Clinical trials: Preterm Infants
Retinopathy of Prematurity
Changes in Vital Signs and Pupil Diameter Related to Pharmacologic Mydriasis in Premature Infants: A Randomized Double Blind Clinical Study
Retinopathy of prematurity (ROP) is one of the common anatomic causes of blindness among Filipinos, accounting for 47.7% of the cases.
- Trial name
- NCT04838665
- Testing
- 0.5% cyclopentolate and 2.5% phenylephrine, 0.5% tropicamide + 0.5% phenylephrine, 0.5% tropicamide + 0.5% phenylephrine with a cotton wick
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of the Philippines
Measles, Mumps
Responses of Premature Infants to Measles-Mumps-Rubella (MMR) and Varicella Vaccines
The purpose of this study is to see if the MMR and chickenpox vaccines work as well in premature infants as in children that were carried to full term.
- Conditions
- Measles, Mumps, Rubella, Varicella
- Trial name
- NCT00138255
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Behavioral Assessment of Children, Early Intervention
PaREnting ProgrAm to Enhance PREterm Infants' Health and Development (PREPARE Trial)
Preterm infants are at high risk of developmental delay or disabilities and they do benefit from early intervention programs. Many programs aiming at improving preterm infants' developmental outcome have been proposed with mixed…
- Trial name
- PREPARE (NCT04783220)
- Testing
- Comprehensive structured parent intervention
- Where
- Lebanon
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Music, Premature Infant
The Effect of Classical and Harp Music Practice on Premature Infants
Aim of the study is to determine the effects of classical and harp music practice on physiological parameters (heart rate, respiratory rate and oxygen saturation value), cerebral oxygenation value (rSO2) and comfort of premature…
- Conditions
- Music, Premature Infant, Cerebral Oxygenation, Comfort
- Trial name
- NCT05647005
- Testing
- Classical music, Harp music
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Premature Birth of Newborn, Enterocolitis, Necrotizing
A Randomized Controlled Trial Investigating if Antibiotic Use in the First 48 Hours of Life Adversely Impacts the Preterm Infant Microbiome
The purpose of this study is to determine whether antibiotics given immediately after birth alter the development of the developing preterm infant's microbiome, which may further alter overall clinical outcomes.
- Trial name
- NCT02477423
- Testing
- Ampicillin, Gentamicins
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Dengue, Pregnancy Preterm
Materno-fetal Consequences of Symptomatic Dengue in Pregnant Wowen in French Guiana
Symptomatic dengue virus infection in pregnant women could affect the mother, fetus and the newborn at birth. The risks of postpartum hemorrhage, prematurity and low birth weight are increased in dengue fever.
- Conditions
- Dengue, Pregnancy Preterm, Women, Fever
- Trial name
- CMFdeng (NCT04989673)
- Testing
- Biological sampling and collection (serum), Biological sampling and collection (placenta), Questionnaire
- Where
- French Guiana
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cayenne
Bronchopulmonary Dysplasia
Early Predictors of Bronchopulmonary Dysplasia in Extremely Preterm Infants
Bronchopulmonary dysplasia (BPD) remains one of the most common complications in extremely preterm infants despite advances in neonatal intensive care.
- Trial name
- EPIRESP (NCT07771387)
- Where
- Austria
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Low Birth Weight Babies, Preterm Babies
Use of a Foot Length Card to Improve Careseeking Practices of Vulnerable Newborns in Sarlahi District, Nepal
This study will evaluate whether or not provision of a simple card ("footlength card") that allows identification of low birth weight and/or preterm babies through measurement of the length of a baby's foot, can improve basic…
- Trial name
- NCT02802332
- Testing
- Footlength Card
- Where
- Nepal
- Volunteers
- 4,574 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Bronchopulmonary Dysplasia, Child Development
Enteral High-dose DHA Supplementation on Bronchopulmonary Dysplasia in Very Preterm Infants: a Collaborative Study
This one-stage individual participant data (IPD) meta-analysis study will aim to determine whether high-dose docosahexaenoic acid (DHA) enteral supplementation during the neonatal period is associated with the risk for severe…
- Conditions
- Bronchopulmonary Dysplasia, Child Development, Neonatal and Perinatal Conditions
- Trial name
- NCT05915806
- Testing
- High-dose DHA, Control
- Where
- Canada
- Volunteers
- 1,801 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Postpartum Depression, Lifestyle, Healthy
Nutrition and Physical Activity Intervention on Psychosocial Well-Being of Postpartum Mothers
This study aims to examine the effectiveness of nutrition and physical intervention to improve psychosocial well-being of postpartum mothers with preterm infants.
- Trial name
- NCT05444179
- Testing
- Mommies can Eat & Exercise with No Stress (MomEENS)
- Where
- Malaysia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universiti Teknologi Mara
Premature Infants
The Impact of Nasogastric Indwelling Versus Oral Intermittent Tube Feeding Methods on Premature Infants
This clinical pilot trial is being conducted to learn more about the infant's feeding behavior while being fed by indwelling nasogastric tube placement or by intermittent oral tube placement.
- Trial name
- NCT00798824
- Testing
- Indwelling nasogastric tube placement, Intermittent orogastric tube placement, Nasogastric tube
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Other Preterm Infants
Cognitive Processing in Preterm Infants and NICU Music Therapy
Several positive physiological and behavioural outcomes have been observed in preterm infants exposed to music therapy during their stay at Neonatal Intensive Care Units (NICU).
- Trial name
- NICU-MT (NCT04314440)
- Testing
- Music therapy
- Where
- Canada
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Positive Pressure Ventilation, Preterm Infants
Applied Forces During Neonatal Face Mask Ventilation With Different Face-mask Air Cushion Volumes
Positive pressure ventilation (PPV) is the most important intervention in neonatal resuscitation. During PPV, it is important to hold the face-mask with care, as applying excessive pressure could cause injury to the infant, while…
- Conditions
- Positive Pressure Ventilation, Preterm Infants, Apnea
- Trial name
- ForVol (NCT06161389)
- Testing
- Partially inflated mask, Fully inflated mask
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital Padova
Metabolic Acidosis, Neonatal Disease
Prevention of Metabolic Acidosis in Preterm Neonates by Replacing Sodium Chloride With Sodium Acetate in Parenteral Nutrition
The goal of this clinical trial is to learn if the addition of sodium acetate in neonatal PN works to prevent and treat metabolic acidosis and associated comorbidities in preterm neonates.
- Conditions
- Metabolic Acidosis, Neonatal Disease, Neonatal Complication
- Trial name
- PROTECT (NCT06545565)
- Testing
- sodium acetate group will receive sodium acetate in the neonatal PN., sodium chloride group will receive sodium chloride in the neonatal PN.
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aga Khan University Hospital, Pakistan
Thyroid Dysfunction
Thyroid Function in Sick and Healthy Preterm Infants Admitted in NICU of Assiut University Children Hospital
Thyroid hormones are the cornerstones of a complex system that plays an important role in the growth and development of children, especially in the development of the nervous system and brain.
- Trial name
- NCT05632965
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Retinopathy of Prematurity, ROP
Automated Screening Device to Detect MTMROP
The purpose of the study is to evaluate the i-ROP DL system for autonomous ROP screening. To demonstrate the sensitivity and specificity of the i-ROP DL system on images obtained by healthcare providers in the neonatal intensive…
- Trial name
- NCT06517836
- Testing
- iROP DL
- Where
- United States
- Volunteers
- 1,284 people, healthy volunteers welcome
- Sponsor
- Siloam Vision
Preterm, Ventilator Lung; Newborn
Evaluation of Nasal Non Invasive Ventilation in Management of Neonates With Respiratory Distress Using Lung Ultrasound
This study aims to evaluate the effect of non-invasive ventilation (nIPPV) , (nCPAP), and nasal high flow cannula (NHFC) as a primary mode of ventilation in preterm neonates <37 gestational week with moderate to severe RD using…
- Trial name
- NCT06550219
- Testing
- Nasal humidified heated high flow cannula (NHHHC), Nasal intermittent positive pressure ventilation (NIPPV), Nasal continuous positive airway pressure NCPAP
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Pain
Breast Feeding Analgesia in Preterm Infants
The purpose of this study is to compare the effects of mothers' breastfeeding with the effects of pacifier sucking on preterm infant biobehavioural responses during and immediately after a painful procedure Hypothesis: 1.
- Trial name
- NCT00175409
- Testing
- Blood collection
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Bronchopulmonary Dysplasia (BPD), Chronic Lung Disease of Newborn
Long-Term Burden of BPD and Health-Related Quality of Life (BronQ Family)
The objective of this study is to examine the long-term impact of having a child with Bronchopulmonary Dysplasia (BPD) on the parents and caregivers from the time of diagnosis through adulthood.
- Conditions
- Bronchopulmonary Dysplasia (BPD), Chronic Lung Disease of Newborn, HRQOL (Health Related Quality Of Life)
- Trial name
- BronQ Family (NCT07134387)
- Testing
- N/A, no intervention, participation in survey
- Where
- Germany
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Global Foundation for the Care of Newborn Infants
Bronchopulmonary Dysplasia
MRI in BPD Subjects
The investigators are wanting to learn more about early development of the lungs and to help them better understand prematurity and the development of a breathing disorder call BPD (Bronchopulmonary Dysplasia)
- Trial name
- NCT03657693
- Testing
- NICU MRI, Polysomnography
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati