Clinical trials: Placebo
Turmeric, Placebo
Effects of 8 Weeks of Turmeric Ingestion on Physiology and Wellbeing in Healthy Older Adults
Curcumin (a bioactive compound found in turmeric) has demonstrated anti-inflammatory and antioxidant properties, and there is evidence to suggest that it may produce improvements in quality of life and markers of health in humans…
- Trial name
- NCT07196514
- Testing
- Raw turmeric shots
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Placebo Analgesia, Pediatric Pain
Applying a Small Procedure Prior to Injection/Vaccination Reduces Pain in Children
In this proposed study, the investigators aim to apply a minor procedure prior to a treatment that induces pain (e.g., injection/vaccination) to help manage pediatric pain.
- Conditions
- Placebo Analgesia, Pediatric Pain, Vaccination
- Trial name
- NCT06313788
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Lingnan University
Placebo Effect, Mindfulness
Interactions Between Placebo Effects and Mindful Awareness State
In this experiment,the investigators study the effects of interpersonally induced placebo effects and a mindful awareness induction on negative affect.
- Conditions
- Placebo Effect, Mindfulness, Pain, Transcranial Direct Current Stimulation (tDCS)
- Trial name
- NCT07108101
- Testing
- tDCS stimulation (real), Mindful state induction, No minfulness induction
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Nitrate, Placebo - Control
Beetroot Juice and Neuromuscular Performance in Female Basketball Players
A randomized, double-blind, placebo-controlled study investigates the effects of 5 days of nitrate-rich beetroot juice supplementation (70 mL·day-¹; 6.4 mmol NO₃-·day-¹) on physical performance in female basketball players.
- Trial name
- BASKET_BEET (NCT07833579)
- Testing
- Beetroot juice supplementation
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Physical Performance, Placebo Effect
Placebo Effect on Cycling Performance: Laboratory Crossover Study
This study aims to determine the impact of the placebo (PLA) effect on physical and cognitive performance in a controlled laboratory setting.
- Conditions
- Physical Performance, Placebo Effect, Cognitive Performance
- Trial name
- NCT07748429
- Testing
- Caffeine (6mg/kg)
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Naltrexone, Placebo
Understanding How Opioids Affect the Experiential and Neural Signatures of Social Experiences
The study is a randomized, placebo-controlled design with the opioid antagonist, oral naltrexone. Following random assignment, participants will take 50mg of naltrexone or placebo once a day for 7 days.
- Trial name
- NCT05007561
- Testing
- Naltrexone Hydrochloride
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Beta Alanine Supplementation, Placebo - Control
Beta-Alanine Effects on Neuromuscular and Cardiovascular Performance in Female Rugby Players
This study will examine the effects of beta-alanine supplementation on physical performance in female rugby players, who will ingest 4.8 grams/day over a four-week period.
- Trial name
- BA_RUGBY (NCT07809321)
- Testing
- Beta-Alanine
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Physical Performance, Placebo Effect
Placebo Effect in Field-Based Physical Performance
This study aims to investigate the placebo (PLA) effect on physical performance across different sports disciplines in real-world, field-based settings.
- Conditions
- Physical Performance, Placebo Effect, Cognitive Performance
- Trial name
- NCT07742150
- Testing
- Caffeine (6mg/kg)
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Caffeine, Placebo - Control
Acute Caffeine Intake in Older Adults
Evidence regarding the ergogenic effects of caffeine is well-established in young adults, but evidence in older adults remains scarce, particularly during dynamic resistance exercise.
- Trial name
- CAF+OLD (NCT07711665)
- Testing
- Caffeine
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Caffeine, Placebo
Acute Caffeine Intake in Young vs Older Adults
Evidence regarding the ergogenic effects of caffeine is well-established in young adults, but evidence in older adults remains scarce, particularly during dynamic resistance exercise.
- Trial name
- CAF+Age (NCT07711652)
- Testing
- Caffeine
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Placebo - Control, Ketone Monoester
The Effects of Exogenous Ketones on Cognitive Function
The purpose of this study is to evaluate the acute effects of exogenous ketone monoester (KME) supplementation on cognitive function in three groups of adults aged 19-55 years: (1) obese, sedentary individuals; (2) lean…
- Trial name
- NCT07051655
- Testing
- Ketone Monoester (KE)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Negative Affectivity, Non-invasive Brain Stimulation
Neural Mechanisms of Interpersonal Expectations on Negative Affect
The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence…
- Conditions
- Negative Affectivity, Non-invasive Brain Stimulation, Placebo Effect, Expectations
- Trial name
- NCT06980090
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia
A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication.
The goal of this clinical trial is to learn if an educational website can help patients make an informed decision and engage in shared decision-making with their healthcare provider regarding cholesterol lowering medication use…
- Conditions
- Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Cardiovascular Diseases, Pharmacists
- Trial name
- 1821534-10 (NCT06423365)
- Testing
- Virtual Statin Management (VSM)
- Where
- United States
- Volunteers
- 898 people, healthy volunteers welcome
- Sponsor
- University of Utah
Naltrexone HCl 50 MG Oral Tablet, Placebo
Naltrexone for Prolonged Grief Disorder
This is a study to see how effective oral naltrexone is as treatment for prolonged grief disorder (PGD). Participants will take their assigned medication for 8 weeks, with monthly visits to assess symptom severity, social…
- Trial name
- NPGD (NCT06140420)
- Testing
- Naltrexone Oral Product
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Heat Exposure, Exercise Performance
Effects of Creatine and Heat Exposure on Exercise Performance and Body Water Distribution
The goal of this clinical trial is to learn whether creatine supplementation changes how the body adapts to repeated exercise in the heat in healthy recreationally active adults and varsity athletes.
- Conditions
- Heat Exposure, Exercise Performance, Hydration, Body Fluid Compartments
- Trial name
- NCT07593014
- Testing
- Creatine Monohydrate
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Windsor
Scopolamine or Placebo, Schema to Organize Memory or no Schema
Representation of Spatiotemporal Information in Human Episodic Memory and Navigation
Neural diseases such as stroke can have distinct effects on the ability to navigate and orient compared to remembering daily events like when one last took medicine.
- Trial name
- NCT07423923
- Testing
- Scopolamine
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Placebo Effect, Physical Performance
Effects of Conditioning Activities in Female Athletes
This study will investigate how different warm-up strategies affect physical performance in female athletes who practice invasion sports (e.g., soccer, handball, and basketball).
- Conditions
- Placebo Effect, Physical Performance, Countermovement Jump
- Trial name
- NCT07542119
- Testing
- post-activation performance enhancement (PAPE) protocol
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Triangulo Mineiro
Pain, Virtual Reality
Neural Correlates of Hypoalgesia Driven by Observation
Placebo effects held an ambivalent place in health care for at least two centuries. On the one hand, placebos are traditionally used as controls in clinical trials to correct for biases and the placebo response is viewed as an…
- Conditions
- Pain, Virtual Reality, Placebo
- Trial name
- NCT03897998
- Testing
- Naloxone, Saline
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Caffine, Placebo - Control
Effects of Caffeine Ingestion on Morning Cognitive and Muscle Strength Measures in Males
Tournament scheduling and environmental factors often require athletes to compete in the morning. Equally due to time constraints, athletes may choose to train in the morning.
- Conditions
- Caffine, Placebo - Control, No Pill
- Trial name
- NCT07466628
- Testing
- No Pill
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Caffeine, Placebo - Control
Effects of Caffeine Ingestion on Morning Cognitive and Muscle Repeated Sprint Performance in Males
Athletes often compete in the morning when they are biologically weaker; normally in competition heats or quarterfinals to qualify for the finals scheduled in the evening.
- Conditions
- Caffeine, Placebo - Control, No Pill
- Trial name
- NCT07466732
- Testing
- Caffeine, Placabo, No Pill
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University