Clinical trials: Pemphigus Disease, active
Pemphigus Disease, Rituximab (RTx)
A Single Cycle of Intravenous Immunoglobulin as Adjuvant to Rituximab in Patients With Pemphigus: A Retrospective Cohort Study at a Tertiary Referral Center
Pemphigus is a critical autoimmune skin condition mediated by pathogenic autoantibodies mainly against desmoglein (Dsg)1 and Dsg3, and is traditionally managed with systemic corticosteroids and immunosuppressants.The…
- Conditions
- Pemphigus Disease, Rituximab (RTx), Intravenous Immunoglobulin
- Trial name
- NCT06949241
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Ruijin Hospital
Pemphigus
A Clinical Study of B007 in the Treatment of Pemphigus.
The purpose of this study is to evaluate the efficacy and safety of B007 in subjects with pemphigus.
- Trial name
- NCT06454357
- Testing
- B007
- Where
- 12 sites in China
- Volunteers
- 132 people
- Sponsor
- Shanghai Jiaolian Drug Research and Development Co., Ltd
Pemphigus Vulgaris
A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)
A phase 1/2, open-label, safety and dosing study of autologous CART cells (desmoglein 3 chimeric autoantibody receptor T cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T cells [CABA-201]) in subjects with active…
- Trial name
- NCT04422912
- Testing
- DSG3-CAART, CABA-201
- Where
- 13 sites in United States
- Volunteers
- 40 people
- Sponsor
- Cabaletta Bio
Rheumatoid Arthritis, Pemphigus Vulgaris
Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases.
This study will evaluate the safety and activity of AB-101 in combination with rituximab in B-cell associated autoimmune diseases where rituximab is currently FDA approved (e.g., Rheumatoid Arthritis (RA), Pemphigus Vulgaris…
- Conditions
- Rheumatoid Arthritis, Pemphigus Vulgaris, Granulomatosis With Polyangiitis, Systemic Lupus Erythematosus
- Trial name
- IRIS-RD-01 (NCT06581562)
- Testing
- AB-101, Rituximab, Cyclophosphamide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- IRIS Research and Development, LLC
Inherited Epidermolysis Bullosa, Ichthyosis
FARD (RaDiCo Cohort) (RaDiCo-FARD)
The goal of this observational study is to conduct a prospective assessment of the individual Burden of 9 rare skin diseases to assess disability in the broadest sense of the term (psychological, social, economic and physical)…
- Conditions
- Inherited Epidermolysis Bullosa, Ichthyosis, Ectodermal Dysplasia, Incontinentia Pigmenti
- Trial name
- FARD (NCT05954416)
- Where
- 15 sites in France
- Volunteers
- 900 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pemphigus Disease
Impact of a Lifestyle Program on Quality of Life in Pemphigus Patients
The aim of this study is To evaluate the impact of lifestyle modifications, including dietary changes and regular exercise, on skin-related quality of life in patients with pemphigus by assessing changes in Skindex-16 scores over…
- Trial name
- NCT06901427
- Testing
- Mediterranean Diet and exercise
- Volunteers
- 44 people
- Sponsor
- Assiut University
Pemphigus, Dermatologic Disease
Comparison of a Personalized Maintenance Therapy With the Standard Treatment in Pemphigus
Pemphigus diseases are life-threatening chronic autoimmune blistering diseases characterized by split formation within the epidermis and surface-close epithelia accompanied by acantholysis.
- Trial name
- RITUX4 (NCT05898308)
- Testing
- RiTUXimab Injection
- Where
- 34 sites in France, Guadeloupe
- Volunteers
- 133 people
- Sponsor
- University Hospital, Rouen
Pemphigus Vulgaris, Rituximab (RTx)
Rituximab With Corticosteroids Versus Corticosteroids Plus Azathioprine for Moderate-to-Severe Pemphigus Vulgaris
This quasi-experimental study aims to compare the effectiveness and safety of rituximab combined with corticosteroids versus the standard regimen of oral corticosteroids plus azathioprine in patients with moderate to severe…
- Trial name
- NCT07769333
- Testing
- Rituxan (rituximab), Azathioprine (AZA)' plus corticosteroids
- Volunteers
- 92 people
- Sponsor
- Khyber Teaching Hospital
Pemphigus Vulgaris (PV)
Trichoscopy as a Monitoring Tool for Activity and Remission in Pemphigus Vulgaris: A Clinical Study Supported by Immunological Evaluation.
Pemphigus vulgaris (PV) is a potential life-threatening autoimmune bullous disorder presenting with multiple erosions and flaccid blisters that can involve both mucous membrane and skin.
- Trial name
- NCT06863454
- Testing
- Trichoscopy
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pemphigus Vulgaris
Low-level Laser Therapy on Oral Pemphigus Vulgaris Patients.
To assess the therapeutic efficacy of low level laser therapy on oral pemphigus vulgaris patients.
- Trial name
- NCT06971172
- Testing
- Low energy diode Laser, Medication
- Volunteers
- 22 people
- Sponsor
- Cairo University
Hailey Hailey Disease
Efficacy of Guselkumab in Treating Hailey Hailey Disease
Hailey-Hailey disease (HHD) is a debilitating genetic skin disorder, affecting mainly body folds with erythema and painful erosions and blisters.
- Trial name
- NCT06651489
- Testing
- Guselkumab
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yale University
Pemphigus Vulgaris
CD19 CAR-T Therapy for Refractory Pemphigus Vulgaris
This is an investigator-initiated, single-center, single-arm, open-label exploratory clinical study designed to evaluate the safety, tolerability, and preliminary efficacy of autologous CD19 CAR-T cell therapy in patients with…
- Trial name
- RESET-PV-CART (NCT07681388)
- Testing
- Autologous CD19 CAR-T cells
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Jinbo Chen
Pemphigus, Steroid-resistant Pemphigus
ONO-4059 Study in Patients With Steroid-resistant Pemphigus
ONO-4059-10:Multicenter, placebo-controlled, randomized, double-blind, Phase 3 study in patients with steroid-resistant pemphigus
- Trial name
- NCT06696716
- Testing
- ONO-4059
- Where
- 25 sites in Japan
- Volunteers
- 34 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Oral Lesions in Patients With Pemphigus Vulgaris
Comparison of the Efficacy of Clobetasol Propionate 0.05% Mouthwash, Photobiomodulation, and Their Combination in Managing of Oral Lesions in Patient With Pemphigus Vulgaris.
Pemphigus vulgaris (PV) is a chronic, potentially life-threatening autoimmune mucocutaneous disorder that significantly impairs patients' quality of life.
- Trial name
- NCT07641725
- Testing
- Clobetasol propionate 0.05% Mouthwash, diode laser for photobiomodulation, clobetasol propionate 0.05% mouthwash + photobiomodulation
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Damascus University
Pemphigus Vulgaris, Pemphigus Foliaceus
Autoimmune Blistering Diseases Study
Pemphigus and bullous pemphigoid (BP) are severe autoimmune blistering diseases (AIBD) that pose a critical need for new therapeutic approaches.
- Conditions
- Pemphigus Vulgaris, Pemphigus Foliaceus, Bullous Pemphigoid
- Trial name
- AIBD (NCT02753777)
- Testing
- Questionnaires
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Pennsylvania
Pemphigus
A Single-center Study of CM313 in Patients With Pemphigus
A prospective, single-center, single-arm clinical study aimed to explore the efficacy and safety of the anti-CD38 monoclonal antibody CM313 combined with low-dose glucocorticoids in patients with pemphigus.
- Trial name
- NCT06904040
- Testing
- CM313 injection, glucocorticoids
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sichuan Provincial People's Hospital
Pemphigus
IVIG With Rituximab vs Rituximab as First Line Treatment of Pemphigus
Pemphigus is a rare acquired autoimmune disease in which immunoglobulin G (IgG) antibodies target desmosomal proteins to produce intraepithelial, and mucocutaneous blisters.
- Trial name
- NCT04400994
- Testing
- Rituximab, IVIg
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Hailey Hailey Disease, Skin Diseases
A Study to Investigate Safety and Efficacy of KB111 for the Treatment of Hailey-Hailey Disease
An open-label study to evaluate the safety and efficacy of KB111 in pediatric and adult subjects with Hailey-Hailey Disease
- Conditions
- Hailey Hailey Disease, Skin Diseases, Lesion Skin
- Trial name
- HALITE-1 (NCT07717346)
- Testing
- KB111
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Krystal Biotech, Inc.