Clinical trials: Periodontitis
Necrotic Pulp With Symptomatic Apical Periodontitis
The Impact of Using Different Final Irrigation Modes on Postoperative Pain Following Root Canal Treatment of Non-vital Mandibular First Molar With Periapical Lesion.
The goal of this clinical trial is to learn which rinsing of root canals method works best to lower pain after a root canal in adults.
- Trial name
- NCT07623629
- Testing
- root canal treatment
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Ozone-therapy (O3), Periodontitis
Ozone-therapy in Non-surgical Periodontal Therapy
Non-surgical periodontal therapy is a widely adopted procedure for the treatment of periodontitis, particularly in its moderate to severe stages.
- Conditions
- Ozone-therapy (O3), Periodontitis, Antimicrobial Ozone Therapy
- Trial name
- PD-OZONE (NCT07202312)
- Testing
- Ozone-therapy after non-surgical therapy
- Where
- Italy
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Periodontitis With Low Oral Hygiene-related Self-efficacy
Evaluation of Behaviour Intervention on Adherence and Periodontal Outcomes
Periodontitis is a chronic inflammatory disease in which long-term treatment success depends greatly on patients' adherence to oral hygiene practices and periodontal therapy.
- Trial name
- NCT07614737
- Testing
- Behavioural intervention, Conventional oral hygiene instructions
- Where
- India
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontal Disease, Diabete Mellitus
Oral Health and Systemic Diseases: Survey of General Practitioners
This cross-sectional observational study aims to assess the level of knowledge, clinical practices, and professional attitudes of General Practitioners (GPs) regarding oral health and its relationship with major systemic…
- Trial name
- NCT07604493
- Testing
- Questionnaire Survey
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Obesity, Periodontitis
Periodontal Inflammation and Epigenetics in Obese Individuals
The goal of this study is to investigate the long-term changes in host epigenetic modifications in obese individuals with periodontitis.
- Trial name
- NCT07610902
- Testing
- Non-surgical periodontal therapy will be administered
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Tooth Mobility, Periodontitis
Impact of MINST With and Without Splinting in Periodontitis Patients With Mobile Anterior Teeth
The goal of this clinical trial is to evaluate impact of Minimally Invasive Non-Surgical Therapy (MINST) with and without splinting on clinical periodontal parameters and Oral Health Related Quality of Life (OHRQoL) in…
- Trial name
- NCT06436729
- Testing
- Splinting, MINST alone
- Where
- India
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Oral Lichen Planus, Periodontitis
Periodontal Status in Patients With Oral Lichen Planus
This case-control study will enroll 176 patients age- and sex- matched at the Oral Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome.
- Trial name
- NCT07597616
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Periodontitis, Gingivitis and Periodontal Diseases
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)
This observational cross-sectional study investigates the levels of mitochondria-endoplasmic reticulum contact site (MERC) proteins in saliva and gingival crevicular fluid (GCF) of individuals with different periodontal…
- Conditions
- Periodontitis, Gingivitis and Periodontal Diseases, Biomarker Discovery and Validation, Pathways
- Trial name
- EKNMERC-GCF-SL (NCT07601685)
- Testing
- ELISA Biomarker Analysis, Calcium Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Inonu University
Periodontitis, Oxidative Stress
Gingival TrxR1 Expression in Periodontal Health and Periodontitis
This study aims to investigate the role of the thioredoxin system in the development and progression of periodontitis. Researchers will examine the levels of specific antioxidant markers, such as thioredoxin reductase 1 (TrxR1)…
- Trial name
- NCT07598942
- Testing
- Gingival Tissue Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Apical Periodontitis
Effect of Two Different Irrigation Protocols and Activation Techniques on Postoperative Pain in Single-visit Endodontic Retreatment: Prospective Randomized Clinical Trial
The relationship between different root canal irrigation techniques and pain after root canal treatment
- Trial name
- NCT07599254
- Testing
- root canal irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Healthy Adult Participants, Periodontal Disease
Clinical, Microbiological and Immunological Effects of the Adjuvant Use of Systemic Antibiotics and Probiotics in the Non-surgical Treatment of Periodontitis
Although robust evidence supports the benefits of antibiotics in periodontal treatment, the potential adverse effects of this therapy cannot be overlooked.
- Trial name
- NCT07592416
- Testing
- Amoxicilin and Metronidazole, Probiotic Therapy
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Arterial Hypertension, Periodontitis
Clinical and Prognostic Significance of Periodontitis in Patients With Arterial Hypertension
As part of a prospective study, to evaluate the effect of periodontitis on the course of hypertension at baseline, during 6 and 12 months
- Trial name
- NCT07593768
- Testing
- Orthopantomography
- Where
- Russia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Necrotic Pulp With Symptomatic Apical Periodontitis
Evaluation of the Impact of Different Final Irrigation Activation Modes on Healing of Periapical Lesions Related to Permanent Mandibular First Molars Using CBCT.
The goal of this clinical trial is to learn how different ways of activating the cleaning liquid (irrigation) during endodontic treatment affect healing of infections at the root tip (periapical lesions) in adults aged 20 to 40…
- Trial name
- NCT07589556
- Testing
- root canal treatment
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Periodontitis, Periodontitis Stage I
Relationship Between NLRP3 Inflammasome Activation and Stages of Periodontitis: An Association With Inflammaging
This study aims to investigate the relationship between NLRP3 inflammasome activation and different stages of periodontitis, with a focus on its association with inflammaging.
- Conditions
- Periodontitis, Periodontitis Stage I, Periodontitis Stage II, Periodontitis Stage III
- Trial name
- NCT07590089
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Periodontitis, Periodontal Health
Detection And Quantification of Eubacterium Saphenum and Porphyromonas Gingivalis In Periodontal Health and Disease
This case-control study will be conducted between January and June 2026 and will include 148 participants aged over 30 years to investigate differences between individuals with periodontitis (n = 111) and those with periodontal…
- Trial name
- A Case-Control (NCT07579338)
- Testing
- Microbiological sampling After recording the clinical periodontal parameters, subgingival biofilm samples were collected. After selecting the sampling site, it was isolated with cotton rolls to keep i
- Where
- Iraq
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Sarah Al-Rihaymee
Gingivitis and Periodontal Diseases, Periodontitis
Association Between Periodontal Status and the Prevalence of Entamoeba Gingivalis and Trichomonas Tenax
This prospective observational study aims to investigate the prevalence and clinical significance of two oral protozoa, Entamoeba gingivalis and Trichomonas tenax, among patients attending the Bolu Abant İzzet Baysal University…
- Trial name
- NCT07551115
- Testing
- Clinical Periodontal Evaluation, Microscopic Examination of Oral Protozoa
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Periodontal Disease, Periodontal Diseases
Candida Albicans in Syrian Patients With Periodontitis
Periodontitis is a significant oral health issue characterized by inflammation and destruction of the supporting structures of the teeth.
- Conditions
- Periodontal Disease, Periodontal Diseases, Periodontitis
- Trial name
- NCT07574827
- Testing
- Periodontal Assessment and Sample Collection from Subgingival Pockets
- Where
- Syria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Al-Hawash Private University
Periodontitis, Bruxism
Impact of Subgingival Instrumentation on Jaw Symptoms of Probable Bruxers Among Patients With Periodontitis
This study aims to explore the mechanisms by which periodontal disease affects the bruxers and to assess the impact of subgingival instrumentation on jaw symptoms of probable bruxers among patients with periodontitis .
- Trial name
- NCT06429917
- Testing
- Subgingival instrumentation
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontal Disease
Efficacy of Laser Therapy for Periodontitis
The aim of this study is to evaluate the efficacy of diode laser in addition to periodontal treatment in periodontitis patients and to investigate their effects on gingival crevicular fluid (GCF) cytokine levels before and after…
- Trial name
- NCT07013162
- Testing
- High power diode laser + SRT, Low diode diode laser + SRT, Curettage (SRT) only
- Where
- 2 sites in Yemen
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Science and Technology, Yemen
Periodontal Diseases, Periodontitis
Development of A Self-Assessment Tool for Personalized Preventive Periodontal Care Among the Saudi Population Using Semi-Supervised Learning
This observational study will collect labeled data to assess the accuracy of an online periodontal self-assessment tool in adults.
- Conditions
- Periodontal Diseases, Periodontitis, Gingivitis
- Trial name
- NCT07410351
- Testing
- Online periodontal self-assessment questionnaire and clinical periodontal examination (reference standard)
- Where
- Saudi Arabia
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia