Clinical trials: Periodontitis
Endodontic Disease
Effect of Three Mechanical Systems on Removal of Endotoxins From Necrotic Teeth
The patients will be randomly assigned into two equal groups Group : OneShape Group: ProtaperNext Endodontics procedure steps: Patient will be anesthetized by using infiltration local anesthesia or nerve block according to the…
- Trial name
- RCT2019 (NCT04200638)
- Testing
- ProTaper Next
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Apical Periodontitis
Intraoral Cryotherapy on Cytokine Levels and Postoperative Endodontic Pain
The aim of this study is to evaluate the effects of intraoral cryotherapy on the inflammatory cytokine levels during root canal treatment and postoperative pain intensity and incidence.
- Trial name
- NCT05017064
- Testing
- Cryotherapy group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Apical Periodontitis
"Effect of Apical Patency on Post-endodontic Pain"
This study is designed to find out the effect of maintaining apical patency versus non maintaining apical patency on post-operative pain after single visit endodontic treatment in necrotic teeth with asymptomatic apical…
- Trial name
- NCT04551209
- Testing
- Maintaining apical patency
- Where
- Pakistan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National University of Medical Sciences, Pakistan
Periodontal Diseases, Periodontitis
Interaction Between Immune Cells and Bacteria Associated With Periodontitis
This study evaluates the interaction between host immune cells and bacteria associated with periodontitis. It comprises biological material from donors with and without periodontal disease.
- Conditions
- Periodontal Diseases, Periodontitis, Aggressive Periodontitis, Immunologic Disease
- Trial name
- NCT03225950
- Testing
- In vitro stimulation of blood with periodontitis-associated- and control bacteria, Anti-CCP- and anti-P.g.-antibodies titers, Analysis of selected single nucleotide polymorphisms (SNPs)
- Where
- 2 sites in Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Missed Abortion, Periodontitis
Periodontal Pathogens and Inflammatory Biomarkers in Missed Abortion
This observational case-control study will investigate whether periodontal infection and inflammation are associated with missed abortion in pregnancies without detected major fetal chromosomal abnormalities.
- Trial name
- NCT07864220
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Periodontal Pocket
Dietary Intakes and Periodontal Outcomes After Sanative Therapy
Periodontitis is a chronic inflammatory disease and a significant risk factor for tooth loss. While a link between diet and periodontal health exists, the relationship between diet and healing following periodontal therapy has…
- Trial name
- NCT02291835
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Brock University
Type 2 Diabetes Mellitus, Chronic Periodontitis
The Effect Of Glycemic Control On Malondialdehyde, Glutathione Peroxidase, Glutathione And Paraoxonase
The aim of this study was to investigate the impact of glycemic control on clinical periodontal status, levels of malondialdehyde (MDA), glutathione peroxidase (GSH-Px), reduced glutathione (GSH) and paraoxonase (PON) activity in…
- Trial name
- NCT01467674
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Periapical Abscess
Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy
The trial is to test the resolution of pain, swelling and other signs of periapical infection and the antimicrobial efficacy when using the neem leaf extract compared to chlorhexidine as root canal irrigant in Pulpectomy…
- Trial name
- NCT02943759
- Testing
- Neem leaf extract, Chlorhexidine gluconate
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Disease, Gingivitis and Periodontal Diseases
Salivary Biomarkers in Periodontal Disease Progression
This study aims to evaluate salivary biomarkers associated with bone remodeling during the transition from periodontal health to disease.
- Conditions
- Periodontal Disease, Gingivitis and Periodontal Diseases, Periodontitis
- Trial name
- PERIO-BIO (NCT07661784)
- Testing
- Saliva Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Periodontal Pocket
The Proposed Study Aims to Investigate the Efficacy of Quercetin as an Adjunctive to Mechanical Debridement in Treatment of Periodontitis
the proposed study aims to investigate the effect of Quercetin in treatment of periodontitis patients
- Trial name
- NCT06982248
- Testing
- NSP and chitosan nanoparticles gel loaded by quercetin, NSP and chitosan nanoparticles gel, scaling and root planning
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Periodontal Diseases, Periodontal Pocket
Insulin Versus Hyaluronic Acid in Management of Periodontal Defects
in this study, insulin and hyaluronic acid will be used after open flap debridement in treatment of periodontal defects. outcome will be evaluated clinically and radiographically
- Trial name
- NCT05746676
- Testing
- Insulin, Hyaluronic acid
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Chronic Periodontitis
Tissue Plasminogen Activator & Plasminogen Activator Inhibitor Type-1 In Gingival Tissues Of Chronic Periodontitis
Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Type-1 Gene Expression will be evaluated clinically and histopathologically through Hematoxylin and eosin as well as by quantitative reverse transcription…
- Trial name
- NCT03803176
- Testing
- Open Flap Debridement
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Diseases, Periodontal Bone Loss
Adjunctive Antioxidant Effect of Centella Asiatica Nanoemulsion Gel in Management of Periodontitis
The aims of the current study are: 1. Evaluation of the clinical efficacy of local delivery of nanoemulsion gel containing Centella asiatica extract as an adjunct to conventional non-surgical periodontal therapy in periodontitis…
- Trial name
- NCT07697209
- Testing
- Centella asiatica nanoemulsion gel, Scaling and Root Planing (SRP)
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Periodontitis, Gingivitis
Fractalkine-CX3CR1 Axis in Periodontal Therapy
This study aimed to evaluate gingival crevicular fluid (GCF) levels of fractalkine/CX3CL1 and CX3CR1 in patients with gingivitis and periodontitis before and after non-surgical periodontal therapy.
- Conditions
- Periodontitis, Gingivitis, Inflammation Biomarkers
- Trial name
- NCT07307144
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Giresun University
Periodontitis, Periodontal Diseases
Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis).
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Inflammation, Gingival Diseases
- Trial name
- NCT07536204
- Where
- Chile
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Chile
Regeneration
Evaluation of the Survival of Inflamed Mature Single Rooted Teeth
The majority of articles present in literature concerning the enrollment of tissue engineering in the field of root canal treatment is concerned with the treatment of affected teeth with immature apex, after proper systematic…
- Trial name
- NCT03725514
- Testing
- Conventional, PRF
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis, Cardiovascular Diseases
NSPT on Calprotectin and Periostin Levels
Periodontitis is a chronic inflammatory disease is initiated by the oral microbial biofilm where in the response to this infection is mediated by various intracellular signalling pathways leading to the production of numerous…
- Conditions
- Chronic Periodontitis, Cardiovascular Diseases, Periodontal Inflammation
- Trial name
- NCT05618743
- Testing
- Non Surgical Periodontal Therapy
- Where
- India
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Periodontitis and Treatment Need
Evaluation of a New Self-reported Tool for Periodontitis Screening
200 patients took part in the questionnaire and were examined using the PSI. Thereafter the participants were divided into two groups, non-periodontitis persons (group 1; PSI 0-2) and periodontitis persons (group 2; PSI 3-4).
- Trial name
- NCT02754401
- Testing
- 16 Items, PSI
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Renatus, Antonio Renatus, Dent., M.Sc
Periodontal Pocket
Non-surgical Step 3 Periodontal Treatment With/Without Adjunctive Protocol - Pilot RCT.
Study conducted in patients recruited at private praxis setting after completed step 2 periodontal therapy. Residual pockets ≥4mm with positive bleeding or such >5mm randomly allocated to either conventional subgingival…
- Trial name
- NCT06438354
- Testing
- subgingival instrumentation plus Perisolv / hyaDent BG, subgingival instrumentation
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Witten/Herdecke
Chronic Periodontitis
Clinical and Anti-inflammatory Effect of Curcumin Oral Gel as Adjuncts in Treatment of Periodontal Pocket
application of 1% curcumin gel in clinical study design will be used . The study will be conducted in Al-Najaf specialised dentistry center.
- Trial name
- NCT04355416
- Testing
- curcumin Oral gel, subgingival scaling and root planing
- Where
- Iraq
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
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