Clinical trials: Periorbital Wrinkling
Periorbital Hyperpigmentation, Periorbital Edema
A 12 Week Study to Evaluate the Efficacy of an Eye Cream
This single center, open-label clinical study was conducted to assess the efficacy and tolerance of a topical eye cream when used over the course of 12 weeks by healthy women with moderate to severe under-eye dark circles…
- Conditions
- Periorbital Hyperpigmentation, Periorbital Edema, Fine Lines, Wrinkle
- Trial name
- NCT05807620
- Testing
- Gentle Cleansing Lotion, Facial Moisturizer, Sunscreen SPF 30
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Skin Resurfacing
A Phase 4 Clinical Study to Investigate the Effectiveness and Safety of Skin Resurfacing
This study is a prospective, post-marketing (Phase 4) non-registrational single-arm, open-label, multicenter study.
- Trial name
- NCT07214272
- Testing
- Fraxel® FTX Laser System
- Where
- 5 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Glabellar Lines, Midface Volume Deficiency
Prospective, Non-interventional Study Assessing Periorbital Rejuvenation Procedure
The goal of this observation is to assess the time course of holistic extended periorbital rejuvenation using botulinum toxin A, cross-linked hyaluronic acid and polynucleotides corresponding to the application in routine…
- Conditions
- Glabellar Lines, Midface Volume Deficiency, Periorbital Wrinkling
- Trial name
- NCT07398755
- Testing
- Letybo®, Philart® Eye, Saypha® Volume Plus Lidocaine
- Where
- Austria
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Yuvell
Periorbital Wrinkles
Improvement in the Appearance of Periorbital Wrinkles
The primary objective of this study is to evaluate the efficacy of DefenAge 8-in-1 BioSerum supplemented with the enhanced concentration of defensins (enhanced 8-in-1 BioSerum) in the improvement of periorbital wrinkles.
- Trial name
- NCT05082766
- Testing
- enhanced DefenAge 8-in-1 BioSerum
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Skin Wrinkles
Study on the Safety, Efficacy of Home RF Cosmetic Instrument in the Treatment of Facial or Periorbital Wrinkles（F-MFR300-RD-003）
This is a multicenter trial with randomized control and evaluator blind method, which meets the screening criteria total of 224 subjects were enrolled and randomly divided into control group and experiment according to 1:1 ratio…
- Trial name
- NCT06565884
- Testing
- Home radiofrequency skin treatment instrument, Ultrasonic coupler for medical purposes
- Where
- China
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Flossom (GD) Beauty Technology Co., Ltd.
Wrinkles
Silk'n HST for Wrinkle Reduction - Clinical Study Protocol
The objective of the study is to evaluate the safety, efficacy and usage compliance of the home-use device Silk'n HST for self-treatment of periorbital wrinkles and skin laxity and improvement of skin appearance.
- Trial name
- NCT02913547
- Testing
- Silk'n HST
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Home Skinovations Ltd.
Skin Wrinkles
Study on the Safety, Efficacy of Home RF Cosmetic Instrument in the Treatment of Facial or Periorbital Wrinkles
This is a multicenter trial with randomized control and evaluator blind method, which meets the screening criteria total of 224 subjects were enrolled and randomly divided into control group and experiment according to 1:1 ratio…
- Trial name
- YM-1 (NCT06441799)
- Testing
- Home radiofrequency skin treatment instrument, Ultrasonic coupler for medical purposes
- Where
- China
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Glomed(HN)Co.Ltd
Periorbital Wrinkles
Evaluation of the Safety and Performance of Epicare for the Treatment of Periorbital Wrinkles
This is a prospective, interventional, evaluator-blinded, multi-center clinical study designed to assess the safety and performance of the Epicare fractional nano-thulium (Tm:YAP 1938 nm) laser system for the treatment of…
- Trial name
- NCT07114562
- Testing
- Epicare
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Laser team Ltd
Wrinkle, Periorbital
Clinical Study Evaluating the Safety and Effectiveness of The Tixel Fractional System in The Treatment of Periorbital Wrinkles
A Prospective, Multicenter, Single-Arm Clinical Study of 51 study subjects who are seeking a procedure to reduce the appearance of the peri-orbital wrinkles.
- Conditions
- Wrinkle, Periorbital, Tixel 2, Fractional
- Trial name
- NCT04639713
- Testing
- Tixel 2
- Where
- 3 sites in United States, Israel
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Novoxel Ltd.
Wrinkle
Confirmatory Study: Assessing the Efficacy and Safety of the AcusMu Microneedle Patch in Treating Periorbital Wrinkles
The core objective of this study is to validate the safe and efficacious application of the AcusMu microneedle patch (FMD WK) to enhance the appearance of periorbital wrinkle
- Trial name
- NCT06158867
- Testing
- FMD WK
- Where
- Taiwan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AcusMu Medtech Co., Ltd.
Periorbital Wrinkles
Reducing Wrinkles Around the Eyes Using the Ulthera® System
The purpose of this prospective, multi-center, single treatment study is to evaluate the clinical outcomes associated with the non-invasive treatment to reduce wrinkles around the eyes utilizing the Ulthera® System to deliver…
- Trial name
- NCT01368900
- Testing
- Ulthera® System treatment
- Where
- 2 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ulthera, Inc
Lateral Periorbital Wrinkles
Efficacy and Safety of NT 201 in the Treatment of Lateral Periorbital Wrinkles
To investigate the efficacy and safety of incobotulinumtoxinA (Xeomin) in comparison to placebo in the treatment of moderate to severe lateral periorbital wrinkles at maximum smile and to compare two different application schemes…
- Trial name
- NCT00541723
- Testing
- IncobotulinumtoxinA (Xeomin)
- Where
- 12 sites in France, Germany and 2 more
- Volunteers
- 111 people
- Sponsor
- Merz Pharmaceuticals GmbH
Age-related Changes in Skin Appearance and Physiology
Effect of Collagen Peptides on Skin Health: A Clinical Trial
The goal of this clinical trial is to evaluate whether daily oral supplementation with 2.5 g of specific bioactive collagen peptides (SCP) can improve skin physiology in healthy adult women aged 35-55 years.
- Trial name
- BCP-Skin (NCT07516756)
- Testing
- Specific Collagen Peptides
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Collagen Research Institute
Wrinkle
A Safety and Effectiveness Study of the Tixel Device, (Fractional Peri-orbital Wrinkles Treatment ) Compared With Laser
This study is designed to explore the safety and the effectiveness of the Tixel device. This device performs fractional treatment of the skin by applying thermal (heat) energy to the skin.
- Trial name
- NCT03454672
- Testing
- Tixel, Laser
- Where
- 2 sites in United States, Israel
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Novoxel Ltd.
Mild to Moderate Temporal Atrophy, Moderate to Severe Glabellar Rhytids
Upper Facial Remodeling With Perlane-L and Dysport
The purpose of this study is to provide data to support combination treatment of the upper face with Perlane-L® and Dysport™. This study will assess the outcome of upper face rejuvenation in the temporal fossa; outcome of…
- Conditions
- Mild to Moderate Temporal Atrophy, Moderate to Severe Glabellar Rhytids, Moderate to Severe Periorbital Rhytids
- Trial name
- DPL-2010 (NCT01354743)
- Testing
- Dysport, Perlane L
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beer, Kenneth R., M.D., PA
Periorbital Wrinkles
Safety and Efficacy of XP200 Radiofrequency Treatment of Wrinkles
To evaluate the wrinkle-reducing effects of 3.25-MHz radiofrequency (RF) energy delivered in 4 weekly applications to human periorbital skin area by grating pre- and 90-days post treatment photographs on the Fitzpatrick Wrinkle…
- Trial name
- NCT01795417
- Testing
- RF XP200, XP200 RF device
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Wrinkled Structure
A Confirmatory Study for Evaluation of the Treatment by the Celluma3 of Periorbital Wrinkles
The primary objective of this study is to confirm the safe and effective use of the Celluma3 for the reduction in the appearance of periorbital wrinkles.
- Trial name
- NCT02543970
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- BioPhotas
Wrinkles, Photoaging
Investigation of the Efficacy and Tolerability of a Cosmetic Product With Onabotulinumtoxin A in the Treatment of Facial Lines
This randomized, multi-center, double-blinded, placebo-controlled, split-face clinical trial was conducted to evaluate the procedure-pairing of OnabotulinumtoxinA with a peptide anti-aging serum to improve facial lines and…
- Conditions
- Wrinkles, Photoaging, Fine Lines
- Trial name
- NCT05089851
- Testing
- Onabotulinumtoxin A, Facial Cleanser, Facial Moisturizer
- Where
- 3 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Dry Eye, Dry Eye Syndromes
Assessing the Impact of Tixel Treatment of Periorbital Wrinkles on Dry Eye Symptoms and Signs
Pilot study where effect of standard Tixel treatment as used for periorbital wrinkles would be assessed on Dry Eye Disease symptoms and signs
- Trial name
- NCT04730336
- Testing
- Tixel
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- Aston University
Periorbital Wrinkles
Evaluation of the Effectiveness and Safety of the Ulthera™ System for the Treatment of Wrinkles Around the Eyes
The purpose of this study is to look at how safe and effective the Ulthera ultrasound system is at reducing the appearance of wrinkles when used with subjects who have wrinkles around the eyes.
- Trial name
- NCT00747422
- Testing
- Ulthera™ System
- Where
- 4 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ulthera, Inc