Clinical trials: Pancreatic Beta Cell Function
Type 1 Diabetes, Type 2 Diabetes
Glucotoxicity and Acute Exercise
Experimental hyperglycemia (5 hours) will be induced via a constant- or fluctuating-rate glucose infusion to establish different patterns of glycemia in healthy individuals.
- Trial name
- NCT01771614
- Testing
- Exercise, Hyperglycemia
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Type 1 Diabetes
Combination Therapy With Sitagliptin and Lansoprazole to Restore Pancreatic Beta Cell Function in Recent-Onset Type 1 Diabetes
Sanford Research/USD proposes to study the combination therapy of oral administration of sitagliptin and lansoprazole versus placebo for the preservation of pancreatic beta cells still present in patients with recent-onset…
- Trial name
- REPAIR-T1D (NCT01155284)
- Testing
- Sitagliptin and Lansoprazole
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sanford Health
Advanced Glycation Endproducts, AGEs
Restriction of Dietary AGEs to Prevent Diabetes in Overweight Individuals
Current efforts to arrest the epidemic of type 2 diabetes mellitus (T2DM) have had limited success. Thus there is an urgent need for effective approaches to prevent the development of T2DM.
- Conditions
- Advanced Glycation Endproducts, AGEs, Diet, Insulin Sensitivity/Resistance
- Trial name
- NCT03866343
- Testing
- Diet low or high in advanced glycation endproducts
- Where
- Netherlands
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity, Insulin Resistance
Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study)
The undercarboxylated fractions of the two vitamin K-dependent proteins osteocalcin and matrix Gla protein have been shown to play key roles in type 2 diabetes and cardiovascular disease (at least in mouse models).
- Conditions
- Obesity, Insulin Resistance, Insulin Sensitivity, Prediabetes
- Trial name
- NCT01972113
- Testing
- Low-Dose Vitamin K2 (menaquinone-7; 45 mcg/d), High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Diabetes Mellitus
Defining the Molecular and Physiological Mechanisms of Pancreatic Islet Cell Dysfunction Which Lead to Type 2 Diabetes
Defects in insulin secretion are central to the pathogenesis of type 2 diabetes (T2D) but the molecular basis and physiological consequences of those defects are poorly understood, impeding efforts to develop novel therapeutic…
- Trial name
- DIVA-Exeter (NCT02505308)
- Testing
- Glucose-Potentiated Arginine-Induced Insulin Secretion
- Where
- 2 sites in United Kingdom
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Type 2 Diabetes Mellitus
Ghrelin and Beta Cell Function in Diabetes
Ghrelin is a hormone naturally produced in the stomach and the gut. The purpose of this research study is to determine the role of this gut hormone in the regulation of insulin secretion from the pancreas and glucose disposal…
- Trial name
- NCT02440061
- Testing
- Synthetic human AG, Arginine, 0.9% saline solution
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jenny Tong, MD, MPH
Obesity, Insulin Resistance
Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes (Vita-K 'n' Adults Study)
Given that glutamate carboxylation or decarboxylation is key to the metabolic role of osteocalcin (at least in mouse models) and that carboxylation is vitamin K dependent, it is critical to isolate the effect of vitamin K…
- Conditions
- Obesity, Insulin Resistance, Insulin Sensitivity, Beta-Cell Dysfunction
- Trial name
- NCT02366481
- Testing
- Low-Dose Vitamin K2 Supplement (menaquinone-7; 90-mcg/d), High-Dose Vitamin K2 Supplement (menaquinone-7; 180-mcg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Turner Syndrome
Beta Cell Function in Women With Turner Syndrome
Diabetes is more frequent in women with Turner syndrome. The purpose of this study is to see, in what ways the glucose metabolism is different in this study population.
- Trial name
- NCT00419107
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Generation of Anti COVID-19 Antibodies in a Fetus, Whose Mother Was Exposed to COVID or Was Vaccinated During Pregnancy
COVID 19 ANTOBODIES IN PREGNANT WOMEN AND THEIR CONNECTION TO BETA CELL FUNCTION IN THE FETUS
The aim of this study is to check for the presence of COVID 19 antibodies [Covid-19, GAD-65, IA-2, ICA] in the blood of laboring women who have been exposed to either the virus itself or to the vaccine during pregnancy .
- Trial name
- NCT04860908
- Testing
- no intervention, observation only
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maaynei Hayesha Medical Center
Type 2 Diabetes
Impact of Breakfast Composition on Glycemic and Incretin Responses in Individuals With Type 2 Diabetes
This study examined the effect of a high protein or high carbohydrate breakfast on the glucose and insulin response following the breakfast meal, as well as the subsequent response following the lunch meal.
- Trial name
- NCT02180646
- Testing
- High protein breakfast, High carb breakfast
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Type 2 Diabetes Mellitus
Xenin-25: Novel Regulator of Insulin Secretion and Beta-cell Function
An intestinal hormone called Glucose-dependent Insulinotropic Polypeptide (GIP) is released into the blood immediately after ingestion of a meal and plays an important role in regulating blood sugar levels.
- Trial name
- NCT00949663
- Testing
- Glucose-dependent Insulinotropic Polypeptide (GIP), Xenin-25, Glucose-dependent Insulinotropic Polypeptide plus Xenin-25
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
PreDiabetes
A Trial to Assess Diets Containing Beef vs. Poultry on Pancreatic Beta-Cell Function
The objective of this study is to assess and compare the effects of usual diets containing lean beef vs. lean poultry on pancreatic beta-cell responses in men and women with prediabetes.
- Trial name
- NCT05456477
- Testing
- Beef, Poultry
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Overweight
Diurnal Variability in the Regulation of Beta-cell Function and Insulin Sensitivity in Overweight People
The purpose of this research study is to learn more about how our body produces sugar, breaks down fat for fuel, and makes insulin (the major hormone that controls the production of blood sugar and fat breakdown) during a 24-hour…
- Trial name
- 24Hr (NCT02011581)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes Mellitus, Steroids
Incretin Physiology Associated With Steroid Hormone Treatment
The purpose of this study is to evaluate whether the reduced incretin effect and the paradoxical glucagon responses during oral glucose ingestion and isoglycaemic iv glucose infusion observed in patients with type 2 diabetes are…
- Trial name
- NCT00713440
- Testing
- Oral glucose test (OGTT); isoglycaemic iv. clamp; liquid meal test; Gastric Emptying Rate; Prednisolone; Paracetamol
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Insulin Sensitivity
Insulin Sensitivity and Beta Cell Function After Carbohydrate Loading in Hip Replacement Surgery
The purpose of this study is to determine whether preload of carbohydrate or water before elective hip replacement improve insulin sensitivity and or beta cell function in human.
- Trial name
- NCT01774084
- Testing
- Experimental: PreOp, NutriciaNordica AB
- Where
- 2 sites in Sweden
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Type 2 Diabetes Mellitus
The Verona Newly Diagnosed Type 2 Diabetes Study
Type 2 diabetes mellitus is a complex disease whose clinical phenotype results from the variable combination of genetic and nongenetic factors.
- Trial name
- VNDS (NCT01526720)
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Healthy
Postprandial Insulin Secretion and Appetite Regulation After Moderate Alcohol Consumption
A body of epidemiologic studies show that moderate alcohol consumption is associated with a protective effect against type 2 diabetes.
- Trial name
- NCT00524550
- Testing
- moderate alcohol consumption
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TNO
Gestational Diabetes Mellitus
Insulin Action During Pregnancy in Woman at High Risk for Gestational Diabetes
The project objective is to validate a new indirect estimate of insulin status in both pregnant African-American women and Caucasian women in southern Louisiana who are at risk for gestational diabetes mellitus.
- Trial name
- DRM (NCT00687479)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Woman's
Gestational Diabetes
Can Resveratrol Improve Insulin Sensitivity and Preserve Beta Cell Function Following Gestational Diabetes?
The purpose of this study is to determine if resveratrol supplementation preserves beta cell function and insulin sensitivity in post-partum women following a first diagnosis of gestational diabetes.
- Trial name
- NCT01997762
- Testing
- Resveratrol
- Where
- Canada
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Manitoba