Clinical trials: Patient-Centered Care
Emergency Medicine
Propensity to Hospitalize Patients From the ED in European Centers.
The peer-to-peer comparison means center-to-center comparison, which requires adjusting for possible differences among centers to be fair and convincing.
- Trial name
- eCREAM-UC1 (NCT06354764)
- Testing
- no intervention
- Where
- 2 sites in Italy
- Volunteers
- 162,000 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Congenital Heart Disease, Comorbidities and Coexisting Conditions
Congenital Heart Initiative-Redefining Outcomes and Navigation to Adult Centered Care
Congenital heart defects (CHDs) are a heterogeneous group of rare diseases of varying severity, each diagnosis with its unique set of co-morbidities.
- Trial name
- CHI-RON (NCT05185232)
- Testing
- Impact of gaps in care/loss to healthcare follow-up
- Where
- 16 sites in United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Thyroidectomy, Colon Surgery
The Effect of Different Bed-Head Angles on the Haemodynamic Parameters of Intensive Care Patients Lying in the Supine Position
Aim: The aim of this study was to examine the effect of different bed-head angles given to patients lying in the supine position in an intensive care unit on the haemodynamic parameters of central venous pressure, systolic and…
- Conditions
- Thyroidectomy, Colon Surgery, Cholecystectomy, Inguinal Hernia
- Trial name
- NCT06020768
- Testing
- the bed-head was raised to an angle of 0, 20, 30 and 45 degrees
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Uludag University
Ischaemic Stroke, Cognitive Impairment, Mild
Cognitive Care Bundle for Ischaemic Stroke : A Pilot Randomised Controlled Trial
The goal of this clinical trial is to learn if a set of treatments, called a "cognitive care bundle," can help preserve cognitive ability in people who have had a stroke.
- Trial name
- COGIS (NCT07610291)
- Testing
- Cognitive care bundle, Standard Medical Care (SMC)
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- National University of Malaysia
Newly Diagnosed Carcinoma of Breast, Genetic Predisposition to Disease
4R for Guideline Indicated BRCA Testing of Breast Center Patients
Currently, many breast center patients with a positive family history receive information about BRCA testing after breast cancer diagnosis, typically after definitive breast surgery or at a time point that does not allow them to…
- Trial name
- 4R (NCT01320540)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Palliative Care
Pilot Study Evaluating the Therapeutic Effects of Passive Exposure Virtual Reality on Pain, Anxiety, Fatigue, and Well-being in Patients With Complex Palliative Care Needs.
The EPURAVAS "Pilot Study Using Augmented and Virtual Reality to Ease Suffering in Palliative Care" study is designed to investigate a non-medication treatment for complex symptoms in palliative care.
- Trial name
- EPURAVAS (NCT07214090)
- Testing
- Transparent Augmented Reality with Real-World Video Feed Overlay (RVAT), Passive Multisensory Virtual Reality Immersion via Head-Mounted Display (RVEP)
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Advance Care Planning, Dementia
Improving Communication for Primary Care Patients
This is a pragmatic trial of SHARING Choices. Components of SHARING Choices include: 1. A letter from the clinic introducing an initiative to prepare persons and families for Advance Care Planning (ACP); 2.
- Trial name
- NCT04819191
- Testing
- SHARING Choices
- Where
- 54 sites in United States
- Volunteers
- 64,915 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Geriatric Assessment, Frail Elderly
Drug Reduction in Older Patients: The DROP Trial
Project Objectives: The proposed randomized, controlled trial will evaluate the effects of procedures to reduce medications among hospitalized older Veterans discharged to nursing homes using an hybrid study design to inform…
- Conditions
- Geriatric Assessment, Frail Elderly, Skilled Nursing Facilities, Patient-centered Care
- Trial name
- DROP (NCT03722017)
- Testing
- Deprescribing intervention
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- VA Office of Research and Development
Advance Care Planning, Palliative Care
Palliative Care Educator
The investigators propose to conduct a stepped wedge cluster randomized trial of an advance care planning (ACP) educator-led intervention among hospitalized patients aged 65 and over, or any patient with Alzheimer's Disease and…
- Conditions
- Advance Care Planning, Palliative Care, Alzheimer's Disease and Related Dementias, Doctor-patient Communication
- Trial name
- VIDEO-PCE (NCT04857060)
- Testing
- ACP Educator led, video assisted discussion
- Where
- 2 sites in United States
- Volunteers
- 11,174 people
- Sponsor
- Tufts Medical Center
Death, Pain
Intervention to Improve Care at Life's End
The BEACON trial (Best Practices for End-of-Life Care for Our Nations' Veterans) was a six-site implementation study to evaluate a multi-component, education-based intervention to improve the quality of end-of-life care provided…
- Conditions
- Death, Pain, Dyspnea
- Trial name
- BEACON (NCT00234286)
- Testing
- Comfort care education intervention
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- US Department of Veterans Affairs
Chronic Myelogenous Leukemia (CML)
Compliance: Role Emerges for Success in Chronic Myelogenous Leukaemia (CML): Evaluation aND Optimisation
This study on patient's compliance in clinical workaday life aims to assess and to improve CML treatment in Germany by means of adherence supporting measures and to increase adherence awareness by physicians and patients.
- Trial name
- Crescendo (NCT01243489)
- Testing
- compliance supporting measures
- Where
- 23 sites in Germany
- Volunteers
- 104 people
- Sponsor
- Gesellschaft fur Medizinische Innovation - Hamatologie und Onkologie mbH
Critical Illness, Diabetes Mellitus
Central Venous vs Arterial Blood Gas and CO2 Gap in Critically Ill Patients With and Without Diabetes
Frequent monitoring of acid-base status, ventilation, and tissue oxygenation is essential for managing critically ill patients in the intensive care unit (ICU).
- Conditions
- Critical Illness, Diabetes Mellitus, Acid-Base Imbalance, Tissue Hypoperfusion
- Trial name
- NCT07799727
- Volunteers
- 100 people
- Sponsor
- Assiut University
Parkinson Disease
Remote Access to Care, Everywhere, for Parkinson Disease
The primary objective of this study is to evaluate the feasibility, efficacy and the value of providing care to individuals with Parkinson disease directly into their homes. The specific aims are: 1.
- Trial name
- RACE-PD (NCT02144220)
- Testing
- Virtual care visit
- Where
- 3 sites in United States
- Volunteers
- 277 people
- Sponsor
- University of Rochester
Heart Failure With Reduced Ejection Fraction
Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure
An increasing number of guideline-directed medical therapies (GDMT) have been developed for patients with chronic heart failure with reduced ejection fraction (HFrEF).
- Trial name
- IICAPTAIN-HF (NCT06526988)
- Testing
- EPIC-HF Patient-facing Tool, PROMPT-HF Clinician-facing Alert
- Where
- 5 sites in United States
- Volunteers
- 2,200 people
- Sponsor
- University of Colorado, Denver
Placenta Accreta Spectrum
Effectiveness of REBOA in Reducing Blood Loss During Cesarean Section in Patients with PAS
Obstetric hemorrhage is one of the leading causes of maternal mortality and morbidity worldwide. The major risk factors for obstetric hemorrhage include placenta previa and placenta accreta spectrum (PAS) disorders.
- Trial name
- NCT06721182
- Testing
- REBOA
- Volunteers
- 100 people
- Sponsor
- Nazarbayev University
Agitation, Dementia
Depakote Extended Release (ER) Versus Seroquel for Agitated Behaviors in Nursing Home Care Unit Patients With Dementia
The primary objective of the study is to assess the relative efficacy of Depakote ER and Seroquel for agitated behaviors among veterans with a dementia diagnosis residing in a Department of Veterans Affairs (VA) nursing home care…
- Trial name
- NCT00315900
- Testing
- Depakote ER, Seroquel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tuscaloosa Research & Education Advancement Corporation
Medication Therapy Management, Estimated Cost Avoidance
Medication Therapy Management (MTM) for a Medicaid Managed Care Population Within Patient-Centered Medical Homes
The primary objective of this project is to determine the estimated cost avoidance (ECA) resulting from medication therapy management (MTM) interventions in a patient-centered medical home (PCMH).
- Conditions
- Medication Therapy Management, Estimated Cost Avoidance, MTM, Medication Management
- Trial name
- NCT05711771
- Testing
- medication therapy management
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Advance Care Planning, Dementia
Advancing Ethical Goals In Society Trial
The goal of this clinical trial is to make sure that the values of older persons aged 65 years or older with Alzheimer's Disease and Related Dementias (ADRD) or increased risk of mortality are known and respected, thereby…
- Conditions
- Advance Care Planning, Dementia, Alzheimer's Disease
- Trial name
- AEGIS (NCT07824245)
- Testing
- ACP Counselor Video Program
- Where
- 2 sites in United States
- Volunteers
- 12,174 people
- Sponsor
- Tufts Medical Center
Head and Neck Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma HNSCC
Phase II Multi-centered Study of Perioperative Ivonescimab Versus Pembrolizumab Combined with Standard of Care (SOC) in Patients with Resectable, Locally Advanced Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma (HNSCC) is one of the common malignant tumors in the world. More than 60% of HNSCC patients are locally advanced when first diagnosed.
- Trial name
- NCT06814067
- Testing
- Pembrolizumab, Ivonescimab, Surgery
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fudan University
Critical Illness, Critically Ill Patients
Physiological Changes in Adult Intensive Care Patients Following Contact With Their Primary Caregiver
Patients admitted to intensive care units are exposed to multiple environmental and clinical factors that may affect their physiological responses.
- Trial name
- CARE-ICU (NCT07761364)
- Testing
- Standardized therapeutic physical contact
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Universidad Autonoma del Estado de Mexico