Clinical trials: Pharmacotherapy Optimization
Insomnia Disorder
Optimization of Insomnia Treatment in Primary Care
The primary objective of this pragmatic clinical trial is to evaluate the efficacy, feasibility, and adaptability of pharmacological and non-pharmacological treatments for insomnia disorder, delivered in primary care clinics.
- Trial name
- NCT03633305
- Testing
- Hypnotics, Online CBT, Face-to-face CBT
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Laval University
Advanced Non-small Cell Lung Cancer (NSCLC), EGFR Exon 19 Deletion Mutation
Befotertinib Plus Chemotherapy With an MRD-guided Adaptive Strategy for Treatment Escalation and Response Optimization in EGFR-mutated NSCLC Patients
This is a multicenter, phase II exploratory clinical trial in untreated patients with EGFR-mutant non-small cell lung cancer (stages IIIB-IV) .All participants will receive oral befotertinib monotherapy for 3 weeks first, then…
- Conditions
- Advanced Non-small Cell Lung Cancer (NSCLC), EGFR Exon 19 Deletion Mutation, EGFR Exon 21 Mutation, EGFR Exon 21 L858R Mutation
- Trial name
- BE-MASTER (NCT07709585)
- Testing
- Befotinib, Pemetrexed + Cisplatin /Carboplatin
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Advanced Colorectal Cancer Expressing HER2
A Global Trial of Trastuzumab Rezetecan (SHR-A1811) in Combination With Chemotherapy and Bevacizumab as First-Line Treatment in Patients With Advanced Colorectal Cancer Expressing HER2
This global study is being conducted to evaluate the safety and determine the recommended phase 3 dose of trastuzumab rezetecan in combination with mFOLFOX6 chemotherapy (dose level -1) and bevacizumab as first-line treatment in…
- Trial name
- HORIZON-CRC221 (NCT07796763)
- Testing
- Trastuzumab Rezetecan (SHR-A1811) injection; high dose, Trastuzumab Rezetecan (SHR-A1811) injection; low dose
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Cancer
Optimization of the Nursing Time After the Use of Tissue Adhesives During the Chest Port Placement on Patients Treated With Chemotherapy Versus Sutures
Skin adhesive (Octyl cyanoacrylate - LIQUID BAND©) is increasingly used instead of suture for sutures on the superficial plane of the skin. It is frequently used in children, in traumatology and in plastic surgery.
- Trial name
- PAC_COLLE (NCT04848389)
- Testing
- Skin Adhesive procedure, Standard suture procedure
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Metastatic Colorectal Cancer
Toxicity/Benefit Ratio Optimization of Chemotherapy in Colorectal Cancer (CRC) Patients by Determination of Individual Genotypic Determinants
This study intends to optimize a fluorouracil/irinotecan chemotherapy regimen by the identification of individual thymidylate synthase (TS) and UDP-glucuronosyltransferase 1 (UGT1A1) polymorphisms before the first administration.
- Trial name
- NCT00138060
- Testing
- irinotecan, 5 fluorouracil
- Where
- 6 sites in France
- Volunteers
- 71 people
- Sponsor
- Institut de Recherche Clinique sur les Cancers et le Sang
Multimorbidity, Polypharmacy
OPTImization of Medication by Transdisciplinary Assessment of Drug Treatment in Elderly Hospitalized Patients
This study is being done to find out if a multi-faceted intervention designed to optimize medication in hospitalized older people with multiple chronic medical conditions exposed to multiple medications can reduce unplanned…
- Trial name
- OPTIMATE (NCT05387096)
- Testing
- Definitive multi-faceted intervention consisting of several components
- Where
- 3 sites in Belgium, Ireland
- Volunteers
- 642 people
- Sponsor
- University College Cork
Small Cell Lung Cancer, CEA-expressing Non Small Cell Lung Carcinoma (NSCLC)
TF2- Small Cell Lung Cancer Radio Immunotherapy
Lung cancer is currently the leading cause of cancer death in both men and women in Europe, with an estimated 250000 new cases diagnosed in 2005.
- Trial name
- NCT01221675
- Testing
- Antibody TF2, IMP-288-Lutetium, IMP-288-Indium
- Where
- 6 sites in France
- Volunteers
- 18 people
- Sponsor
- Centre René Gauducheau
Locally Advanced Nasopharyngeal Carcinoma
Timing Optimization of Immunotherapy During Neoadjuvant Chemotherapy for Locally Advanced Nasopharyngeal Carcinoma
This is a multicenter, open-label, randomized phase II clinical trial designed to evaluate the optimal timing of toripalimab administration during neoadjuvant chemotherapy in patients with locoregionally advanced nasopharyngeal…
- Trial name
- NCT07388836
- Testing
- Toripalimab
- Volunteers
- 198 people
- Sponsor
- Fujian Cancer Hospital
Pulmonary Large Cell Neuroendocrine Carcinoma
Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma
The primary endpoint is to compare the PFS (progress-free survival ) of etoposide plus carboplatin with paclitaxel combined with carboplatin as first-line treatment for advanced pulmonary large cell neuroendocrine carcinoma.
- Trial name
- NCT02943798
- Testing
- etoposide plus carboplatin, Paclitaxel plus carboplatin
- Volunteers
- 118 people
- Sponsor
- Shanghai Chest Hospital
Hodgkin Disease
Optimization of the Primary Therapy for Patients With Hodgkin's Disease and Evaluation of PET
Prognosis of patients with Hodgkin´s lymphoma (HL) has been improved significantly over the last decade. Therefore, the impact of treatment associated long-term toxicities and late effects such as second cancers increased.
- Trial name
- NCT00188149
- Testing
- Combined chemotherapy (ABVD, BACOPP-D), Radiation therapy
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Carl Gustav Carus
Heart Failure
Safety, Tolerability and Efficacy of Rapid Optimization, Helped by NT-proBNP testinG, of Heart Failure Therapies
STRONG-HF is a multicenter, randomized, parallel group study designed to evaluate the efficacy and safety of up-titration of standard oral heart failure medications during hospitalization for acute heart failure.
- Trial name
- STRONG-HF (NCT03412201)
- Testing
- Usual Care, High Intensity Care
- Where
- 78 sites in Argentina, Austria and 10 more
- Volunteers
- 1,800 people
- Sponsor
- Heart Initiative
Esophageal Squamous Cell Carcinoma
Optimization of Treatment Strategy for Unresectable cN3 Esophageal Squamous Cell Carcinoma
This study aims to investigate a comprehensive therapeutic approach for patients with unresectable esophageal squamous cell carcinoma, clinically staged as Tany, N3, M0, and who are not candidate for concurrent chemoradiotherapy…
- Trial name
- NCT06122493
- Testing
- Tirelizumab, Nab paclitaxel, Carboplatin
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Ruijin Hospital
Acute Lymphoblastic Leukemia, Burkitt's Lymphoma
Rituximab Combined With Chemotherapy in Burkitt's Lymphoma
The purpose of this clinical trial is to prove the efficacy of the following new regimen treatment: Administration of anti-CD20 (Rituximab) combined with chemotherapy.
- Trial name
- NCT00388193
- Testing
- RITUXIMAB
- Where
- 15 sites in Spain
- Volunteers
- 20 people
- Sponsor
- PETHEMA Foundation
Cancer, Neoplasm
Study of SAR444881 Administered Alone and in Combination With Other Therapeutics in Participants With Advanced Solid Tumors
The study enrolled advanced cancer participants with unresectable or metastatic disease who were refractory to or were not candidates for standard approved therapy.
- Trial name
- NCT04717375
- Testing
- SAR444881, Pembrolizumab, Cetuximab
- Where
- 18 sites in United States, Canada and 2 more
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Sanofi
Lymphoma, Lymphoma, B-Cell
ctDNA-guided Therapy Optimization in Newly Diagnosed DLBCL
The purpose of this study is to 1) determine whether it is feasible to measure circulating tumor DNA (ctDNA) in real-time during standard treatment for newly diagnosed diffuse large B-cell lymphoma (DLBCL), and 2) evaluate the…
- Conditions
- Lymphoma, Lymphoma, B-Cell, Diffuse Large B Cell Lymphoma, Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
- Trial name
- NCT06693830
- Testing
- Phased Variant Enrichment and Detection Sequencing (PhasED-seq), Standard of Care Treatment, De-escalated Treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Hua-Jay J Cherng, MD
Solid Tumor, Gastrointestinal Cancer
Optimizing and Personalising Azacitidine Combination Therapy for Treating Solid Tumours QPOP and CURATE.AI
This pilot feasibility study aims to set the foundation to investigate the applicability of QPOP drug selection followed by CURATE.AI-guided dose optimisation of the selected azacitidine combination therapy for solid tumours…
- Conditions
- Solid Tumor, Gastrointestinal Cancer, Breast Cancer
- Trial name
- NCT05381038
- Testing
- QPOP, CURATE.AI, Azacitidine + docetaxel
- Where
- Singapore
- Volunteers
- 10 people
- Sponsor
- National University Hospital, Singapore
Organ Preservation, Rectal Cancer Stage I
Total Neoadjuvant Therapy With Additional Consolidation Chemotherapy Followed by Local Excision Versus Total Neoadjuvant Therapy Followed by Local Excision at Stage I Rectal Cancer
Safety and Efficacy of Organ Preservation Treatment for Stage I Rectal Cancer: Optimization of Consolidation Chemotherapy Before Local Excision After Neoadjuvant Chemoradiotherapy (OPTION); A Multi-center, Prospective, Randomized…
- Conditions
- Organ Preservation, Rectal Cancer Stage I, Total Neoadjuvant Treatment, Consolidation Therapy
- Trial name
- OPTION (NCT07563907)
- Testing
- TNT with additional consolidation chemotherapy followed by local excision, TNT followed by local excision
- Where
- South Korea
- Volunteers
- 292 people
- Sponsor
- Seoul National University Hospital
Schizophrenia, First-Episode
Optimization of Acute Treatment in First Episode Schizophrenia
The study is a multicenter, double-blind, randomized, parallel-group study with first episode schizophrenic patients. During a treatment phase of 8 weeks the patients are treated with Risperidone or Haloperidol.
- Trial name
- NCT00157378
- Testing
- Risperidone, Haloperidol
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Colitis, Ulcerative
Vedolizumab Intravenous (IV) Dose Optimization in Ulcerative Colitis
The purpose of this study is to investigate the efficacy and safety of vedolizumab intravenous (IV) dose optimization on mucosal healing compared with the standard vedolizumab IV dosing regimen over a 30 week treatment period in…
- Trial name
- ENTERPRET (NCT03029143)
- Testing
- Vedolizumab IV
- Where
- 49 sites in United States, Canada
- Volunteers
- 278 people
- Sponsor
- Takeda
Smoking Cessation
Individualizing Pharmacotherapy for African American Smokers
Improving cessation outcomes for African American smokers through the use of novel, empirically-based strategies is a national health priority.
- Trial name
- NCT03897439
- Testing
- Nicotine patch, Varenicline Tartrate, Bupropion
- Where
- United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center