Clinical trials: Pre Diabetic
Prediabetes
Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Fat
Cardiovascular disease (CVD) is the leading cause of death in the United States. Short-term increases in blood sugar, or postprandial hyperglycemia (PPH), affect blood vessel function and increase the risk of CVD.
- Trial name
- NCT02482610
- Testing
- Glucose, Glucose with Whole Fat Milk, Glucose with Non-fat Milk
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ohio State University
PreDiabetes
Lifestyle Modification Intervention in Pre-diabetic Subjects
The lifestyle intervention program focusing on healthy dietary habit and exercise effectively prevents progression to diabetes. Thus, the purpose of this study was to assess the effectiveness of lifestyle intervention program on…
- Trial name
- NCT03211182
- Testing
- lifestyle modification intervention
- Where
- 4 sites in Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Prediabetic State (IGT), Prediabetic State
Intestinal Endotoxemia and Beta- Cell Dysfunction in Prediabetics
the goal of this observation study is to learn about association between intestinal endotoxemia and prediabetes lean patients with the aim of prevention of diabetes in those category of patients
- Trial name
- NCT07557329
- Testing
- hba1c, lbp, fasting blood sugar, lipogram, fastinf insulin
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sohag University
Pre Diabetes, Insulin Resistance
Exenatide and Weight Loss for Diabetes Prevention
Exenatide, a GLP-1 agonist approved for lowering blood glucose concentrations in patients with type 2 diabetes, has been associated with restoration of the first-phase insulin response when administered intravenously to patients…
- Trial name
- NCT02084654
- Testing
- Exenatide 5 and 10 mcg 2 times a day
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity, Insulin Resistance
Resveratrol and the Metabolic Syndrome
Metabolic syndrome is a serious health condition that affects about 35 percent of adults and places them at higher risk of cardiovascular disease, diabetes, stroke and diseases related to fatty buildups in artery walls.
- Conditions
- Obesity, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT01714102
- Testing
- Resveratrol
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Multimodal Risk Factor Graph Mapping, Metabolic Subtyping, and Digital Intelligent Chronic Disease Management for Prediabetes: An Integrated Cohort and Case-Control Clinical Study
This observational study aims to understand the metabolic characteristics and long-term changes in adults with prediabetes and to identify risk and protective factors associated with progression to diabetes or return to normal…
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Impaired Fasting Glucose, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- DM-PIONEER (NCT07854002)
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
PreDiabetes
Home-based Prediabetes Care in Acoma Pueblo - Study 1
The prevalence of overweight, obesity and T2D among American Indians (AIs) in the Albuquerque service area of Indian Health Services (IHS) serving all pueblos in New Mexico including Pueblo of Acoma is disproportionately…
- Trial name
- NCT04029298
- Testing
- Lifestyle Interventions
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of New Mexico
Pre-diabetic
Investigation of the Ability of a Supplement to Increase Good Bacteria in the Human Intestine and Blood Sugar Levels
This study aims to determine whether the use of a supplement called xylooligosaccharide (XOS) increases the number of good bacteria that live in human intestines and can maintain healthy blood sugar levels, and whether XOS has…
- Trial name
- XOS2 (NCT01944904)
- Testing
- Sugar Pill, XOS 2.8
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
PreDiabetes
Effects of Exercise Based Manual in Sedentary Prediabetic Population
The prediabetes is a state in which fasting blood glucose level ranges between 100-126mg/dl or HbA1C ranges between 5.7-6.4mmol. People with prediabetes have 74 percent chance of progression to develop Type 2 diabetes mellitus.
- Trial name
- NCT04949958
- Testing
- Exercise Based Manual (Supervised), Exercise Based Manual (Home Based), Control
- Where
- Pakistan
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Pre Diabetes, Obesity
Community Based DPP Program for Hispanic/Latino Females
Is well known that obesity is increasing in the United States (US) and particularly among Hispanic/ especially in in socially disadvantaged groups.
- Trial name
- NCT04052815
- Testing
- Diabetes prevention program culturally tailored
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loyola University
Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk Adults
The purpose of this clinical trial is to find out whether one type of fish oil works better than another at improving metabolic health in people who are at high risk of developing type 2 diabetes.
- Conditions
- Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Prediabetes / Type 2 Diabetes, Obesity & Overweight
- Trial name
- END-T2D (NCT07575438)
- Testing
- Fish Oil, Corn oil control
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- May Faraj, PDt, PhD
Type 2 Diabetes, Pre-diabetes
Testing the Effectiveness of Different Messaging Approaches to Increase Doctor Visits Amongst Individuals With Risk Factors for Diabetes
The purpose of the research is to test the effectiveness of different messaging approaches to nudge members of Vitality and Discovery Health, with risk factors for diabetes (based on data from the Vitality Health Check and…
- Trial name
- NCT05755555
- Testing
- Visit a doctor
- Where
- South Africa
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Wits Health Consortium (Pty) Ltd
Obesity, Insulin Resistance
Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study)
The undercarboxylated fractions of the two vitamin K-dependent proteins osteocalcin and matrix Gla protein have been shown to play key roles in type 2 diabetes and cardiovascular disease (at least in mouse models).
- Conditions
- Obesity, Insulin Resistance, Insulin Sensitivity, Prediabetes
- Trial name
- NCT01972113
- Testing
- Low-Dose Vitamin K2 (menaquinone-7; 45 mcg/d), High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Diabete Mellitus, MASLD
RESET-INSPIRE Study: Insulin Sensitivity & Population Intervention With Real-time Evaluation Using CGM
The RESET-INSPIRE study is designed to investigate individual variability in glucose response and insulin sensitivity, a key mechanism underlying metabolic-associated steatotic liver disease (MASLD) and cardiometabolic disorders.
- Trial name
- RESET-INSPIRE (NCT07861191)
- Where
- Singapore
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National University Health System, Singapore
PreDiabetes, Obesity
The Time-Restricted Intake of Meals Study
TRIM is a randomized, controlled feeding study to evaluate if eating earlier in the day vs. later in the day impacts weight and glucose homeostasis.
- Trial name
- TRIM (NCT03527368)
- Testing
- Time-restricted feeding, Usual feeding pattern
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Type 2 Diabetes Mellitus (T2DM), Hypertension (HTN)
Cohort Study of Metabolic Disease and Hypertension
The goal of this observational study is to learn how type 2 diabetes and high blood pressure develop over time in adults in Mexico.
- Trial name
- NCT07577063
- Testing
- Observational Study
- Where
- Mexico
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Prediabetes, Prehypertension
Prediabetes, Prehypertension and Vitamin D Supplementation - A Practice Based Clinical Intervention Pilot Study
This randomized, double-blind, placebo-controlled, multi-site study is to reverse modest elevations of fasting blood sugar (prediabetes) and resting blood pressure(Prehypertension) or both co existing prediabetes and…
- Trial name
- NCT01425424
- Testing
- Vitamin D supplementation
- Where
- 7 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
NAFLD, Obesity
Ernährungs-Interventions-Fettleber-Studie (Interventional Study on Nutritional Effects on NAFLD)
Epidemiological data and studies in animal models suggest, that polyunsatured fatty acids (PUFA) rather than mono-unsatured fatty acids (MUFA) are associated with lower hepatic lipid content (HCL) and may facilitate a decrease of…
- Conditions
- NAFLD, Obesity, Prediabetes, Dyslipoproteinemia
- Trial name
- UFOP-2 (NCT02458586)
- Testing
- Dietary intervention / counseling
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
PreDiabetes, Pre Diabetes
Comparative Effects of High-Intensity Interval Training and Continuous Endurance Training Among Prediabetic Patients
Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes.
- Conditions
- PreDiabetes, Pre Diabetes, Prediabetic State
- Trial name
- NCT07713030
- Testing
- High-Intensity Interval Training, Continuous Endurance Training
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Type 2 Diabetes Mellitus, Prediabetic State
Opportunistic Screening for Prediabetes and Early Diabetes in Primary Care
People who might have prediabetes or unrecognized diabetes will be screened for these problems at an outpatient visit. For screening, they will take a sugary drink containing 50 grams of glucose, and have a blood sample one hour…
- Trial name
- NCT00787839
- Testing
- Glucose challenge test, Glucose tolerance test
- Where
- United States
- Volunteers
- 1,939 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs