Clinical trials: Persistent Postsurgical Pain
Acute Pain, Chronic Pain
The Effects of TAP Block on Postsurgical Pain After Minimally Invasive Partial Nephrectomy:
Single-center study in order to assess whether the tap block can make extremely beneficial in terms of reducing the acute and chronic pain as well as for use of opioids and side effects related to it in patients undergoing…
- Trial name
- NCT02460640
- Testing
- Tap block, intravenous Patient controlled analgesia, Morphine
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- Regina Elena Cancer Institute
Pain, Chronic Post-Surgical
PERIoperative Holistic RIsk Factor SCreening in the Prevention of Persistent Pain
Assessment and management for improved wellbeing after elective surgery (PERISCOP³E-Care) Diagnostic assessment tool evaluation and cut-off determination for participation in a transmural perioperative care program
- Trial name
- PERISCOPEcare (NCT05526976)
- Testing
- PERISCOPE-care
- Where
- 2 sites in Belgium
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Primary Inguinal Hernia
The Effect of Preemptive Regional Anesthesia (TAP-block) on Acute and Chronic Pain After Transabdominal Preperitoneal Inguinal Hernia Repair (TAPP)
The study is devoted to the impact of preemptive regional Transversus abdominal plane block on the postoperative acute and chronic pain after elective Transabdominal preperitoneal (TAPP) inguinal hernia repair.
- Trial name
- ERA-TAPP (NCT06406959)
- Testing
- Transversus abdominal plane block (TAP block)
- Where
- Russia
- Volunteers
- 78 people
- Sponsor
- Pirogov Russian National Research Medical University
Chronic Pain, Surgery
Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain
The investigators will approach elective cardiac and thoracic surgery patients in the preoperative consultation clinic. Consenting individuals will be administered, before surgery validated pain, psychological and sleep…
- Trial name
- CT-Pain (NCT04798573)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University Health Network, Toronto
Chronic Post Operative Pain
Cytokine Alterations and Chronic Post-Surgical Pain
Chronic Post-Surgical Pain (CPSP) is a condition that involves experiencing pain and/or discomfort that lasts for more than 3 months following surgery without any explainable cause of this pain such chronic infection or pain…
- Trial name
- NCT06418295
- Testing
- Unilateral thoracotomy
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Persistent Post-surgical Pain, Acceptance and Commitment Therapy
Preventing Persistent Post-Surgical Pain and Opioid Use In At-Risk Veterans: Effect of ACT
A large number of veterans suffer from distress-based conditions, such as anxiety and depression, putting them at high risk of experiencing persistent pain and prolonged opioid use following surgery.
- Conditions
- Persistent Post-surgical Pain, Acceptance and Commitment Therapy, Substance Use Disorder
- Trial name
- PreACT (NCT02437188)
- Testing
- ACT (Acceptance and Commitment Therapy)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Barbara A Rakel
Esketamine, Pregabaline
Esketamine Combined With Pregabalin on CPSP in Spinal Patients.
Chronic postsurgical pain has become one of the most common complications of surgery. The quality of life will be impacted once the postsurgical patients are combined with persistent pain.
- Conditions
- Esketamine, Pregabaline, Chronic Post Operative Pain
- Trial name
- NCT06117917
- Testing
- S-ketamine and pregabalin
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Postoperative Delirium, Postoperative Cognitive Dysfunction
The Impact of Repetitive Transcranial Magnetic Stimulation on the Prognosis of Elderly Surgical Patients
Exploring the effects of repeated transcranial magnetic stimulation (rTMS) during the perioperative period on the incidence of postoperative delirium, postoperative cognitive dysfunction, and chronic postoperative pain in elderly…
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Chronic Post-surgical Pain
- Trial name
- NCT06392919
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Affiliated Hospital of Nantong University
Inguinal Hernia, Femoral Hernia
Factors Influencing the Results of Treatment in Patients With Hernias of Various Localizations
The study attempts to quantify the relative risks for acute postoperative pain, complications rate, chronic postoperative pain (CPIP) and recurrence rate after different methods of repair of groin, umbilical and incisional hernia…
- Conditions
- Inguinal Hernia, Femoral Hernia, Umbilical Hernia, Ventral Hernia
- Trial name
- NCT05920200
- Testing
- open non-mesh hernia repair, open mesh hernia repair, MIS hernia repair
- Where
- Russia
- Volunteers
- 4,000 people
- Sponsor
- Immanuel Kant Baltic Federal University
Chronic Postoperative Pain, Pediatric ALL
Chronic Postsurgical Pediatric Pain. Evaluation Risk Factors to Develop Chronic Postsurgical Pain in Children and Adolescents Undergoing Surgery in a First Level Hospital
Chronic postsurgical pain had number of prevalence on 20%. Its derivates from risk factors, but recent research provide new potential risk factors to develop chronic postsurgical pediatric pain.
- Trial name
- NCT04735211
- Testing
- Surgery
- Where
- Spain
- Volunteers
- 260 people
- Sponsor
- Guillermo Ceniza Bordallo
Breast Cancer, Survivorship
Dance Study for Post-surgical Pain in Breast Cancer Survivors
The purpose of this study is to examine how a 12-week, virtual dance program may improve pain and quality of life in participants with persistent post-surgical pain, or PPSP, following mastectomy or lumpectomy.
- Conditions
- Breast Cancer, Survivorship, Pain, Postoperative
- Trial name
- NCT06758102
- Testing
- Dance Program
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Patients Scheduled for Thoracic Surgery/Esophagectomy Will be Enrolled, Persistent Post Surgical Pain
The Emerging Role of Resolvins in the Prevention of Chronic Pain After Thoracic Surgery
The aim of the study is to investigate whether pre-operative dysregulated systemic lipid mediator pathways are associated with increased risk for the development of persistent post surgical pain.
- Trial name
- NCT03095157
- Testing
- fractionated marine lipid concentrate derived from anchovy and sardine oil
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Chronic Post-surgical Pain
Chronic Post Surgical Pain-Cardiac
The CPSP-Cardiac is a large, multi-center, observational study with the aim to investigate the incidence of chronic pain in the 3rd month postoperatively in cardiac surgery and its affecting factors.
- Trial name
- CPSP-Cardiac (NCT06382077)
- Where
- 29 sites in Turkey (Türkiye)
- Volunteers
- 2,442 people
- Sponsor
- Ondokuz Mayıs University
Lumbar Surgery
Study of PEMF (Pulsed Electromagnetic Field) Therapy in the Treatment of Persistent Post-Operative Pain Following Lumbar Surgery
To demonstrate the analgesic effectiveness of 2 modalities of PEMF treatment compared to sham treatment in patients with persistent pain following lumbar surgery when treatment is administered twice daily over a 60 day period.
- Trial name
- NCT02416973
- Testing
- Provant
- Where
- 8 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Regenesis Biomedical, Inc.
Pain, Postoperative
Observational Study of an Automatic Detection of Patients at Risk of Chronic Postoperative Pain ("Alerte Douleur")
Following surgery, some but not all patients develop persistent (or chronic) postoperative pain CPSP. Several risk factors for this persistent pain have been confirmed in previous studies, but neither surgeons nor…
- Trial name
- ALDO (NCT03164954)
- Testing
- automatic risk detection
- Where
- Switzerland
- Volunteers
- 355 people
- Sponsor
- Benno Rehberg-Klug
Somatic Pain, Neuropathic Pain
C2-C4 Compartment Block Versus Block of Costagliola, in TEAC
C2-C4 compartment block compared to the Costaiola block, in the control of persistent postoperative pain (somatic and neuropathic) in patients undergoing carotid thromboendarterectomy
- Trial name
- TEAC (NCT03409068)
- Testing
- C2-C4 compartment anesthetic block, Costagliola block
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- San Salvatore Hospital of L'Aquila
Chronic Post-surgical Pain
Duloxetine to Prevent Chronic Postsurgical Pain After Inguinal Hernia Repair in Patients at High Risk
The clinical trial will be conducted in 14 Spanish hospitals. It is estimated, based on our previous studies, that 2855 patients scheduled for elective inguinal hernia surgery will have to be assessed to detect patients with ≥…
- Trial name
- GENDOLCAT3 (NCT06606067)
- Testing
- Duloxetine
- Where
- Spain
- Volunteers
- 294 people
- Sponsor
- Parc de Salut Mar
Chronic Post-surgical Pain, Acute Postoperative Pain
CROPS Study: Chronification of Post-Surgical Pain and Risk Assessment
Chronic post-surgical pain (CPSP) represents a major clinical problem associated with impaired functional recovery, reduced quality of life, prolonged opioid use, and increased healthcare utilization.
- Conditions
- Chronic Post-surgical Pain, Acute Postoperative Pain, Cardiac Surgery
- Trial name
- CROPS (NCT07629453)
- Testing
- Standard Multimodal Opioid-Based Analgesia, Regional Anesthesia-Based Analgesia
- Volunteers
- 180 people
- Sponsor
- Kočan Ladislav
Acute Post Operative Pain, Chronic Post Operative Pain
Combined Use of Naldebain® ER Injection and Precedex® After VATS
The goal of this clinical trial is to investigate the effects of combined use of Naldebain® ER Injection and Precedex® in patients received video-assisted thoracoscopic surgery.
- Conditions
- Acute Post Operative Pain, Chronic Post Operative Pain, Postoperative Complications
- Trial name
- NCT06176222
- Testing
- PRECEDEX INJ★ 2ML, Normal saline
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Breast Cancer, Surgery
Pain After Breast Surgery
This is a pilot observational study assessing various predictors for acute pain and persistent pain following breast surgery for cancer.
- Trial name
- NCT03307525
- Volunteers
- 141 people
- Sponsor
- Duke University