Clinical trials: Photobiomodulation
Head and Neck Cancer, Trismus
Photobiomodulation and Sonophoresis Improving Jaw Mobility and Quality of Life Among Head and Neck Cancer Survivors
Head and neck cancer originate from the several different anatomical subsites especially the squamous cell carcinoma. This involves mainly Oropharynx, Hypopharynx, and Larynx.
- Trial name
- NCT04082793
- Testing
- Photobiomodulation therapy with mandibular exercises, Sonophoresis with mandibular exercises
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Asir John Samuel
Healthcare Associated Infection, Nosocomial Infection
Red Light Photobiomodulation and Topical Disinfectants
The goal of this clinical trial is to evaluate the potential effects of photobiomodulation when used with topical disinfectants in the anterior nares of healthy adults.
- Conditions
- Healthcare Associated Infection, Nosocomial Infection, Surgical Site Infection
- Trial name
- NCT05797818
- Testing
- Methylene Blue Only, Chlorhexidine Gluconate Only, Methylene Blue + Chlorhexidine Gluconate
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ondine Biomedical Inc.
Photobiomodulation Therapy
Reversal of Anaesthesia with Diode Laser
Background: After local anesthesia, which is frequently used in pediatric dentistry, long-term soft tissue numbness can cause various problems.
- Trial name
- NCT06841120
- Testing
- Actual laser application
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Malocclusion Class I
Diode Laser Versus LED for Maxillary Canine Retraction in Orthodontic Patients
This study aims to compare the effects of diode laser and light-emitting diode (LED) photobiomodulation on maxillary canine retraction during fixed orthodontic treatment.
- Trial name
- NCT07810699
- Testing
- Diode Laser Photobiomodulation, LED Photobiomodulation
- Where
- Vietnam
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Pain Threshold, Pain Tolerance
Acute Effects of LLLT on Pain Threshold and Pain Tolerance
Pain is defined by the International Association for the Study of Pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage." Low-Level Laser…
- Conditions
- Pain Threshold, Pain Tolerance, Acute Pain, Low-level Laser Therapy
- Trial name
- NCT07422272
- Testing
- Low-Level Laser Therapy (LLLT)
- Where
- Cyprus
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- European University of Lefke
Trigeminal Neuralgia
Effect of Non-invasive Photobiomodulation Therapies in Patients With Trigeminal Neuralgia
The aim of this study was to compare the effectiveness of two different photobiomodulation (PBM) therapies as an alternative to medical treatment to reduce pain and improve quality of life in patients with trigeminal neuralgia…
- Trial name
- NCT06440356
- Testing
- laser therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Malocclusion, Angle Class II
Effect of Photobiomodulation by 808nm Diode Laser on the Stability of Orthodontic Mini-implants.
The study aimed to evaluate the influence of a 635nm diode laser on the stability of orthodontic mini-implants in vitro, as well as mini-implants failure rate (mini-implant loss) and patients pain level after the treatment.
- Trial name
- NCT04276402
- Testing
- Irradiation of implants with 808nm laser
- Where
- Poland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Bruxism, Sleep Bruxism
Low-Level Laser Therapy Versus Occlusal Splint Therapy for Bruxism in Children
Many children grind or clench their teeth, especially during sleep. Doctors call this bruxism. It can wear down teeth and cause jaw pain. This study compared two treatments for bruxism in children.
- Trial name
- NCT07865845
- Testing
- Low-Level Laser Therapy (LLLT), Occlusal Splint
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Alveolar Bone Loss, Maxillary Sinus Bone Loss
Anti-HLA Antibodies After Bone Regeneration Surgery
This study evaluates the occurrence of anti-human leukocyte antigen (anti-HLA) antibodies following bone regeneration procedures performed prior to dental implant therapy.
- Trial name
- Anti-HLA Bone (NCT07474857)
- Testing
- Xenogeneic Bone Graft, Allogeneic Bone Graft, Low-Level Laser Therapy
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical Innovation Center Wroclaw
Hypomineralization Molar Incisor
Photobiomodulation and Glass Ionomer Sealant as Complementary Treatment for Hypersensitivity in Molars With MIH
Introduction: Photobiomodulation (PBM) shows promising results for the complementary treatment of dentin hypersensitivity; however, few studies have evaluated this treatment specifically for teeth affected by molar incisor…
- Trial name
- NCT05370417
- Testing
- Use of fluoride toothpaste, Photobiomodulation, Simulated Laser Therapy
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Symptoms of Anxiety
Transcranial Photobiomodulation in Anxiety Disorders
The investigators have previously shown that safe, non-invasive methods of brain stimulation such as the administration of transcranial infrared light can result in improvements to cognition and emotion.
- Trial name
- NCT07133893
- Testing
- Attention bias assessment and modification, Transcranial photobiomodulation
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Francisco Gonzalez-Lima, PhD
Malocclusion
OrthoPulse 2.0 and 2.1 Feasibility Evaluation
OrthoPulse is a device that uses near-infrared light therapy in order to decrease orthodontic treatment time. The aim of this study is to evaluate OrthoPulse products modified with extended arrays, OrthoPulse 2.0 and OrthoPulse…
- Trial name
- BX13 (NCT03683017)
- Testing
- OrthoPulse 2.0, OrthoPulse 2.1, Invisalign 3.5 Day Wear
- Where
- 7 sites in United States, Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Biolux Research Holdings, Inc.
Low Level Laser Therapy, Performance
Photobiomodulation in Different Doses on Strength Capacities and Functional Performance
Background: Photobiomodulation has been explored for years, with wide clinical use for wound healing and analgesia in varied orthopedic conditions, but the number of research and clinical use has increased during the last decade.
- Conditions
- Low Level Laser Therapy, Performance, Sport
- Trial name
- NCT03860766
- Testing
- Photobiomodulation
- Where
- Brazil
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Photobiomodulation Therapy, Cyclists
Photobiomodulation Therapy on Performance in Successive Cycling Tests
The goal of this study was to investigate the effects of Photobiomodulation therapy (PBMT) on performance, oxygen uptake (VO2 kinetics), and lower limb muscle oxygenation during three successive time-to-exhaustion tests (TTEs) in…
- Conditions
- Photobiomodulation Therapy, Cyclists, Performance
- Trial name
- NCT06252467
- Testing
- Photobiomodulation Therapy
- Where
- Brazil
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Marco Aurélio Vaz, PhD
Extracting Own Teeth, Bone Substitutes
Study of Alveolar Bone Preservation Using Photobiomodulation Combined With Grafting With Scaffold Biomaterial
Bone graft added to the dental socket immediately after tooth extraction prevents atrophy and deformity of the bone at the site of element loss, enabling rehabilitation with implants.
- Trial name
- NCT06150456
- Testing
- extraction, low level laser therapy, Plenum® OSShp and Plenum® Guide
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Macula Edema, Retinal Vein Occlusion
Near-Infrared Light Photobiomodulation Treatment for Retinal Vein Occlusion Macular Oedema
This pilot study aims to establish that treatment with near infrared light (NIR) reduces cystic macular oedema in patients with a retinal vein occlusion.
- Trial name
- NIRVO (NCT04847869)
- Testing
- Ellex Integre NIR laser
- Where
- Australia
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Burning Mouth Syndrome, Quality of Life
Effect to the Photobiomodulation in the Burning Mouth Syndrome
Introduction: Burning mouth syndrome (BMS) is a pathology with a low prevalence, affecting between 0.1% and 3.7% of the general population, the ratio between women and men is between 3 and 7:1.
- Conditions
- Burning Mouth Syndrome, Quality of Life, Anxiety Depression, Dry Mouth
- Trial name
- PBM-BMS (NCT05871580)
- Testing
- Low frequency laser activated photobiomodulation, Low frequency laser photobiomodulation inactive
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Low Level Laser Therapy, Photobiomodulation
Influence of PBM on Anaerobic Capacity Under Normoxia and Hypoxia
The photobiomodulation (PBM) shows positive results in muscle performance, fatigue reduction, management of blood lactate production, analgesia and in the increase of VO2 maximal, favoring the increase of ATP production and thus…
- Conditions
- Low Level Laser Therapy, Photobiomodulation, Performance, Sport
- Trial name
- NCT05595564
- Testing
- Photobiomodulation therapy
- Where
- Brazil
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dental Implant, Tooth Absence
Comparative Study of Immediate Single Unit Implants in Early Loading Protocols, With or Without Photobiomodulation.
Post-extraction implants are an alternative to traditional implant placement on completely healed bone, in order to reduce the number of surgical interventions, shorten treatment time, maintain bone architecture and thus provide…
- Conditions
- Dental Implant, Tooth Absence, Tooth Extraction
- Trial name
- NCT05106855
- Testing
- Low Laser Radiation, Changing the implant surface, Low Laser Radiation off
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Chronic Pain
Effect of LASER Photobiomodulation Therapy on Chronic Pain and Opioid Weaning
This study will examine the effect of LASER photobiomodulation therapy on pain and opioid pain medication weaning on patients who are undergoing opioid pain medication weaning.
- Trial name
- NCT03437967
- Testing
- LightForce EXPi
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- LiteCure LLC