Clinical trials: Placebo Effect
Placebo Effect, Mindfulness
Interactions Between Placebo Effects and Mindful Awareness State
In this experiment,the investigators study the effects of interpersonally induced placebo effects and a mindful awareness induction on negative affect.
- Conditions
- Placebo Effect, Mindfulness, Pain, Transcranial Direct Current Stimulation (tDCS)
- Trial name
- NCT07108101
- Testing
- tDCS stimulation (real), Mindful state induction, No minfulness induction
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Physical Performance, Placebo Effect
Placebo Effect on Cycling Performance: Laboratory Crossover Study
This study aims to determine the impact of the placebo (PLA) effect on physical and cognitive performance in a controlled laboratory setting.
- Conditions
- Physical Performance, Placebo Effect, Cognitive Performance
- Trial name
- NCT07748429
- Testing
- Caffeine (6mg/kg)
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Physical Performance, Placebo Effect
Placebo Effect in Field-Based Physical Performance
This study aims to investigate the placebo (PLA) effect on physical performance across different sports disciplines in real-world, field-based settings.
- Conditions
- Physical Performance, Placebo Effect, Cognitive Performance
- Trial name
- NCT07742150
- Testing
- Caffeine (6mg/kg)
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Negative Affectivity, Non-invasive Brain Stimulation
Neural Mechanisms of Interpersonal Expectations on Negative Affect
The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence…
- Conditions
- Negative Affectivity, Non-invasive Brain Stimulation, Placebo Effect, Expectations
- Trial name
- NCT06980090
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia
A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication.
The goal of this clinical trial is to learn if an educational website can help patients make an informed decision and engage in shared decision-making with their healthcare provider regarding cholesterol lowering medication use…
- Conditions
- Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Cardiovascular Diseases, Pharmacists
- Trial name
- 1821534-10 (NCT06423365)
- Testing
- Virtual Statin Management (VSM)
- Where
- United States
- Volunteers
- 898 people, healthy volunteers welcome
- Sponsor
- University of Utah
Placebo Effect, Physical Performance
Effects of Conditioning Activities in Female Athletes
This study will investigate how different warm-up strategies affect physical performance in female athletes who practice invasion sports (e.g., soccer, handball, and basketball).
- Conditions
- Placebo Effect, Physical Performance, Countermovement Jump
- Trial name
- NCT07542119
- Testing
- post-activation performance enhancement (PAPE) protocol
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Triangulo Mineiro
Placebo Effect, Pain
Context Interventions: Social Modeling and Initial Treatment Experience
In this experiment, the investigators study the brain pathways underlying several promising context interventions that enhance the strength of placebo effects.
- Trial name
- NCT04646460
- Testing
- Observed Success, Observed Failure, Experienced Success
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Pain, Rejection
The Role of the Opioid System in Placebo Effects on Pain and Social Rejection
The current study probes the involvement of the opioid system in placebo effects on social pain, using the opioid antagonist naloxone.
- Conditions
- Pain, Rejection, Placebo Effect
- Trial name
- NCT04650841
- Testing
- Control Cream with Naloxone, Control Cream with Saline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Placebo Effect, Nocebo Effect
Neurophysiological Mechanisms of Placebo and Nocebo Effects in Sports - a Protocol Paper
This clinical trial aims to investigate the neurophysiological mechanisms of placebo and nocebo effects on sports performance, using Electroencephalography (EEG) and isometric strength testing of the lower extremities.
- Trial name
- NCT06835777
- Testing
- Positive Expectation, Negative Expectation, Control
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Canterbury Christ Church University
Placebo Effect, Attention
The Role of Attention in Modulating the Placebo Effect
This project aims to examine whether these forms of attention to sensory information can modulate the mind-body interaction. This will be demonstrated through a study focused on the placebo effect with attention manipulation.
- Trial name
- NCT06827444
- Where
- Italy
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Vitamin D Effects on MPS, Placebo Effects on MPS
Effects of Vitamin D Supplementation on Muscle Protein Synthesis
Background: Healthy adults maintain muscle tissue by continuously building up and breaking down muscle proteins throughout the day.
- Trial name
- VIPER (NCT06746389)
- Testing
- 3000 IU per Day Spray
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Active Ethanol and Active Iomazenil, Active Ethanol and Placebo Iomazenil
Ability of Partial Inverse Agonist, Iomazenil, to Block Ethanol Effects in Humans
Alcohol is abused commonly, but there is no remedy for alcohol intoxication. This project is looking at the substance iomazenil and its effect on alcohol intoxication and alcohol's effects on driving using a driving simulator.
- Conditions
- Active Ethanol and Active Iomazenil, Active Ethanol and Placebo Iomazenil, Placebo Ethanol and Active Iomazenil, Placebo Ethanol and Placebo Iomazenil
- Trial name
- NCT01590277
- Testing
- Active Ethanol, Active Iomazenil
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Placebo Effect on Mood Improvement
The Role of Dopamine, Reward Learning and Prefrontal Activity in Expectation-induced Mood Enhancement
Although placebo effects on depressive symptoms are well documented, the underlying mechanisms and moderating factors of expectation effects on mood and depression are poorly understood.
- Trial name
- CRC289A07 (NCT05208294)
- Testing
- Sulpiride 400 MG, High expectation manipulation, Low expectation manipulation
- Where
- Germany
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Attention Deficit Disorder With Hyperactivity, Placebo Effect
Attention and Pain in Children With and Without Attention Deficit and/or Hyperactivity Disorder
In Quebec, there has been an important increase of Attention Deficit Hyperactivity Disorder (ADHD) diagnosis since 2015. ADHD symptoms, related to behavioural and/or concentration difficulties, are very similar to other disorders…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Placebo Effect, Nocebo Effect, Pain
- Trial name
- ADE (NCT04766580)
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Placebo Effect, Pain Intensity
The Influence of Expectations on Post-needling Soreness and Pain Processing After Dry Needling Treatment
The general objective of the study is to determine the effectiveness on local mechanical hypoalgesia, pain intensity, disability and psychological variables of the deep dry needling technique on a latent trigger point of the…
- Conditions
- Placebo Effect, Pain Intensity, Disability, Dry Needling
- Trial name
- NCT04571827
- Testing
- Dry Needling
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Healthy, Placebo Effect
Experimental Pain Reporting Accuracy and Placebo Response
Good clinical care relies on precise evaluation of patients' conditions. Chronic pain and other neurological and psychiatric diagnoses pose challenges because their assessment depends on subjective patient-reported outcome…
- Conditions
- Healthy, Placebo Effect, Pain
- Trial name
- NCT03950999
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Placebo Effect
The Effect of Tablet Size on Cognitive Performance Caffeine
This study aims to assess if tablet size, due to placebo effect, alters participants' performance on cognitive tests after consuming caffeine.
- Trial name
- CaC (NCT03694886)
- Testing
- Caffeine Anhydrous with small sucrose pill, Caffeine Anhydrous with large sucrose pill
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Musculoskeletal Manipulations, Placebo Effect
Non-Specific Effects of Manual Therapy
The mechanism responsible for improvement following manual physical therapy techniques is unknown. Previous studies have indicated both biomechanical and neurophysiologic effects which may be responsible for clinical changes…
- Trial name
- NCT03017534
- Testing
- Spinal Manual Therapy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Shenandoah University
Placebo Effect, Pain
Back to Basics - Effects, Narratives and Routes of Administration of Open-label Placebo
To date, very little is known about the mechanisms of open-label placebo treatment and there is a lack in highly controlled experimental designs.
- Conditions
- Placebo Effect, Pain, Expectancy
- Trial name
- NCT02578420
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Placebo Effect, Placebo Drug Interaction
Interaction Between Drug and Placebo Effect:Randomized Placebo Controlled Trials May Not be Accurate in Determining Drug Effect Size
The total effect of a medication is the sum of its drug effect, placebo effect (meaning response of placebo), and their possible interaction.
- Trial name
- NCT01501591
- Testing
- Hydroxizine
- Where
- Saudi Arabia
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- King Faisal Specialist Hospital & Research Center