Clinical trials: Preventive Intervention
Malaria
Evaluation of the Public Health Impact of Seasonal Intermittent Preventive Treatment (IPT) in Children in Senegal
In areas of seasonal malaria transmission the burden of severe disease and mortality due to malaria is mainly among children under 5 years of age.
- Trial name
- NCT00712374
- Testing
- sulfadoxine-pyrimethamine plus amodiaquine
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Upper Respiratory Tract Infection
Montelukast as Prophylaxis for Upper Respiratory Tract Infections in Children: a Randomised, Double-blind, Placebo-controlled Study
Viral upper respiratory tract infection (URI) is one of the most common diseases among toddlers and pre-school children.Complete and effective prevention measures for URI are currently unavailable.
- Trial name
- NCT00551382
- Testing
- Muntelukast
- Where
- 3 sites in Israel
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Street-crossing Ability, Pedestrian Safety
Using Virtual Reality to Train Children in Pedestrian Safety
Pedestrian injuries are among the leading causes of morbidity and mortality in American children ages 7-8, but existing behavior-oriented interventions achieve only modest success.
- Trial name
- NCT00850759
- Testing
- virtual pedestrian environment, computer and video, streetside training
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Leprosy
Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy (Phase 2)
This study will evaluate a combination of bedaquiline and rifampicin as post exposure prophylaxis (PEP) for leprosy in Comoros. It will be a follow-up to the PEOPLE trial on PEP with rifampicin, which is ending in 2022.
- Trial name
- BE-PEOPLE P2 (NCT05406479)
- Testing
- BE-PEP (Bedaquiline), SDR-PEP, BE-PEP (Rifampicine)
- Where
- Comoros
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
HIV
Comparing the PrePex™ Device to Surgical Circumcision for Rapid Scale Up of Male Circumcision in Resource Limited Setting
The World Health Organization and UNAIDS cite that male circumcision can reduce the lifetime risk of HIV infection by 60% in high risk areas such as Sub Saharan Africa.
- Trial name
- NCT01284088
- Testing
- PrePex™ device for adult male circumcision, Surgical circumcision
- Where
- Rwanda
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Mastitis
Study of a Probiotic Strain to Prevent Mastitis and to Eradicate GBS Colonization
In previous studies, the investigators have seen that carefully-selected Lactobacillus strains are a good alternative to antibiotics for the treatment of lactational mastitis.
- Trial name
- PROBIOPREG (NCT01505361)
- Testing
- Lactobacillus salivarius PS2, Excipient (milk powder)
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Interventional
Mama Empoderada: Adapting a Novel Mental Health Prevention Intervention for Migrant Mothers With Young Children
This pilot randomized controlled trial will test a theory-based, trauma-informed, and culturally-tailored intervention [Mama Empoderada' (Mom Power)] to promote mental health and positive parenting among migrant mothers with…
- Trial name
- NCT06468046
- Testing
- Mama Empoderada [Mom Power]
- Where
- Mexico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- San Diego State University
HIV, Sexually Transmitted Diseases
Mobile-Based Application "MyChoices"
This study is testing the acceptability and feasibility of MyChoices, a mobile application (app), to promote HIV testing and pre-exposure prophylaxis (PrEP) uptake among young men who have sex with men (YMSM).
- Conditions
- HIV, Sexually Transmitted Diseases, Pre-exposure Prophylaxis, Risk Reduction
- Trial name
- NCT03179319
- Testing
- MyChoices
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fenway Community Health
Dermatitis, Knowledge, Attitudes, Practice
Impact of Combining Incontinence-associated Dermatitis Prevention and Management Course and Directive Wheel Chart
Background: Knowledge, attitudes, and behaviors regarding the prevention and care of incontinence-associated dermatitis (IAD) need to be enhanced through educational training.
- Trial name
- NCT06835192
- Testing
- Experimental group, Control Group
- Where
- Taiwan
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Prevention, Health Behavior
Evaluation of the International Diffusion of the European Code Against Cancer Through Mobile Telephony
We conducted an implementation research pilot study to assess the adoption, fidelity, appropriateness and acceptability on an intervention to effectively disseminate cancer prevention messages to the public throught a mHealth…
- Trial name
- CECC-OMS (NCT05992792)
- Testing
- App message, SMS message, Internet
- Where
- Spain
- Volunteers
- 1,990 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Reina Sofia de Cordoba
HIV Prevention
Evaluation of a Differentiated Point-of-care Active Case Finding & Management Model to Eliminate Mother-to-Child Transmission of HIV in Malawi
Purpose: To conduct a hybrid effectiveness-implementation stepped-wedge trial to: 1. Estimate the effect of the PAC-Man model, compared to SOC, on the proportion of infants who receive timely EID testing. 2.
- Trial name
- PAC-Man (NCT06493357)
- Testing
- PAC-Man, Standard of Care
- Where
- 3 sites in Malawi
- Volunteers
- 2,426 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Prophylaxis of Acute Mountain Sickness
Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing
This is a phase 4, randomized, double-blinded interventional trial comparing alternative doses of Acetazolamide for the prevention of High Altitude Illness.
- Trial name
- NCT01993667
- Testing
- Low Dose Acetazolamide, Normal Dose Acetazolamide
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Utah
Hantavirus Pulmonary Infection, Immunisation
Andes Virus DNA Vaccine for the Prevention of Hantavirus Pulmonary Syndrome Using the PharmaJet Stratis(R) Needle-Free Injection Delivery Device
This is a Phase 1, randomized, placebo controlled, double-blind, dose escalation trial of 48 males and non-pregnant females, 18-49 years old, inclusive, who are in good health and meet all eligibility criteria.
- Trial name
- NCT03682107
- Testing
- Andes virus DNA vaccine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis, HIV/AIDS
TB Reduction Through ART and TB Screening Project
Tuberculosis (TB) has overtaken HIV as the leading infectious cause of death worldwide and requires a major policy shift for it to be controlled in line with the WHO Stop-TB goal to "end TB".
- Trial name
- TREATS (NCT03739736)
- Testing
- Combination of TB/HIV prevention activities (arm A), Combination of TB/HIV prevention activities (arm B), Standard of care (arm C)
- Where
- 2 sites in South Africa, Zambia
- Volunteers
- 4,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Infections
Motiv82Change: an HIV Prevention Study for Young Latino Men
The purpose of this study is to develop and pilot test a culturally and developmentally tailored Motivational Enhancement Intervention (MEI) to reduce risky sex (unprotected anal sex and multiple partners) among young Hispanic…
- Trial name
- Motiv82Change (NCT00877695)
- Testing
- Entre Culturas: Navigating Culture, Identity, and HIV Risk
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Diabetes Prevention
The Reach and Effectiveness of Technology-enhanced Diabetes Prevention Programs
The aim of this project is to evaluate the reach, effectiveness, and costs of two patient-centered, theory-based, technology-enhanced diabetes prevention programs to initiate and sustain weight loss among pre-diabetic adults…
- Trial name
- DiaBEAT-it (NCT02162901)
- Testing
- Choice-Class with IVR Calls, Random-Class with IVR calls, Random-Class only
- Where
- United States
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Influenza
Safety, Tolerability, and Immunogenicity Study of a Cell-based Virosomal Influenza Vaccine in Healthy Adults
The purpose of this study is to examine the safety and tolerability after administration of trivalent and quadrivalent cell-based virosomal influenza vaccine in healthy adults.
- Trial name
- NCT02148328
- Testing
- Trivalent virosomal influenza vaccine, Commercial vaccine 1, Quadrivalent virosomal influenza vaccine
- Where
- 4 sites in Belgium
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
Skin Tumors, Melanoma
Skin Cancer Screening Education Study
The overall aim of this population-based screening study is to assess whether the skin cancer screening training of family physicians and dermatologists leads to improved screening outcomes.
- Conditions
- Skin Tumors, Melanoma, Basal Cell Carcinoma, Squamous Cell Carcinoma
- Trial name
- SCSES (NCT02352428)
- Testing
- Skin Cancer Screening Training
- Where
- Canada
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Association of Dermatological Prevention, Germany
Prevention of Childhood Obesity, Community Health Education
EFFECT OF A ONLINE NUTRITION EDUCATION PROGRAM IN PRESCHOOLER'S FAMILIES ON THEIR ADHERENCE TO THE MEDITERRANEAN DIET
Questions: What's the effect of an online nutritional educational program in preschoolers families on the adherence to the mediterranean diet? What's the effect of this program on the BMI at 3 years follow-up? Study Description A…
- Trial name
- ELIKUME (NCT06828367)
- Testing
- Online family educational intervention and cooking workshop
- Where
- Spain
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Atopic Dermatitis, Atopic Disorders
A Community-based Assessment of Skin Care, Allergies, and Eczema
Atopic dermatitis (AD) affects over 9 million children in the U.S. and often heralds the development of asthma, food allergy, skin infections and neurodevelopmental disorders.
- Conditions
- Atopic Dermatitis, Atopic Disorders, Eczema, Atopic Eczema
- Trial name
- CASCADE (NCT03409367)
- Testing
- Participant choice of over-the-counter emollients: Vaseline, Vanicream, CeraVe Healing Ointment, CeraVe cream, Cetaphil cream
- Where
- 4 sites in United States
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
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