Clinical trials: Periodontal Intrabony Defects
Periodontitis, Periodontal Intrabony Defects
Impact of Platelet-Rich Fibrin on Periodontal Tissue Regeneration
The purpose of this research is to assess the efficacy of Platelet-Rich Fibrin (PRF) in the regeneration of periodontal tissues in patients suffering from periodontal disease.
- Trial name
- NCT07395726
- Testing
- Open Flap Debridement, Platelet-Rich Fibrin with Open Flap Debridement
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Periodontitis, Intrabony Periodontal Defect
MIST Versus M-MIST for the Treatment of Intrabony Defects
This is a 12-month longitudinal, double-blind, parallel-design randomized controlled clinical trial involving surgical therapeutic intervention (Phase 4).
- Conditions
- Periodontitis, Intrabony Periodontal Defect, Periodontitis, Chronic
- Trial name
- NCT06058923
- Testing
- M-MIST, MIST
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Periodontitis, Intrabony Periodontal Defect
Effectiveness of Hyaluronic Acid (hyaDENT BG® Gel) Compared With Enamel Matrix Proteins (Emdogain®) in the Treatment of Angular Bone Defects in Combination With a Xenograft (Bio-Oss Collagen®)
The goal of this clinical trial is to learn whether hyaluronic acid (HyaDent® BG) provides similar benefits to Emdogain® when both are used with Bio-Oss® Collagen during periodontal surgery in adults with periodontal (intrabony)…
- Conditions
- Periodontitis, Intrabony Periodontal Defect, Periodontal Bone Loss
- Trial name
- NCT07230522
- Testing
- Bio-Oss Collagen + HyaDent BG, Bio-Oss Collagen + Emdogain
- Where
- Bulgaria
- Volunteers
- 17 people
- Sponsor
- Medical University of Sofia
Periodontal Diseases, Intrabony Periodontal Defect
Papilla Preservation Technique in Combination With Tooth Enamel Proteins and Animal Derived Bone Graft in Treating Isolated Bone Defects Between Teeth
The present three-arm study compared the clinical and tomographic efficacy of the Entire Papilla Preservation Surgical Technique (EPPT) alone and combined with enamel matrix derivative (EMD) plus bone mineral derivedxenograph…
- Trial name
- NCT07119307
- Testing
- Entire Papilla Preservation Technique, Entire Papilla Preservation Surgical Technique (EPPT) alone, Entire Papilla Preservation Surgical Technique (EPPT) alone and combined with enamel matrix derivative (EMD)
- Where
- India
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Rungta College of Dental Sciences and Research
Periodontal Intrabony Defects, Bone Regeneration
Comparison of Effects of Eggshell Derived Nano Hydroxyapatite and Hydroxyapatite in Management of Periodontal Intrabony Defects
The aim of the study is to evaluate osseous regenerative efficacy of eggshell derived nanohydroxyapatite in comparison with hydroxyapatite The test group includes patients with intrabony defects where flap surgery will be…
- Trial name
- NCT07160101
- Testing
- Eggshell derived nano hydroxyapatite, Hydroxyapatite
- Where
- India
- Volunteers
- 28 people
- Sponsor
- Dr R Viswa Chandra
Periodontal Intrabony Defect
Impact of Minimally Invasive Non-surgical Periodontal Treatment on Infrabony Defects
Fifty-two periodontitis patients (26 per group) were randomly assigned to the test (Minimally invasive non-surgical therapy - MINST) or the control group (Quadrantwise Subgingival Instrumentation - Q-SI) NPT protocols.
- Trial name
- Infra-MINST (NCT06992219)
- Testing
- Non surgical periodontal treatment evaluated through probing pocket depth reduction
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- University of Catania
Intrabony Defect, Periodontal Diseases
RGD With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defect
Periodontal regeneration is a complex process that involves coordinated activities and interactions of many cell types, extracellular matrix, cytokines, and specific growth factors to restore tissue integrity.
- Conditions
- Intrabony Defect, Periodontal Diseases, Alveolar Bone Loss
- Trial name
- MINST + RGD (NCT06936605)
- Testing
- RGD Peptide
- Volunteers
- 45 people
- Sponsor
- Minia University
Periodontal Intrabony Defect
Entire Papilla Preservation and Conventional Flap Surgery in Treating Intrabony Defects: A 6-Month Clinical Trial
Intraosseous defects are characterized by vertical bone loss within the borders of the alveolar bone surrounding the teeth due to periodontal disease and are considered a clinically concerning condition.
- Trial name
- NCT06687785
- Testing
- Entire Papilla Preservation Technique, Conventional Flap Surgery Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Intrabony Periodontal Defect
Evaluation of Volume Stable Collagen Matrix in the Regenerative Outcome of Periodontal Intrabony Defects
Periodontal intrabony defect is a specific osseous defect with definite morphology. Numerous therapeutic modalities for restoring such defects have been investigated.
- Trial name
- NCT05569473
- Testing
- TEST GROUP: VCMX + OFD, CONTROL GROUP : OFD ONLY
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontal Regeneration, Minimally Invasive Surgical Technique
Efficacy of the Entire Papilla Preservation Technique With and Without the Use of L-PRF as a Regenerative Material for the Treatment of Infrabony Defects
The goal of this clinical trial is to evaluate the efficacy of using L-PRF (leukocyte and platelet rich fibrin clot) as an autologous filling material in conjunction with the EPP (entire papilla preservation) technique for the…
- Conditions
- Periodontal Regeneration, Minimally Invasive Surgical Technique, Platelet Rich Fibrin, Microsurgery
- Trial name
- NCT06694168
- Testing
- Periodontal Regeneration, clinical and radiographic results, modified minimal invasive surgery, REGEND001 Autologous Therapy Product
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad de los Andes, Chile
Intrabony Periodontal Defect, Periodontitis
Evaluation of an Algae-Based Biphasic Bone Graft Material and Collagen Membrane in the Treatment of Periodontal Intrabony Defects
Periodontal diseases are one of the most prevalent chronic diseases involving a spectrum of inflammatory conditions. Intrabony defects, also known "vertical defects," are specific osseous and morphological defects and one of the…
- Trial name
- NCT06633640
- Testing
- Conventional flap with algae-based substitute (AlgOss) combined with collagen membrane.
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Intrabony Periodontal Defect
Evaluation of Autogenous Demineralized Dentin Graft Vs Autogenous Bone Graft in Management of Intrabony Defects
The main goal is to evaluate and compare the clinical and radiographic efficacy of autogenous demineralized dentin as bone graft substitute versus autogenous bone graft when performed with modified minimally invasive surgical…
- Trial name
- NCT06048042
- Testing
- Autogenous Demineralized Dentin Graft, Autogenous Bone Graft
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intrabony Periodontal Defect
Clinical Evaluation of Injectable Alb-PRF in the Management of Intrabony Defect in Stage-III Periodontitis Patients
Clinical Evaluation of Injectable Albumin Platelet Rich Fibrin Versus Platelet Rich Fibrin in the Management of Intra-bony Defect in Stage-III Periodontitis Patients.
- Trial name
- NCT06297577
- Testing
- Albumin Platelet Rich Fibrin (Alb-PRF) combined with minimally invasive surgical technique (MIST), Minimally invasive surgical technique (MIST)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intrabony Periodontal Defect
Simplified Papilla Preservation Flap(SPPF) and Enamel Matrix Derivative(EMD) With or Without Connective Tissue(CTG) Wall for the Treatment of Non Contained Infrabony Defects. A Randomized Controlled Clinical Trail
Research is to compare and evaluate the clinical and radiographic outcomes of the enamel matrix derivative with or without connective tissue wall graft for noncontained infrabony defects using simplified papilla preservation…
- Trial name
- NCT06530199
- Testing
- Enamel matrix derivative
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Isolated Intrabony Periodontal Defects in Patients With Periodontitis
Clinical and Radiographic Evaluation of Using the Entire Papilla Preservation Technique With and Without Autogenous Bone Graft and Injectable Platelet Rich Fibrin in Treatment of Periodontal Intraosseous Defects
The goal of this Clinical trial is to evaluate the clinical and radiographic outcomes of using entire papilla preservation technique with and without autogenous bone and injectable platelet rich fibrin in treatment of isolated…
- Trial name
- NCT06347263
- Testing
- Entire papilla preservation technique
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intrabony Periodontal Defect
Efficacy of Insulin Like Growth Factor-1(IGF-1) on Bone Regeneration in Intrabony Defects : A Clinico-radiograph Study
The aim of this study is to clinically evaluate the efficacy of Insulin like Growth Factor (IGF-1) on bone regeneration in intrabony defects.
- Trial name
- NCT06426524
- Testing
- IGF-1 Gel, Hydroxyapatite
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dr R Viswa Chandra
Intrabony Periodontal Defect
Allograft With Enamel Matrix Derivative Versus Allograft Alone in the Treatment of Intrabony Defects .
Periodontal intrabony defects represent a major challenge for the clinician in periodontal therapy. If left untreated, these defects represent a risk factor for disease progression and additional attachment and bone loss.
- Trial name
- NCT06041854
- Testing
- Freeze-dried bone allograft combined with Enamel Matrix derivative, Freeze-dried bone allograft
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Intrabony Periodontal Defect
Novel Silk Fibroin Nanofiber Membrane Using Minimally Invasive Surgery in Treatment of Periodontal Intrabony Defects: A Randomized Clinical Trial
Clinically and radiographically by cone beam CT evaluate the regenerative potentials of silk fibroin (SF) nanofiber membrane, using minimally invasive surgery, for the regenerative treatment of intrabony periodontal defects.
- Trial name
- NCT06371027
- Testing
- Minimally Invasive Surgery Technique (MIST) + Novel Silk Fibroin (SF) nanofiber membrane, Minimally Invasive Surgery Technique (MIST) + collagen membrane, Minimally Invasive Surgery Technique (MIST)
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- October 6 University
Periodontitis, Adult, Intrabony Periodontal Defect
The Flapless Approach in Periodontal Regeneration
The present investigation is designed in order to compare the radiographic and clinical effectiveness of flapless procedure performed alone or in combination with enamel matrix derivatives in the periodontal regenerative…
- Trial name
- NCT05456555
- Testing
- Flapless with Enamel Matrix Derivatives (EMD), Flapless without Enamel Matrix Derivatives (EMD)
- Where
- Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Periodontitis, Tooth Migration
Timing of Orthodontic Therapy and Regenerative Periodontal Surgery in Advanced Periodontitis Patients With Pathologic Tooth Migration
Pathologic tooth migration (PTM) is a common complication of advanced periodontitis and often motivation for patients to seek orthodontic therapy.
- Conditions
- Periodontitis, Tooth Migration, Intrabony Periodontal Defect
- Trial name
- NCT02761668
- Testing
- ParS+Ortho 4W, ParS+Ortho 6M
- Where
- 2 sites in Germany, Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Bonn