Clinical trials: Physical Frailty
Physical Inactivity Frailty
A Digitally Supported Outdoor Physical Activity Intervention for Mildly Frail Older Adults in Hong Kong
The aging population in Hong Kong is projected to reach 36.6% by 2046, with roughly 16.6% of older adults estimated to be mildly frail-a condition linked to higher risks of falls, hospitalization, and mortality.
- Trial name
- NCT07752615
- Testing
- OUTDOOR-FIT, Active Control
- Where
- Hong Kong
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Aging, Frailty
Mitophagy and Autophagy in Elderly Subjects
In recent years, evidence has shown that mitochondrial dysfunction plays an important role in the development of age-related muscle decline that may lead to frailty.
- Conditions
- Aging, Frailty, Mitophagy
- Trial name
- NCT02472340
- Testing
- Muscle Biopsy
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Hiv, Fatigue
High-Intensity Exercise to Attenuate Limitations and Train Habits in Older Adults With HIV
This is a multi-site, randomized, single-blind (researchers), active treatment concurrent control trial with individuals aged 50-80 living with HIV who experience fatigue and live a sedentary lifestyle.
- Conditions
- Hiv, Fatigue, Mobility Limitation
- Trial name
- HEALTH (NCT04550676)
- Testing
- HIIT (intervention), CME (active control), Coaching
- Where
- 3 sites in United States
- Volunteers
- 118 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Aging
MY PALS: A Community-Based Physical Activity Support Program for Older Adults
This is a study of whether physical activity of older adults can be improved by linking primary care clinics serving older adults to a community-based program that provides motivational support, including peer counselors, for…
- Trial name
- NCT00132288
- Testing
- Motivational support, PALS - Physical activity for lifetime success
- Where
- United States
- Volunteers
- 305 people
- Sponsor
- University of Washington
Esophageal Atresia, Healthy Children
Symptoms, Pulmonary Function, Muscle Strength, Exercise Capacity, and Frailty in Esophageal Atresia vs. Healthy Peers
Esophageal atresia is the most common congenital anomaly of the esophagus and is caused by abnormal development of the esophagus during intrauterine life.
- Trial name
- NCT06975982
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Frail Elderly Syndrome
Frailty and Complexity Among Home Service Recipients
The purpose of the study is to develop frailty and complexity computation algorithms based on the French version of the interRAI-HC and, in doing so, to provide homecare nurses with valid and reliable screening tools for their…
- Trial name
- fraXity (NCT03883425)
- Testing
- interRAI-HC assessments
- Where
- Switzerland
- Volunteers
- 231 people
- Sponsor
- School of Health Sciences Geneva
Frailty
Frailty Assessment in Cardiac Surgery
With increasing life expectancy, cardiac surgical procedures are increasingly being performed in older adults. The biological syndrome of frailty is an aging-associated state with diminished physiological reserve and resistance…
- Trial name
- NCT04191915
- Where
- Turkey (Türkiye)
- Volunteers
- 164 people
- Sponsor
- Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital
Chronic Kidney Diseases, End Stage Renal Disease on Dialysis
A Study of Wrist Worn Accelerometers in End-Stage Renal Disease
The kidneys are important at getting rid of toxins and excess water from the body. If they fail, then toxins and excess water builds up within the body.
- Conditions
- Chronic Kidney Diseases, End Stage Renal Disease on Dialysis, Frailty
- Trial name
- W-WARD (NCT04860440)
- Testing
- GeneActiv wrist worn accelerometer
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Hematologic Malignancy
Patient-Centered Care for the Older Adult With Hematologic Malignancy
This research study is evaluating if co-management by a geriatrician embedded in the oncology clinic can improve outcomes for frail older adults with blood cancers.
- Trial name
- NCT02359838
- Testing
- Baseline Geriatric Screening/Assessment, Geriatrician Co-Management
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Dana-Farber Cancer Institute
Chronic Kidney Disease
Chronic Kidney Disease Among Frail Elderly
Chronic kidney disease is a common diagnosis in the elderly population and it is associated with significant morbidity and health care costs. The prevalence rates increase with age to about 40% for adults aged > 65 years.
- Trial name
- FRED-CKD (NCT02351349)
- Testing
- multidisciplinary intervention
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Sameena Iqbal
Hematologic Malignancy, Treatment Adherence
Improving Quality of Life in Older Patients With Frailty and Hematological Cancer Through Geriatric Assessment
The Improve study is a randomized controlled trial investigating the efficacy of adding comprehensive geriatric assessment and treatment to standard of care compared with standard of care in older, frail patients with…
- Conditions
- Hematologic Malignancy, Treatment Adherence, Treatment Complication, Frailty
- Trial name
- IMPROVE (NCT06373471)
- Testing
- Comprehensive geriatric assessment (CGA) and treatment
- Where
- Denmark
- Volunteers
- 152 people
- Sponsor
- Odense University Hospital
Frailty
Nutraceuticals and Drug Treatment in Frail Older Adults
Frailty is a multidimensional condition due to reserve loss leading to physical and cognitive impairment that is very common in older adults; in fact, its incidence increases with age.
- Trial name
- NCT04962841
- Testing
- Nutraceuticals
- Where
- Italy
- Volunteers
- 485 people
- Sponsor
- University of Campania Luigi Vanvitelli
Hospital Acquired Condition, Frailty
Effect of a Multicomponent Exercise Program With Virtual Reality (MEP-VR) vs Standard Approaches on Functional and Cognitive Domains in Hospitalized Geriatric Patients: Study Protocol for a Randomized Controlled Trial.
The goal of this clinical trial is to test the effectiveness of a Multicomponent Exercise Program with Virtual Reality (MEP-VR) compared to a Multicomponent Exercise Program (MEP-only) or usual care, in terms of functional and…
- Trial name
- MEP-VR (NCT06469554)
- Testing
- MEP-only group, MEP-VR group
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Fundacion Miguel Servet
Kidney Transplant; Complications, Frailty Syndrome
Comprehensive Geriatric Assessment in Kidney Transplantation
This observational study aims to analyze the results of comprehensive geriatric assessment and to monitor the development of functional status in geriatric kidney transplant candidates and recipients.
- Conditions
- Kidney Transplant; Complications, Frailty Syndrome, Depressive Syndrome
- Trial name
- CoGeriaTx (NCT06104696)
- Testing
- Functional geriatric assessment
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Frail Older Adults
The Effects of an AIoT-Based Exercise System on Frail Older Adults
This clinical trial aims to evaluate the effectiveness of an Artificial Intelligence of Things (AIoT)-based feedback assistive strengthening ergometer (AIFASE) exercise system on frail older adults in geriatric wards.
- Trial name
- NCT07698912
- Testing
- AIoT-based Feedback Assistive Strengthening Ergometer
- Where
- Taiwan
- Volunteers
- 376 people
- Sponsor
- National Cheng Kung University
Fragility
Biological Markers of Functional Effects of Physical Activity in an Elderly Population
Circulating biomarkers are promising tools for the early diagnosis of aging-associated pathologies. Inflammation and immunity are associated with the risk of sarcopenia and frailty in elderly patients.
- Trial name
- BIO-APAS (NCT04080063)
- Testing
- adapted physical activity
- Where
- France
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Older Adults (65 Years and Older), Balance
Gait Reeducation Program in Older Adults
The sequential square mat (SSM) Fisior® program is a novel functional gait training tool designed to enhance motor control, coordination, and strength through guided step sequences on a visual-tactile platform.
- Conditions
- Older Adults (65 Years and Older), Balance, Gait Disorders, Physical Performance
- Trial name
- NCT07006584
- Testing
- Experimental, Active Comparator #1
- Where
- Peru
- Volunteers
- 47 people
- Sponsor
- Universidad Europea de Madrid
Falls, Frailty
VIVI-OLIVE: Multicomponent Exercise and Extra Virgin Olive Oil in Older Adults at High Risk of Falls
VIVI-OLIVE is a multicenter randomized clinical trial evaluating whether a 24-month intervention combining an individualized multicomponent exercise program (VIVIFRAIL), Mediterranean diet counselling, and supplementation with 60…
- Trial name
- VIVI-OLIVE (NCT07829484)
- Testing
- VIVIFRAIL multicomponent exercise program, Mediterranean diet counselling, Extra virgin olive oil supplementation
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Fundacion Miguel Servet
Frailty, Survivorship
Remote Exercise Video Adaptations to Maximize Physical Activity in Childhood Cancer
The goal of this observational study is to leverage childhood cancer survivor input to adapt video content of a digital video disc-(DVD) delivered evidence-based PA intervention, originally designed for community-dwelling older…
- Conditions
- Frailty, Survivorship, Childhood Cancer
- Trial name
- NCT06411704
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- St. Jude Children's Research Hospital
Frailty, Physical Activity
VIVIFRAIL Program in Improving the Frailty and Physical Function in the Elderly
The global population is aging, and Taiwan has become an aging society. The aging population continues to rise. When the physical function and mental state of the elderly gradually decline, it is easy for the elderly to enter a…
- Conditions
- Frailty, Physical Activity, Cognitive Function
- Trial name
- NCT05935319
- Testing
- Vivifrail
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences