Clinical trials: Preventive Medicine
Malaria
Kilimanjaro IPTi Drug Options Trial
Malaria and anaemia are major causes of morbidity and mortality in children in sub-Saharan Africa. Administration of three courses of sulfadoxine/pyrimethamine (SP) as intermittent preventive treatment (IPTi) to infants when they…
- Trial name
- NCT00158574
- Testing
- sulphadoxine-pyrimethamine, mefloquine, Chlorproguanil-dapsone
- Where
- Tanzania
- Volunteers
- 2,419 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Cervical Cancer, Human Papillomavirus Infection
Effect of Health Belief Model-Based Education on Cervical Cancer Knowledge and HPV Vaccine Attitudes in Women
This study evaluated the effect of a Health Belief Model-based educational intervention on women's knowledge of cervical cancer and their attitudes and beliefs toward HPV vaccination.
- Conditions
- Cervical Cancer, Human Papillomavirus Infection, Preventive Health Services
- Trial name
- HBM-HPV (NCT07521163)
- Testing
- Health Belief Model-Based Education
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Muhammet Faruk Yigit
Preleukemia, Myelodysplastic Neoplasm
Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS
This is a single-arm pilot study of the feasibility and safety of metformin in patients with clonal cytopenia of undetermined significance (CCUS) or lower-risk myelodysplastic neoplasms (LR-MDS).
- Conditions
- Preleukemia, Myelodysplastic Neoplasm, Cytopenia, Preleukemic Anemia
- Trial name
- NCT04741945
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kirsten Grønbæk
Stress (Psychology), Well-Being, Psychological
Forest Therapy and Mindfulness for Highly Sensitive Persons
This randomized, multicenter interventional study evaluates a combined forest therapy (shinrin-yoku) and mindfulness-based program in adults with high sensory-processing sensitivity confirmed using a validated instrument.
- Conditions
- Stress (Psychology), Well-Being, Psychological, Mind-Body Therapies, Complementary Therapies
- Trial name
- HSP-FOREST (NCT07368231)
- Testing
- Forest Therapy + Mindfulness + Psychotherapy, Behavioral: Indoor Sensory Control (Art and Aromatherapy)
- Where
- 2 sites in Spain
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- IFM International Forest Medicine
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Clinical Effect of Preventive Use of Tylenol on Fever After Removal of Drainage Tube in Lumbar Fusion Surgery
This study evaluates the influence of Non-steroidal Anti-inflammatory Drugs on preventing fever after the removal of drainage tube in the patients who suffered lumbar fusion surgery, if the outcome turn out positive, the…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Radiculopathy
- Trial name
- NCT04042948
- Testing
- Tylenol
- Where
- China
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Preventive Medicine, HIV Infections
Retention in PrEP Care for African American MSM in Mississippi
Innovative and novel HIV prevention interventions are urgently needed for African American (AA) young men who have sex with men (YMSM) in the South, and in Mississippi in particular.
- Trial name
- NCT03256435
- Testing
- RAMP PrEP initiation, adherence, and retention intervention
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Brown University
Immunization Programs
Email-based Reminders Promoting Recommended Pediatric Preventative Visits
The purpose of this study is to assess, prospectively, the effect of email reminders for well-child check (WCC) visits on adherence to these visits among those who have not yet scheduled the visit.
- Trial name
- NCT05317884
- Testing
- Reminder
- Where
- United States
- Volunteers
- 1,186 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Malaria
Comparison of Two Strategies for the Delivery of IPTc
Antimalarial chemoprophylaxis can reduce morbidity and mortality from malaria in children. However, this approach to malaria control has not been implemented widely because of concerns over its possible effect on the development…
- Trial name
- NCT00376155
- Testing
- sulfadoxine /pyrimethamine plus amodiaquine
- Where
- The Gambia
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Genetic Predisposition to Disease, Hereditary Diseases
Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
This research study is exploring the use of genomic sequencing in the newborn period to screen healthy babies for current and future health risks.
- Trial name
- NCT05161169
- Testing
- Genome Sequencing
- Where
- 3 sites in United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Depression, Healthy
Bone Loss in Premenopausal Women With Depression
The purpose of this study is to determine whether women with major depression lose bone mass at a faster rate than women without depression.
- Conditions
- Depression, Healthy, Osteopenia, Osteoporosis
- Trial name
- NCT00006180
- Testing
- Alendronate
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cardiovascular Diseases (CVD), Type 2 Diabetes
Epigenetics and NCD Prevention in Kazakhstan: Personalized Approaches and Biological Age Prediction
This study aims to enhance personalized and preventive care for non-communicable diseases (NCDs) in Kazakhstan by examining epigenetic factors, predicting biological age and reproductive function using machine learning, and…
- Conditions
- Cardiovascular Diseases (CVD), Type 2 Diabetes, Chronic Respiratory Diseases, Obesity (Disorder)
- Trial name
- NCT06953180
- Testing
- Genetic: DNA analysis
- Where
- Kazakhstan
- Volunteers
- 6,720 people, healthy volunteers welcome
- Sponsor
- Asfendiyarov Kazakh National Medical University
Breast Cancer Screening, Oncology
Project Insight: Feasibility of a Breast Cancer Screening Decision Support Tool
The purpose of this investigation is to conduct a feasibility study to evaluate the potential for implementing the developed decision support tool with Latina, Black, and non-Latina White women.
- Conditions
- Breast Cancer Screening, Oncology, Preventative Medicine, Mammography
- Trial name
- NCT04741503
- Testing
- Breast Cancer Screening Decision Support Tool, National Cancer Institute Breast Cancer Screening PDQ
- Where
- United States
- Volunteers
- 1,277 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Multiple Sclerosis
Description of Adherence to the Main Preventive Health Campaigns of Persons With Multiple Sclerosis
Persons with multiple sclerosis (PwMS) might be more susceptible to infections and cancers and chronic diseases than general population, not because of the presence of the disease itself, but in relation to some specific…
- Trial name
- preventionMS (NCT04930380)
- Testing
- phone interview
- Where
- 12 sites in Italy
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- University of Siena
Malaria
Three Alternative Drug Regimens for Malaria Seasonal Preventive Treatment in Senegal
The purpose of this trial is to compare the acceptability, efficacy and safety of three alternative drug regimens for use for seasonal Intermittent Preventive Treatment to prevent malaria in children.
- Trial name
- NCT00529620
- Testing
- sulfalene-pyrimethamine plus amodiaquine, dihydroartemisinin plus piperaquine, sulfadoxine pyrimethamine plus piperaquine
- Where
- Senegal
- Volunteers
- 1,833 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Poverty, Income
addressInG iNcome securITy in Primary carE
Social processes that impact the health of individuals have been labeled the social determinants of health (SDOH). These are "the conditions in which people are born, grow, live, work and age.
- Conditions
- Poverty, Income, Social Determinants of Health
- Trial name
- IGNITE (NCT02459184)
- Testing
- Income Security Health Promotion
- Where
- Canada
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
HIV Infections, HIV Seronegativity
A Phase I Clinical Trial to Evaluate: Part A. The Safety of MTP-PE/MF59 Adjuvant Emulsion. Part B. The Safety and Immunogenicity of Env 2-3, a Yeast Derived Recombinant Envelope Protein of Human Immunodeficiency Virus-1, in Combination With MTP-PE/MF59
To evaluate the safety of a fixed antigen dose with an increasing dose of adjuvant (MTP-PE/MF59, a substance to enhance the immune response to vaccine) in volunteers. To evaluate local and systemic reactions (Part A).
- Trial name
- NCT00000972
- Testing
- MTP-PE/MF59, Env 2-3
- Where
- 3 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Phase I Safety and Immunogenicity Trial of HIV-1 gp120 C4-V3 Hybrid Polyvalent Peptide Immunogen Mixed in Mineral Oil Containing Mannose Mono-Oleate (IFA)
To evaluate the safety of HIV-1 gp120 C4-V3 hybrid polyvalent peptide immunogen (C4-V3 peptides) formulated in mineral oil containing mannose mono-oleate (IFA) in HIV-1 uninfected volunteers.
- Trial name
- NCT00000886
- Testing
- HIV-1 C4-V3 Polyvalent Peptide Vaccine
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
"Forest Therapy and Mindfulness for Stress Reduction and Well-being in Highly Sensitive Persons (Pilot RCT)"
This study aims to evaluate the effects of Shinrin-Yoku (Forest Bathing) and Forest Medicine interventions on psychological well-being, stress reduction, and overall health outcomes in adults.
- Trial name
- HSP-FOREST (NCT07183917)
- Testing
- Forest Therapy and Mindfulness, Indoor Wellness Control
- Where
- Spain
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- IFM International Forest Medicine
HIV Infections, HIV Seronegativity
A Study to Test the Safety of Three Experimental HIV Vaccines
The purpose of this study is to test three experimental HIV vaccines. This study will look at whether it is safe to give these vaccines together and how the immune system responds to the vaccines.
- Trial name
- NCT00000946
- Testing
- HIV p24/MF59 Vaccine, ALVAC-HIV MN120TMG (vCP205), ALVAC-RG Rabies Glycoprotein (vCP65)
- Where
- 7 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Breast Neoplasms, Breast Self-Examination
Health Belief Model-Based Survey on Breast Self-Examination Awareness and Practice Among Community-Dwelling Middle-Aged and Older Women
This observational study aims to evaluate the current status of breast self-examination (BSE) practices and related influencing factors among middle-aged and older women in urban communities, using the Health Belief Model (HBM)…
- Conditions
- Breast Neoplasms, Breast Self-Examination, Cancer Screening, Health Belief Model
- Trial name
- HBM-BSE (NCT07149636)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital