Clinical trials: Post Menopause
Vaginal Atrophy, Genitourinary Syndrome of Menopause
The Efficacy of Topical Vaginal Oxytocin Gel in Postmenopausal Women With Vulvovaginal Atrophy
A Phase three randomized, double-blinded, study to asses the efficacy and safety of oxytocin gel in postmenopausal women with vaginal atrophy due to Genitourinary Syndrome of Menopause GSM.
- Conditions
- Vaginal Atrophy, Genitourinary Syndrome of Menopause, Vulvar Atrophy
- Trial name
- NCT06514586
- Testing
- Oxytocin, Hydroxypropyl methylcellulose
- Where
- Egypt
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Oxagon
Dyspareunia
Treating Postmenopausal Dyspareunia Where it Hurts
The purpose of this study is to compare the effectiveness of two low doses of estrogen cream applied to a new location for the treatment of moderate or severe pain during sexual intercourse in postmenopausal women.
- Trial name
- NCT03240081
- Testing
- 50mcg estradiol cream, 100mcg estradiol cream
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Menopause
TRANSDERMAL HRT RELIEVING POSTMENOPAUSAL SYMPTOMS
There is a dilemma and a permanent debate about side effects on drugs administered orally. The first-pass metabolism is related with many side effects, since the metabolites of these compounds affect the course of human…
- Trial name
- THRT (NCT02033512)
- Testing
- Transdermal Hormone Replacement Therapy, Transdermal Nanoformulation, Transdermal formulation
- Where
- Brazil
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Potiguar
Postpartum Depression, Depression
Screening Evaluation for Women With Postpartum Depression
This study evaluates the relationship between mood changes and hormones in women with postpartum depression (PPD). This is an observational study; volunteers who participate will not receive any new or experimental therapies.
- Trial name
- NCT00056901
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy
Estradiol/Norethindrone Acetate Tablets, 1/0.5 mg Under Fed Conditions
The objective of this study was to determine and compare the rate and extent of absorption of norethindrone and unconjugated estradiol from a test formulation of Estradiol/Norethindrone Acetate Tablets, 1 mg/0.5 mg versus the…
- Trial name
- NCT01181726
- Testing
- Estradiol/Norethindrone acetate, Activella®
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Bioequivalance, Post-menopause
An Open-label, Randomized, Single-dose, Two-treatment, Four-period, Fully Replicate Crossover Bioequivalence Study in Healthy Female Adult Participants Under Fasting Conditions Comparing the Test Product, Prontogest Solution for IM Injection With the Reference Product, Progesterone Injection
Bioequivalence study of two injectable formulation of progesterone in healthy post-menopausal women
- Trial name
- Prontogest (NCT07495007)
- Testing
- Progesterone IM of 100 mg
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Zi Diligence Biocenter
Postmenopausal Period
Efficacy and Safety of HPC-03 for Postmenopausal Symptom
In women, as the age increases, ovarian function is lost, resulting in the deficiency of female hormones, resulting in menopause, in which menstruation is permanently lost.
- Trial name
- NCT03061799
- Testing
- HPC-03
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Jae Hoon Lee
Osteoporosis, Postmenopausal
Determination of Adipocyte Parameters in Iliac Crest Biopsies From Post Menopausal Women
To evaluate the effect of estrogen treatment on adipocytic and osteoblastic parameters by histomorphometrically measuring adipocyte volume (AV/TV) and adipocyte numbers in goldner's stained iliac crest bone biopsy specimens…
- Trial name
- NCT00443716
- Testing
- estrogen
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy, Postmenopausal
Progesterone Reduces Wakefulness in Sleep EEG and Has no Effect on Cognition in Healthy Postmenopausal Women
Sleep is impaired in postmenopausal women (difficulty falling asleep, frequent awakenings). Progesterone prompted benzodiazepine-like effects on sleep EEG in young normal male subjects.
- Trial name
- NCT00530582
- Testing
- progesterone
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Max-Planck-Institute of Psychiatry
Menopause, Depression
Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder
The purpose this study is to measure cortical gama-aminobutyric acid levels (GABA) levels in menopausal women with major depressive disorder and healthy subjects using nuclear magnetic resonance spectroscopy (MRS).
- Trial name
- NCT00626340
- Testing
- MDD diagnosis and Estrogen treatment, MDD diagnosis and Fluoxetine treatment, MDD diagnosis with both Estrogen and Fluoxetine treatment
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hot Flashes, Menopause
TU 025 Keishi Bukuryo Gan for Post-menopausal Hot Flash Management
This study tests to see if TU 025 Keishi Bukuryo Gan reduces the frequency and severity of hot flashes in post-menopausal American women.
- Trial name
- NCT00119418
- Testing
- TU 025 Keishi Bukuryo Gan
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Plotnikoff, Gregory A., M.D.
Cardiovascular Diseases, Osteoporosis
A Study on the Impact of Calcium on Woman's Vascular Health
The overarching aim of this randomized clinical trial is to estimate the effect of dietary intake of calcium as compared to supplemental calcium on the vascular system and markers of vascular and bone health in postmenopausal…
- Trial name
- NCT01731340
- Testing
- Calcium Citrate, Low Dietary Calcium, High Dietary Calcium
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Healthy, Postmenopause
Fat Distribution in Healthy Early Postmenopausal Women
The aim of this study is to explore the effects of hormone replacement therapy with EV/DNG on abdominal fat distribution measured by magnetic resonance imaging.
- Trial name
- NCT00335218
- Testing
- Climodien / Lafamme (BAY86-5027)
- Where
- 3 sites in Austria
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Bayer
Endometrial, Asymptomatic Post-menopause
Asymptomatic Women With Thick Endometrium: Hysteroscopic and Histopathological Report
The primary objective of this study is to determine the histopathological diagnosis of endometrial tissue obtained from asymptomatic postmenopausal women with incidentally detected thickened endometrium, and to evaluate the…
- Trial name
- NCT07695077
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sohag University
Thrombosis, Menopause
Exercise Training and Thrombotic Risk in Post-menopausal Women
At menopausal transition, the risk of cardiovascular diseases increases. This is partly due to aging, but largely also the loss of estrogen, which has many positive effects on the circulation and protects against cardiovascular…
- Conditions
- Thrombosis, Menopause, Exercise Training, Vascular Dilation
- Trial name
- TIME (NCT04596501)
- Testing
- Early and late postmenopausal women
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Fall Injury, Incontinence
The Effect of Yoga on Decreasing Risk of Fall-Related Injury in Peri and Post-Menopausal
The primary objective of this study is to evaluate the effect of yoga on both fall risk factors AND capacity to successfully control landing and descent during a simulated fall among peri-and post- menopausal women.
- Conditions
- Fall Injury, Incontinence, Balance; Distorted
- Trial name
- NCT05106010
- Testing
- Balance Flow Yoga
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Cardiovascular Risk Factor, Menopause Related Conditions
The Clinical Utility of Resistance Training for Improving Cardiovascular Disease Risk in Post-Menopausal Women
Given the heightened cardiovascular disease (CVD) risk in post-menopausal women, studies are needed to explore novel, feasible methods for reducing risk in this population.
- Conditions
- Cardiovascular Risk Factor, Menopause Related Conditions, Neuromuscular Function, Aerobic Capacity
- Trial name
- NCT03752060
- Testing
- Resistance Exercise, Aerobic Exercise
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Breast Cancer
A Prospective,Open-label Study of Anastrozole in Post-menopausal Women With Hormone Sensitive Advanced Breast Cancer
The overall objective of the clinical study is to assess the tolerability and clinical efficacy of anastrozole in post-menopausal women with hormone sensitive advanced breast cancer in India.
- Trial name
- NCT00544986
- Testing
- Anastrozole
- Volunteers
- healthy volunteers welcome
- Sponsor
- AstraZeneca
Obesity, Menopause Hot Flashes
The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity
The purpose of this study is to determine the effect of tirzepatide on vasomotor symptoms and on measures of biological aging.
- Trial name
- NCT07218445
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Aging
Effect of Estrogen & Stress for Postmenopausal Women
The study tests the hypothesis that estradiol administration exacerbates the effects of the stress hormone cortisol on cognition and mood for postmenopausal women.
- Trial name
- NCT00220454
- Testing
- Climara, Hydrocortone
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research