Clinical trials: Primary Knee Arthroplasty
Knee Osteoarthritis, Blood Loss
Extended Postoperative Oral Tranexamic Acid in Knee Replacement
A comparison of outcomes between use of oral tranexamic acid as compared to oral placebo in the first days after total knee replacement will be made to determine impact on clinical indications and patient reported outcomes.
- Conditions
- Knee Osteoarthritis, Blood Loss, Pain, Postoperative
- Trial name
- NCT05099276
- Testing
- Tranexamic Acid Pill
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Campbell Clinic
Joint Diseases, Arthritis Knee
Anterior Knee Pain in Mobile Bearing Versus Fixed Bearing in TKA
Osteoarthritis is the most common cause of chronic joint disease, and its incidence has increased due to the high average life expectancy, in addition to the high incidence of obesity.
- Conditions
- Joint Diseases, Arthritis Knee, Arthroplasty Complications
- Trial name
- NCT05696418
- Testing
- Total knee arthroplasty with a Mobile Bearing system., Total knee arthroplasty with a Fixed Bearing system.
- Where
- Syria
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Damascus University
Arthropathy of Knee, Osteo Arthritis Knee
Meditation and Opioid Consumption in Total Joint Replacement Patients Undergo Primary Total Hip and Knee Replacement
The main purpose of this study is to look at whether meditation techniques can help reduce pain and opioid use after surgery.
- Conditions
- Arthropathy of Knee, Osteo Arthritis Knee, Osteonecrosis, Meditation
- Trial name
- NCT05669066
- Testing
- Mindful meditation
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Arthroplasty Replacement, Knee, Anesthesia Conduction
Migration Rate for Continuous Adductor Canal Block Catheters After Primary Total Knee Arthroplasty Surgery: a Comparison Between Two Insertion Techniques
Continuous adductor canal block (CACB) is becoming increasingly popular for providing postoperative analgesia following knee arthroplasties.
- Trial name
- ISAFExOOPS (NCT07681622)
- Testing
- ISAFE technique for adductor canal catheter insertion, OOPS technique
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Acute Pain, Chronic Pain
The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement
Patients experience pain after their knee replacement surgery - and some may continue to experience persistent pain long after their knee replacement surgery.
- Conditions
- Acute Pain, Chronic Pain, Knee Pain Chronic, Neuropathic Pain
- Trial name
- NCT05023278
- Testing
- Venlafaxine 37.5 MG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Postoperative Nausea and Vomiting
Effect of Ramosetron in Prevention of Intrathecal Morphine Induced Nausea and Vomiting
We would like to know the prophylactic anti-emetic effect of ramosetron compare to ondansetron in patient undergone total knee arthroplasty with spinal anesthesia and intrathecal morphine .
- Trial name
- NCT02830906
- Testing
- ramosetron, Ondansetron
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Surgical Blood Loss
To Evaluate the Safety and Efficacy of the Saline-coupled Bipolar Sealer in Primary Unilateral Total Knee Arthroplasty
The purpose of this study is to investigate whether the saline-coupled bipolar sealer compared to the unipolar electrocautery provides superior hemostasis in patients undergoing primary unilateral total knee arthroplasty.
- Trial name
- NCT03952546
- Testing
- Saline-coupled Bipolar Sealer, Unipolar electrocautery
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Total Knee Arthroplasty, Osteoarthritis
Blood Flow Restriction Training Following Total Knee Arthroplasty
This study will evaluate blood flow restriction training as a rehabilitation modalities following total knee arthroplasty in order to determine if patient reported outcomes and objective functional outcomes can be improved…
- Trial name
- NCT02763488
- Testing
- DelfiPTS tourniquet system, Standard physical therapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- San Antonio Military Medical Center
Pain, Postoperative
Addition of Muscle Relaxants in a Multimodal Analgesic Regimen for Analgesia After Primary Total Knee Arthroplasty
This is a prospective, cluster-randomized, two-arm, comparative study aimed at determining whether addition of tizanidine ( an oral muscle relaxant) to a multimodal pain regimen following primary TKA reduces opioid consumption.
- Trial name
- NCT04574791
- Testing
- TiZANidine 2 MG Oral Capsule
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Total Knee Replacement, Wound Complication
Wound Healing in Primary TKA
Wound complications after total knee arthroplasty (TKA) can arise from many patient-specific factors, such as vascular or immune-related medical conditions, obesity, and smoking, among others.
- Trial name
- NCT06007599
- Testing
- Skin closure using skin adhesive, Skin closure without skin adhesive
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Total Knee Replacement Surgery, Total Hip Replacement Surgery
Xperience™ vs Normal Saline Irrigation Solution for Decreasing Bioburden After Primary Total Hip and Knee Arthroplasty
The purpose of this study is to evaluate the effectiveness of Xperience, a no rinse antimicrobial solution, on joint infection rates in patients undergoing total hip (THA) and total knee (TKA) arthoplasty surgery.
- Trial name
- NCT05577936
- Testing
- XPERIENCE Advanced Surgical Irrigation, Standard of Care Irrigation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pain, Postoperative, Total Knee Arthroplasty
Duloxetine RCT on Postop TKA Outcomes
The aim of this study is to determine if duloxetine is associated with differences in post-operative pain, patient-reported outcome measures, and opioid consumption in patients undergoing primary total knee arthroplasty compared…
- Trial name
- NCT05086393
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Osteoarthritis, Knee Arthritis Osteoarthritis
The Effect of Two Different Analgesic Methods on QoR-40 Score in Primary Unilateral Knee Arthroplasties
Total knee arthroplasty (TKA) is a very common operation that increases in frequency with advancing age. Similar to other surgical procedures, strategies are being developed to minimize morbidity and mortality while allowing for…
- Conditions
- Osteoarthritis, Knee Arthritis Osteoarthritis, Knee Arthroplasty, Total
- Trial name
- NCT07236073
- Testing
- PRİMER TEK TARAFLI DİZ ARTOPLASTİSİNDE İKİ FARKLI ANALJEZİK YÖNTEMİ, knee replacement
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Arthritis Knee, Pain
The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA
This interventional study aims to compare the effectiveness of local multimodal drug periarticular injection in TKA patients with the standard pain control regime that includes opioids, NSAIDs, and other analgesics.
- Conditions
- Arthritis Knee, Pain, Arthroplasty Complications
- Trial name
- NCT06112548
- Testing
- primary unilateral TKA, Bupivacain, ketorolac
- Where
- Syria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Damascus University
Osteoarthritis
Gait and Functional Improvement in Total Knee Arthroplasty With the Use of Verasense for Soft Tissue Balancing
The primary objectives of this study are to understand the effects of soft-tissue balancing on Gait, function and rehabilitation potential after sensor-assisted Total Knee Arthroplasty and correlate Intra-operative subjective…
- Trial name
- NCT02290119
- Testing
- Sensor-assisted TKR (Verasense), Control - Without the use of Verasense
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Orthosensor, Inc.
Osteoarthritis, Knee
Oral Steroid Taper After Total Knee Arthroplasty
This study aims to evaluate the effectiveness of an oral methylprednisolone taper in reducing postoperative pain, opioid consumption, and nausea following primary total knee arthroplasty (TKA).
- Trial name
- NCT07070882
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Columbia University
Total Knee Arthoplasty
Antibiotic Loaded Cement After TKA
This study will provide us with clear information about the postoperative concentration of antibiotic reached in synovial fluid, thereby helping surgeons to determine if concentration could potentially prevent the growth and…
- Trial name
- NCT05429671
- Testing
- total knee arthroplasty, Tobramycin, Gentamicin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Primary Osteoarthritis of Knee Nos
Rate of Infection After Using Antibiotic Loaded Cement and Regular Cement in Total Knee Arthroplasty
Our study will be a prospective study To compare between the rate of infection after using antibiotic loaded cement and regular cement after total knee arthroplasty in primary knee osteoarthritis.this will be at assiut university…
- Trial name
- NCT06117839
- Testing
- using antibiotic loaded cement and regular cement after total knee arthroplasty in primary knee osteoarthritis.
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Assiut University
Knee Arthropathy
Comparison of Accuracy and Functional Outcome Between Robotic and Gyroscopic Assisted Surgery in Primary TKA
A randomized controlled trial was conducted with 72 participants who had moderate knee osteoarthritis (Kellgren and Lawrence grade 2-3).
- Trial name
- NCT06321952
- Testing
- ROSA robotic assist TKA, iassist TKA
- Where
- Thailand
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Total Knee Arthroplasty
Perfusion Assessment of Wound Closure Techniques in Primary Total Knee Arthroplasty
This study will assess which of the three most common methods of wound closure in primary total knee arthroplasty (staples, interrupted vertical mattress, or running subcuticular suture) provide the best wound vascular perfusion.
- Trial name
- NCT01924403
- Testing
- Staple Closure, Vertical Mattress Closure, Running Subcuticular Closure
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic