Clinical trials: Pragmatic Randomized Controlled Trial
Alcohol Misuse
Nurse-led Alcohol Brief Intervention Plus Mobile Personalized Chat-based Support on Reducing Alcohol Use in University Students
This study aims to assess the effect of personalized support using instant messaging application on alcohol drinking reduction in university students proactively recruited from universities in Hong Kong.
- Trial name
- NCT04025151
- Testing
- Alcohol brief intervention, 12-page health warning leaflet, Regular messages through Instant Messaging (IM)
- Where
- Hong Kong
- Volunteers
- 770 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Plasmodium Vivax Malaria, Malaria
FocaL Mass Drug Administration for Vivax Malaria Elimination
FLAME is an open-label cluster-randomized controlled trial that aims to determine the effectiveness of focal mass drug administration (fMDA) to reduce the incidence of Plasmodium vivax malaria in the Loreto Department in Peru.
- Trial name
- FLAME (NCT05690841)
- Testing
- Focal Mass Drug Administration (fMDA)
- Where
- Peru
- Volunteers
- 7,530 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nurse-led Supportive Care
Effects of Nurse-led Supportive Care Programme on Caregiver Burden and Resilience of Family Caregivers
Lung cancer is the leading cause of cancer-related deaths worldwide, with a mortality rate of 18%. The prognosis of lung cancer is progressive and devastating, which may cause patients to experience problems during the treatment…
- Trial name
- NCT06204289
- Testing
- Nurse-led Supportive Care Programme
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University
Stroke, Influenza Human
Vaccination Nudges From Pharmacists
The goal of this individual-level pragmatic randomized policy trial is to learn about the impact of behavioural nudges via mailed letters on increasing influenza and travel vaccination uptake in Alberta, Canada.
- Conditions
- Stroke, Influenza Human, Influenza Vaccines, Health Behavior Change
- Trial name
- NCT07161739
- Testing
- Behavioural Nudge (Influenza Risk Reduction), Behavioural Nudge (Travel Vaccination Benefit)
- Where
- Canada
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Smokers, Workplace
Evaluation of a Workplace Smoking Cessation Program in Hong Kong (Phase VI)
This study aims to test, by a 2-arm RCT, the effectiveness of an intervention that includes mobile phone-supported simple physical exercise for smoking cessation in workplaces in Hong Kong.
- Conditions
- Smokers, Workplace, Exercise
- Trial name
- NCT05758272
- Testing
- mobile phone-based simple physical exercise reminder to help quit smoking, regular text-based intervention
- Where
- Hong Kong
- Volunteers
- 646 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Substance Withdrawal Syndrome
EA for PAAS: A pRCT
In 2019, around 27 million people worldwide, corresponding to 0.5% of the adult population, have used amphetamine-type stimulants (ATS). More than one-third of these 27 million users of ATS were in East and South-East Asia.
- Trial name
- NCT04917185
- Testing
- Electro-Acupuncture
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Organ Donation, Registration for Deceased Organ Donation
Promoting Organ Donor Registration in Family Physician Offices
This study evaluates the effects of using reception staff to prompt patients by providing a pamphlet and an opportunity to register in the waiting room via a mobile tablet on deceased organ donor registration rates.
- Trial name
- NCT03213171
- Testing
- Reception staff providing handout., Mobile Tablet (e.g. iPad)
- Where
- 2 sites in Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Abortion Early
Transabdominal and Transvaginal Sonography in Medical Abortion
The investigator will perform a multicenter, randomized controlled trial in practices that routinely use transvaginal sonography (TVS) to compare how often clinicians order additional testing prior to medical abortion after the…
- Trial name
- TASvTVS (NCT03047551)
- Testing
- Transabdominal sonography, Transvaginal sonography
- Where
- 2 sites in United States
- Volunteers
- 634 people, healthy volunteers welcome
- Sponsor
- Columbia University
Preventive Effectiveness, Elderly With Qi-deficiency Constitution
The Preventive Effectiveness of the Individualized Jade Wind-Barrier Herbal Tea Bag on the Common Cold in Elderly With Qi-deficiency Constitution (CCJWBT): A Pragmatic Randomized Controlled Trial
Objectives Based on the individualized Jade Wind-Barrier Herbal Tea Bag intake after randomization, to evaluate the relationship of the individualized Jade Wind-Barrier Herbal Tea Bag intake and the improvement of Qi-deficiency…
- Conditions
- Preventive Effectiveness, Elderly With Qi-deficiency Constitution, The Individualized Jade Wind-Barrier Herbal Tea Bag, Common Cold
- Trial name
- CCJWBT (NCT05640570)
- Testing
- The individualized Jade Wind-Barrier Herbal Tea Bag
- Where
- China
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Fracture, Fractures, Hip
The PREVENT Trial: a Pragmatic Cluster Randomized Controlled Trial of a Multifaceted Fracture Prevention Model for Long-term Care
Hip fractures occur nearly twice as often for older adults residing in long-term care as they do in older adults of a similar age still living in other settings.
- Conditions
- Fracture, Fractures, Hip, Osteoporosis
- Trial name
- PREVENT (NCT04947722)
- Testing
- PREVENT Program
- Where
- Canada
- Volunteers
- 3,060 people, healthy volunteers welcome
- Sponsor
- McMaster University
Immunization Coverage, Vaccination
Increasing Measles Vaccination Coverage Through Supplementation With an SQ-LNS Incentive in Children Aged 6-23 Months
Provision of SQ-LNS also holds promise in incentivizing vaccination as well as other health services. The investigators will estimate 1) the effectiveness of a SQ-LNS mass supplementation program added to routine immunization…
- Conditions
- Immunization Coverage, Vaccination, Nutrition
- Trial name
- NCT06387511
- Testing
- Small-quantity lipid-based nutrition supplements (SQ-LNS) NutriVax, Sensitization on vaccination and on Infant and Young Child Feeding (IYCF) practices
- Where
- Nigeria
- Volunteers
- 3,814 people, healthy volunteers welcome
- Sponsor
- Alliance for International Medical Action
Smoking Cessation
Effectiveness of WhatsApp Online Group Discussion for Smoking Relapse Prevention
This study aims to examine the effectiveness and cost-effectiveness of WhatsApp group discussion for smoking relapse prevention.
- Trial name
- NCT03760224
- Testing
- WhatsApp group, SMS group
- Where
- Hong Kong
- Volunteers
- 928 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Herpes Zoster
A Study to Evaluate the Effect of Recombinant Zoster Vaccine on New Diagnosis of Dementia in an Older Adult Population Aged 76 Years or Older in Finland
The purpose of this study is to evaluate the effect of the recombinant zoster vaccine on the risk of new diagnosis of dementia among adults aged 76 years or older in Finland.
- Trial name
- NCT07502560
- Testing
- Recombinant zoster vaccine
- Where
- 8 sites in Finland
- Volunteers
- 33,609 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dermatitis, Atopic
Atopic Dermatitis in Atopy Predisposed Infants
The primary objective of this study is to investigate the effectiveness of a standardized skin care regimen using a milk lotion once daily and a bathing addendum as needed during the first 52 weeks of life on the development of…
- Trial name
- ADAPI (NCT02906475)
- Testing
- standardized skin care regimen
- Where
- Germany
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- HiPP GmbH & Co. Vertrieb KG
Tobacco Dependence, COPD Asthma
Cytisine vs Nicotine Replacement Therapy
Tobacco is the most preventable cause of disease and death in Canada. Although the tobacco use rate has substantially gone down in the general population, significant differences exist between sub-populations in Canada, for…
- Conditions
- Tobacco Dependence, COPD Asthma, Mental Illness, Substance Use
- Trial name
- NCT03249428
- Testing
- Cytisine, Nicotine replacement therapy (NRT)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Cervical Disc Herniation
Pharmacopuncture Therapy for Cervical Disc Herniation: A Pilot Study
This is pilot study for a 3-arm parallel pragmatic randomized controlled trial that will compare pharmacopuncture therapy, acupunture therapy and physical therapy, medication(prn) for cervical disc herniation.
- Trial name
- NCT05240586
- Testing
- pharmacopuncture therapy, acupuncture therapy, physical therapy, medication(prn)
- Where
- 7 sites in South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Jaseng Medical Foundation
Vaccine Acceptance
Peer Education as a Strategy to Promote Vaccine Acceptance
Effective interventions to improve uptake of vaccines among hesitant groups are urgently needed. Peer education is an effective intervention in modifying health behaviors in other conditions and may be effective in promoting…
- Trial name
- NCT05875779
- Testing
- Peer-led vaccine education intervention
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Emotional Distress, Quality of Life
At-risk and vulNerable Individuals To Infection With COVID-19 and ProActive inTervention With intEgrated Health and Social Care
This randomized control trial aims to explore a data-driven, proactive approach to identifying patients at greatest risk during the pandemic, and assess the impact of an embedded System Navigator in a primary health care setting.
- Conditions
- Emotional Distress, Quality of Life, Mental Health
- Trial name
- ANTICIPATE (NCT05197608)
- Testing
- System Navigator, Tailored list of resources
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Tuberculosis (TB)
Research on Key Interventional Technologies for Controlling the Epidemic in High-prevalence Areas of Tuberculosis in Guangxi, China
The goal of this study is to find out if using mobile vans with advanced technology can help reduce tuberculosis (TB) in rural Guangxi, China. The study will also examine how practical and cost-effective this approach is.
- Trial name
- NCT06702774
- Testing
- Active case finding
- Where
- China
- Volunteers
- 43,067 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Mental Health, Child Wellbeing
Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents
Generation Victoria (GenV) is a longitudinal, population-based study of Victorian children and their parents that will bring together data on a wide range of conditions ,exposures and outcomes.
- Conditions
- Mental Health, Child Wellbeing, Infant Health, Child Health
- Trial name
- GenV (NCT05394363)
- Where
- Australia
- Volunteers
- 150,000 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute