Clinical trials: Pre-diabetic State
Healthy, PreDiabetes
Efficacy of Milk Product Supplemented With Bioactives in Lowering Post Meal Glucose Response
This is a monocentric, randomized controlled, open-label, 2x2 cross-over study. The main objective of the study is to Evaluate the efficacy of Nestle YIYANG TangLv milk powder in lowering the Post Prandial Glucose Response (PPGR)…
- Conditions
- Healthy, PreDiabetes, Adult, Asian
- Trial name
- NCT05570435
- Testing
- Blood collection
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Type 2 Diabetes, PreDiabetes
Promote Health With Digital Tools Among Adults With Type 2 Diabetes/Prediabetes and/or Hypertension
The goal of this hybrid type II effectiveness-implementation trial is to evaluate whether an intersectoral, digitally enabled, family-based intervention can prevent and manage type 2 diabetes mellitus (T2DM) and hypertension…
- Conditions
- Type 2 Diabetes, PreDiabetes, Hypertension, Obesity & Overweight
- Trial name
- DigiCare4You (NCT05648383)
- Testing
- mHealth self-management intervention, Standard care
- Where
- 4 sites in Albania, Bulgaria and 2 more
- Volunteers
- 1,215 people, healthy volunteers welcome
- Sponsor
- Harokopio University
PreDiabetes, Obesity
Promotora-Led Intervention for Metabolic and Mental Health
Evidence-based programs to prevent diabetes among high-risk individuals are less effective among those who also have mental health needs.
- Conditions
- PreDiabetes, Obesity, Metabolic Disease, Body Weight Changes
- Trial name
- PRIME2 (NCT03372018)
- Testing
- Promotora-led Intervention (PLI), Usual care (UC)
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Bread, Hyperglycemia
Bread Replacement - Facing the Challenge to Improve Its Quality for Better Metabolic Health
This is a multicenter study testing the effect of bread containing beta-glucan on glycemic control in participants with intermediate hyperglycemia.
- Conditions
- Bread, Hyperglycemia, Glycemic Control, PreDiabetes
- Trial name
- NCT04994327
- Testing
- Beta-glucan bread
- Where
- Norway
- Volunteers
- 155 people
- Sponsor
- University of Bergen
Prediabetes
Role of Slowly Digesible Starch on Diabetes Risk Factors
The purpose of this study is to determine the effect of a slowly digesting starch on gut bacteria, sugar and fat metabolism, hunger hormones, and body fat in people with pre-diabetes.
- Trial name
- STARCH (NCT01708694)
- Testing
- Amylose, Amylopectin
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Pennington Biomedical Research Center
PreDiabetes, Obesity
Dinner Time for Obesity and Prediabetes
Obesity and its metabolic complications are leading causes of global morbidity and mortality. Evidence is mounting that inappropriate timing of food intake contributes to obesity.
- Conditions
- PreDiabetes, Obesity, Healthy
- Trial name
- DTOP (NCT05745441)
- Testing
- Early Dinner, Late Dinner, Early Dinner tracer
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Type 2 Diabetes Mellitus, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Antidiabetic Effect of Olive Pomace Oil
This clinical trial aims at assessing whether consumption of olive pomace oil in the diet may benefit persons with type 2 diabetes mellitus or persons at risk of developing the disease (prediabetic persons).
- Conditions
- Type 2 Diabetes Mellitus, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Prediabetic State, Diabetes
- Trial name
- OPODIABE (NCT06723886)
- Testing
- Experimental arm: Olive pomace oil, High-oleic acid sunflower oil
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Ciencia y Tecnología de Alimentos y Nutrición
PreDiabetes
Effects of Moringa Oleifera Leaves on Glycemia, Lipemia and Inflammatory Profile in Prediabetic Patients
Moringa oleifera (MO) is a traditional food in tropical and subtropical areas and has attained a growing interest for its medicinal properties. It's a nutrient-rich vegetable, high in protein and polyphenol content.
- Trial name
- NUTRIMOL-DB (NCT04734132)
- Testing
- Moringa
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Prediabetes
Effectiveness of a Virtual Health Management Community (VHMC) for Pre-diabetes in China
Individuals with prediabetes are at high risk for developing type 2 diabetes mellitus (T2DM) and are therefore prone to serious complications such as stroke, kidney failure, blindness, and lower-limb amputation.
- Trial name
- VHMC (NCT07338552)
- Testing
- Usual Care, VHMC-based Group Interaction Management
- Volunteers
- 146 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Diabetes, Gestational, Prediabetic State
Evaluating for Type-2 Diabetes in the Very Early Postpartum Period
Pregnancy-associated diabetes, known as gestational diabetes mellitus (GDM), is associated with an increased lifetime risk of developing diabetes mellitus (DM) or pre-diabetes.
- Conditions
- Diabetes, Gestational, Prediabetic State, Glucose Metabolism Disorders, Diabetes Mellitus
- Trial name
- NCT01988987
- Testing
- Inpatient Postpartum GTT
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- NYU Langone Health
Prediabetes, Hyperglycemia
Benefit of IQP-VV-102 in Reducing Postprandial Glucose Level in Overweight Caucasian Subjects
In this trial, the investigational product , the active ingredients which has been proven to reduce postprandial glucose in healthy and diabetic patients, will be tested.
- Trial name
- NCT02541344
- Testing
- Dose 1 of IQP-VV-102, Dose 2 of IQP-VV-102
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- InQpharm Group
PreDiabetes
Mechanisms for Activation of Beige Adipose Tissue in Humans
Mirabegron (Myrbetriq®, Astellas) is a highly specific and well-tolerated ß3 agonist marketed for overactive bladder. This trial will assess the effects of mirabegron on glucose tolerance and adipose tissue in prediabetic patients
- Trial name
- NCT04666636
- Testing
- Mirabegron, Mirabegron 50 MG, Mirabegron 100 mg
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Insulin Resistance, Obesity
Efficacy of Lyophilized Dried Cornus Mas L. on Anthropometric and Biochemical Parameters in Insulin Resistance
The aim of this study is to determine the effect of 3 months supplementation of lyophilize dried cornelian cherry (Cornus mas L.) on women diagnosed with insulin resistance.
- Conditions
- Insulin Resistance, Obesity, PreDiabetes
- Trial name
- NCT05292300
- Testing
- Cornelian Cherry (Cornus mas L.), Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Marmara University
Menopause, Prediabetes
Effects of Novel Estrogens on Glucose and Lipids in Postmenopausal Prediabetic Women Veterans
The purpose of this study is to determine the effect of a novel menopause hormone therapy on blood sugar (glucose) and blood and liver fats (lipids) in obese menopausal women Veterans.
- Conditions
- Menopause, Prediabetes, Obesity
- Trial name
- CE/BZA (NCT05073237)
- Testing
- conjugated estrogens/bazedoxifene (CE/BZA)
- Where
- United States
- Sponsor
- VA Office of Research and Development
Childhood Obesity, Prediabetes
Clinical Utility of SUDOSCAN in the Pediatric Population
The main purpose of this study is to evaluate whether SUDOSCAN is a valid, accurate clinical device for the the determination of sweat gland function in the pediatric population.
- Conditions
- Childhood Obesity, Prediabetes, Diabetes
- Trial name
- NCT02216201
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Impeto Medical
Prediabetes, Impaired Fasting Glucose
Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity in Patients With Prediabetes
Prediabetes is a term that refers to alterations in glucose homeostasis, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both, involving a higher risk of progression type 2 diabetes mellitus (T2DM).
- Conditions
- Prediabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance
- Trial name
- NCT02700334
- Testing
- Dapagliflozin
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- University of Guadalajara
Prediabetes, Insulin Resistance
Food and Metabolism Study
In this study, Investigators are interested in looking at the influence of eating avocados regularly, which are rich in healthy fats, fibers, and unique carbohydrates, on triglyceride and glucose metabolism in people with…
- Conditions
- Prediabetes, Insulin Resistance, Triglycerides, Lipids Metabolism
- Trial name
- FAM (NCT07624500)
- Testing
- Avocado meal plan, Control meal plan
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Overweight and Obesity, Diabetes Mellitus, Type 2
AI-Driven Metabolic Cohort in Overweight/Obese Chinese Adults
The goal of this observational cohort study is to delineate the five-year dynamic trajectories of metabolic phenotypes in Chinese adults with overweight or obesity, with or without type 2 diabetes, focusing on transition rates…
- Conditions
- Overweight and Obesity, Diabetes Mellitus, Type 2, Prediabetic State, Metabolic Syndrome
- Trial name
- COMET-AI (NCT07584330)
- Where
- China
- Volunteers
- 2,800 people
- Sponsor
- Zhujiang Hospital
PreDiabetes, Type 2 Diabetes Mellitus
Is the Degree of Perceived Effort During Resistance Exercise Important for Improvements in Blood Glucose
The goal of this clinical trial is to compare the degree of effort during a resistance exercise session on blood glucose levels in individuals with prediabetes or type 2 diabetes mellitus.
- Trial name
- NCT06208189
- Testing
- High-effort session, Low-effort session, Control
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of New Mexico
Prediabetic State & High Risk Individuals on the Basis of Diabetes Risk Score
(Pakistan Diabetes Prevention Program PDPP)
The Karachi-based Pakistan Diabetes Prevention Study aims to address key issues in the prevention of type 2 diabetes. Approximately 20,000 people From four communities will be screened for diabetes risk factors using a…
- Trial name
- PDPP (NCT01530165)
- Testing
- Life style intervention
- Where
- Pakistan
- Volunteers
- 1,564 people, healthy volunteers welcome
- Sponsor
- Aga Khan University