Clinical trials: Primary
Ovarian Cancer
Primary Debulking Surgery Including Bowel Resection in Advanced Stage Ovarian Cancer Using Caiman® Technology
Longitudinal prospective study on primary debulking surgery including bowel resection in advanced stage ovarian cancer patients using Caiman® technology
- Trial name
- CAIMAN (NCT03219242)
- Testing
- Caiman® device
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Carious Primary Molars
Comparison of ZOE vs ZON in Primary Mandibular Molars Pulpectomy of 5-7-Year-Olds
The goal of this clinical trial is to evaluation of Zinc oxide-eugenol compared to Zinc oxide with Neem as obturating materials in primary mandibular molars pulpectomy for 5-7 Year-Old Children.The main question(s)it aim to…
- Trial name
- NCT07090252
- Testing
- Group I zinc oxide Neem, Group II zinc oxide eugenol
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Risky Health Behavior, Drinking, Alcohol
STUN (STop UNhealthy) Alcohol Use Now! Implementing Evidence-Based Services for Unhealthy Alcohol Use in Primary Care
STUN Alcohol Use Now is an intervention designed to use primary care practice support services (practice facilitation) to help small to medium-size practices (10 or fewer providers) identify and provide services for people with…
- Conditions
- Risky Health Behavior, Drinking, Alcohol, Alcohol Use Disorder, Drinking, Binge
- Trial name
- STUN (NCT04317989)
- Testing
- Practice Facilitation
- Where
- 7 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Endotoxemia, Inflammation
In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia
Excessive inflammation is associated with tissue damage caused by over-activation of the innate immune system. This can range from mild disease to extreme conditions such as multiple organ failure (MOF).
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome
- Trial name
- VECTOR (NCT00785018)
- Testing
- C1-esterase inhibitor, Endotoxin administration
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pulmonary Disease, Chronic Obstructive
Prevalence of Chronic Airway Obstruction in Subjects With a History of Cigarette Smoking in a Primary Care Setting
This is a cross-sectional study to determine the prevalence of symptomatic airway obstruction using the LFQ as a screening tool in primary care patients with a history of cigarette smoking and to provide descriptive data of this…
- Trial name
- NCT01013948
- Testing
- Non-Interventional
- Where
- 40 sites in United States
- Volunteers
- 1,574 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Pulp Capping
Prospective Comparison of Indirect Pulp Therapy and Mineral Trioxide Aggregate Pulpotomy in Decayed Primary Molars
This prospective study compares the use of indirect pulp therapy and mineral trioxide aggregate pulpotomy for pulp therapy of the primary molar with dental caries approaching the pulp.
- Trial name
- NCT02620826
- Testing
- Indirect pulp therapy, Pulpotomy
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Root Canal Infection
Radicular Dentin Remaining, Risk of Perforation and Canal Transportation in Manual Versus Rotary Instrumentation in Primary Molars
Background: Root canal preparation techniques using manual instruments have found to be time-consuming and may lead to iatrogenic errors such as ledging, zipping, canal transportation, and apical blockage.
- Trial name
- NCT04793308
- Testing
- Endodontic files
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Delivery of Health Care, Smoking Cessation
Increasing Smoking Cessation Counselling in Primary Care Using a Chronic Disease Management System
This pilot study will determine the feasibility of studying a new smoking cessation management module in an existing chronic disease management system.
- Trial name
- NCT01004276
- Testing
- New, improved smoking cessation management module
- Where
- 2 sites in Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cervical Cancer
CervIcal Cancer Screening Trial by Randomization of HPV Testing Intervention for Upcoming Screening （CITRUS Study）
The aim of this study is to assess efficacy of the screening with concurrent liquid-based cytology and HPV DNA testing for the primary cervical cancer screening over 7 years.
- Trial name
- NCT01895517
- Testing
- LBC, LBC plus HPV DNA testing
- Where
- Japan
- Volunteers
- 18,471 people, healthy volunteers welcome
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Healthy Participants
A Phase 2 Study to Learn About a Monovalent Pneumococcal Conjugate Candidate in Healthy Toddlers
The purpose of the study is to learn about the effects of a monovalent (single component) pneumococcal conjugate candidate (mPnC candidate) when given to toddlers between 11 and 15 months of age.
- Trial name
- NCT06116591
- Testing
- mPnC candidate, mPnC control
- Where
- 11 sites in Finland, Poland
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Pfizer
Primary Dysmenorrhea
The Effect Of Reiki And Massage With Sage Oil On Primary Dysmenorrhea
This study was a randomized controlled trial. It included young girls with primary dysmenorrhea in a district located in the south of Turkey and was conducted between March 01, 2021 and June 30, 2021.
- Trial name
- NCT05129852
- Testing
- Sage oil group, Reiki group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mehmet Akif Ersoy University
COVID-19
PRevention of COVID-19 With Oral Vitamin D Supplemental Therapy in Essential healthCare Teams
In this 16-week randomized control study, health care workers will receive a bolus dose followed by a weekly dose of vitamin D or a placebo bolus and weekly dose.
- Trial name
- PROTECT (NCT04483635)
- Testing
- Vitamin D
- Where
- 2 sites in Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Progression of Rheumatoid Arthritis, Osteoarthritis of Multiple Joints
To Examine Whether or Not the Primary Causes of OA or RA Might be Bone Alterations
Generally, osteoarthris (OA) is considered as primarily cartilage disease. However, as we and others have previously reported, a portion of OA might be caused primarily by bone alterations.
- Trial name
- NCT02327650
- Testing
- The examinations for bones in joints of OA and RA patients
- Where
- 2 sites in Japan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shinshu University
Glaucoma, Primary Open Angle
LSFG in Patients With Normal Tension Glaucoma Tension Glaucoma
Glaucoma is the second leading cause of blindness worldwide. Literature shows increasing evidence that dysfunction of ocular microcirculation in the optic nerve influences the progression of glaucoma.
- Trial name
- NCT03318510
- Testing
- Laser Speckle Flowgraphy
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
Diphtheria, Tetanus
Antibody Persistence at Age 3.5 and 4.5 Years After Primary and Booster DTaP-IPV-Hep B-PRP~T or Infanrix Hexa Vaccination
This is a follow-up of the primary series vaccination schedule in Study A3L24 (NCT01177722) and booster vaccination in Study A3L27 (NCT01444781).
- Conditions
- Diphtheria, Tetanus, Whooping Cough, Hepatitis B
- Trial name
- NCT01983540
- Testing
- DTaP-IPV-Hep B- PRP~T + Prevenar + Rotarix vaccine, DTaP- IPV-Hep B-PRP~T + Prevenar + Rotarix + Infanrix hexa vaccine, Infanrix hexa + Prevenar + Rotarix vaccine
- Where
- 2 sites in Colombia, Costa Rica
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Healthy
The Lifestyle moDIfCation Study
Rationale: Lifestyle modifications, such as increasing physical exercise and reducing dietary salt and saturated fat intake contribute to prevention of cardiovascular morbidity and mortality.
- Trial name
- LUDIC (NCT01574040)
- Testing
- Promotion of stair climbing, Promotion of a low-salt soup alternative for the 'soup of the day', Promotion of a low-fat alternative for the butter croissants
- Where
- Netherlands
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Angle Closure Glaucoma
Evaluation of Clinical Decisions and Assessment of Those at Risk of Primary Angle Closure by Community Optometrists
Increases in the aging population has resulted in increased demand for glaucoma services. Glaucoma is a disease that if untreated, can lead to blindness.
- Trial name
- NCT05543889
- Testing
- Educational package
- Where
- United Kingdom
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Cluster Headache, Sleep
Actigraphy and Nocturnal Heartrate Variability in Cluster Headache Patients
Cluster headache is one of the most painful headaches, characterized by recurring episodes of unilateral, periorbital pain, which is accompanied by autonomic symptoms that seem to be of both sympathetic and parasympathetic…
- Trial name
- NCT03010189
- Testing
- Actigraphy, Heart-rate variability monitoring, Pupillometry
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nordlandssykehuset HF
Severe Combined Immunodeficiency, Atypical
Generalized Neonatal Screening of Severe Combined Immunodeficiencies
Severe combined Immunodeficiencies ( SCID ) are a group of inherited diseases of the immune system by characterised profound abnormalities of T cell development .
- Trial name
- DEPISTREC (NCT02244450)
- Testing
- SCID screening
- Where
- 51 sites in France
- Volunteers
- 190,539 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Primary Prevention
New Families- Innovation and Development of the Child Health Services in Oslo
The New Families (NF) program will improve quality of existing services, secure personalised service and early intervention in Child Health Service (CHS) in Oslo.
- Trial name
- NF (NCT04162626)
- Testing
- Supportive home visits to new families, Treatment as usual
- Where
- Norway
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- VID Specialized University
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