Clinical trials: Particle Therapy
Melanoma, Soft Tissue Sarcoma
Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization
The goal of this phase I trial is to evaluate the toxicity and feasibility of a tumor-specific RNA-NP vaccine in patients with stage IIB-IV melanoma who have evidence of progressive disease by RECIST 1.1 criteria while receiving…
- Trial name
- NCT05264974
- Testing
- Autologous total tumor mRNA loaded DOTAP liposome vaccine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Florida
Sarcoma,Soft Tissue, Brachytherapy
Brachytherapy (Iodine-125 Seeds) and Fluzoparib Combination Therapy for Advanced Unresectable Soft Tissue Sarcoma
To evaluate the effectiveness and safety of radioactive particles in combination with the PARP inhibitor fluzoparib in the treatment of advanced inoperable soft tissue sarcoma.
- Conditions
- Sarcoma,Soft Tissue, Brachytherapy, Poly(ADP-ribose) Polymerase Inhibitors
- Trial name
- RAFAS-001 (NCT05894018)
- Testing
- Fluzoparib, Radioactive particle implantation
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Fujun Zhang
Atherosclerosis, Hypercholesterolemia
Investigating the Effects of Lipid-therapy Intensification With Alirocumab on Endothelial Function, Carotid Arteries, Lipoprotein Particle Subfractions, Inflammation and Post-prandial Lipemia
A prospective, open-label, pilot study with 24 cardiovascular high risk patients (N=24) having insufficient Low density lipoprotein cholesterin (LDL-C) reduction despite standard of care lipid-modifying therapies (LMTs), to…
- Conditions
- Atherosclerosis, Hypercholesterolemia, Post Prandial Lipemia, Cardiovascular Diseases
- Trial name
- ALIROCKS (NCT03559309)
- Testing
- Magnet Resonance Tomography, Carotid Arteries Sonography, Flow-mediated Dilation, Fat-tolerance Test, Laboratory Testing
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Graz
Particle Therapy
Innovative SolutIons for DosimEtry in Hadrontherapy (INSIDE)
The study aim is to test the clinical feasibility and effectiveness of an online qualitative monitoring device named INSIDE system during hadrontherapy treatments.
- Trial name
- INSIDE (NCT03662373)
- Testing
- carbon ions radiation therapy, protons radiation therapy
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- CNAO National Center of Oncological Hadrontherapy
Non-small Cell Lung Cancer
Randomized Study of Carbon Ion Boost in Hypoxic Lesions for Locally Advanced Non-small Cell Lung Cancer
The goal of this randomized clinical trial is to learn about if carbon ion radiotherapy dose boost in hypoxia lesions detected by 18F-Misonidazole PET/CT could improve clinical outcomes in locally advanced non-small cell lung…
- Trial name
- NCT06205927
- Testing
- Standard carbon ion beam radiotherapy, Carbon ion beam radiotherapy simultaneously dose boost
- Where
- China
- Volunteers
- 77 people
- Sponsor
- Jian Chen
Diabetic Gastroparesis
Evaluation of Diagnostic Methods and Dietary Treatment of Diabetic Gastroparesis
The objective of the study is in subjects with Insulin Treated Diabetes Mellitus type 1 or 2 and gastroparesis: validate radiopaque markers with fluoroscopy with gastric scintigraphy method study the difference of metabolic…
- Trial name
- NCT01557296
- Testing
- dietary treatment: food of small particle size, Validate X-ray diagnostic method., Can the motility be improved
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Göteborg University
Healthy
Bioequivalence Study of Divalproex Sodium Capsules(Sprinkle),125 mg of Dr. Reddy's Under Fasting Condition (Apple Sauce)
An open label, balanced, randomized, two-treatment, two-period, two-sequence, single dose, crossover, bioequivalence study of Divalproex Sodium coated particles in capsules 125 mg with Depakote® Sprinkle125 mg capsules in…
- Trial name
- NCT01132183
- Testing
- Divalproex Sodium
- Where
- India
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Healthy
A Pharmacokinetic Study of Three Different Particle Sizes of PH-797804
The purpose of this study is to investigate the effects of varying particle size on the pharmacokinetics of PH-797804
- Trial name
- NCT01924650
- Testing
- PH-797804
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Periodontitis
Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment
Periodontitis is a destructive chronic inflammatory disease characterized by periodontium damage and pocket formation between the tooth and the gingival margin resulting in ultimate tooth loss.
- Trial name
- NCT05583643
- Testing
- Atorvastatin Calcium, Scaling and debridement only
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Chronic Obstructive Pulmonary Disease
Assess Particle Deposition and Acute Effects of Symbicort® Forte Turbohaler®) in COPD Patients.
Computational Fluid Dynamics (CFD) is a new functional imaging method. Since CFD is very sensitive to detect small changes, it might be worthwhile to study the acute effect of formoterol and budesonide combination therapy…
- Trial name
- NCT01329276
- Testing
- Symbicort® forte Turbohaler®
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Antwerp
Carcinoma, Hepatocellular
Therapeutic Effect of Ethanol-gelfoam Mixture for the Treatment of Arterioportal Shunts (APS) in Patients With HCC
Transcatheter arterial chemoembolization (TACE) is a key palliative treatment for patients with inoperable hepatocellular carcinoma (HCC).
- Trial name
- NCT02338297
- Testing
- TACE, EGM, PVA
- Where
- 2 sites in China
- Volunteers
- 236 people
- Sponsor
- Nanjing Medical University
Asthma
Qvar Versus Clenil, a General Practice Research Database Study
This study will compare the absolute and relative effectiveness of asthma management in patients on inhaled corticosteroid (ICS) maintenance therapy as either extra-fine-particle or larger-particle formulation beclomethasone…
- Trial name
- NCT01400217
- Testing
- extra fine particle hydrofluoroalkane beclomethasone dipropionate via metered dose inhaler, standard particle particle hydrofluoroalkane beclomethasone dipropionate via metered dose inhaler
- Where
- United Kingdom
- Volunteers
- 56,985 people
- Sponsor
- Research in Real-Life Ltd
Recurrent Osteosarcoma
Single-Patient Expanded Access Protocol - RNA-LP in a Patient With Recurrent Osteosarcoma
Treatment of a patient with recurrent osteosarcoma with personalized pp65/tumor mRNA RNA-LP under an individual patient expanded access protocol.
- Trial name
- NCT07560709
- Testing
- pp65/tumor mRNA RNA-LP
- Where
- United States
- Sponsor
- University of Florida
Apical Extrusion During Root Canal Treatment
Measuring Apical Debris Extrusion With a Novel Laboratory Technique
Endodontic treatment occupies a critical role in dentistry, serving to prolong the longevity of teeth within the oral cavity and prevent early tooth loss.
- Trial name
- NCT07341451
- Testing
- ProTaper Gold Rotary File System, ProTaper Next Rotary File System
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Fatma Selenay Ucas Yildiz
Inflammatory Bowel Disease
Immunogenicity to Human Papillomavirus Vaccine (Gardasil) Among IBD Patients on Immunosuppressive Therapy
Many IBD patients take immunosuppressive agents and we are uncertain as to their capacity to mount a truly protective response after vaccination.
- Trial name
- HPV (NCT00727636)
- Testing
- Gardasil vaccine
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Boston Children's Hospital
Acne Vulgaris
Long-term Follow-up Study of Subjects Who Completed Clinical Studies 755.1100_FA, 810.1100_FA, or 1064.1100_FA
This study evaluates the safety, effectiveness, and maintenance of effect of a novel topical silver particle solution (Sienna 755.1100, 810.1100, or 1064.1100) used in conjunction with a laser for the treatment of Acne Vulgaris.
- Trial name
- NCT03039634
- Where
- 16 sites in United States
- Volunteers
- 76 people
- Sponsor
- Sienna Labs
Thyroid Neoplasms
Clinical Efficacy of 125I Seed Implantation in the Treatment of Refractory Differentiated Thyroid Cancer
A retrospective analysis was conducted on RAIR-DTC patients who underwent radioactive 125I seed implantation from January 2015 to February 2022 at Jiangxi Cancer Hospital. Prescription dose: 80~120 Gy.
- Trial name
- NCT06362772
- Testing
- Iodine-125 brachytherapy
- Volunteers
- 36 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Advanced Hepatocellular Carcinoma (HCC)
A Study Comparing Immunotherapy Alone Versus Immunotherapy Combined With Radiotherapy in Patients With Hepatocellular Carcinoma (HCC) With Vascular Invasion
In the present study, we aim to investigate the efficacy and safety of concurrent therapy of Immunotherapy based combination therapy and Radiotherapy in patients with advanced HCC showing macrovascular invasion.
- Trial name
- IOPT (NCT06828380)
- Testing
- Particle beam radiation therapy
- Where
- 2 sites in South Korea
- Volunteers
- 128 people
- Sponsor
- National Cancer Center, Korea
Asthma
Responsiveness of Lower Airways in Adult Patients (18-60 Years) With Stable Asthma After Treatment With Ciclesonide and Fluticasone Propionate (BY9010/NL-101)
The aim of this study is to compare the responsiveness of lower airways in adult patients with stable asthma after treatment with ciclesonide and fluticasone propionate.
- Trial name
- NCT00306163
- Testing
- Ciclesonide, Fluticasone
- Where
- Netherlands
- Volunteers
- 37 people
- Sponsor
- AstraZeneca
Norovirus Prevention
Safety and Immunogenicity of Norovirus Bivalent Virus-Like Particle Vaccine in Healthy Adults
The purpose of this study is to evaluate the safety of the norovirus bivalent virus-like particle (VLP) vaccine for further development by assessing the rates of serious adverse events (SAEs), unsolicited adverse events (AEs)…
- Trial name
- NCT02142504
- Testing
- Norovirus Bivalent VLP Vaccine
- Where
- 10 sites in United States
- Volunteers
- 454 people, healthy volunteers welcome
- Sponsor
- Takeda