study.
It is estimated that there will be 670,000 new cases of cancer worldwide in 2020-2022 and it is known that the most commonly instituted treatments in cancer are chemotherapy, radiotherapy and surgery.
- Conditions
- Radiodermatitis; Acute, Radiotherapy Side Effect, Cancer Patients, Palliative Care
- Trial name
- NCT05561803
- Testing
- Photobiomodulation Therapy
- Where
- Brazil
- Sponsor
- University of Nove de Julho
Bone Metastases, Radiotherapy
Pain Relief in Symptomatic Bone Metastases With Adjuvant Hyperthermia MR Guided HIFU
Metastatic disease to the bone is a common cause of pain. External beam radiation therapy (EBRT) is the standard palliative treatment BUT pain improvement is observed in 60% to 80%.
- Conditions
- Bone Metastases, Radiotherapy, Pain, MRI
- Trial name
- BM-RT-HIFU (NCT05167669)
- Testing
- HIFU-MRI guided
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Sana Boudabbous
Cancer, Radiotherapy
Prognosis of Patient Evaluated for Palliative Radiotherapy
Many patients with incurable cancer will receive palliative oncological treatment before their death, and radiotherapy (RT) is an important element of this.
- Trial name
- PROPER (NCT03797755)
- Testing
- palliative radiotherapy
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Tuen Mun Hospital
Palliative, Advanced Cancer
Immunotherapy And Palliative Radiotherapy Combined In Patients With Advanced Malignancy
Immunotherapy includes a class of medication called checkpoint inhibitors, which are a relatively new medication therapy for many types of cancer which are metastatic, meaning it has spread to other parts of the body.Immune…
- Conditions
- Palliative, Advanced Cancer, Immunotherapy, Radiation Therapy
- Trial name
- NCT03042156
- Testing
- Palliative Radiation Therapy
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University Health Network, Toronto
Neoplasm Metastasis, Bone Neoplasms
The Palliative Radiotherapy And Inflammation Study - PRAIS
Radiation therapy (RT) is one of the primary treatments for bone cancer pain due to metastatic cancer disease. About 6 of 10 patients obtain pain relief from RT.
- Trial name
- PRAIS (NCT02107664)
- Testing
- Palliative RT for bone cancer pain
- Where
- 3 sites in Norway
- Volunteers
- 580 people
- Sponsor
- Norwegian University of Science and Technology
Patients With Symptomatic or Bulky Tumors (More Than 8 cm) or With Tumors Resistant to Radiation
GRID Therapy as Palliative Radiation for Patients With Advanced and Symptomatic Tumors
Palliative radiation therapy represents 40% of the on-going radiation at the Jewish General Hospital. In a traditional palliative radiation treatment to bulky or radioresistant tumors, radiotherapy schema varies from 24 to 30 Gys…
- Trial name
- NCT02333110
- Testing
- spatially fractionated radiation therapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Bone Metastases in Subjects With Advanced Cancer, Radiotherapy
Timely Integration of Palliative Care in Oncology Care for Patients Referred for Palliative Radiotherapy on Bone Metastases: A Randomized Trial
Rationale: With improvements in systemic tumour-directed treatments for primary tumours, survival rates for patients with bone metastases are improving.
- Trial name
- TIPZO-RT (NCT06805396)
- Testing
- Palliative Care Consult
- Where
- 5 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Roxanne Gal
Bone Metastases
Dexamethasone vs Placebo in the Prophylaxis of Radiation-Induced Pain Flare Following Palliative Radiotherapy for Bone Metastases
This research is being done because is is not known if dexamethasone can prevent pain flare (their pain temporarily gets worse before it gets better) caused by the radiation used to treat painful bone metastases.
- Trial name
- NCT01248585
- Testing
- Dexamethasone
- Where
- 22 sites in Canada
- Volunteers
- 298 people
- Sponsor
- NCIC Clinical Trials Group