Clinical trials: Post Traumatic Stress Disorders
Mild Traumatic Brain Injury
Remediation of Impaired Self-Regulation in Patients With Mild TBI
The ability to regulate impulses enables us to plan for the future, to maintain focus in the face of distractions (i.e. to encode memories), and to manage emotions.
- Trial name
- NCT02260570
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder
A Correlation Between Hair Cortisol Levels and the Development of Post Traumatic Stress Disorder (PTSD)
This observational study follows subjects who have been exposed to a traumatic event and are at risk of developing PTSD symptoms.
- Trial name
- NCT02033395
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
PTSD
Post-Traumatic Stress Disorder (PTSD) Symptom Study
The primary goals for this investigation are to quantify: (1) fluctuations in PTSD symptom reports when assessed at bi-weekly intervals; (2) change in PTSD symptoms associated with stressful life events; and (3) change in PTSD…
- Trial name
- NCT00018798
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Burnout, Professional, Self Compassion
Better Together Physician Coaching to Mitigate Burnout Amongst Clinicians
Better Together Physician Coaching ("Better Together", or "BT"), a 4-month, web-based positive psychology multimodal coaching program was built to decrease burnout in medical trainees.
- Conditions
- Burnout, Professional, Self Compassion, Flourishing, Imposter Syndrome
- Trial name
- NCT05635448
- Testing
- Better Together Physician Coaching Program, No intervention - waitlist control
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Nightmare, Insomnia
INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention
The INSIGHT study is a multi-site clinical research program designed to examine how insomnia and symptoms of sympathetic hyperactivity impair sleep, cognition, and physiological restoration in warfighters, and to evaluate whether…
- Conditions
- Nightmare, Insomnia, PTSD, TBI
- Trial name
- INSIGHT (NCT07288593)
- Testing
- NightWare smartwatch configured to detect physiological signs of sympathetic activation during sleep, such as heart-rate spikes and movement patterns.
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Respiratory Failure, SARS-CoV 2
Stress Related Disorders in Family Members of COVID-19 Patients Admitted to the ICU
Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Conditions
- Respiratory Failure, SARS-CoV 2, Corona Virus Infection, Post Intensive Care Unit Syndrome
- Trial name
- NCT04476914
- Where
- 9 sites in United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Generalized Anxiety, Stress Disorder, Posttraumatic
CBT for Anxiety Sensitivity vs. Disorder-specific CBT: An RCT
Adults with high anxiety sensitivity (AS) and a mental health diagnosis of anxiety, depression, or posttraumatic stress will be recruited and will be randomly assigned to either transdiagnostic cognitive behavioural therapy (CBT)…
- Conditions
- Generalized Anxiety, Stress Disorder, Posttraumatic, Social Anxiety, Major Depression
- Trial name
- NCT03015285
- Testing
- Cognitive Behavioural Therapy
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Post Intensive Care Syndrome, Anxiety
Sensation Awareness Focused Training for Spouses
The purpose of the feasibility study is prevention of Post Intensive Care Syndrome in Family (PICS-F), specifically in spouses of critically ill, mechanically ventilated patients, using a nonpharmacological intervention called…
- Conditions
- Post Intensive Care Syndrome, Anxiety, Depression, Posttraumatic Stress Disorder
- Trial name
- SAF-T (NCT03129204)
- Testing
- SAF-T
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Intimate Partner Violence, Depression
Feasibility Study for Abused Chinese Immigrant Women
Intimate partner violence (IPV) is a serious social and public health issue. In the U.S., more than 1 in 3 women experience physical or sexual violence, and/or stalking by an intimate partner during their lifetime.
- Conditions
- Intimate Partner Violence, Depression, Anxiety, PTSD
- Trial name
- NCT05011552
- Testing
- Self-Compassion, Health, and Empowerment (SHE), The Control Condition
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Anxiety Symptoms, Post-traumatic Stress Symptoms
Improving Student Mental Health Through a Universal Trauma-Informed Intervention
The goal of this trial is to identify the most effective ways for schools to deliver RAP Club, a universal school-based mental health intervention.
- Conditions
- Anxiety Symptoms, Post-traumatic Stress Symptoms, Depressive Symptoms, Behavioral Problems
- Trial name
- PPP (NCT07842432)
- Testing
- RAP Club Delivered by a School Clinician, RAP Club Delivered by a Teacher, Standard Supervision
- Where
- 3 sites in United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Post-Traumatic Stress Disorder in Adolescence, Post Traumatic Stress Disorder
Adolescent PCIP Randomized Feasibility Trial
There are three research questions: (1) whether the Primary Care Intervention for PTSD (PCIP) improves health outcomes; (2) whether and how the PCIP can be sustainably delivered via telehealth; and (3) how PCIP compares to…
- Trial name
- APCIP (NCT05088915)
- Testing
- Primary Care Intervention for PTSD (PCIP), Treatment As Usual
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Post-traumatic Stress Disorders
Tetris to Reduce Intrusive Memories in Parents After PICU
The purpose of this study is to examine the acceptability and feasibility of a brief behavioural intervention involving Tetris gameplay to prevent intrusive traumatic memories in parents after paediatric intensive care.
- Trial name
- NCT04186962
- Testing
- Behavioral: Simple cognitive task
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- King's College London
Stress-related Problem, Stress, Emotional
Effects of Parent-Adolescent Joint I-Interventions for Adolescents with Adverse Childhood Experiences
The study aims to examine the effectiveness of internet-based Parent-Adolescent Joint Interventions in improving the mental health outcomes of participants, specifically by reducing symptoms of depression, anxiety, and PTSD, as…
- Trial name
- EASY-PEP-i (NCT06650696)
- Testing
- PCE promotion, Psychoeducation, Emotiaonl skill enhancement
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University
PTSD (Childbirth-Related)
Preventing Childbirth-Related PTSD With Expressive Writing
The goal of this clinical trial is to test a brief psychological intervention given to individuals in the first days following childbirth who have experienced a potentially stressful childbirth.
- Trial name
- CARES (NCT05662423)
- Testing
- Expressive Writing about Childbirth, Neutral Writing
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Stress Disorders, Post-Traumatic
Augmenting Massed Prolonged Exposure With a Stellate Ganglion Block to Treat PTSD
This is a small, open-label treatment study that tests the potential safety and treatment effectiveness of a stellate ganglion block combined with Massed Prolonged Exposure (PE).
- Trial name
- NCT04302181
- Testing
- Ropivacaine injection
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Intrusive Memories
The Effect of Oxytocin on the Acquisition and Consolidation of Trauma-Associated Memories
The purpose of the study is to examine whether oxytocin and oxytocin receptor gene polymorphism affect the development of intrusive memories, a cardinal symptom of PTSD.
- Trial name
- NCT03031405
- Testing
- Oxytocin nasal spray
- Where
- Germany
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Mental Health Issue, Mental Stress
"OnCall": Implementation Study of M-Health for Canadian Public Safety Personnel
First Responders, or Public Safety Personnel (PSP), play a key role in protecting the health and safety of Canadians, yet this important work can take a toll on their mental health, leading to an elevated risk of post-traumatic…
- Conditions
- Mental Health Issue, Mental Stress, Post Traumatic Stress Disorder
- Trial name
- OnCall (NCT05255419)
- Testing
- OnCall mobile health peer support app
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- McMaster University
Posttraumatic Stress Disorder
Assessing and Enhancing Social Support
Posttraumatic stress disorder (PTSD) is a common and impairing problem among Veterans, many of whom first seek treatment in primary care settings. PTSD is linked to reduced quality of life and increased rates of suicide.
- Trial name
- NCT05187156
- Testing
- Behavioral Activation and Social Engagement, Treatment as usual
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Burnout, Professional, Self Compassion
Better Together Physician Coaching to Mitigate Burnout in Male-Identifying Trainees
Better Together Physician Coaching ("Better Together", or "BT"), a 4-month, web-based positive psychology multimodal coaching program was built to decrease burnout in medical trainees.
- Conditions
- Burnout, Professional, Self Compassion, Flourishing, Imposter Syndrome
- Trial name
- BTPC (NCT05550753)
- Testing
- Better Together Physician Coaching Program
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Trauma, Psychological, Sexual Violence
CFT Self-Help for Accessing Cervical Screening After Sexual Assault
The aim of this study is to evaluate the feasibility of a new self-help intervention designed to support individuals (anyone with a cervix) to access cervical cancer screening following the experience of sexual assault, by…
- Conditions
- Trauma, Psychological, Sexual Violence, Cervical Cancer
- Trial name
- NCT04104724
- Testing
- Self-help
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Royal Holloway University