Clinical trials: Perfusion
Myocardial Dysfunction, Heart Failure
The Effect of Inflammation in Heart Failure
Background: Heart failure is a serious health condition. Researchers believe inflammation plays a role. They want to see if adding an additional heart drug to a person s treatment can help treat heart failure with preserved…
- Conditions
- Myocardial Dysfunction, Heart Failure, Inflammation
- Trial name
- NCT05330013
- Testing
- Dapagliflozin, MRI scan, CMR imaging
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Upper Limb Ischemia, Vascular Disease
Hand Acceleration Time Assessment With Ultrasound Doppler
Chronic upper limb ischemia syndrome is uncommon compared to lower limb ischemia, with several potential causes (e.g., arteriosclerosis, compressive syndromes, arteritis, connective tissue diseases, trauma, and thrombosis).
- Trial name
- HAT (NCT05977725)
- Testing
- Hand Doppler Ultrasound
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Spinal Cord Injury, Degenerative Spinal Disease.
Perfusion and Diffusion Mechanism of Intervertebral Disc-Significance With Age, Degeneration, Posture and Stress Loading.
The purpose of our study is to evaluate the perfusion of the IVDs and their diffusion ability by using the Dynamic contrast-enhanced MR perfusion technique and Diffusion weighted image with ADC value measurement, and to determine…
- Trial name
- NCT01973257
- Testing
- imaging diagnostics
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Liver Diseases
Liver Micro Flow - MRI
This study integrates and evaluates a series of novel MRI methods for quantifying blood perfusion and tissue microstructure. The proposed perfusion and microstructure measures may provide biomarkers for fibrosis, cirrhosis…
- Trial name
- NCT07634939
- Testing
- Novel MRI Software, Ensure Plus Nutrition Shake
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Maternal-Fetal Exchange
Maternal Uterine Artery Doppler Study
The purpose of this study is to detect if adding resistance to maternal blood flow from the arm will help increase the blood flow through the uterine arteries to the placenta and the baby.
- Trial name
- NCT01698957
- Testing
- Any patient eligible for an Ultrasound greater than or equal to 18 weeks gestation without a fetal or uterine anomaly.
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Obstetrix Medical Group
Peripheral Perfusion
Assessment of Peripheral Perfusion in the Critically Ill Patient
The purpose of this study is to evaluate PPI as a surrogate for clinical signs of peripheral perfusion in patients in septic shock and after cardiac surgery.
- Trial name
- CRTPPI (NCT02771002)
- Testing
- Peripheral Perfusion index by Carescape Patientenmonitor
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Neuropsychiatric Systemic Lupus Erythematosus
Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus
The purpose of this study is to determine if three functional Magnetic Resonance brain imaging techniques: Magnetic Resonance Spectroscopy(MRS),Magnetic Resonance perfusion, and Diffusion Tensor Imaging(DTI) can detect brain…
- Trial name
- NCT00730002
- Testing
- Magnetic Resonance Angiography (MRA), Magnetic resonance imaging, MRA
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Hemorrhage
Pulsatile Perfusion Therapy Phase II
Individuals who suffer from a stroke, cardiac arrest, or traumatic bleeding (hemorrhage) injuries often have compromised blood flow and oxygen to the brain which can lead to the death of brain cells, and if the patient survives…
- Trial name
- PPT2 (NCT05983744)
- Testing
- 0 Hz Control, 0.1 Hz PPT, 0.05 Hz PPT
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Caroline Rickards
Breast Cancer
Screening in Myocardial Perfusion Patients
To expand the understanding of the uptake and distribution of Tc-99m sestamibi in the breast in a normal female population undergoing myocardial perfusion imaging using Molecular Breast Imaging (MBI).
- Trial name
- NCT00943241
- Where
- United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pressure Distribution, Military Litters
NATO Litter: Fluid Immersion System (FIS) Versus Traditional Mattress for Pressure Dispersion
The purpose of this study is to measure peak skin interface pressures and the total area of the body exposed to skin interface pressure above 30 mm Hg at different areas of the body in the supine position on two different support…
- Conditions
- Pressure Distribution, Military Litters, Peak Pressure Index, Total Surface Area
- Trial name
- NCT03483623
- Testing
- NATO WELP combination, NATO FIS combination, RAVEN WELP combination
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Coronary Artery Disease
Combined Supine/Prone Acquisitions in Stress-First/Stress-Only Myocardial Perfusion Imaging to Reduce Equivocal Results
Participants are being asked to participate in this research study because the participant's doctor has ordered a myocardial perfusion SPECT (Single-Photon Emission Computed Tomography) scan to look at the blood flow in the…
- Trial name
- SFSO-MPI (NCT02576886)
- Testing
- Gamma Camera, Prone Imaging
- Where
- Canada
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Complication of Extracorporeal Membrane Oxygenation, Cerebral Microembolism
Cerebral Microemboli in Venoarterial ECMO Patients
Extracorporeal membrane oxygenation (ECMO) is progressively used in critically ill patients with cardiac or respiratory failure as a bridging option for potential organ recovery.
- Conditions
- Complication of Extracorporeal Membrane Oxygenation, Cerebral Microembolism, Cerebral Perfusion
- Trial name
- NCT02020759
- Testing
- Transcranial Doppler Ultrasound
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Myocardial Perfusion
Assessment of Myocardial Perfusion by Tomography and Scintigraphy in Patients With Cardiac Stress Test With Ischemia
Cardiovascular diseases are important cause of death, and of these have highlighted the Coronary Artery Disease (CAD) and its various clinical manifestations.
- Trial name
- Perfusão (NCT02810106)
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Peripheral Artery Disease, Diabetes Mellitus
Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease
The aim of this clinical study is to 1) establish a healthy database for nuclear perfusion imaging of the lower extremities and 2) assess the prognostic value of radiotracer-based perfusion imaging for predicting clinical…
- Conditions
- Peripheral Artery Disease, Diabetes Mellitus, Chronic Limb-Threatening Ischemia
- Trial name
- NCT03622359
- Testing
- SPECT/CT perfusion imaging, PET/CT perfusion imaging
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Nicotine Dependence, Vaping
Influence of the Consumption of Conventional and Electric Cigarettes on Skin Circulation
The survey participants are divided into a smoking and non-smoking group. The smoker group is further divided according to the quantity and quality of nicotine ("normal" smoking, vaping).
- Conditions
- Nicotine Dependence, Vaping, Smoking
- Trial name
- NCT04645914
- Testing
- Use of nicotine product (smoking/vaping)
- Where
- Germany
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Type 2 Diabetes Mellitus
Orthogonal Polarisation Study in Young, Elderly and Type 2 Diabetics
Aging is accompanied by a progressive loss of skeletal muscle mass and strength, leading to the loss of functional capacity and an increased risk of developing chronic metabolic disease.
- Trial name
- NCT01476384
- Testing
- Glucose
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Ocular Physiology, Optic Disk
Role of Endothelin- and Nitric Oxide-system in the Regulation of Optic Nerve Head Blood Flow During Changes in Ocular Perfusion Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. The existence of an effective autoregulation in the optic nerve circulation has been shown in animals and humans.
- Conditions
- Ocular Physiology, Optic Disk, Regional Blood Flow
- Trial name
- NCT00406731
- Testing
- NG-monomethyl-L-arginine (L-NMMA), Endothelin-1 (ET-1), Laser Doppler flowmetry
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Perfusion; Complications
Perfusion Index in the Follow-up of Postoperative Pain
Background: The effect of the perfusion index (PI) as an indicator of postoperative pain was investigated. To this end, the presence of the perfusion index in predicting the need for analgesia and its effect in hypertensive…
- Trial name
- NCT06535581
- Testing
- surgery patient
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amasya University
MRI Scans
Comparison of Quantitative MRI Perfusion Methods With Quantitative PET Perfusion Imaging
This work seeks to develop, evaluate and use new MRI methods for non-invasive quantitative assessment of myocardial perfusion and perfusion reserve (MPR), and to compare with quantitative PET imaging.
- Trial name
- NCT02608944
- Testing
- Adenosine, Regadenoson, O-15 labeled radioactive water
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Utah
Complications; Anesthesia, Spinal and Epidural, in Pregnancy
The Effect of the Timing of Colloid and Crystalloid Infusions on Postspinal Hypotension After Spinal Anesthesia for Caesarian Section
Prevention of postspinal hypotension after spinal anesthesia for caesarian section by use of preoperative or intraoperative volume replacement.
- Trial name
- NCT02680678
- Testing
- Colloid Preload, colloid co-load, Crystalloid preload
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Balikesir University