Clinical trials: Physical Functioning
Cerebrovascular Disorders, Cerebrovascular Disease
Development of a Clinically-relevant Test for Assessment of Cerebral Vascular Function
The goal of this study is to develop a test of cerebral vessel function by inducing a reactive hyperemia that will elicit a rapid and profound increase in cerebral vessel shear stress.
- Trial name
- NCT04336852
- Testing
- Flow mediated dilation (brachial and femoral arteries), Cerebral vascular reactivity to carbon dioxide (CO2), Cerebral vascular function test
- Where
- 2 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Schizophrenia, Bipolar Disorder
Multi-modal Assessment of Gamma-aminobutyric Acid (GABA) Function in Psychosis
The purpose of this study is to better understand mental illness and will test the hypotheses that, while viewing affective stimuli, patient groups will show increased blood oxygenation level dependent (BOLD) signal by fMRI after…
- Conditions
- Schizophrenia, Bipolar Disorder, Healthy, Psychosis
- Trial name
- GABAmech (NCT04004416)
- Testing
- Lorazepam and fMRI
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Urea Cycle Disorder
Functional Evaluation in Patients With Urea Cycle Disorders (UCD) During a Driving Task
This study is being done to understand how the brain works while people with urea cycle disorder (UCD) perform driving tasks that range from easy to difficult and to look at how that compares to traditional tests of thinking and…
- Trial name
- NCT07701694
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Respiration Disorders
Comparative Study Between the AirGoTM System and Standard Tests in the Assessment of the Respiratory Function
The study aims at evaluating the AirGoTM system's performance, as compared to standard pulmonary function tests.
- Trial name
- AirGoTM (NCT03368612)
- Testing
- Electronic evaluation system
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ospedale Santa Croce-Carle Cuneo
Obesity
Effect of Weight Loss and Exercise on Liver and Muscle Fat in Obese Elderly
The purpose of this study is to determine the effect of weight loss and exercise on liver and muscle fat.
- Trial name
- NCT00779207
- Testing
- weight loss and exercise, weight loss
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Sarcoidosis, Sarcoidosis, Pulmonary
The Role of Physical Activity and Diet Within Pulmonary Sarcoidosis
This project focuses on the sub-group population with pulmonary sarcoidosis - a condition that causes red swollen tissue called granulomas to develop in organs such as the lungs.
- Conditions
- Sarcoidosis, Sarcoidosis, Pulmonary, ILD, Interstitial Lung Disease
- Trial name
- NCT03336736
- Testing
- Exercise
- Where
- 2 sites in United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Kingston University
Aging
Fit & Active Seniors Trial
The investigators propose to test the hypothesis that a six-month intervention of combined fitness and cognitive training in the form of dancing will have a significant positive effect on a variety of executive control and memory…
- Trial name
- FAST (NCT01472744)
- Testing
- Dance Group, Strength, Stretching, Stability, Walking
- Where
- United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Respiratory Muscle, Exercise
The Effect of Functional Respiratory Muscle Training on Respiratory Function and Physical Performance
The study aims to investigate the effects of core stabilization exercise, which includes functional respiratory muscle training, on respiratory function, aerobic capacity, trunk stabilization, and physical performance in football…
- Trial name
- NCT06494930
- Testing
- F-IMT, Core Stabilization Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istinye University
Cerebral Palsy (CP)
FES Implementation Pediatrics
Physical rehabilitation interventions that promote activity-dependent neuroplasticity are desired for children with CP as this will result in improved motor skill and function.
- Trial name
- NCT06689007
- Testing
- Implementation Intervention
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Caregiver Distress, Physical Function
Caring for Caregivers With Mind-body Exercise
This pilot study will lay the foundation for the first large-scale trial evaluating the psychosocial and physical health benefits of a widely available and promising Qigong intervention (Eight Brocades) for distressed cancer…
- Conditions
- Caregiver Distress, Physical Function, Quality of Life
- Trial name
- NCT04019301
- Testing
- Baduanjin Qigong, Community-based, Baduanjin Qigong, Internet-based
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Houston
Concussion Mild, Concussion, Brain
Sport-Related Concussion Recovery in Athletes
The goal of this study is to enhance the accuracy and sensitivity of concussion evaluation by integrating traditional assessment tools with emerging neuroimaging technologies, such as Functional Near-Infrared Spectroscopy…
- Trial name
- NCT06852300
- Testing
- Concussion Assessment Battery
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Central Arkansas
Healthy, Lupus Nephritis
Functional MRI in Lupus Nephritis
The primary objectives of the study are as follows: To develop and optimize a renal functional magnetic resonance imaging (MRI) protocol consisting of Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI), Blood-Oxygen…
- Trial name
- NCT01731054
- Where
- 4 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Biogen
Gastrointestinal Motility
Contrast-enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Transit
This clinical trial aims to characterize a novel method of imaging the gastrointestinal tract in healthy subjects. The method is using laser-light and soundwaves and it is performed in a similar manner as conventional ultrasound.
- Trial name
- NCT05933096
- Testing
- Contrast-enhanced multispectral optoacoustic tomography
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hepatic Impairment
Assessment of the Single Dose Pharmacokinetics and Tolerability of Sativex in Patients With Impaired Hepatic Function and Healthy Patients
A Phase I open-label study to evaluate the pharmacokinetics (what the body does to a drug), safety and tolerability of a single dose of Sativex (containing 10.8 mg tetrahydrocannabinol [THC] and 10 mg cannabidiol [CBD]) in…
- Trial name
- NCT01887301
- Testing
- Sativex
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Jazz Pharmaceuticals
Alzheimer's Disease (AD), Lewy Body Dementia (LBD)
Social-cognitive Functioning: Validation of a New Neuropsychological Test
It is now established that disturbances in social cognition are frequent in neurology and that they contribute to the development of social conduct disorders.
- Conditions
- Alzheimer's Disease (AD), Lewy Body Dementia (LBD), Frontotemporal Degeneration (FTD)
- Trial name
- REALSOCOG (NCT05558709)
- Testing
- REALSOCOG, BCS, Hetero-questionnaires
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Sarcopenia
Evaluating and Monitoring Physical Fatigue While Performing Functional Activities
Fatigue is a critical health parameter in older adults and stroke patients and is associated with negative health outcomes. Current assessment tools predominantly focus on walking related fatigue, neglecting other activities of…
- Conditions
- Stroke, Sarcopenia, Fatigue
- Trial name
- NCT06513377
- Testing
- Performance test
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Physical Therapy
Core Stability, Trunk Position Sense, Balance and Functional Mobility in Patients With Multiple Sclerosis
The aim of this study is to compare balance, functional mobility, core stability and trunk position sense in patients with Multiple Sclerosis (PwMS) and healthy controls and investigate the relationship between core stability and…
- Trial name
- NCT03566251
- Testing
- Balance, Functional mobility, Core stability
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Overweight
The Effects of Almond Consumption on Functional Performance and Activity in Overweight Active Older Adults
The overall objective of this proposed randomized, crossover study is to determine the effect of 12 weeks of almond consumption, ingested as a snack twice daily, on energy expenditure, performance and functional related outcomes…
- Trial name
- NCT04778371
- Testing
- Almonds
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Florida State University
Impulse Control Disorders, Borderline Personality Disorder
fMRI in Impulsivity
This study aims to use resting-state and task based functional Magnetic Resonance Imaging (fMRI) as a tool to evaluate trait characteristics of impulsivity in subjects with borderline personality disorder.
- Trial name
- NCT02755181
- Testing
- Experimental
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Obesity
The Effects of Interrupting Prolonged Sitting With Bouts of Physical Activity on Neurocognitive Function in Obesity
It is projected that by 2030 almost 50% of adults in the USA will have obesity. High sedentariness and physical inactivity contribute to the obesity pandemic. Neurocognitive deficits compound the global burden of obesity.
- Trial name
- SITLess (NCT04926207)
- Testing
- Physical Activity Breaks Intervention, Talking Breaks Control
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign