Clinical trials: Physiological Responses
Lactate Blood Increase, Exhaustion - Physiological
Pilot Study to Examine the Acute Impact of Veillonella Supplementation on Exercise and Lactate Responses
The purpose of this study is to assess the health and performance outcomes associated with supplementation of Veillonella atypica.
- Trial name
- VP (NCT05816291)
- Testing
- Time to Exhaustion at velocity at VO2max
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Surgical Injury, Stress, Physiological
Effect of a Bundle of Non-pharmacological Interventions on the Stress Response to Surgery
Rationale: Surgical trauma and post-surgical pain induce a physiological stress response that can be detrimental to the patient.
- Conditions
- Surgical Injury, Stress, Physiological, Stress, Psychological, Pain, Postoperative
- Trial name
- SPACU-lab (NCT05638152)
- Testing
- implementation of a bundle of non-pharmacological interventions aimed at stress reduction
- Volunteers
- 90 people
- Sponsor
- The Netherlands Cancer Institute
Chocolate Consumption
Renal Ultrasound Response After Chocolate Consumption
The consumption of dark chocolate (DC) has antihypertensive (3) and anti-inflammatory effects. Some studies also suggest that dark chocolate may also have cardiovascular benefits, but its physiological effects on the kidneys have…
- Trial name
- Choco (NCT05755217)
- Testing
- Dark chocolate, White chocolate
- Where
- 2 sites in Switzerland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gregoire Wuerzner; MD
Ischemic Preconditioning
The Biology of Chronic Preconditioning: Genomic and Physiologic Mechanisms of Response
The purpose of this study is to assess the effects of repeated RIPC and exercise, on exercise performance, skeletal muscle responses and circulating cellular and humoral biology in humans
- Trial name
- NCT01164618
- Testing
- Remote ischemic preconditioning (RIPC), Exercise
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Physiological Response to Exercise, Perception of Exercise Difficulty
Perception of Physical Exertion in Healthy Weight and Obese Adolescents
Little is known regarding the relationship between perceived and physiological exertion in adolescents. The purpose of this study is to investigate the association between physiological and perceptual markers of effort during…
- Trial name
- NCT01695785
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Refractive Errors, Accommodation Disorder
Choroidal Thickness Change in Response to Physiological and Refractive Changes
There is a great need for precise and repeatable measurements of the choroidal thickness. Including the diurnal physiological changes, accommodation and refractive error impact on those measurements.
- Trial name
- NCT03906279
- Where
- Poland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Wrocław University of Science and Technology
Breast Cancer
Consequences of Eccentric Cycling on Exercise-related Neuromuscular Responses and Biomarkers in Breast Cancer Patients
This is a monocentric, prospective and interventional study aimed to investigating the physiological responses of eccentric compared to concentric cycling realized 1) at the same metabolic demand and 2) at the same mechanical…
- Trial name
- PROTECT-05 (NCT05166148)
- Testing
- Session (a), Session (b), Session (c)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Institut de cancérologie Strasbourg Europe
Hysterectomy, Ovariectomy
TDSM- Testosterone Dose Response in Surgically Menopausal Women
TDSM will study the physiology of testosterone in women ages 21-60 who have had surgical menopause (uterus and both ovaries removed).
- Conditions
- Hysterectomy, Ovariectomy, Menopause, Testosterone Deficiency
- Trial name
- NCT00494208
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Breast Cancer
Neoadjuvant Chemotherapy Using Doxorubicin and Paclitaxel in Treating Women With Large Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as doxorubicin and paclitaxel, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00096291
- Testing
- Doxorubicin followed by Paclitaxel, Paclitaxel followed by Doxorubicin
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Healthy Adult Participants
EFFECTS OF SMALL-SIDED GAME MANIPULATIONS ON NEUROMUSCULAR FATIGUE, PHYSIOLOGICAL RESPONSES, PHYSICAL PERFORMANCE, AND TECHNICAL SKILLS IN FEMALE FOOTBALL PLAYERS
Small-sided games will represent a prevalent component of branch-specific training methodologies in football. The objective of this study will be to examine the impact of small-sided games with sprint manipulation played in a 3v3…
- Trial name
- NCT07845318
- Testing
- Sprint, Recovery
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people
- Sponsor
- Istanbul Gelisim University
Attention Deficit Hyperactivity Disorder
A Dose-Response Study of the Cognitive and Physiological Effects of tDCS to the DLPFC
To determine the cognitive and neurophysiological dose-response relationships of anodal tDCS to the left DLPFC as a function of absolute current intensity, individualized E-field intensity, and stimulation duration.
- Trial name
- NCT04175041
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy
Training Study to Characterize Biomarkers to Flu Vaccines
It is thought that vaccines trigger innate inflammatory responses to induce antigen-specific adaptive immunity (the desired effect), but excessive inflammation may lead to serious inflammatory complications or unwanted side…
- Trial name
- NCT01771367
- Testing
- Fluad, Agrippal
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Gastric Emptying, Diabetes Mellitus
The Effect of Natural Food Flavourings on Gastrointestinal and Cardiovascular Physiological Responses.
The purpose of this study is to determine whether 3 g cinnamon was sufficient to delay the gastric emptying rate of a high-fat solid meal and subsequently reduce postprandial blood glucose and lipid responses, oxidative stress…
- Trial name
- CinnGastEmpt (NCT01350284)
- Testing
- Cinnamon
- Where
- Ireland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Dental Anxiety, Frenectomy
Virtual Reality During Periodontal Frenectomy
The goal of this clinical trial is to learn whether virtual reality can reduce anxiety, pain, and physiological stress responses during periodontal frenectomy in adults who need this surgical procedure.
- Conditions
- Dental Anxiety, Frenectomy, Virtual Reality
- Trial name
- VRFren (NCT07760987)
- Testing
- Virtual Reality-Based Audiovisual Distraction, Standard Periodontal Frenectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Muhammed Emin Kalender
Healthy, Pre Hypertension
Race, Natriuretic Peptides and Physiological Perturbations
The purpose of the study is to understand the origins of differential response to beta-blockers in African-Americans and may provide insight regarding racial differences in cardiovascular risk.
- Trial name
- NCT03070184
- Testing
- Exercise capacity VO2 max determination, Standardized meals, Exercise challenge
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Mucosal Congestion
Changes in Nasal Patency With Changes in Posture, Temperature, Humidity and Nasal Patency Seen by Acoustic Rhinometry
To study nasal physiologic responses to changes in posture, temperatures, humidity and nasal patency with acoustic rhinometry.
- Trial name
- NCT00147888
- Testing
- Acoustic rhinometry (procedure)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Healthy Participants
Mountain Hiking & Environmental Influences
In a randomized crossover design, approximately 50 healthy participants will be randomly exposed to outdoor mountain hiking (approximately 6 hours each) in two different areas: an anthropogenically influenced area and in a widely…
- Trial name
- NCT03229434
- Testing
- Mountain hiking
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaet Innsbruck
Osteoporosis, Hypercalcemia of Malignancy
One Week Comparison Study of PTH and PTHrP Infusions
This is a dose escalation study to determine the maximum tolerable dose of Parathyroid Hormone-related Protein, PTHrP, or Parathyroid Hormone, PTH, that can be given safely over one week in healthy African-American volunteers.
- Conditions
- Osteoporosis, Hypercalcemia of Malignancy, Hyperparathyroidism, Bone Diseases, Endocrine
- Trial name
- NCT01333267
- Testing
- Parathyroid Hormone-related Protein (1-36), parathyroid hormone (1-34), PTH (1-34) and PTHrP (1-36)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Stress, Physiological, Stress, Psychological
Daoist Zhanzhuang and Human Flourishing
This project investigates the impact of Daoist Zhanzhuang (sometimes spelled as Chan Chuang) on human flourishing, and explores the physiological, psychological, and spiritual mechanisms.
- Conditions
- Stress, Physiological, Stress, Psychological, Inflammatory Response, Well-Being, Psychological
- Trial name
- Z-Flo (NCT06573034)
- Testing
- Daoist Zhanzhuang
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Charlotte
Energy Drinks
The Effect of Energy Drinks Consumption on Acute Physiological and Psychological Responses of Israeli Arab Adolescents
Quasi-experiment and Cross-sectional study, six-arm design protocol will be carried out. The study will be conducted under the Declaration of Helsinki.
- Trial name
- EDE (NCT04808128)
- Testing
- Drink A + SC, Drink B + SC, Drink C + SC
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tel Hai College