Clinical trials: Pathophysiology
Alzheimer Disease, Dementia
Movement Intervention for Memory Enhancement
Dancing is a complex sensorimotor rhythmic activity that integrates cognitive, physical, and social components and is applicable to seniors with various fitness levels.
- Conditions
- Alzheimer Disease, Dementia, Cognitive Decline, Cognitive Impairment
- Trial name
- MIME (NCT03475316)
- Testing
- Social Dancing, Treadmill Walking
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Erectile Dysfunction
Differential Plasma MicroRNA Profiles in ED and Normal Erectile Function in Older Males
Erectile dysfunction (ED) is strongly associated with aging. With the rapidly expanding aging population and the increase in life expectancy, an increase in the prevalence of ED is expected in the years to come.
- Trial name
- NCT01830049
- Testing
- Take blood
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
CADASIL
Development and Validation of a Functional MRI Biomarker of Cerebral Small Vessel Dysfunction in CADASIL
Cerebral small vessel diseases (cSVD) are diseases of brain tissue involving vessels (arterioles or capillaries) with a diameter of less than 400 microns.
- Trial name
- fMRI BioSVD (NCT06859658)
- Testing
- Functional MRI at 3T
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Hypoxia, Carotid Stenosis
The Effect of Hypoxic and Normoxic Cerebral Oximetry Levels on Cognitive Functions After Carotid Endarterectomy
In this study, we investigated the effect of the capacity to cope with oxidative stress (oxidative stress response during and after clamping) in individuals with cerebral oximetry level between 40- 60 % and above 60 % and their…
- Conditions
- Cerebral Hypoxia, Carotid Stenosis, Cognitive Dysfunction
- Trial name
- NCT05652426
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Duzce University
Endotoxemia
Anti-inflammatory Effects of Enriched Enteral Nutrition During Human Experimental Endotoxemia
During sepsis and septic shock the immune response can be overwhelming leading to excessive tissue damage, organ failure and death.
- Trial name
- VIHE (NCT01100996)
- Testing
- control enteral nutrition, enriched enteral feeding
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Fibromyalgia, Autonomic Dysfunction
Association Between Autonomic Dysfunction and Choroidal Vascularity Index in Fibromyalgia
Fibromyalgia is frequently accompanied by autonomic nervous system dysfunction, often characterized by sympathetic predominance.
- Trial name
- NCT07345546
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Dementia, Telemedicine
EpxCogScreen -- A Phone-based Rapid Cognitive Screen (RCS)
EpxCogScreen is a phone-based intervention to administer the Rapid Cognitive Screen, a validated screening tool for dementia, over SMS text messaging.
- Conditions
- Dementia, Telemedicine, Cognitive Dysfunction
- Trial name
- NCT03569722
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Theodore Malmstrom, PhD
Cognitive Impairment
Preoperative Cognitive Screening in Older Surgical Patients Utility for Predicting Morbidity
The purpose of this work is to determine whether preoperative cognitive screening of patients over the age of 65 can be used as predictor of postoperative outcomes in patients undergoing lower extremity surgical procedures.
- Trial name
- NCT02598050
- Testing
- No Interventions as this is a observational study
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Mild Cognitive Impairment, Alzheimer Disease
White Matter Hyperintensities in Amnestic Mild Cognitive Impairment or Alzheimer's Disease
This study focuses on assessing and measuring white matter hyperintensities in individuals with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease.
- Trial name
- NCT06179680
- Testing
- Magnetic Resonance Imaging
- Where
- Italy
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Peripheral Vascular Disease, Lipid Disorder
Effect of Plasma Ceramides on Peripheral Vascular Function
The goal of this clinical trial is to determine the effect of elevated plasma ceramides on peripheral vascular function. Subjects will consume a high fat meal consisting of long chain fatty acids (to increase plasma ceramides) or…
- Conditions
- Peripheral Vascular Disease, Lipid Disorder, Endothelial Dysfunction
- Trial name
- NCT05107869
- Testing
- High Saturated Fat
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Anesthesia, Cognitive Dysfunction
Evaluation of Cognitive Functions by Cerebral Pulse Oximetry
General and Spinal Anesthesia can be used in geriatric patients in orthopedic surgery. Post-op cognitive dysfunction can be seen in orthopedic surgeries in this group of patients.
- Trial name
- NCT03827083
- Testing
- cerebral pulse oximetry
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tepecik Training and Research Hospital
Sedentary Time, Insomnia
mPATH for Low-income Older Adults
Although empirical research suggests that physical activity interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is understudied in low-income older adults.
- Conditions
- Sedentary Time, Insomnia, Cognitive Decline
- Trial name
- NCT05935241
- Testing
- mPATH, Attention Control
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Vulvovaginal Atrophy
Clinical Study to Evaluate the Efficacy of Prasterone Treatment for Atrophy Vulvovaginal in Postmenopausal Women With Vulvar / Vestibular Pain
A prospective, open, randomized and controlled clinical intervention study in women over 45 years of age with a diagnosis of vulvovaginal atrophy (dryness and / or dyspareunia, etc.) and vulvar and / or vestibular pain.
- Trial name
- ROSA (NCT04898556)
- Testing
- Prasterone 6.5 MG
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dr. Santiago Palacios
Alzheimer Disease, Healthy Aging
Developing an Artificial Intelligence System to Detect Cognitive Impairment
Alzheimer's disease dementia (AD) is a debilitating and prevalent neurodegenerative disease in older adults globally. Cognitive impairment, a hallmark of AD, is assessed through verbal tests that require high specialization, and…
- Conditions
- Alzheimer Disease, Healthy Aging, Mild Cognitive Impairment
- Trial name
- NCT05794451
- Where
- Israel
- Volunteers
- 3,413 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Post-Traumatic Headache, Concussion, Mild
Clinical Characteristics and Pathophysiology of Post-Traumatic Headache
To better understand the clinical characteristics and complex pathophysiological events that constitute persistent post-traumatic headache (PPTH) and to identify possible calcitonin gene-related peptide (CGRP) hypersensitivity in…
- Trial name
- NCT03791515
- Testing
- Calcitonin Gene-Related Peptide
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Olfactory Disorder
cAMP (Cyclic Adenosine Monophosphate) Levels in the Nose
The purpose of this study is to determine the normal distribution of nasal tissue cathelicidin antimicrobial peptides (cAMP) levels in subjects with normal smell and subjects with smell dysfunction.
- Trial name
- NCT01332825
- Testing
- saline nasal irrigation
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Washington
Mild Cognitive Impairment, Mild Dementia
Resistance Training to Individuals for Cognitive Impairment With Dementia
This research project aims to analyze the effects of different resistance training volumes on cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function…
- Trial name
- TRAIN4BRAIN (NCT06185010)
- Testing
- One Resistance Training Set (Single Session), Three Resistance Training Sets (Single Session), One Resistance Training Set (8 Weeks)
- Where
- Portugal
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Beira Interior
Mild Cognitive Impairment, Healthy
The Aerobic & Cognitive Exercise Study
The purpose of this study is to clarify the benefits to brain health and thinking processes that result from different forms of exercise.
- Trial name
- ACES (NCT02237560)
- Testing
- Cybercycle-Game, Cybercyle-Tour, Game Only
- Where
- 12 sites in United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Union College, New York
Glucocorticoid-induced Glucometabolic Abnormalities, Glucocorticoid-induced Beta-cell Dysfunction
PREDnisolone-induced Beta-cell Dysfunction Prevented by EXenatide
The purpose of this study is to explore whether the GLP-1 receptor agonist exenatide, may prevent glucocorticoid-induced glucometabolic abnormalities and beta-cell dysfunction in healthy subjects.
- Trial name
- PREDEX (NCT00744224)
- Testing
- Prednisolone, Prednisolone and Exenatide
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Alzheimer Disease, Mild Cognitive Impairment
Cognitive Screening Made Easy for PCPs
In the United States and around the world, people are living longer lives. As the population ages, so does the number of older adults who may experience declines in memory, attention, reasoning, or other thinking skills.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- NCT05082883
- Testing
- Risk Assessment Cognitive Screening
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
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