Clinical trials: Primary
Healthy
Safety, Tolerability and Pharmacokinetics of Multiple Rising Doses of Butylated Hydroxytoluene and BI 54903 XX Via Respimat® Soft MistTM Inhaler B in Healthy Male Volunteers
The objective of the study was to investigate safety, tolerability and pharmacokinetics of butylated hydroxytoluene (BHT) (sub-study 1) administered via Respimat® Soft MistTM Inhaler B (SMI B); to assess safety, tolerability and…
- Trial name
- NCT02221375
- Testing
- BHT low, BHT medium, BHT high
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Primary Sjögren's Syndrome
Primary Sjögren Syndrome
Primary Sjögren syndrome (pSS) is an inflammatory, autoimmune, multiorgan disease often involving the central and peripheral nervous systems.
- Trial name
- NeuroSenSS (NCT01989819)
- Testing
- skin biopsy
- Where
- 7 sites in France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Structural Heart Disease
AI-Assisted Smart Stethoscope Screening for Structural Heart Disease in School Students in Ruyang County
The goal of this observational diagnostic study is to evaluate whether an artificial intelligence (AI)-enabled smart stethoscope can accurately detect structural heart disease in school-aged children and adolescents (10-18 years)…
- Trial name
- RY-CHD Screen (NCT07194785)
- Testing
- AI-Assisted Cardiac Auscultation using the HearTech Smart Stethoscope
- Where
- China
- Volunteers
- 6,614 people, healthy volunteers welcome
- Sponsor
- Heart Health Research Center
Primary Prevention
Prevention Program Promoting Self Resilience, Positive Self-Image and Body Image Among Adolescents
The study is a group randomized controlled trial. High school classes were allocated by randomization to the intervention or control group by a Randomization function in Excel computer program.
- Trial name
- NCT03216018
- Testing
- Prevention program: "In Favor of Resilient Self"
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tel Hai College
Obesity
Treatment of Childhood Obesity in Primary Care
This project will apply the concepts from the Chronic Care Model to the problem of pediatric obesity and proposes: 1) to assess the effectiveness of teaching primary care providers (in diverse practice settings) to use specific…
- Trial name
- NCT00398359
- Testing
- Motivational Interviewing (physicians), Behavior Modification (families)
- Where
- 6 sites in United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Knee Osteoarthritis, Blood Loss
Extended Postoperative Oral Tranexamic Acid in Knee Replacement
A comparison of outcomes between use of oral tranexamic acid as compared to oral placebo in the first days after total knee replacement will be made to determine impact on clinical indications and patient reported outcomes.
- Conditions
- Knee Osteoarthritis, Blood Loss, Pain, Postoperative
- Trial name
- NCT05099276
- Testing
- Tranexamic Acid Pill
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Campbell Clinic
Primary Progressive Aphasia, Nonfluent Progressive Aphasia
Language Treatment for Progressive Aphasia
Progressive aphasia is characterized by a steady and progressive loss of language skills in the presence of relatively preserved memory, attention, and thinking.
- Conditions
- Primary Progressive Aphasia, Nonfluent Progressive Aphasia, Semantic Dementia
- Trial name
- NCT00957710
- Testing
- Errorless learning
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Baycrest
Fibromyalgia, Fibromyalgia, Primary
Understanding Health Services Delivery for Fibromyalgia
This research study aims to: i) Explore and understand how health and social care for people with fibromyalgia living in the UK is organised and delivered.
- Conditions
- Fibromyalgia, Fibromyalgia, Primary, Fibromyalgia, Secondary
- Trial name
- NCT04771260
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Stroke, Neurologic Disorder
Manual Dexterity Modifications After Application of tSMS Over the Primary Motor Cortex (M1)
Transcranial static magnetic field stimulation (tSMS) is a novel brain stimulation technique that has been shown to be safe and effective in modifying biological parameters when applied to the cerebral cortex.
- Conditions
- Stroke, Neurologic Disorder, Manual Dexterity
- Trial name
- NCT05260190
- Testing
- tSMS
- Where
- Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Primary Ciliary Dyskinesia, Cystic Fibrosis
Respiratory Function, Exercise Capacity and Peripheral Muscle Strength Among Patients With CF, PCD and Healthy Children
The aim of this study is to compare pulmonary function, respiratory muscle strength, exercise capacity and peripheral muscle strength of patients with CF, PCD and healthy childrens.
- Trial name
- NCT04161313
- Testing
- Measurement of functional capacity, pulmonary function test, Functional capacity
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Work-Related Musculoskeletal Disorders, Work-Related Stress Disorders
Physiological and Psychological Strain in Elementary School Teacher
Survey will enquire the physical and psychological conditions in primary school teachers in Upper Austria. All primary teachers of the 553 Upper Austrian elementary schools (approximately 5105 persons) will be interviewed between…
- Trial name
- BelaPrim (NCT04413760)
- Where
- Austria
- Volunteers
- 891 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences for Health Professions Upper Austria
Preeclampsia, Immunologic Disease
Patients Pregnant Women With or Without Primary Antiphospholipid Antibody Syndrome
The purpose of the study is to evaluate the ability of placental angiogenesis markers to predict the risk of PE in pregnancy in women with primary APS.
- Conditions
- Preeclampsia, Immunologic Disease, Antiphospholipid Antibody Syndrome Primary, Pregnancy Complications
- Trial name
- NCT05786235
- Testing
- Collection of epidemiological and anamnestic data and collection of biological material (peripheral blood)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Healthy
The Effect of Transcranial Direct Current Stimulation of the Primary Motor and Somatosensory Cortex on Pain Thresholds.
The purpose of this study is to investigate the modulatory effect of a novel tDCS configuration on the pain sensitivity in healthy subjects.
- Trial name
- NCT04658485
- Testing
- Active tDCS
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pterygium of Conjunctiva and Cornea
Recurrence Rate of Mini-SLET vs. Limbal-Conjunctival Autograft in Primary Pterygium Excision
To study the efficacy and safety of amniotic membrane transplantation as an adjunctive therapy after surgical excision of primary pterygium and compare the clinical outcomes with conjunctival autograft
- Trial name
- NCT03363282
- Testing
- Pterygium Excision
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Rheumatic Heart Disease, Rheumatic Heart Disease in Children
Effectiveness of a School-centered Prevention Program on Prevalence of Latent Rheumatic Heart Disease
The overall objective is to evaluate the effectiveness of a school-centered primary and secondary prevention program on the prevalence of latent rheumatic heart disease among schoolchildren in Nepal, and to investigate the role…
- Trial name
- NEPAL4 (NCT05504928)
- Testing
- School nurse program
- Where
- Nepal
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Postural Tachycardia Syndrome, Ehlers-Danlos Syndrome
Standing Cognition and Co-morbidities of POTS Evaluation
The purpose of this study is to evaluate cognition in patients with postural tachycardia syndrome (POTS) while lying down and standing and to assess the prevalence of hypermobile Ehlers-Danlos Syndrome in POTS.
- Trial name
- SCOPE (NCT03602482)
- Testing
- Standing, Supine
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Primary Generalized (Osteo)Arthritis, Post-traumatic Arthrosis of Other Joints, Upper Arm
Simpliciti IDE Trial; Replacing the Humeral Head in Total Shoulder Arthroplasty
The purpose of this study is to demonstrate safety and efficacy of the Simpliciti Shoulder System in total shoulder arthroplasty.
- Trial name
- NCT01390038
- Testing
- Simpliciti™ Shoulder System
- Where
- 14 sites in United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Stryker Trauma and Extremities
PreDiabetes
Behavioral Nudges for Diabetes Prevention (BEGIN) Trial in Primary Care
A large body of research has demonstrated that intensive lifestyle interventions and metformin are effective treatments to prevent or delay diabetes among high-risk adults, yet neither treatment is routinely used in practice.
- Trial name
- BEGIN (NCT04869917)
- Testing
- Decision Aid intervention, Text Messaging intervention, Usual Care
- Where
- United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Migraine Disorders
Topiramate and Cerebrovascular Response in Migraineurs
The purpose of this study is to evaluate the effect of topiramate on cerebrovascular reactivity and mean flow velocity to photic stimulation in migraineurs.
- Trial name
- NCT02424318
- Testing
- Topiramate
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- SMG-SNU Boramae Medical Center
Glaucoma, Open-Angle
Comparation of CLASS Combined With Phacoemulsification and CLASS Alone in the Treatment of Primary Open Angle Glaucoma
To compare the effect of intraocular pressure control and the incidence of peripheral anterior synechia between CLASS combined with phacoemulsification and CLASS alone in the treatment of primary open-angle glaucoma
- Trial name
- NCT04920227
- Testing
- phacoemulsification;
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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