Clinical trials: Preoxygenation
Healthy
Inspiratory Support Improves Preoxygenation in Healthy Subjects
Preoxygenation optimizes oxygen content in the functional residual capacity (FRC). Adequate preoxygenation is defined by an expiratory oxygen fraction (FEO2) > 90%.
- Trial name
- NCT00922753
- Testing
- VS, AI-4/PEEP-4, AI-6/PEEP-4
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maisonneuve-Rosemont Hospital
Healthy Volunteers
A Novel Method of Preoxygenation Using a Bain Circuit
The purpose of this study is to determine whether rebreathing for a short time (a bit like breathing into a paper bag) will stimulate faster breathing and thus make the giving of Oxygen more effective.
- Trial name
- NCT00958178
- Testing
- Oxygen
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Health Service, United Kingdom
MRI, MRI Image Enhancement
Optimizing Liver MRI Using Breath-Holding With and Without Oxygen
The goal of this interventional study (clinical trial) is to learn if different breath-holding techniques, with and without extra oxygen, can improve the quality of abdominal Magnetic Resonance Imaging (MRI) images in healthy…
- Trial name
- NCT07135401
- Testing
- Breath-hold conditions
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Preoxygenation, Apnoea, Anaesthesia
Optiflow Preoxygenation
Optiflow can be used to prolong the apnoea period under anaesthesia without falls in blood oxygen saturation. This study is designed to assess whether the Optiflow system can efficiently replace conventional anaesthetic mask and…
- Trial name
- NCT02981511
- Testing
- optiflow
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Anesthesia, Airway Morbidity
Preoxygenation Using High Flow Oxygen : Efficacy and Tolerance in Healthy Volunteers
High flow nasal cannula oxygen has been proposed to perform preoxygenation in patients with acute respiratory failure requiring orotracheal intubation in intensive care units.
- Conditions
- Anesthesia, Airway Morbidity, Safety Issues
- Trial name
- PreOx-OHD (NCT03399695)
- Testing
- preoxygenation
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Obesity, Morbid
Preoxygenation With Optiflow™ in Morbidly Obese Patients is Superior to Face Mask
Optiflow™ may provide an opportunity to prolong apnea time in the morbidly obese patient population. This study will examine whether Optiflow can do this, and compare the pre-oxygenation with Optiflow to the pre-oxygenation…
- Trial name
- NCT03009877
- Testing
- Optiflow F&P 850™ System, facemask, Rocuronium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Anesthesia
Evaluation of Different Methods for Preoxygenation
The goal of this randomised cross-over study is to compare pre-oxygenation using a standard nasal cannula to pre-oxygenation using humidified high-flow nasal oxygen and a tight-fitting facemask in adult volunteers with a BMI…
- Trial name
- NCT05839665
- Testing
- Humidified high-flow nasal oxygen, Standard nasal cannula, Facemask
- Where
- 2 sites in Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Malin Jonsson Fagerlund
Hypoxia, Hyperoxia
Different Preoxygenation Methods In Cesarean Section
The study aimed to evaluate different preoxygenation methods (tidal volume for 3 minutes and 4 deep breaths) in pregnant women with oxygen reserve index (ORI).
- Trial name
- NCT05395975
- Testing
- Oxygen Reserve Index
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Preoxygenation
UMOX - New Device for Oropharyngeal Preoxygenation
The UMOX is a device that has been designed as an alternative to the conventional face mask for preoxygenation to be used when an optimal preoxygenation with a facemask is difficult to achieve(i.e: when a leak is present.
- Trial name
- NCT01018316
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maisonneuve-Rosemont Hospital
Intubation Complication, Preoxygenation
PreOxygenation for EndoTracheal Intubations
Hypoxemia is a life threatening complication during emergency airway management. Despite advances in technology and training, hypoxemia still occurs in up to a quarter of all intubations placing patients at high risk for damage…
- Conditions
- Intubation Complication, Preoxygenation, Hypoxemia
- Trial name
- POET (NCT03240614)
- Testing
- Non-rebreather oxygen mask, Bag-valve-mask, High Flow Nasal Cannulae
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Preoxygenation
Verbal Breathing Coaching to Improve Preoxygenation and Extend Safe Apnea Time in Anesthesia
This study explores whether simply guiding patients to breathe slowly and calmly before anesthesia can help improve oxygen levels and keep them safe for longer during induction.
- Trial name
- NCT07565259
- Testing
- Verbal Breathing Coaching
- Where
- Saudi Arabia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Prince Sultan Military Medical City
Healthy
Comparison of Preoxygenation Techniques in Healthy Volunteers With Monitoring of End-tidal Oxygen Fraction (FeO₂) and Oxygen Reserve Index (ORI)
The objective of this physiological study is to compare two preoxygenation techniques (non-invasive ventilation combined with high-flow nasal oxygen versus non-invasive ventilation alone) by monitoring end-tidal oxygen fraction…
- Trial name
- OXYGAME1 (NCT07334041)
- Testing
- Preoxygenation with VNI + OHD, Preoxygenation with VNI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Cesarean Section Complications, Pregnancy Related
Assessment of Transnasal Humidified Rapid-insufflation Ventilatory Exchange (THRIVE) for Maternal Pre-oxygenation
The main objective of this study is to determine if the use of transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) can reduce by 90 seconds the time between the entry into the operating room of the volunteer…
- Conditions
- Cesarean Section Complications, Pregnancy Related, Anesthesia
- Trial name
- PREOXCE (NCT04814628)
- Testing
- scenario 1 : pre-oxygenation with a face mask held by the anaesthetist, scenario 2: one anaesthetist in charge, face mask held by the patient for pre-oxygenation, scenario 3: one anaesthetist in charge, THRIVE used for pre-oxygenation
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Respiratory Failure
Four Methods of Pre-oxygenation
Four methods of preoxygenation will be compared in healthy volunteers
- Trial name
- NCT02708862
- Testing
- Preoxygenation
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hennepin Healthcare Research Institute
Obesity, Anaesthesia
CPAP/PSV Preoxygenation in Obese Patients
The purpose of this study is to determine whether continuouse positive airway pressure (CPAP), during induction of anaesthesia in morbidly obese patients, result in higher levels of oxygen in the blood.
- Trial name
- NCT01780571
- Testing
- CPAP 5 cm H2O + PSV 5 cm H2O
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Pulmonary Atelectasis
Effects of Different Oxygen Concentrations on Lung Ultrasound Score During Spontaneous Ventilation
The goal of this study is to observe the effects of different oxygen concentrations during preoxygenation in spontaneous breathing patients with modified lung ultrasound scores before induction of general anesthesia.
- Trial name
- NCT05850988
- Testing
- %80 Oxygen concentration, %100 Oxygen concentration
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Obese
The Effect of Mask Combined With High Flow Oxygen on Preoxygenation During Induction of General Anesthesia in Obese Patients
There is a risk of airway-related incidents during anaesthesia associated with obesity. High-flow nasal oxygen is advocated for perioperative preoxygenation in obese patients to reduce airway adverse reactions.
- Trial name
- NCT06562660
- Testing
- apnoeic
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Preoxygenation, Non Invasive Ventilation
Preoxygenation Method With a Calibrated Leak
During preoxygenation, imperfect seal between the face mask and patient's face can induce an inward air leak decreasing its effectiveness. We assume that noninvasive ventilation could cancel the effect of the leak.
- Trial name
- NCT03087825
- Testing
- preoxygenation without inward leak, preoxygenation with inward leak
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Preoxygenation
Pre-Oxygenation Techniques in Pregnancy
A trial comparing outcomes of two pre-oxygenation techniques in obstetric patients.
- Trial name
- POP (NCT03310723)
- Testing
- Face Mask preoxygenation, OptiFlow preoxygenation
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Preoxygenation
Preoxygenation Using THRIVE Versus Facemask in Parturients
This study aims to determine the duration for pre-oxygenation using THRIVE and facemask for parturients.
- Trial name
- NCT03772574
- Testing
- Facemask preoxygenation, THRIVE preoxygenation
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of British Columbia