Clinical trials: Primary Total Knee Arthroplasty
Venous Thromboembolism
BIBR 1048 Dose Range Finding Study in Prevention of Venous Thromboembolism in Patients With Primary Elective Total Hip or Knee Replacement Surgery
The primary objective of this study is to establish the dose-response relationship with regard to efficacy and safety of BIBR 1048 (50 mg bis in die(b.i.d), 150 mg b.i.d, 225 mg b.i.d.
- Trial name
- NCT01225822
- Testing
- Enoxaparin, BIBR 1048
- Where
- 59 sites in Austria, Belgium and 10 more
- Volunteers
- 1,973 people
- Sponsor
- Boehringer Ingelheim
Primary Total Knee Arthroplasty
The Efficacy of Local Infiltration Analgesia for Postoperative Pain Management After Total Knee Arthroplasty
This prospective, double-blinded, randomized controlled study evaluates the effects of peripheral nerve blocks with and without local infiltration analgesia for postoperative pain management after primary total knee arthroplasty.
- Trial name
- NCT04258241
- Testing
- Local infiltration analgesia with local anesthetic, Local infiltration analgesia without local anesthetic, Needle
- Where
- Lithuania
- Volunteers
- 80 people
- Sponsor
- Lithuanian University of Health Sciences
Knee Arthroplasty, Total
The Analgesic Efficacy of Protocol for Primary Total Knee Arthroplasty (TKA)
This is a perspective, randomized, blinded study with a parallel design and an allocation ratio of 1 to 1 for the treatment groups to assess the analgesic efficacy of adding the iPACK (injection between the popliteal artery and…
- Trial name
- NCT03703206
- Testing
- ultrasound guided injection of local anesthetic between the popliteal artery and the capsule of the knee (iPACK)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
Acute Pain, Chronic Pain
The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement
Patients experience pain after their knee replacement surgery - and some may continue to experience persistent pain long after their knee replacement surgery.
- Conditions
- Acute Pain, Chronic Pain, Knee Pain Chronic, Neuropathic Pain
- Trial name
- NCT05023278
- Testing
- Venlafaxine 37.5 MG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Osteoarthritis
Medico-economic Study of Patient Matched Cutting Blocks (Ancillary) MyKnee ® LBS During Knee Arthroplasty GMK ®.
Total knee arthroplasty represents over 70 000 surgical procedures per year in France, increasing about 10% each year since the early 1990s.
- Trial name
- NCT01814384
- Testing
- prosthesis GMK ® without the ancillary MyKnee ® LBS, Matched patient cutting blocks MyKnee ® LBS
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Bilateral Total Knee Arthroplasty, Gonarthrosis; Primary, Bilateral
Bilateral Simultaneous Total Knee Arthroplasty for Bilateral Gonarthrosis
The effects of two-team and single-team simultaneous bilateral total knee arthroplasty (SBA) on peri- and postoperative complications are not clear.
- Trial name
- NCT04299516
- Testing
- Two-team simultaneous bilateral total knee arthroplasty, Single-team simultaneous bilateral total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 246 people
- Sponsor
- Bezmialem Vakif University
Osteo Arthritis Knee, Rheumatoid Arthritis of Knee
A Study on the Use of Tourniquet Use In Primary Total Knee Arthroplasty
A tourniquet is often used in total knee arthroplasty (TKA) to achieve better visualization, reduce intra-operative bleeding and facilitate cement interdigitation.
- Trial name
- NCT04502459
- Testing
- Tourniquet
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Postoperative Nausea and Vomiting
Effect of Ramosetron in Prevention of Intrathecal Morphine Induced Nausea and Vomiting
We would like to know the prophylactic anti-emetic effect of ramosetron compare to ondansetron in patient undergone total knee arthroplasty with spinal anesthesia and intrathecal morphine .
- Trial name
- NCT02830906
- Testing
- ramosetron, Ondansetron
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Postoperative Pain
Transdermal Fentanyl as a Form of Rebound Pain Reduction in Fast Track Programme in Primary Knee Arthroplasty.
Total knee arthroplasty is a common surgery in routine clinical practice that, although it achieves an improvement in the functionality and quality of life of patients, it causes intense postoperative pain.
- Trial name
- FENTRA (NCT06431906)
- Volunteers
- 106 people
- Sponsor
- Oscar Diaz-Cambronero
Hip-arthroplasty, Knee-arthroplasty
Performance of Flexible Self-adherent Absorbent Dressing Coated With a Soft Silicone Layer After Hip -,Knee- Arthroplasty,Primary Spine Surgery in Comparison to a Standard Wound Dressing
Male or female subjects, 18 years and above, undergoing hip, knee or spinal surgery with an expected hospital stay for 4 days or more will be included in the trial. Individual trial duration will be for 7 days (follow-up).
- Conditions
- Hip-arthroplasty, Knee-arthroplasty, Spine Surgery
- Trial name
- wounddressing (NCT02771015)
- Testing
- Mepilex Border®, Cosmopor steril®
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Cologne
Primary Total Knee Replacement
Clinical Study Evaluating the Outcomes of a New Knee System with a Physiological Rollback Mechanism
The aim of this study is to assess the clinical, radiographic and patient-reported outcome measures (PROMs) after total knee replacement with Physica KR, define the survivorship of the implants and identify possible risk factors…
- Trial name
- K-06 (NCT02118272)
- Testing
- Physica KR
- Where
- 3 sites in Italy, United Kingdom
- Volunteers
- 156 people
- Sponsor
- Limacorporate S.p.a
Osteoarthritis, Pain, Postoperative
Liposomal Bupivacaine Versus Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Total Knee Arthroplasty
The purpose of this study is to compare the efficacy and duration of pain relief after total knee arthroplasty provided by a single injection of liposomal bupivacaine (EXPAREL®) versus standard bupivacaine with an adjuvant…
- Trial name
- NCT02624856
- Testing
- Liposomal bupivacaine, Bupivacaine plus dexamethasone
- Where
- United States
- Sponsor
- Albany Medical College
Osteoarthritis, Post-traumatic Arthritis
China ATTUNE® Study
The study was designed as prospective, single-arm, multi-center which was intended to broadly capture all patients as the technology is adopted.
- Trial name
- NCT03542045
- Testing
- Cemented ATTUNE® Knee System
- Where
- China
- Volunteers
- 120 people
- Sponsor
- DePuy Orthopaedics
Pain, Postoperative, Satisfaction
Comparing Ropivacaine Adductor Canal Blockade by Surgeon Versus Anesthesiologist
The purpose of this study is to evaluate the efficacy of two methods of administering an adductor canal block (ACB) following total knee arthroplasty (TKA); intraoperative surgeon performed intra-articular adductor canal block…
- Trial name
- NCT03864588
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Rothman Institute Orthopaedics
Total Knee Arthroplasty
Outcomes for Manual Lymphatic Drainage
In this context, the purpose of our study is to investigate the effect of MLD(manual lymphatic drainage) technique applied in addition to the standard postoperative rehabilitation protocol on pain, kinesophobia and quality of…
- Trial name
- NCT04795011
- Testing
- exercise and manual lymphatic drainage, exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Selcuk University
Surgical Blood Loss
To Evaluate the Safety and Efficacy of the Saline-coupled Bipolar Sealer in Primary Unilateral Total Knee Arthroplasty
The purpose of this study is to investigate whether the saline-coupled bipolar sealer compared to the unipolar electrocautery provides superior hemostasis in patients undergoing primary unilateral total knee arthroplasty.
- Trial name
- NCT03952546
- Testing
- Saline-coupled Bipolar Sealer, Unipolar electrocautery
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Rehabilitation Exercise
Evaluating the Efficacy of a "Quiet Knee Protocol" in Primary Total Knee Arthroplasty (TKA): A Prospective Randomized Study
The goal of this randomized clinical trial is to access the following: 1. Compare the effectiveness of the QKP versus a standard rehabilitation protocol in improving postoperative pain control, ROM, and functional recovery…
- Trial name
- QKP (NCT07879014)
- Testing
- Quiet Knee Protocol, Post Operative Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Mayo Clinic
Total Knee Arthroplasty, Osteoarthritis
Blood Flow Restriction Training Following Total Knee Arthroplasty
This study will evaluate blood flow restriction training as a rehabilitation modalities following total knee arthroplasty in order to determine if patient reported outcomes and objective functional outcomes can be improved…
- Trial name
- NCT02763488
- Testing
- DelfiPTS tourniquet system, Standard physical therapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- San Antonio Military Medical Center
Knee Arthritis
Perioperative Analgesia for Knee Arthroplasty (PAKA)
Peri-articular knee infiltration with Levobupivicaine 150mg, Morphine 10mg and Ketorolac 30mg reduces postoperative pain following primary total knee replacement compared with the current standard treatment of femoral nerve…
- Trial name
- PAKA (NCT01560767)
- Testing
- Femoral Nerve Block, peri-articular infiltration
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- University of Warwick
Obesity, Aseptic Loosening
Analysis of Varus Collapse in Obese Patients With Stem and Non-Stem Tibial Components Following Primary Total Knee Arthroplasty
The purpose of this study is to compare rates of varus collapse, aseptic loosening, and implant failure in female obese patients undergoing total knee arthroplasty (TKA) and will review the degree of influence of stemmed tibial…
- Conditions
- Obesity, Aseptic Loosening, Varus Collapse
- Trial name
- SvNS (NCT06019832)
- Testing
- Total Knee Arthroplasty (TKA), Stemmed Tibial Implant, Non-stemmed tibial implant
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Jacob M. Elkins