Clinical trials: Placenta
Placenta Previa, Post Partum Hemorrhage
Glove-loaded Foley's Catheter Tamponade for Cesarean Section for Placenta Previa
Objective: To investigate the effect of A glove-loaded Foley's catheter tamponade versus stepwise uterine devascularization on blood loss during cesarean section (CS) in patients with complete placenta previa.
- Trial name
- NCT03570723
- Testing
- A glove-loaded Foley's catheter tamponade, stepwise uterine devascularization
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Aswan University Hospital
Placenta Previa
Relation of Implantation Site to Placental Site in Presence or Absence of Cesarean Section Scar
After gaining verbal consent , Patients included in this study will be subjected to: 1. history taking : peronal history . obstetric history. past history 2. general examination including vital signs 3.
- Trial name
- NCT03208842
- Testing
- trans vaginal ultrasound
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Placenta Accreta, Placenta Previa
Antenatal Diagnosis of Placental Attachment Disorders
The accuracy of sonographic prenatal detection of invasive placentation is unclear. The objective of this prospective, multicenter, observational study is to assess the performance of ultrasound for prenatal identification of…
- Trial name
- ADoPAD (NCT02442518)
- Testing
- antenatal ultrasound
- Where
- 3 sites in Italy
- Volunteers
- 2,254 people
- Sponsor
- NICOLA FRATELLI
Pre-Eclampsia, HELLP Syndrome
PlacEntal Acute Atherosis RefLecting Subclinical Atherosclerosis
Pregnancy is considered a cardiovascular (CV) stress test, and complicated pregnancies are associated with an increased risk for cardiovascular disease (CVD) later in life.
- Conditions
- Pre-Eclampsia, HELLP Syndrome, Intrauterine Growth Restriction, Pregnancy
- Trial name
- PEARLS (NCT05500989)
- Where
- Netherlands
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Preterm Birth, Low Birth Weight
Perinatal Conditions Influencing Morbidity, Mortality, and Medical Care in Newborns
This study focuses on understanding the conditions that affect newborn health and survival from pregnancy to the first weeks of life at the Isidro Ayora Hospital.
- Conditions
- Preterm Birth, Low Birth Weight, Intrauterine Growth Restriction (IUGR), Perinatal Asphyxia
- Trial name
- UCE (NCT06653374)
- Testing
- Infant, Premature
- Where
- Ecuador
- Volunteers
- 26,000 people
- Sponsor
- HOSPITAL GINECO OBSTETRICO ISIDRO AYORA
Preeclampsia
New Therapeutic Strategy Against Preeclampsia
Preeclampsia is a hypertensive disorder of pregnancy associated with important maternal and perinatal mortality. It complicates 2 to 5% of pregnancies and causes more than 70 000 maternal deaths each year worldwide.
- Trial name
- APHERESE2 (NCT06464159)
- Testing
- Biological collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pregnancy-induced Hypertension
Basic and Clinical Research of Pregnancy-Induced Hypertension
Collect blood pressure, blood, amniotic fluid, placenta and other samples from normal pregnant women, patients with pregnancy-induced hypertension and those who have experienced miscarriage, and conduct tests on them.
- Trial name
- BCRPIH (NCT07464379)
- Testing
- no Intervention
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Pregnancy
HexafluOride, a Contrast Agent for Placenta Echo-angiography
The purpose of this study is to quantify the placental perfusion during the first trimester of pregnancy by 3D Doppler ultrasound angiography without a contrast agent and by ultrasound with a contrast agent: SonoVue®
- Trial name
- HOPE (NCT02884297)
- Testing
- Contrast agent: SonoVue®.
- Where
- 2 sites in France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
COVID-19
Evaluation of the Safety and Efficacy of XoGlo Pro, a Placental Mesenchymal Stem Cell-derived Extracellular Vesicles in Treating COVID-19 Symptoms
Investigational New Drug trial investigating safety as primary endpoint and clinical efficacy as secondary endpoint of placental, mesenchymal stem cell-derived extracellular vesicles for the treatment of COVID-19 symptoms in…
- Trial name
- NCT07664696
- Testing
- IV infusion using an isolated, placental, mesenchymal stem cell derived EVs
- Volunteers
- 64 people
- Sponsor
- Kimera Labs Inc.
Placenta Abruptio
Effect of Placenta Delivery Method on Pain, Bleeding and Comfort
The aim of this thesis is to examine the effect of the placenta delivery method on women's postpartum pain, bleeding and comfort. It is a randomized controlled experimental study.
- Trial name
- NCT06413186
- Testing
- Uteratonic administration, cord clamping, delivery of the placenta
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Tarsus University
Placenta Accreta
Diagnostic Accuracy of Doppler Ultrasound and Role of Uterine Artery Doppler
This study will be conducted on (100) pregnant women diagnosed as placenta previa by ultrasonography and are candidates for either emergency or elective repeated cesarean section or hysterectomy (if the diagnosis of placenta…
- Trial name
- NCT03530475
- Testing
- ultrasound and doppler
- Volunteers
- 100 people
- Sponsor
- Kasr El Aini Hospital
Placenta Previa
Antenatal Tranexamic Acid in Women With Symptomatic Placenta Previa
200 pregnant women with symptomatic placenta previa with previous bleeding attacks attending Ain Shams University maternity hospital will be recruited and randomized to receive either tranexamic acid tablets (500mg four times…
- Trial name
- NCT04055194
- Testing
- Tranexamic acid tablets
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
Pregnancy Complications, Perinatal Problems
The Relation Between Placental Volume at the 1st Trimester and Perinatal Prognosis
It has been known for years that placental transport and endocrine and metabolic functions of the placenta are the main determinants of fetal nutrition and homeostasis.
- Conditions
- Pregnancy Complications, Perinatal Problems, Maternal-Fetal Relations
- Trial name
- NCT05429242
- Testing
- Ultrasonographic examination
- Where
- Turkey (Türkiye)
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Siirt University
Chorioamnionitis, Brain Injury
Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio)
The purpose of this trial was to find the best dose of N-acetylcysteine (NAC) to decrease brain injury in babies exposed to intrauterine infection without causing significant side effects.
- Trial name
- NCT00724594
- Testing
- N-acetylcysteine, Control
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Medical University of South Carolina
Bladder Injury, Complications; Cesarean Section
Cystoinflation to Prevent Bladder Injury in Obstetrics and Gynaecology Surgery
Part1:The healthy pregnant women with previous operative deliveries admitted for elective C-section will be counselled and conditioned informed consent will be taken to be included in either study group if dense pelvic adhesions…
- Conditions
- Bladder Injury, Complications; Cesarean Section, Adhesions Pelvic
- Trial name
- NCT04302545
- Testing
- Cystoinflation
- Where
- Pakistan
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Shazia Saaqib
Obstructive Sleep Apnea, Pregnancy
Positive Airway Pressure, Sleep Apnea, and the Placenta (PAP-SAP)
This study is testing the hypothesis of whether continuous positive airway pressure (CPAP) therapy improves placental histopathology and secretory function.
- Conditions
- Obstructive Sleep Apnea, Pregnancy, Obesity, Preeclampsia
- Trial name
- PAP-SAP (NCT02412696)
- Testing
- Positive Airway Pressure, Nasal Dilator Strips
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- The Miriam Hospital
Postpartum Contraception, Reproductive Health
Predictors of PPIUCD Discontinuation at Two Years: A Clinical Study in Pakistan
This prospective cohort study evaluated the continuation rates, complications, and satisfaction associated with postpartum intrauterine contraceptive devices (PPIUCDs) as a long-acting reversible contraception (LARC) method.
- Conditions
- Postpartum Contraception, Reproductive Health, Family Planning
- Trial name
- NCT06766396
- Testing
- Postpartum Intrauterine Contraceptive Device (PPIUCD).
- Where
- Pakistan
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Placenta Accreta
Evaluation of Clinical Outcomes and Acceptability of an Anatomical Classification for Placenta Accreta Spectrum
This study evaluates the clinical implementation of intra-operative topographic classification system for PAS. In addition to a standard of care risk stratification prenatal ultrasound for patients with a risk of PAS, this study…
- Trial name
- NCT07283042
- Testing
- Total Hysterectomy, Modified subtotal hysterectomy, One-Step Conservative Surgery
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Hypoxic-Ischemic Encephalopathy, Birth Asphyxia
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries Developmental Follow Up
An extension of the CORDMILK trial, the CORDMILK follow-up trial will evaluate the neurodevelopmental outcomes at 22-26 months age of term/late preterm infants who were non-vigorous at birth and received umbilical cord milking…
- Trial name
- CORDMILK-FU (NCT03682042)
- Testing
- Umbilical Cord Milking
- Where
- 9 sites in India
- Volunteers
- 3,442 people
- Sponsor
- Nemours Children's Clinic
Multiple Sclerosis
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for MS
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of multiple sclerosis
- Trial name
- NCT05003388
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 15 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine