Clinical trials: Post Menopause
Metabolic Syndrome, Diet Modification
Diet for the Maintenance of Weight Loss and Metabolic Health in Obese Postmenopausal Women
The aim of the study will be comparing the effectiveness of two diets: moderate in fat with a high proportion of monounsaturated fatty acids (MUFAs) - the Mediterranean diet (MED) and 2) the low in fat and high in dietary fiber…
- Conditions
- Metabolic Syndrome, Diet Modification, Postmenopause
- Trial name
- WELCOME (NCT04136093)
- Testing
- the MED, the DASH, Control diet
- Where
- Poland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Dyspareunia, Menopause
Use of Estriol at Distal Third of Vagina Improving Coital Pain in Post-menopause Women
Hypoestrogenism leads to vaginal wall changes resulting in diminished vaginal lubrication and, consequently, causing pain during intercourse. Topical estrogen therapy (THT) may control this complaint.
- Conditions
- Dyspareunia, Menopause, Sexual Dysfunction
- Trial name
- NCT03116022
- Testing
- Estriol, Distal estriol, Vaginal Gel
- Where
- Brazil
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Genitourinary Syndrome of Menopause
Vaginal Changes After CO2 Laser
Genitourinary syndrome of menopause (GSM) occurs due to a decline in estrogen levels as a woman approaches menopause. The syndrome negatively impacts women's quality of life and is characterized by vaginal dryness, burning…
- Trial name
- OCTRCT (NCT06691178)
- Testing
- Optical coherence tomography (OCT)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Healthy
Bioavailability Study of Letrozole Tablets 2.5 mg of Dr.Reddy's Under Fed Conditions
The purpose of this study is to compare bioavailability in healthy, post menopausal women subjects under fed conditions.
- Trial name
- NCT01372982
- Testing
- Letrozole
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Postmenopausal Atrophic Vaginitis, Genitourinary Syndrome of Menopause
Difference in Serum Estrogen Level Based on Methods of Vaginal Estrogen Application (fingertip Vs Applicator Use) in Post-menopausal Women
Study the change in serum estrogen level based on the method of vaginal cream application (applicator vs fingertip application) and Measure patient satisfaction with vaginal estrogen cream application based on the method of…
- Trial name
- NCT06808347
- Testing
- application of the vaginal estrogen cream
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Hot Flashes, Hot Flushes
Stellate Ganglion Blockade in Post-Menopausal Women
Hot flashes and night sweats (vasomotor symptoms, VMS) affect 80% of women during the menopausal transition (MT). VMS are associated with decreased quality of life, increased depressive and anxiety symptoms, memory complaints…
- Conditions
- Hot Flashes, Hot Flushes, Vasomotor Symptoms
- Trial name
- R01 (NCT02907983)
- Testing
- Stellate Ganglion Block Injection with Bupivicaine, Saline injection
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Genitourinary Syndrome of Menopause (GSM), Vaginal Dryness
To Assess Signs and Symptoms in Women Affected by GSM After One Cycle of Pixel CO2-Alma Fractionated Laser
Genitourinary syndrome of menopause (GSM) occurs in approximately 50% of menopausal women but is both underrecognized and undertreated despite numerous treatment options.
- Conditions
- Genitourinary Syndrome of Menopause (GSM), Vaginal Dryness, Burning, Pain
- Trial name
- NCT05156502
- Testing
- Fractionated Laser (Pixel CO2-Alma), Fractionated Laser (Pixel CO.2-Alma)
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Dr. Filippo Murina
Menopause
Estrogen and the Urogenital Microbiome in GSM
This is a study of how local estrogen treatment affects the microbiome of the vagina and bladder in postmenopausal women experiencing symptoms as part of "Genitourinary Syndrome of Menopause." The goal is to understand more about…
- Trial name
- NCT03336437
- Testing
- Estradiol vaginal ring
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Menopause
Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females
Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal…
- Trial name
- NCT06480695
- Testing
- Nitrate-Rich Beetroot Juice, High Intensity Exercise, Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cardiovascular Diseases, Diabetes Mellitus, Type 2
Exercise Training in Older Diabetic Women
Type 2 diabetics (non-insulin-dependent) are more than five times as likely to suffer an initial myocardial infarction (MI; heart attack) compared to nondiabetics.Female diabetics in particular, have a higher mortality rate for…
- Trial name
- NCT00341614
- Testing
- 3-month Exercise Training and Diet Education
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of San Francisco
Post Menopausal, Osteoporosis
EFFECT OF CIRCUIT TRAINING ON BONE MINERAL DENSITY IN POST MENOPAUSAL PERIOD
This study will be conducted to determine the effect of circuit training on bone mineral density in post menopausal period.
- Trial name
- CWT and BMD (NCT06950463)
- Testing
- Group A (control group): It will be consisted of twenty two post menopausal women who will receive daily dosage of vitamin D3 supplement (600 IU/day) (Schleicher et al., 2016), for 6 week, 1-Dumbbells (set B08Z7SY6SP ,Gymbit , made in China) :They will be used for the treatment procedures of circuit training for all postmenopausal women in group B. Its surface is coated with vinyl fo
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hormone Replacement Therapy, Cardiovascular Diseases
A Prospective Multicenter Cohort Study of Contemporary Menopausal Hormone Therapy and Cardiovascular Outcomes
This prospective registry study investigates the impact of new hormone replacement therapy (HRT) delivery methods, such as creams, gels, and sprays, on cardiovascular risk in postmenopausal women.
- Conditions
- Hormone Replacement Therapy, Cardiovascular Diseases, Hormone Replacement Therapy, Post-Menopausal, Menopause
- Trial name
- CATCH-Menopaus (NCT07394049)
- Where
- 2 sites in Germany
- Volunteers
- 3,408 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Obesity, Insulin Resistance
Race, Menopause and Metabolism After Exercise and Diet
The purpose of this study is to test the hypotheses that there are ethnic and genetic differences in the mechanisms and magnitude by which hypocaloric weight loss and aerobic exercise affect body composition, glucose, lipid…
- Conditions
- Obesity, Insulin Resistance, Sedentary Lifestyle
- Trial name
- NCT00882141
- Testing
- Diet modification, Aerobic exercise
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Menopause
Study to Investigate the Pharmacokinetics & Safety Following One Application of 3 Different Doses 0.5,0.75,& 1.25 gm,a Transdermal Estradiol Cream (VML-0203), in Comparison to a Single Dose of EstroGel 1.25 gm to Healthy Post-menopausal Women.
This study is a Phase I, Randomized, Open-Label, Single Center, Cross-over Study to Investigate the Pharmacokinetics and Safety following a Single Application of Three Different Doses 0.5 gm (0.5 mg estradiol), 0.75 gm (0.75 mg…
- Trial name
- NCT03556800
- Testing
- Estrogel
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Viramal Limited
Sexual Dysfunction, Physiological
Effect Of Menstrual Cycle On Vaginal Blood Flow In Pre-Menopausal Healthy Women.
The Pfizer developed Heat Wash-Out (HWO) system is a software controlled electromechanical system designed to measure vaginal wall blood flow. A small vaginal probe is attached to a control unit. Output data is collected on a PC.
- Trial name
- HWO VBF (NCT00443027)
- Testing
- Vaginal Heat Wash-Out Device
- Where
- 2 sites in Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Evaluation of IM Letrozole ISM® Pharmacokinetics, Safety, and Tolerability in Healthy Post-menopausal Women (LISA-1)
This is a Phase I, open label, dose escalation study designed to evaluate the pharmacokinetics, safety, and tolerability of single intramuscular injections of Letrozole ISM® at different strengths in voluntary healthy post…
- Trial name
- NCT03401320
- Testing
- Letrozole ISM
- Where
- Czechia
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Rovi Pharmaceuticals Laboratories
Fatigue
Effect of Pilates Exercises On Fatigue In Post Menopausal Women
Pilates is a system of exercises using special apparatus, designed to improve physical strength, flexibility, and enhance mental awareness.
- Trial name
- NCT05002894
- Testing
- Pilates exercises, medical standard care for fatigue
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Cairo University
Bone Loss, Age Realted, Post Menopausal
Flaxseed Consumption and Bone Metabolism in Postmenopausal Women.
This proposed randomized double blinded, placebo-controlled, parallel trial; with two arms, in females aged 50-70 years, volunteers will be postmenopausal with a BMI between 25-35 kg/m2.
- Trial name
- FLAX (NCT03036722)
- Testing
- Flaxseed
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Reading
Aging, Postmenopause
Beetroot Supplementation in Women Enjoying Exercise Together
This study seeks to determine the feasibility of an exercise training progression with the consumption of beetroot juice prior to exercise in postmenopausal women.
- Conditions
- Aging, Postmenopause, Obesity
- Trial name
- BEE SWEET (NCT04370756)
- Testing
- Beetroot Juice, Exercise Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Post-menopausal Women, Post-menopausal Status
Dairy Choline Bioavailability
The goal of this clinical trial is to find out if dairy is a good source of choline compared to eggs. The main questions it aims to answer are: How the body uses choline; and, What effect WPPC has on choline metabolism.
- Trial name
- NCT06902480
- Testing
- WPPC, Whole egg powder
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison