Clinical trials: Postoperative Depression
Surgical Stress Response, Stress Physiological
Feasibility of Breathwork Intervention With Older Adults After Knee Surgery
Postoperative complications after surgical procedures, including following total knee arthroplasty (TKA), have a negative impact on the health and well-being of surgical patients.
- Conditions
- Surgical Stress Response, Stress Physiological, Stress Physiology, Stress Psychological
- Trial name
- NCT07464860
- Testing
- A 5-minute Asynchronous Breathwork Intervention, A 5-minute Asynchronous Card Game Video
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Respiratory Complications, Opioid Induced Respiratory Depression
Timing of Opioid Administration and Postoperative Respiratory Depression.
The goal of this study is to determine if a relationship can be detected between the administration of an opioid and quantitative respiratory depression in spontaneously breathing non-intubated patients who have undergone general…
- Conditions
- Respiratory Complications, Opioid Induced Respiratory Depression, Postoperative Respiratory Complications
- Trial name
- NCT07227389
- Testing
- Respiratory volume monitoring
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Caesarean Section, Mother-Child Relations
Effect of Mother's Push at Cesarean Delivery Mother's PUSHING AT CS A RANDOMIZED CONTROLLED TRIAL
The purpose of this study is to assess the safety and efficacy of the mother's active pushing during cesarean delivery.
- Conditions
- Caesarean Section, Mother-Child Relations, Post Operative Pain, Postpartum Depression
- Trial name
- NCT05520580
- Testing
- Mother's push during CS
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Postoperative Pain, Cesarean Section
Effects of Nerve Blocks on Pain After Caesarean Section and Postpartum Depression
At the end of your cesarean section surgery, which is started by applying medication to the spinal cavity from your waist, pain medication will be applied between the relevant muscle and its covering from your lower abdomen or…
- Conditions
- Postoperative Pain, Cesarean Section, Postpartum Depression
- Trial name
- NCT06221280
- Testing
- Nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Respiratory Depression
Observation of Respiration Following Regional Anaesthesia With Intrathecal Opioids for Caesarean Section
Spinal Administration of opioids offers segmental analgesia, but has side effects including pruritus, nausea and vomiting, urinary retention, hypotension, and respiratory depression, both early and delayed.
- Trial name
- NCT00544947
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- NHS Greater Clyde and Glasgow
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Pain, Postoperative, Depression, Postpartum
Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)
The purpose of this study is to identify a tolerable dose for postpartum ketamine infusion using a maximum tolerated dose (MTD) 3+3 design.
- Trial name
- NCT05907213
- Testing
- Ketamine (Ketalar) Dose Level 1, Ketamine (Ketalar) Dose Level 2, Ketamine (Ketalar) Dose Level 3
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Postoperative Depression
The Impact of Preoperative Chronic Pain on Postoperative Depressive States in Elderly Patients Undergoing Joint Replacement Surgery: A Secondary Analysis Based on Prospective Data
Background: Postoperative depression is a significant complication that hinders recovery in elderly patients undergoing joint replacement surgery.
- Trial name
- NCT07403838
- Where
- China
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Hysterectomy, Chronic Pain
Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With Chronic Pain After Hysterectomy
Phase 1 (started in July 2019): Central Sensitization Inventory (CSI), Fear-Avoidance Components Scale (FACS), pain-pressure threshold are factors associated with chronic post-hysterectomy pain (CPHP), but a complete…
- Conditions
- Hysterectomy, Chronic Pain, Central Sensitisation, Anxiety Depression
- Trial name
- EPOCH (NCT04014829)
- Testing
- Pain-Pressure Threshold, Mechanical Temporal Summation, Hospital Anxiety and Depression Scale
- Where
- Singapore
- Volunteers
- 436 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Postoperative Pain, Acute, Postoperative Depression
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
The purpose of this research study is to learn how two different supportive programs may help women feel better after surgery. This study will measure if one type of supportive program is more useful than the other for improving…
- Conditions
- Postoperative Pain, Acute, Postoperative Depression, Anxiety, Sleep Disturbance
- Trial name
- NCT05625360
- Testing
- eHealth Mindful Movement and Breathing, Life Impacts Reflection, PROMIS Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Postoperative Pain, Postpartum Depression
Dose Low Dose Ketamine in Casesarian
The results of ketamine, ketamine and midazolom can be copied after birth in cesareans subjected to spinal anesthesia.
- Trial name
- ketamine (NCT06237569)
- Testing
- Application of ketamine and midazolam or ketamine alone to patients undergoing cesarean section under spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Inonu University
Respiratory Depression
Postoperative Respiratory Monitoring After Neuraxial Opioid Administration for Cesarean Delivery
Respiratory depression occurs in labor and delivery; noticeably when neuraxial opioids are given.Pathophysiological respiratory depression -failure to respond to hypercapnia or hypoxia - is challenging to measure…
- Trial name
- NCT02417038
- Testing
- Capnostream
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stanford University
Opioid-Induced Respiratory Depression, Postoperative Complications (Cardiopulmonary)
Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillectomy
This study will evaluate whether quantitative pupillometry measurements can be used to identify children at risk for postoperative opioid-induced respiratory depression (OIRD) following tonsillectomy.
- Conditions
- Opioid-Induced Respiratory Depression, Postoperative Complications (Cardiopulmonary), Respiratory Complications Due to Anesthesia
- Trial name
- NCT07573150
- Testing
- Infrared Pupillometry
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- NeurOptics Inc
Depression, Unipolar, Pain, Postoperative
Maternal Mindfulness: Depression and Postpartum Pain
This phase I clinical trial tests the feasibility and safety of a self-guided, mobile mindfulness-based intervention to reduce post-cesarean pain and prevent postpartum depression.
- Trial name
- MaMiDaPP (NCT05400382)
- Testing
- Mindfulness
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Postoperative Complications
Application of Capnography Monitoring on the General Care Nursing Unit
The aim of this study is to increase the detection of undiagnosed obstructive sleep apnea (OSA) and secondly to increase the sensitivity for detection of respiratory depression (< 6 breaths per minute) in post operative patients…
- Trial name
- ETCO2 (NCT00457080)
- Testing
- Alaris ETCO2 monitor - cont. resp. rate, & apnea events
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Texas Health Resources
Total Knee Replacement, Post Operative Pain
Effect of Mindfulness on Pain After Total Knee Arthroplasty
This study will be a prospective randomized controlled trial evaluating the effectiveness of using Headspace before and after undergoing total knee replacement surgery.
- Conditions
- Total Knee Replacement, Post Operative Pain, Opioid Use
- Trial name
- NCT06118073
- Testing
- Headspace, Total Knee Replacement
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Cognitive Dysfunction, Burns
PRIME: Cognitive Outcome Following Major Burns
PRIME aims to demonstrate through neurocognitive assessment that BICU patients will have a degree of neurocognitive dysfunction following a major burn, that this neurocognitive dysfunction is due to an underlying…
- Conditions
- Cognitive Dysfunction, Burns, Inflammation, Brain, Quality of Life
- Trial name
- PRIME (NCT03242395)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Postpartum Anxiety, Postpartum Depression
Postpartum Screening for Anxiety and Comorbid Conditions
The goal of this project is to facilitate the design of individualized postpartum anxiety (PPA) screening strategies in British Columbia (BC), Canada.
- Conditions
- Postpartum Anxiety, Postpartum Depression, Postpartum Disorder, Postoperative Pain
- Trial name
- PPA (NCT06242717)
- Where
- Canada
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Anxiety-depression
Effect of Esketamine on Reducing Postoperative Anxiety and Depression in Adolescent Patients
This study intends to conduct a prospective, double-blind, randomized, controlled trial. Adolescents aged 8-17 years old are selected as subjects.
- Trial name
- NCT06073015
- Testing
- Esketamine
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital