Clinical trials: Postural Hypotension
Orthostatic Hypotension, Autonomic Failure
Automated Abdominal Binder for Orthostatic Hypotension
The automated inflatable abdominal binder is an investigational device for the treatment of orthostatic hypotension (low blood pressure on standing) in patients with autonomic failure.
- Conditions
- Orthostatic Hypotension, Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy
- Trial name
- NCT03482297
- Testing
- automated abdominal binder, Midodrine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt University Medical Center
Orthostatic Hypotension
Phase II Study of Midodrine for Neurogenic Orthostatic Hypotension
OBJECTIVES: I. Study further the safety and efficacy of the alpha-receptor agonist midodrine in patients with neurogenic orthostatic hypotension. II. Assess the quality of life in these patients with this treatment regimen.
- Trial name
- NCT00004268
- Testing
- midodrine
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Center for Research Resources (NCRR)
Spinal Cord Injuries
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury
The purpose of this study is to stimulate the circuits in the spinal cord that are directly responsible for hemodynamic control to restore hemodynamic stability in participants with chronic cervical or high-thoracic spinal cord…
- Trial name
- HEMO (NCT05044923)
- Testing
- Targeted Epidural Spinal Stimulation
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Aaron Phillips
Orthostatic Hypotension
Frequency of Orthostatic Hypotension in Patients Who Underwent Colonoscopy
Patients who will undergo colonoscopy accompanied by sedoanalgesia will be admitted at Aksaray Training and Research Hospital Gastroenterology Clinic between May and July 2024.
- Trial name
- NCT06439498
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ankara University
Spinal Cord Injury, Orthostatic Hypotension
Prevention of Orthostatic Hypotension With Electric Stimulation in Persons With Acute SCI
Background: The presence of orthostatic hypotension (OH) as a consequence of blood volume redistribution during verticalisation in persons with spinal cord injury (SCI) is a common condition.
- Trial name
- NCT01891110
- Testing
- ES of the abdominal muscles, ES of the limb muscles, ES of limbs & abdomen
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Orthostatic Hypotension
Research, Development, and Application of Intelligent Diagnostic System for Orthostatic Hypotension
Orthostatic hypotension (OH) has a high incidence rate of 30%-50% in the elderly and populations with neurodegenerative diseases.
- Trial name
- NCT07309666
- Testing
- Intelligent diagnostic system for orthostatic hypotension
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Orthostatic Hypotension, Pure Autonomic Failure
Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension
The autonomic or automatic nervous system helps control blood pressure. Diseases of the autonomic nervous system may result in a drop in blood pressure on standing in many cases leading to fainting.
- Conditions
- Orthostatic Hypotension, Pure Autonomic Failure, Multiple System Atrophy, Parkinson's Disease
- Trial name
- 6103 (NCT01316666)
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
Multiple System Atrophy, Autonomic Failure
Deep Brain Stimulation for Autonomic and Gait Symptoms in Multiple System Atrophy
Patients referred to neurosurgery routinely and safely undergo deep brain stimulation (DBS) for treatment of symptoms related to neurodegenerative conditions, most commonly Parkinson's disease.
- Conditions
- Multiple System Atrophy, Autonomic Failure, Postural Hypotension, Bladder, Neurogenic
- Trial name
- STAG-MSA (NCT03593512)
- Testing
- Deep brain stimulation
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Oxford
Spinal Cord Injuries, Orthostatic Hypotension
Speed of Robotic Leg Movements and Orthostatic Hypotension in Subacute SCI
This study seeks to evaluate whether the speed (cadence) of lower extremity robotic movement has an impact on orthostatic hypotension and upright tolerance when training with the ErigoPro robotic tilt-stepper.
- Trial name
- NCT04029974
- Testing
- ErigoPro
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Methodist Rehabilitation Center
Orthostatic Hypotension
Droxidopa / Pyridostigmine in Orthostatic Hypotension
This study is being done to study the combination of pyridostigmine and low-dose Droxidopa for the treatment of orthostatic hypotension.
- Trial name
- NCT01370512
- Testing
- Droxidopa, Pyridostigmine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Orthostatic Hypotension, Falls
Orthostatic Hypotension Treatment on Rehab Unit
For patients recovering from acute illness, the ability to stand, walk, climb stairs, and participate in therapy are critical to their recovery and eventual discharge to the least restrictive environment.
- Trial name
- NCT01030874
- Testing
- Medication review, Nutrition/Salt intake, Education
- Where
- United States
- Volunteers
- 356 people
- Sponsor
- VA Office of Research and Development
Multiple System Atrophy
Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSA
Evaluate the effects of L-Threo DOPS on orthostatic hypotension symptoms and other non-motor symptoms in patients with Multiple System Atrophy (MSA) after 12 weeks following randomization to continued therapy with droxidopa or…
- Trial name
- DOPS-AMS (NCT02071459)
- Testing
- L-Threo DOPS
- Where
- 13 sites in France
- Volunteers
- 107 people
- Sponsor
- University Hospital, Toulouse
Hypotension Symptomatic, Parkinson's Disease
Epidural Electrical Stimulation to Support Hemodynamic Management in Individuals With Parkinson's Disease
The PD-HemON study aims to evaluate the safety and preliminary efficacy of ARC-IM Therapy (Epidural Electrical Stimulation) to support hemodynamic management in people with typical and atypical Parkinson's Disease, who suffer…
- Conditions
- Hypotension Symptomatic, Parkinson's Disease, Orthostatic Hypotension, Dysautonomic, Multiple System Atrophy (MSA) With Orthostatic Hypotension
- Trial name
- PD-HemON (NCT06920134)
- Testing
- ARC-IM Investigational System
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Symptomatic Neurogenic Orthostatic Hypotension, MSA - Multiple System Atrophy
Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic nOH in Participants With Multiple System Atrophy
This is a Phase 3, multi-center, randomized withdrawal study to evaluate the efficacy and durability of ampreloxetine in participants with MSA and symptomatic nOH after 20 weeks of treatment.
- Trial name
- CYPRESS (NCT05696717)
- Testing
- Ampreloxetine
- Where
- 79 sites in United States, Argentina and 18 more
- Volunteers
- 102 people
- Sponsor
- Theravance Biopharma
Orthostatic Hypotension, Postural Hypotension
Transcranial Electrical Stimulation for Management of Orthostatic Instability in Acute Cervical Spinal Cord Injury
Individuals with acute cervical spinal cord injury (SCI) can suffer from an excessive and prolonged fall in blood pressure when assuming an upright position, such as transitioning from lying to sitting or standing, a condition…
- Trial name
- NCT01874782
- Testing
- transcranial electrical stimulation
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of British Columbia
Parkinson's Disease, Multiple System Atrophy
Efficacy of Therapeutic Interventions for Orthostatic Hypotension in Parkinson's Disease and Multiple System Atrophy
Patients with Parkinson's Disease or Multiple System Atrophy (MSA), and symptoms of orthostatic hypotension, are eligible for the study.
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Orthostatic Hypotension
- Trial name
- NCT00103597
- Testing
- Fludrocortisone, Domperidone, Conservative Measures for Orthostatic Hypotension
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Royal Brisbane and Women's Hospital
Blood Pressure, Orthostatic Hypotension
Effects of Blueberries in Older Adults
This randomized, parallel-design trial will evaluate specific clinical and physiological effects of whole blueberries in adults 70 years of age or older.
- Conditions
- Blood Pressure, Orthostatic Hypotension, Vascular Diseases
- Trial name
- BnD (NCT05358210)
- Testing
- Blueberry Consumption, Dried Date Consumption
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Dysautonomia
MRI to Assess the Effects of Dysautonomia and Chronic Nausea on Brain Transmitters
The purpose of this research study is to better understand what causes dysautonomia and how this affects blood pressure and pulse. Dysautonomia is a condition of the autonomic nervous system.
- Trial name
- NCT01692561
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Orthostatic Hypotension
Water and the Gastropressor Response - Diurnal Variability
We will test the null hypothesis that there is no diurnal (morning to afternoon)variability in the blood pressure response to the ingestion of water 16 oz.
- Trial name
- NCT00581373
- Testing
- water 16 fl oz
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Satish R. Raj
Neurogenic Orthostatic Hypotension
Spinal Cord Stimulation for Neurogenic Orthostatic Hypotension
Neurogenic orthostatic hypotension is a disabling manifestation of synucleinopathies including Parkinson's disease, multiple system atrophy, dementia with Lewy bodies, and pure autonomic failure.
- Trial name
- NCT07879391
- Testing
- Lower thoracic epidural spinal cord stimulation
- Volunteers
- 20 people
- Sponsor
- Aerospace Center Hospital