Clinical trials: Periodontal Bone Defects
Treatment of Periodontal Intra-bony Defects
The Present Study Was Performed to Evaluate the Efficacy of Lyophilized-PRF in Treatment of Periodontal Intra-bony Defects
The present study will be performed to evaluate the efficacy of lyophilized platelet-rich fibrin alone and combined with nanocrystalline hydroxyapatite in treatment of periodontal intra-bony defects through: 1.
- Trial name
- NCT06625528
- Testing
- open flap debridement
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Furcation Defects
Rosuvastatin Gel With 1:1 Mixture of Platelet-rich Fibrin and Bone Graft in Mandibular Degree II Furcation Defects
Rosuvastatin (RSV) is a new synthetic, second-generation, sulfur-containing, hydrophilic statin, that stimulate bone formation in critical-size cortical bone defects adjacent to titanium implants, when administered locally in…
- Trial name
- NCT02369250
- Testing
- Rosuvastatin, platelet rich fibrin
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Evaluation of Amnion Chorion Membrane and Demineralized Bone Matrix Putty Allograft in Periodontal Intrabony Defects
A clinical and radiographic evaluation of 2 regenerative techniques, bioresorbable membrane and bone allograft for management of periodontal intrabony defects.
- Trial name
- NCT02679209
- Testing
- Demineralized bone matrix in putty form, Amnion chorion membrane
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Periodontal Diseases
Clinical and Radiographic Evaluation of PPF With or Without NCHA Bone in Treatment of Intrabony Defects
This study is meant to assess clinically and radiographically the possible predictable results regarding the use of nanocrystalline hydroxyapatite bone graft substitute together with papilla preservation flap versus papilla…
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Pocket, Intrabony Periodontal Defect
- Trial name
- NCT03588507
- Testing
- PPF+NCHA bone graft substitute
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Bone Loss, Periodontal Pocket
Locally Injected Vit D as a Non-surgical Modality for Periodontal Regeneration of Infrabony Defects
vitamin D has great role in bone regenration and soft tissue health. in the past periodontal regeneration was performed using bone graft and barrier membrane
- Trial name
- NCT03716765
- Testing
- locally injected vitamin D
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis, Bone Loss
Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®).
The aim of this study is to evaluate and compare the regenerative potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) bone graft in the treatment of intrabony defects in chronic periodontitis…
- Conditions
- Chronic Periodontitis, Bone Loss, Intrabony Periodontal Defect
- Trial name
- NCT04767243
- Testing
- open flap debridement and filled with A-PRF ( Advanced platelet rich fibrin), open flap debridement and filled with Bioactive glass (Perioglas®), open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Tooth Loss
Treatment of Post-Extraction Dehisced Socket - A Case Series Study
PURPOSE The purpose of this case series is to clinically, radiographically and histologically evaluate the treatment of dehiscence defects in extraction sockets using a minimally-invasive GBR technique that involves the…
- Trial name
- OSTEO2 (NCT02980211)
- Testing
- Alveolar Ridge Reconstruction
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Gustavo Avila-Ortiz DDS, MS, PhD
Periodontal Bone Loss
The Use of Chlorhexidine Gel Following EDTA Root Surface Etching as an Adjunctive to Open Flap Debridement in Treating Intra-Bony Defects
SUMMARY Chronic periodontitis is regarded as an inflammatory disease that affects the supporting tissues of teeth which could lead to bone destruction.
- Trial name
- NCT05170932
- Testing
- CHX gel 2 % + 24% EDTA
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Intrabony Periodontal Defect
Injectable Platelet Rich Fibrin With Demineralized Freeze-dried Bone Allograft in Treatment of Intraosseous Defects
Clinical and radiographic evaluation of injectable platelet rich fibrin (i-PRF) and demineralized freeze-dried bone allograft (DFDBA) compared to demineralized freeze-dried bone allograft (DFDBA) alone in management of…
- Trial name
- NCT03900013
- Testing
- Injectable platelet rich fibrin combined with DFDBA, Demineralized Freeze Dried Bone Allograft
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Bone Loss
Decortication With Calcium Phosphosilicate Putty in the Treatment of Non-contained Intrabony Periodontal Defects
To overcome the disadvantage of complex morphology and availability of less favorable support to retention of graft and clot stabilization in 1-, 1-2-wall periodontal defects, it was hypothesized that placement of CPS putty…
- Trial name
- NCT03435757
- Testing
- OFD+IMP+CPS, OFD+IMP
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis
Evaluation of Advanced PRF Combined With Nano-crystalline Hydroxyapatite for Management of Grade II Furcation Defects
this study is to evaluate the use of advanced platelet rich fibrin (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (OPD) versus open flap debridement alone in the management of…
- Trial name
- NCT03804086
- Testing
- Advanced PRF (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement, Open flap debridement
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hadeer Ashraf Hassan Roushdy
Furcation Defects, Periodontitis
Effect of Laser Use on Guided Tissue Regeneration in Treatment of Molar Teeth With Class 2 Furcation Affected by Periodontitis
Purpose: The proposed study will evaluate and compare the clinical response of using bioresorbable collagen membrane alone or defect debridement with erbium Laser irradiation in conjunction with bioresorbable collagen membrane in…
- Conditions
- Furcation Defects, Periodontitis, Alveolar Bone Loss Beyond Furcation
- Trial name
- NCT01522131
- Testing
- bioresorbable membrane alonewill be used for regeneration of the periodontium(control)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Periodontal Intrabony Defect
Entire Papilla Preservation and Conventional Flap Surgery in Treating Intrabony Defects: A 6-Month Clinical Trial
Intraosseous defects are characterized by vertical bone loss within the borders of the alveolar bone surrounding the teeth due to periodontal disease and are considered a clinically concerning condition.
- Trial name
- NCT06687785
- Testing
- Entire Papilla Preservation Technique, Conventional Flap Surgery Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Periodontitis, Tooth Migration
Timing of Orthodontic Therapy and Regenerative Periodontal Surgery in Advanced Periodontitis Patients With Pathologic Tooth Migration
Pathologic tooth migration (PTM) is a common complication of advanced periodontitis and often motivation for patients to seek orthodontic therapy.
- Conditions
- Periodontitis, Tooth Migration, Intrabony Periodontal Defect
- Trial name
- NCT02761668
- Testing
- ParS+Ortho 4W, ParS+Ortho 6M
- Where
- 2 sites in Germany, Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Bone Loss, Alveolar
Evaluation of Bone Gain Using Customized 3D Zirconia Barrier Versus Titanium Mesh
Evaluation of clinical and radiographical amount of bone gained using customized 3D printed zirconia barrier compared to titanium mesh in combined ridge defect at the esthetic zone.
- Trial name
- NCT06559605
- Testing
- zirconia barrier, titanium mesh
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Bone Loss, Periodontal Pocket
Treatment of Intraosseous Periodontal Defects With Hyaluronic Acid
The aim of the present investigation will be evaluate the healing of periodontal intraosseous defects following Minimally Invasive Non Surgical Debridement (MINSD) and application of a hyaluronic acid-based gel, compared to MINSD…
- Trial name
- NCT05188898
- Testing
- MINSD and Hyaluronic acid, MINSD
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Federico II University
Periodontal Attachment Loss, Periodontal Bone Loss
Platelet-Rich Fibrin and Anorganic Bovine Bone vs Collagen Membrane and Anorganic Bovine Bone in Intrabony Defects
The primary outcome of periodontal reconstructive therapy is to regenerate all tissues of the periodontium including a functional periodontal ligament, alveolar bone and cementum.
- Conditions
- Periodontal Attachment Loss, Periodontal Bone Loss, Periodontal Diseases
- Trial name
- NCT03715374
- Testing
- Periodontal Surgery with PRF+ABB, Periodontal Surgery with Collagen Membrane +ABB
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Bone Loss in Jaw
Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects
The goal of this clinical trial is to assess the effectiveness of local delivery of melatonin and metformin loaded nanoparticle gel as adjunct to scaling and root planning (SRP) in the treatment of periodontal intra bony defect.
- Trial name
- NCT05906563
- Testing
- Melatonin gel, Metformin and melatonin gel, scaling and root planning
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Amira ragab
Periodontal Diseases, Periodontal Inflammation
Minimally Non Surgical Periodontal Therapy Compared to Traditional Approach
This study aims to evaluate the clinical results of non-surgical periodontal therapy performed with micro-instruments compared to traditional approach (standard curettes) after 6 months of follow-up.
- Trial name
- NCT05060601
- Testing
- Gracey micro-curettes, Standard Gracey curettes
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federico II University
Periodontitis
Regeneration of Human Intrabony Defects With rhFGF-2/HA
BACKGROUND: Periodontal disease is an infection that results in progressive loss of dental support, which may lead to tooth loss..
- Trial name
- NCT02337166
- Testing
- a gel containing 4mg/ml rhFGF-2 in sodium hyaluronate, Periodontal flap surgery
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense