Clinical trials: Persistent Pain After Injury
Carpal Tunnel Syndrome (CTS)
Evaluation of Dynavisc in Pain Reduction Following Revision Surgery for Persistent or Recurrent Carpal Tunnel Syndrome
The trial will evaluate the efficacy of DYNAVISC in subjects with a diagnosis of persistent or recurrent carpal tunnel syndrome. This is a prospective, multicenter, randomized, evaluator-blinded clinical trial.
- Trial name
- NCT06593977
- Testing
- Dynavisc
- Where
- 4 sites in Belgium, Brazil and 1 more
- Volunteers
- 50 people
- Sponsor
- FzioMed
Phantom Limb Pain After Amputation, Chronic Pain Due to Injury
Negative Pressure Wound Therapy as a Predictor of Persistent Pain After War-Related Trauma
War-related trauma frequently causes complex soft tissue injuries that require repeated surgical treatment and advanced wound management techniques such as Negative Pressure Wound Therapy (NPWT).
- Conditions
- Phantom Limb Pain After Amputation, Chronic Pain Due to Injury, Postoperative Pain, Trauma (Including Fractures)
- Trial name
- NPWT-Pain Stud (NCT07475897)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Spinal Disk Injury
Triple Therapy Strategy for Managing Persistent Pain After Spinal Microdiscectomy
This interventional study evaluates a "triple therapy" approach-combining percutaneous spinal fixation, facet radiofrequency ablation, and epidural steroid/hyaluronidase injection-for patients with Failed Back Surgery Syndrome…
- Trial name
- NCT07370233
- Testing
- Epidural Injection, thermal Radiofrequency Ablation, Spinal Fixation
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Benha University
Brain Injuries, Traumatic, Concussion, Brain
rTMS Treatment of Persistent Headache and Post Concussion Symptoms Attributed to Mild Traumatic Injury to the Head
The objective of this study is to investigate the treatment effect of repetitive transcranial magnetic stimulation in patients with a history of both persistent post-traumatic headache and post-concussion symptoms.
- Conditions
- Brain Injuries, Traumatic, Concussion, Brain, Headaches Chronic, Headache
- Trial name
- TOPiCS-rTMS (NCT03691272)
- Testing
- rTMS - Real Air Film Coil
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Persistent Pain After Injury, Functional Decline After Injury
Persistent Pain Among Elderly Experiencing Motor Vehicle Collision
Chronic problems after traumatic events are common in non-elderly adults. Previous studies have shown that after minor motor vehicle collision (MVC), 10-30% of non-elderly adult patients develop chronic regional pain (neck or…
- Trial name
- Elderly CRASH (NCT02054962)
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- University of North Carolina, Chapel Hill
Residual Limb Pain, Stump Pain
Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Cohort Study
Persistent residual limb pain is common after traumatic amputation and significantly impairs rehabilitation and prosthetic use. Postoperative stump infection may contribute to peripheral nerve sensitization, scar fibrosis, and…
- Conditions
- Residual Limb Pain, Stump Pain, Post-Amputation Pain, Surgical Site Infection
- Trial name
- INF-STUMP-PAIN (NCT07438795)
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Marginal Ulcer, Chronic Ulcer Disease
Chronic Marginal Ulcers After Gastric Bypass
The purpose of this study is to determine the feasibility, safety, and efficacy of revision gastroplasty along with other adjunct procedures in the treatment of intractable / chronic marginal ulcers after Roux-en-Y gastric…
- Conditions
- Marginal Ulcer, Chronic Ulcer Disease, Persistent Ulcer Disease, Recurrent Ulcer Disease
- Trial name
- ChronicMU (NCT01041079)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Burn Scar Pain, Neuropathic Pain
Ultrasound Predictors of Persistent Burn Scar Pain After Blast and Drone-Related Injuries: A Prospective Cohort Study
Persistent burn scar pain is common after blast and drone-related injuries and may be driven by scar fibrosis, vascular activity, and peripheral nerve involvement within scar tissue.
- Conditions
- Burn Scar Pain, Neuropathic Pain, Combat-Related Burn Injury, Scar-Related Pain
- Trial name
- US-SCAR-PAIN (NCT07438769)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Breast Cancer, Surgery
Analgesic Effect of Resistance Training for Breast Cancer Survivors
Persistent pain after treatment for breast cancer is a major clinical problem, affecting 25-60 % of the patients and is a source of considerable physical disability and psychological distress.
- Conditions
- Breast Cancer, Surgery, Chemotherapy Effect, Radiotherapy Side Effect
- Trial name
- (ANTRAC) (NCT04509284)
- Testing
- Training, Control
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aalborg University
Disorders of Consciousness, Severe Brain Injury
Use of Analgesic Treatment to Reduce Signs of Pain in Patients With Disorders of Consciousness.
The purpose of this study is to characterize and improve pain and nociception management in patients with disorders of consciousness (DOC).
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Post-comatose Non-communicative Patients, Vegetative State
- Trial name
- NCT04330547
- Testing
- Analgesic administration
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- University of Liege
Brain Injury, Chronic
Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury
The purpose of this study is to examine whether 40 hyperbaric oxygen sessions has effect on long-term symptoms after brain injury.
- Trial name
- HYBOBI2 (NCT01986205)
- Testing
- Hyperbaric Oxygen, Minimal pressure air
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- Lindell Weaver
Post-Traumatic Neck Pain, Whiplash-associated Disorders
StressModex for Post-Traumatic Neck Pain
Post-traumatic neck pain is a common consequence of traffic-related and other accidental injuries. While many individuals recover, a subgroup develops persistent pain, disability, and psychological distress.
- Trial name
- StressModex (NCT07824557)
- Testing
- StressModex plus Treatment as Usual
- Where
- 3 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- University of Southern Denmark
Chronic Pain, Chronic Pain Due to Injury
Virtual Pain Education for Spinal Cord Stimulation Patients
Chronic pain is a leading cause of disability in the United States. When standard treatments fail, many patients develop treatment resistant pain and undergo Spinal Cord Stimulation (SCS) therapy.
- Conditions
- Chronic Pain, Chronic Pain Due to Injury, Failed Back Syndrome, Persistent Spinal Pain Syndrome
- Trial name
- SCS-PNE (NCT07743905)
- Testing
- SCS-PNE intervention
- Volunteers
- 50 people
- Sponsor
- University of Arkansas
Orthopaedic Trauma, Chronic Pain
Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma
The purpose of this single-arm trial is to determine the feasibility of emotional awareness and expression therapy (EAET) for individuals with persistent pain following orthopedic trauma.
- Conditions
- Orthopaedic Trauma, Chronic Pain, Musculoskeletal Injury
- Trial name
- NCT05989230
- Testing
- Emotional Awareness and Expression Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Pain, Postoperative, Fractures, Closed
Cognitive Behavioural Therapy to Reduce Persistent Post-Surgical Pain After Fracture
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures.
- Conditions
- Pain, Postoperative, Fractures, Closed, Fractures, Open
- Trial name
- SPOC_CBT (NCT03196258)
- Testing
- Cognitive behavioural therapy
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McMaster University
Post-Traumatic Headache
Behavior Therapy vs Education for Persistent Headache After Mild TBI
This study will test a new treatment, called Headache reprocessing, for persistent post-traumatic headache. The new treatment will be compared to a headache education intervention.
- Trial name
- NCT07229391
- Testing
- Headache reprocessing, Headache education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Post-Concussion Syndrome, Concussion, Brain
Personalized Brain Stimulation to Treat Chronic Concussive Symptoms
The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old.
- Conditions
- Post-Concussion Syndrome, Concussion, Brain, Mild Traumatic Brain Injury, Head Injury
- Trial name
- NCT06073886
- Testing
- Active cTBS, Imaginal exposure
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, Los Angeles
Acute Orthopedic Injury
Toolkit for Optimal Recovery After Orthopedic Injury
This is a multi-site randomized feasibility trial of the Toolkit for Optimal Recovery after Orthopedic Injury (TOR), a mind-body program to prevent persistent pain and disability in at-risk patients with acute orthopedic injury…
- Trial name
- TOR (NCT04973696)
- Testing
- Toolkit for Optimal Recovery after Orthopedic Injury, Minimally Enhanced Usual Care (MEUC)
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Massachusetts General Hospital
Neuropathic Pain
Cryoneurolysis for Cutaneous Neuropathic Pain
Feasibility study with 25 patients investigating the effect of cryoneurolysis on persistent cutaneous neuropathic pain after surgery and trauma. All patients receive active treatment (cryoneurolysis).
- Trial name
- NCT04911569
- Testing
- Cryoneurolysis
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Aarhus University Hospital
Neck Pain, Whiplash Injuries
Implementation and Evaluation of Neck-specific Exercises
Persistent pain and disability in whiplash-associated disorders (WAD) grade II and III are common. Randomized controlled studies (RCTs) have shown promising result for neck-specific exercise (NSE) programmes in chronic WAD with…
- Conditions
- Neck Pain, Whiplash Injuries, Neck Disorder
- Trial name
- NCT05198258
- Testing
- Implementation strategy - experimental group, Implementation - control group
- Where
- 7 sites in Sweden
- Volunteers
- 20 people
- Sponsor
- Sormland County Council, Sweden