Clinical trials: Physiological Responses
Blood Pressure, Stress, Physiological
Cardiovascular Reactivity to Physical Stress
It is well-accepted that an exaggerated blood pressure (BP) response to physical stress has a prognostic value, indicating a higher cardiovascular risk (e.g., sudden cardiac death, myocardial infarction, future hypertension, and…
- Trial name
- REACT (NCT06319001)
- Testing
- Low-volume high intensity exercise, Combined intermittent sauna and cold water bath (sauna+cold bath).
- Where
- Norway
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Western Norway University of Applied Sciences
Anxiety Physiological Stress Responses ,Fiberoptic Bronchoscopy, Sensory Isolation
Sensory Isolation to Reduce Anxiety During Bronchoscopy
TThis randomized controlled trial aims to evaluate the effect of sensory isolation on anxiety and physiological parameters in patients undergoing fiberoptic bronchoscopy.
- Trial name
- Bronchoscopy (NCT07374783)
- Testing
- Sensory Isolation (Eye Mask and Earplugs)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Melek YÜKSEL
Dental Anxiety
Comparison of Dental Pain Response in Children
Study involves the observation of the child's behavior during a dental treatment procedure. This allows for the evaluation of the child's experience of pain and discomfort through their facial expressions, body movements, and…
- Trial name
- NCT05883566
- Testing
- experimental
- Where
- 2 sites in Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
Heart Diseases
APPROPRIATE - Rate Adaptive Pacing Sensor
The APPROPRIATE study will compare differences in functional capacity (peak VO2) between chronotropically incompetent patients randomized to receive rate responsive pacing driven by either the minute ventilation…
- Trial name
- APPROPRIATE (NCT00757666)
- Testing
- Rate adaptive pacemaker
- Where
- 2 sites in United States
- Volunteers
- 566 people
- Sponsor
- Boston Scientific Corporation
Computer Simulation, Energy Expenditure
Modelling of Energy Expenditure From Heart Rate, Accelerometry and Other Physiological Parameters
At this time, 24h energy expenditure is rarely assessed under free-living conditions for specific individuals because of the lack of cheap and accurate software/materials to record the energy expenditure.
- Conditions
- Computer Simulation, Energy Expenditure, Energy Metabolism
- Trial name
- Modelheart (NCT01209572)
- Testing
- calorimetric chamber, Free living conditions
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Mechanically Ventilated Patients
Effect Of Clustered Nursing Interventions On Physiological Response In Critically Ill Patients
To determine physiological responses related to clustered nursing interventions among critically ill patients.
- Trial name
- NCT04134481
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Self-Perception
Production of Nonverbal Acoustic Signals and Resulting Physiological Responses
Like many other animals, humans produce nonverbal vocal signals including screams, grunts, roars, cries and laughter across a variety of contexts.
- Trial name
- SINOVE-PRO (NCT05238285)
- Testing
- Production of vocal sounds
- Where
- France
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Exercise Training
Exercise-Induced Metabolic Compensation; a Physiological Adaptive Response to Exercise Training
The primary aim of this proposal is to identify changes in the volume of highly metabolic organs (liver, kidneys, and brain) that occur as a physiological adaptation to exercise training and lower the resting energy expenditure.
- Trial name
- NCT04460040
- Testing
- Exercise training
- Where
- Israel
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Healthy Volunteers
Prolonged Hypoxic Breathing in Healthy Volunteers: a Safety Study
The purpose of this study is to define the safety and the biochemical-physiological response of prolonged exposure to a normobaric low-oxygen environment in healthy volunteers.
- Trial name
- MGH-nitrogen (NCT02860975)
- Testing
- Inhaled Nitrogen
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Physiological Adaptations, Sport Performance
Molecular Hydrogen Inhalation: Effects on Health, Exercise Capacity and Inflammatory Response - in Vivo/in Vitro Studies
Summary To comprehensively address the research aims and explore the state of knowledge of the mechanisms of biochemical response to specific tissue affecting method in form of a molecular hydrogen inhalation and will allow to…
- Conditions
- Physiological Adaptations, Sport Performance, Aerobic Capacity, Anaerobic Power
- Trial name
- NCT07130942
- Testing
- Inhalation using a molecular hydrogen generator
- Where
- Poland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Physiological Response of Sphingolipids to a Single HIIT Session
Investigating the Circulating Sphingolipidome Response to a Single High-intensity Interval Training Session
The purpose of this study is to examine the response of a comprehensive panel of circulating sphingolipids to a single high-intensity interval training (HIIT) session in healthy individuals in their twenties.
- Trial name
- SphingoHIIT (NCT05390866)
- Testing
- HIIT
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Basel
Candidemia, Mycoses
Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation
The purpose of this pivotal study is to determine if intravenous Rezafungin is efficacious and safe in the prevention of invasive fungal diseases when compared to the standard antimicrobial regimen.
- Conditions
- Candidemia, Mycoses, Fungal Infection, Fungemia
- Trial name
- ReSPECT (NCT04368559)
- Testing
- Rezafungin for Injection, Posaconazole, Fluconazole
- Where
- 53 sites in United States, Belgium and 7 more
- Volunteers
- 602 people
- Sponsor
- Mundipharma Research Limited
Tinnitus
Regulating Homeostatic Plasticity and the Physiological Response to rTMS
This device-study includes a pilot, physiological investigation of normal human subjects. The aim is to determine how existing non-invasive neuromodulation devices affect brain circuitry as measured by EEG recording.
- Trial name
- NCT03309696
- Testing
- active tDCS and active rTMS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Physiological Stress
Impact of Supplements on Stress Markers
The goal of this clinical trial is to examine the effects of caffeine, theanine and tyrosine ingestion on markers of stress in healthy college aged individuals that are exposed to a mental stress task.
- Trial name
- NCT05592561
- Testing
- mental stress task
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Texas State University
Sepsis, Respiratory Physiological Phenomena
Respiratory Variations for Predicting Fluid Responsiveness
Hypovolemia and acute circulatory failure affects more than 60% of patients hospitalized in intensive care or resuscitation. The volume expansion (VE) by fluid replacement therapy is the first treatment improve circulatory…
- Conditions
- Sepsis, Respiratory Physiological Phenomena, Circulatory Failure
- Trial name
- ReVaPreF (NCT03066362)
- Testing
- Echocardiography-Doppler
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Lille
Exergame, Active Video Games (AVG)
Affective and Physiological Outcomes of Virtual and Mixed Reality Workplace Exergames
The aim of this study was to compare the acute effects of virtual reality (VR) and mixed reality (MR) based exergame practices on physical and psychological health indicators during micro-breaks among university administrative…
- Conditions
- Exergame, Active Video Games (AVG), Virtual Reality, Mood Changes
- Trial name
- NCT06830772
- Testing
- Experimental, Active comparator
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Septic Shock, Microcirculatory Dysfunction
Papaverine and Sublingual Microcirculation in Septic Shock
This is a prospective, multicenter, single-arm, open-label, pilot physiological study designed to evaluate the effects of intravenous papaverine on sublingual microcirculation and the vascular waterfall phenomenon in adult…
- Conditions
- Septic Shock, Microcirculatory Dysfunction, Sublingual Microcirculation, Hemodynamic Instability
- Trial name
- NCT07657741
- Testing
- Papaverine
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Burns
Metabolic Rate in Burns
Severe burn patients are some of the most challenging critically ill patients with an extreme and continuous state of physiological stress.
- Trial name
- MrBurn (NCT03024931)
- Testing
- observational study
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Alcohol Drinking, Drinking Behavior
Behavior Brain Responses
To compare responses to acute oral doses of ethanol in healthy young adults who experience mainly stimulant subjective effects from the drug or mainly sedative effects.
- Conditions
- Alcohol Drinking, Drinking Behavior, Physiological Effects of Drugs, Central Nervous System Depression
- Trial name
- BBR (NCT03964350)
- Testing
- Ethanol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Mild Traumatic Brain Injury
Post-Concussion Differences Between Buffalo Concussion Treadmill Test (BCTT) and Modified Dynamic Exertion (mEXiT) Test
This study aims to compare symptom provocation, physiologic response, and rate of perceived (RPE) between the Buffalo Concussion Treadmill Test (BCTT) and a Modified Dynamic Exertion (mEXiT) test after sport related concussion in…
- Trial name
- NCT06276660
- Testing
- BCTT, Dynamic ExIT
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Pittsburgh