Clinical trials: Pathophysiology
Healthy Participants, Mild Cognitive Impairment
Cognitive Enhancement Through Transcranial Laser Therapy
This is a mechanism-driven translational project to test the efficacy of transcranial low-level light/laser therapy (LLLT), for enhancing cognitive function in middle-aged and older adults and participants with Mild Cognitive…
- Trial name
- LLLT (NCT02851173)
- Testing
- LLLT
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Endothenial Dysfunction, Iron Status
Inflamation, Gut Leakage, Iron Status After 6000m Ergometer Test in Elite Rowers.
The influence of a 6000m ergometer test on the markers of gut injury, endotoxemia, iron status, stress and inflammation in elite rowers.
- Conditions
- Endothenial Dysfunction, Iron Status, Oxidative Stress
- Trial name
- 6000m (NCT06890741)
- Testing
- exercise test
- Where
- Poland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
The Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial
The purpose of this study IS to explore the underlying pathophysiology of chronic fatigue syndrome (CFS) in adolescents, particularly focusing on genetics, infections/immunology, endocrinology, autonomic control and cognitions to…
- Trial name
- NorCAPITAL (NCT01040429)
- Testing
- Clonidine, Lactose capsula
- Where
- Norway
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Breast Cancer-Related Lymphedema, Autonomic Dysfunction
Evaluation of Sympathetic Skin Response and Its Relationship With Clinical Response to Complex Decongestive Therapy in Patients With Postmastectomy Lymphedema
This prospective observational single-center study aimed to evaluate sympathetic skin response (SSR) in patients with postmastectomy upper extremity lymphedema and to investigate the relationship between SSR parameters and…
- Conditions
- Breast Cancer-Related Lymphedema, Autonomic Dysfunction, Postmastectomy Lymphedema
- Trial name
- BCRL-SSR (NCT07585253)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Postmenopausal Women
Vitamin D Deficiency: Bone Loss and Vascular Dysfunction
To learn if there is a connection between low vitamin D level and hardening of the arteries.
- Trial name
- NCT00235586
- Testing
- 10 vit. D deficient subjects take vit. D for 3 months.
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Kansas
Periodontitis, Intimal Medial Thickness of Internal Carotid Artery
PERIODONTITIS AND VASCULAR DYSFUNCTION
The investigators wish to assess whether intensive periodontal therapy will reduce the burden of chronic periodontal disease and will cause regression or prevent progression of atherosclerosis assessed by a surrogate end-point…
- Trial name
- NCT03072342
- Testing
- Intensive Periodontal Treatment, Control Periodontal Treatment
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University College, London
Aging
Technology-assisted Vocal Exercise for Older Adults
Many detrimental effects of aging have been identified in the human voice, most of which are accepted as "normal". However, age-related vocal deficits disrupt communication and decrease quality of life in older adults and may be…
- Trial name
- NCT03015870
- Testing
- Vocal exercise with real-time feedback, Vocal exercise with recording
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Alzheimer's Disease, Mild Cognitive Impairment
A Light Exposure Tracker Designed to Improve Circadian Rhythms - Aim 1
The purpose of this research study is to investigate the relationship between reminder messages sent via text and compliance with a daily morning light intervention designed to advance the circadian clock.
- Trial name
- NCT06356337
- Testing
- Light goggles, Daily reminder test message
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Healthy Aging, Cognitive Decline
Cognitively Enriched Walking Program
Dementia currently affects more than 47 million people worldwide, its prevalence is forecasted to triple by 2050, and it has been reported to be one of the most costly disorders in Belgium.
- Conditions
- Healthy Aging, Cognitive Decline, Physical Inactivity
- Trial name
- NCT05500183
- Testing
- Cognitively enriched walking program, walking program
- Where
- 2 sites in Belgium
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University Ghent
Childhood Obesity, Insulin Resistance
Leipzig Adipose Tissue Childhood Cohort
In this study the investigators hypothesize that pathological alterations in adipose tissue biology already occur during the development and progression of obesity in children and adolescents.
- Trial name
- NCT02208141
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Ventilator Induced Diaphragm Dysfunction
Randomized Study of TransAeris® System in Cardiac Surgery Patients at Risk of Prolonged Mechanical Ventilation
This study will be conducted as a randomized trial of the TransAeris system for the prevention and treatment of ventilator-induced diaphragm dysfunction (VIDD) in patients identified prior to surgery to be at greater risk of…
- Trial name
- ERAS (NCT04899856)
- Testing
- TransAeris
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Synapse Biomedical
Blood Pressure, Endothelial Dysfunction
Neurovascular Effects of Empagliflozin
The goal of this clinical trial is to examine whether empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, improves vascular and autonomic function in adults with prehypertension.
- Trial name
- NEURO-EMPA (NCT07799441)
- Testing
- Empagliflozin (EMPA)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kanokwan Bunsawat
Cognitive Disorders
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of SUVN-G3031 in Healthy Subjects
The purpose of this study is to investigate the safety, tolerability and pharmacokinetics of SUVN-G3031 in healthy male subjects following single or multiple ascending doses.
- Trial name
- NCT02342041
- Testing
- SUVN-G3031
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Suven Life Sciences Limited
Left Ventricular Dysfunction, Ventricular Dysfunction
Low Ejection Fraction in Single Lead ECG- Ochsner
The purpose of this research is to prospectively test and validate the single-lead Low EF algorithm in outpatients in order to test the performance of a single-lead ECG based algorithm to identify people with decreased left…
- Conditions
- Left Ventricular Dysfunction, Ventricular Dysfunction, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT05010642
- Testing
- Use of Eko DUO electronic Stethoscope
- Where
- United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Eko Devices, Inc.
Hepatitis b & Liver Dysfunction
Study on PK of Hydronidone in Patients and Special Population
1. Evaluate the pharmacokinetic (PK) characteristics of Hydronidone capsule in target patients (patients with chronic viral hepatitis b with liver fibrosis) and special population (patients with mild liver dysfunction). 2.
- Trial name
- NCT04123769
- Testing
- Hydronidone
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Beijing Continent Pharmaceutical Co, Ltd.
Acne Vulgaris
Sexual Dysfunction in Female Patients With Adult Acne Vulgaris
Assessment of sexual dysfunction in adult females with acne vulgaris and its relation to other variables as quality of life, acne severity and hormonal dysfunction.
- Trial name
- NCT03879369
- Testing
- Hormonal assay
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Microvascular Dysfunction, Ischaemia With Non Obstructed Coronary Arteries
Mechanisms Behind Microvascular Dysfunction in INOCA
The purpose of the study is to identify the causes of chest pain in patients experiencing chest pain with no signs of narrowing in the coronary arteries of the heart.
- Trial name
- ExINOCA-P1 (NCT06529861)
- Testing
- [15O]H2O-PET Imaging
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Type 2 Diabetes, Coronary Heart Disease
Myocardial Dysfunction in Type 2 Diabetes Mellitus (T2DM)
The purpose of this study is to examine the existence of heart abnormalities in patients with diabetes and the effect of pioglitazone in correcting these abnormalities.
- Trial name
- NCT01588470
- Testing
- pioglitazone
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Radiation Disease
Pelvic Radiation Disease in Childhood Cancer Survivors
This study aims to characterise the impact of radiotherapy on physical symptoms and quality of life in childhood and young adult cancer survivors.
- Trial name
- NCT05533541
- Where
- United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Cerebrovascular Circulation, Cognitive Impairment
Effects of Dietary Nitrate From Vegetable/Fruit Juice on Cerebral Blood Flow Parameters
Nitrate provides the body with an alternative source of Nitric Oxide which plays a large role in promoting blood flow and reducing blood pressure.
- Trial name
- NCT01169662
- Testing
- Vegetable/fruit juice
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northumbria University
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