Clinical trials: Placebo Response
Oxytocin Effect on Memory Performance During Phase 1, Oxytocin Effect on Memory Performance During Phase 2
Can Oxytocin Enhance the Placebo Effect?
The current study aimed to investigate whether oxytocin (OXT) had effect on placebo effect.
- Conditions
- Oxytocin Effect on Memory Performance During Phase 1, Oxytocin Effect on Memory Performance During Phase 2, Oxytocin Effect on Memory Performance During Phase 3, Oxytocin Effect on Memory Performance During Phase 4
- Trial name
- NCT02745522
- Testing
- Oxytocin
- Where
- China
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Systemic Sclerosis (SSc), Scleroderma
Tibulizumab Systemic Sclerosis Understanding and Response Evaluation (TibuSURE)
The study is a Phase 2, multi-center, randomized, double-blind, placebo-controlled study to evaluate the effects of tibulizumab over 24 weeks (Period 1) in adult participants with systemic sclerosis, followed by an open-label…
- Trial name
- NCT06843239
- Testing
- Tibulizumab
- Where
- 60 sites in United States, Argentina and 8 more
- Volunteers
- 80 people
- Sponsor
- Zura Bio Inc
Gout
Combining Lesinurad With Allopurinol in Inadequate Responders
This study that compare the serum uric acid lowering effects, clinical benefits, and safety of lesinurad in combination with allopurinol to allopurinol alone in subjects with gout who have had an inadequate response to…
- Trial name
- CLEAR 1 (NCT01510158)
- Testing
- Lesinurad, Allopurinol
- Where
- 165 sites in United States
- Volunteers
- 607 people
- Sponsor
- Ardea Biosciences, Inc.
Dietary Supplement
A Study to Evaluate the Effects of Pre-Meal Whey Protein Microgels Administration on Post-Prandial Glycemic Response.
This is a mechanistic, randomized, investigator-blinded, placebo-controlled, single-center, crossover study designed to evaluate the effects of premeal administration of whey protein microgels compared to placebo on postprandial…
- Trial name
- NCT04639726
- Testing
- Whey Protein Micro Gel, Water without Whey Protein.
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Ulcerative Colitis
Evaluation of Efficacy and Safety of Tralokinumab in Patients With Active, Moderate-to-severe Ulcerative Colitis
The study is designed to evaluate the clinical efficacy and safety of tralokinumab as compared to placebo. Investigational product will be administered as subcutaneous injection.
- Trial name
- NCT01482884
- Testing
- tralokinumab
- Where
- 28 sites in Czechia, France and 4 more
- Volunteers
- 147 people
- Sponsor
- AstraZeneca
Rheumatoid Arthritis
Abatacept Post-marketing Clinical Study in Japan
The purpose of this study is to compare the clinical efficacy including joint damage progression and safety of Abatacept plus Methotrexate (MTX) to placebo plus MTX.
- Trial name
- NCT01758198
- Testing
- Abatacept, Methotrexate
- Where
- 74 sites in Japan
- Volunteers
- 405 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
A Dose-range Study of the Safety and Efficacy of Treatment in Adult Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate
The RESOLVE study is a two-part, randomized, double-blind, multi-center, placebo-controlled study of the safety, dose-range finding confirmation, and efficacy of 4 (Part A) and 12 weeks (Part B) of treatment with AP1189 in adult…
- Trial name
- RESOLVE (NCT05604885)
- Testing
- AP1189, 60 mg, AP1189, 80 mg, AP1189, 100 mg
- Where
- Moldova
- Volunteers
- 125 people
- Sponsor
- SynAct Pharma Aps
Ebola Sudan Virus Disease
Monovalent Chimpanzee Adenoviral-Vectored Sudan Ebolavirus Vaccine in Healthy Adults
A Phase 2, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Safety, Tolerability, and Immune Responses of an Investigational Monovalent Chimpanzee Adenoviral-Vectored Sudan Ebolavirus Vaccine in Healthy Adults
- Trial name
- NCT06036602
- Testing
- cAD3-Sudan Ebolavirus Vaccine
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Myocardial Ischemia, Blood Coagulation Disorders
"Salvage Use" of Recombinant Factor VIIa After Inadequate Haemostasis in Complex Cardiac Surgery
Aims and Hypotheses: This randomised placebo controlled study will test the hypothesis that Recombinant Activated Factor VII (rVIIa) will improve haemostasis after an inadequate response to conventional therapy in complex cardiac…
- Conditions
- Myocardial Ischemia, Blood Coagulation Disorders, Coronary Artery Disease, Heart Valve Diseases
- Trial name
- NCT00214656
- Testing
- Recombinant Activated Factor VII
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Austin Health
Healthy
Acute Effects of a Botanical Extract and Its Main Volatile Compound on Stress Response in Healthy Adults
The prevalence of stress in daily human life increase in the investigator's modern life style. Short stress, could be benefit for memory, but prolonged stress may conduct to disturbance in cardiovascular, neuroendocrine and…
- Trial name
- NCT04523870
- Testing
- Botanical extract, Main compound of the botanical extract
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Activ'inside
Rhinitis
SB705498 Proof of Concept Chamber Challenge in Subjects With Non Allergic Rhinitis
The purpose of this study is to assess the pharmacodynamic (PD) effects (Total Symptom Score (TSS) and its individual components: rhinorrhoea, nasal congestion, post-nasal drip) of intranasal, repeat dose SB-705498 in…
- Trial name
- NCT01424514
- Testing
- SB-705498
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- GlaxoSmithKline
Colitis, Ulcerative
Efficacy and Safety of Vedolizumab Subcutaneously (SC) as Maintenance Therapy in Ulcerative Colitis
The purpose of this study is to assess the effect of vedolizumab subcutaneous (vedolizumab SC) maintenance treatment on clinical remission at Week 52 in participants with moderately to severely active ulcerative colitis (UC) who…
- Trial name
- NCT02611830
- Testing
- Vedolizumab 300 mg IV, Vedolizumab 108 mg SC
- Where
- 174 sites in United States, Argentina and 29 more
- Volunteers
- 383 people
- Sponsor
- Takeda
Meningitis, Cryptococcal, HIV Infections
Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis
The purpose of this study is to examine the antifungal activity of recombinant interferon-gamma 1b (rIFN-gamma 1b) given with standard antifungal therapy.
- Trial name
- NCT00012467
- Testing
- Itraconazole, Flucytosine, Fluconazole
- Where
- 9 sites in United States, Peru
- Volunteers
- 60 people
- Sponsor
- InterMune
Healthy Volunteers
Study to Evaluate the Pressor Effect of Oral Tyramine During Ozanimod Treatment in Healthy Adult Participants
This is a Phase 1, randomized, double-blind, placebo-controlled, active-controlled, comparator controlled, multi-dose, parallel-group study divided into three treatment periods and a follow-up period with five treatment groups.
- Trial name
- NCT04978298
- Testing
- Rasigiline, Phenelzine, Ozanimod
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Celgene
Major Depressive Disorder
Efficacy and Safety of GLYX-13 in Subjects With Inadequate/Partial Response to Antidepressants
GLYX-13 is a NMDA receptor glycine site partial agonist being studied in subjects with major depressive disorder (depression) who have responded inadequately to another antidepressant drug during the current episode.
- Trial name
- NCT01684163
- Testing
- GLYX-13 5 mg/kg, GLYX-13 10 mg/kg
- Where
- 26 sites in United States
- Volunteers
- 369 people
- Sponsor
- Naurex, Inc, an affiliate of Allergan plc
Sepsis, Septic Shock
Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis
In this single-center, randomized, single-blind, placebo-controlled pilot clinical trial. The effect of apigenin on the improvement of organ function will be investigated in elderly patients with sepsis.
- Trial name
- NCT05999682
- Testing
- apigenin, sterilized water
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Ulcerative Colitis
A Study of Abatacept in Patients With Active Ulcerative Colitis
The purpose of this clinical research study is to learn if abatacept can improve signs and symptoms of active ulcerative colitis in patients who have not had an adequate response to other therapies.
- Trial name
- NCT00410410
- Testing
- abatacept (ABA), abatacept
- Where
- 143 sites in United States, Australia and 17 more
- Volunteers
- 591 people
- Sponsor
- Bristol-Myers Squibb
Sepsis
The Effect of Moderate-Dose Steroid Therapy in Sepsis
Despite the new developments in sepsis treatment, mortality rate is still high. Discussions on steroid treatment in sepsis are going on.
- Trial name
- NCT01275638
- Testing
- Prednisolone
- Volunteers
- 55 people
- Sponsor
- TC Erciyes University
Severe Sepsis, Septic Shock
A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock
The primary purpose of this study to evaluate the effect of two different doses of AZD9773 (CytoFab™) versus placebo on ventilator free days (VFDs) over the first 28 days after the start of dosing with AZD9773 in patients with…
- Trial name
- NCT01145560
- Testing
- AZD9773
- Where
- 52 sites in Australia, Belgium and 5 more
- Volunteers
- 300 people
- Sponsor
- AstraZeneca
HIV Infections
A Multicenter, Randomized, Placebo-Controlled, Double-Blinded, Phase I Trial to Evaluate the Safety and Immunogenicity of Live Recombinant Canarypox ALVAC-HIV vCP205 Combined With GM-CSF in Healthy, HIV-1 Uninfected Volunteers
To evaluate the safety and immunogenicity of live recombinant canarypox ALVAC-HIV vCP205 in combination with recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) at 80 microg and 250 microg.
- Trial name
- NCT00001090
- Testing
- APL 400-047, ALVAC-HIV MN120TMG (vCP205), Sargramostim
- Where
- 4 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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