Clinical trials: Preexposure Prophylaxis
HIV Pre-exposure Prophylaxis, HIV Prevention and Care
MyPrEP Plus: Development and Pilot Testing of Novel Preexposure Prophylaxis Decision Support Tools for Transgender Women
The primary goal of this randomized controlled trial is to learn if a decision support tool called MyPrEP Plus can help transgender women make decisions about taking pre-exposure prophylaxis (PrEP) for HIV prevention.
- Conditions
- HIV Pre-exposure Prophylaxis, HIV Prevention and Care, Mobile Health Technology (mHealth), Adherence
- Trial name
- NCT07146139
- Testing
- MyPrEP Plus Package, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
Human Immunodeficiency Virus (HIV), HIV Pre-Exposure Prophylaxis
A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)
Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: If taking MK-8527 once a month works to prevent HIV-1 infection as well as or…
- Trial name
- NCT07044297
- Testing
- MK-8527, FTC/TDF
- Where
- 81 sites in United States, Argentina and 14 more
- Volunteers
- 4,390 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
HIV-I, Human Immunodeficiency Virus Type 1
Oral ISL QM as PrEP in Cisgender Women at High Risk for HIV-1 Infection (MK-8591-022)
This study will evaluate whether oral islatravir (ISL) is effective in preventing Human Immunodeficiency Virus Type 1 (HIV-1) infection in women at high-risk for HIV-1 infection.
- Conditions
- HIV-I, Human Immunodeficiency Virus Type 1, Prophylaxis
- Trial name
- Impower-022 (NCT04644029)
- Testing
- Islatravir, FTC/TDF
- Where
- 24 sites in United States, South Africa and 1 more
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
HIV Prevention
The Shauriana Intervention for GBMSM in Kenya
The Shauriana intervention, developed from qualitative work using a community-based participatory approach, aims to integrate PrEP, sexual health, and mental health support for gay, bisexual, and other men who have sex with men…
- Trial name
- NCT04550221
- Testing
- Shauriana
- Where
- Kenya
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV
PrEP Demonstration Project (PRELUDE Study)
Significant increases in HIV diagnoses among gay and other homosexually active men, in Australia and internationally, have been observed since the late 1990s.
- Trial name
- PRELUDE (NCT02206555)
- Testing
- emtricitabine/tenofovir disoproxil fumarate
- Where
- 5 sites in Australia
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Human Immunodeficiency Virus (HIV), HIV Pre-Exposure Prophylaxis
A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)
Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: If taking MK-8527 once a month works to prevent HIV-1 infection better than a…
- Trial name
- NCT07071623
- Testing
- MK-8527, Emtricitabine/tenofovir disoproxil (FTC/TDF)
- Where
- 30 sites in Kenya, South Africa and 1 more
- Volunteers
- 4,580 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
HIV Chemoprophylaxis, HIV Preexposure Prophylaxis
Sustainable Healthcenter Implementation PrEP Pilot Study
A health services implementation pilot study, conducted with an observational cohort of HIV-uninfected persons including men who have sex with men, heterosexual women and men, and injection drug users receiving daily oral…
- Trial name
- SHIPP (NCT02074891)
- Testing
- coformulated TDF/FTC
- Where
- 5 sites in United States
- Volunteers
- 1,420 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
HIV Seropositivity
A Multilevel, Multiphase Optimization Strategy for PrEP (MOST:PrEP)
What is known: There are 1.2 million people in the US who meet the indications for PrEP; yet, disparities exist in uptake. For example, only 9% of Black and 16% of Latino individuals, compared to 65% of White individuals, have…
- Trial name
- MOST:PrEP (NCT06334341)
- Testing
- Computer-based simulation training for providers, Best Practice Alert, HIV Risk Assessment
- Where
- United States
- Volunteers
- 1,380 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
HIV Preexposure Prophylaxis
Oral Islatravir (MK-8591) Once-Monthly as Preexposure Prophylaxis (PrEP) in Men and Transgender Women Who Are at High Risk for HIV-1 Infection (MK-8591-024)
The main purpose of the study is to evaluate the safety and tolerability of oral Islatravir (ISL) once monthly (QM) as Preexposure Prophylaxis (PrEP) in cisgender men who have sex with men (MSM) and transgender women (TGW) who…
- Trial name
- Impower-024 (NCT04652700)
- Testing
- ISL, FTC/TDF, FTC/TAF
- Where
- 25 sites in United States, Brazil and 5 more
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
HIV Prevention, HIV Preexposure Prophylaxis
Social Media as a Risk Tool for HIV Prevention Needs
The impact of effective HIV prevention tools is limited because many people do not know that they are at risk for HIV acquisition, despite the availability of various risk assessment scores and criteria.
- Trial name
- SMaaRT (NCT06566417)
- Where
- Kenya
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
HIV/AIDS
Demonstration Project of PrEP Among Female Sex Workers in Dakar, Senegal
Recent breakthroughs in antiretroviral (ARV)-based prevention provide new opportunities to rethink HIV prevention and treatment strategies, especially for key populations such as Female Sex Workers (FSWs).
- Trial name
- NCT02474303
- Testing
- Truvada
- Where
- 4 sites in Senegal
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Réseau Africain de Recherche sur le SIDA
HIV/AIDS, HIV Infections
Harm Reduction Program For Informal PrEP Users In A Community-based Setting (seguiPrEP)
Pre-Exposure Prophylaxis (PrEP) is a biomedical strategy consisting of the use of antiretroviral therapy by HIV-seronegative people at high risk of acquiring HIV, to prevent the infection.
- Conditions
- HIV/AIDS, HIV Infections, Sexually Transmitted Diseases, Vaccination
- Trial name
- seguiPrEP (NCT03996941)
- Testing
- Harm reduction of informal PrEP use, PrEP follow up based on point of care testing
- Where
- Spain
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- BCN Checkpoint
HIV Prevention, HIV Pre-exposure Prophylaxis
Client-Centered Care Coordination for Black Men Who Have Sex With Men
The goal of this clinical trial is to determine the efficacy of a client-center care coordination intervention (C4) in improving pre-exposure prophylaxis (PrEP) adherence in Black men who have sex with men (MSM).
- Trial name
- NCT06056544
- Testing
- Client Centered Care Coordination
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
HIV
Exploring HIV Entry Blockade as a Pre-exposure Prophylaxis Strategy in Women
Pre-exposure prophylaxis (PrEP) is an HIV prevention strategy in which HIV medicines are used by a person before they are exposed to HIV in order to decrease his or her chance of getting infected.
- Trial name
- MVC-PREP (NCT01749566)
- Testing
- maraviroc
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Emory University
HIV Prevention Program
Welcome to PrEP School Utilizing Peer Educators to Improve Uptake of Preexposure Prophylaxis for HIV at an HBCU
This study involves a peer-educator/navigation model targeting gaps in PrEP awareness, uptake, and access in priority populations.
- Trial name
- PrEPSchool (NCT07053527)
- Testing
- PrEP Awareness and Uptake Educational Program
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
HIV Preexposure Prophylaxis
A Promotion and Implementation Project of HIV Pre-Exposure Prophylaxis Among High Risk Population
This study aims to use a social media mini-application-enabled intervention to successfully promote the initiation and persistence of pre-exposure prophylaxis (PrEP) among at-risk people 18 years and above (including men who have…
- Trial name
- NCT04754139
- Testing
- WeChat mobile mini-application
- Where
- 2 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Rabies, Japanese Encephalitis
Safety and Immunogenicity of 2 Different Vaccination Schedules of Rabies and Japanese Encephalitis Vaccines in Healthy Adult Subjects
Establish non-inferiority of the immune response and evaluate the safety and tolerability of Rabies and Japanese Encephalitis (JE) vaccines given concomitantly or alone and according to either of 2 schedules for preexposure…
- Trial name
- NCT01662440
- Testing
- Rabies, Japanese Encephalitis
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 661 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
HIV, Infertility
Pre-Exposure Prophylaxis and Timed Intercourse for HIV-Discordant Couples
Human immunodeficiency virus (HIV) infection has now become a treatable disease and many infected individuals are interested in having a family.
- Trial name
- PrEP-HIVD (NCT02572505)
- Testing
- Truvada
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
HIV, Substance Use Disorders
The Collaborative Care PrTNER Study
A randomized controlled trial to assess the ability of a Collaborative Care Prevention, Treatment, Navigation, Engagement, Resource (PrTNER) intervention to increase initiation of preexposure prophylaxis (PrEP) (for those at-risk…
- Conditions
- HIV, Substance Use Disorders, Substance Use, AIDS
- Trial name
- PrTNER (NCT06585631)
- Testing
- CC PrTNER
- Where
- 2 sites in United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
HIV-1-infection
Immediate or Deferred Pre-exposure Prophylaxis for HIV Prevention: Safe Options for Pregnant and Lactating Women
An Open Label randomized control study. To explore the safety of Truvada when used as PrEP during pregnancy and lactation. Pregnant women considered at risk for HIV infection and willing to participate in this randomized control…
- Trial name
- PrEP (NCT03227731)
- Testing
- Truvada
- Where
- South Africa
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu