Clinical trials: Priming
Healthy
Study of Brain Function During Cognitive Tasks
This study will use magnetic resonance imaging (MRI) to examine which areas of the brain are involved in performing certain cognitive tasks.
- Trial name
- NCT00076739
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Functional Magnetic Resonance Imaging, Habits
Neuronal Correlates of Priming on Goal-directed and Cue-dependent Behavior
The current proposal aims to investigate neuronal correlates of implicit and explicit priming paradigms for changing cue-dependent and goal-directed nutritional behavior.
- Conditions
- Functional Magnetic Resonance Imaging, Habits, Eating Behavior
- Trial name
- NCT03735732
- Testing
- prime
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Spinal Cord Injury
Functional Electrical Stimulations With and Without Motor Priming Exercises in Spinal Cord Injury
As functional electrical stimulations has evident role in improving motor control in tenodesis function (power and precision grip) but its results are considered to be short term so addition of task oriented approach i.e.
- Trial name
- NCT05411692
- Testing
- Functional electrical stimulations and motor priming exercise, Functional electrical stimulations, Conventional physical therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Metastatic Pancreatic Cancer
Safety and Efficacy of Combination Listeria/GVAX Immunotherapy in Pancreatic Cancer
Test the safety, immune response and efficacy of GVAX pancreas vaccine (with cyclophosphamide) and CRS-207 compared to GVAX pancreas vaccine (with cyclophosphamide) alone in adults who have failed or refused prior treatment for…
- Trial name
- NCT01417000
- Testing
- GVAX Pancreas, CRS-207, Cyclophosphamide
- Where
- 10 sites in United States
- Volunteers
- 93 people
- Sponsor
- Aduro Biotech, Inc.
Multiple Myeloma
Phase I/II Clinical Trial Combining hTERT Tumor Vaccine & Autologous T Cells in Patients With Advanced Myeloma
The purpose of this study is: 1. To evaluate the safety of activated T cell infusions and immunization with hTERT multi-peptide vaccine in the post-transplant setting and whether the combination can delay hematopoietic recovery…
- Trial name
- NCT00834665
- Testing
- hTERT vaccine, GM-CSF, PCV, T cell infusion, GM-CSF, PCV, T cell infusion
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- University of Pennsylvania
Stroke
Exercise Primed Stroke Rehabilitation
Stroke is a leading cause of disability in the U.S. and many Veteran stroke survivors live with severe disability. Despite recent advances in rehabilitation treatments many stroke survivors have persistent physical and mental…
- Trial name
- NCT04877444
- Testing
- Duck Duck Punch, Aerobic exercise, Lower extremity stretching
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Meningococcal Disease, Meningococcal Meningitis
Safety, Tolerability and Immunogenicity of Meningococcal B Recombinant Vaccine Administered as Booster Dose at 12, 18 or 24 Months of Age in Toddlers (12-24 Months) Primed With a Three-Dose Immunization Series as Infants in Study V72P12
This extension study V72P12E1 will investigate the safety, tolerability and immunogenicity of a fourth (booster) dose of rMenB+OMV NZ at 12, 18 and 24 months of age in subjects previously primed with rMenB+OMV NZ according to two…
- Trial name
- NCT00944034
- Testing
- rMenB+OMV NZ with routine vaccinations, rMenB+OMV NZ, two doses of rMenB+OMV NZ
- Where
- 72 sites in Belgium, Czechia and 4 more
- Volunteers
- 1,588 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Extracorporeal Circulation, Cardiac Surgery
Priming of Cardiopulmonary Bypass With Hydroxyethyl Starch 130/0.4 or Sodium Chloride 0.9% : Pilot Study in Adult Elective Conventional Cardiac Surgery
Best priming for cardiopulmonary bypass in cardiac surgery is unknown. Efficacy and toxicity of Hydroxyethyl Starch 130/0.4 used in this context are uncertain.
- Trial name
- OPTIMUS-PRIME (NCT02906514)
- Testing
- Non balanced Hydroxyethyl starch 130/0.4 (Voluven®, Fresenius), Sodium Chloride 0.9% (Fresenius)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Athletic Performance Enhancement, Neuromuscular Performance in Athletes
Acute Effects of Neuroathletic Training-Integrated Resistance Training in Collegiate Athletes
This study investigated the acute and short-term effects of neuroathletic training (NAT)-integrated resistance training compared with conventional resistance training on physical and neuromuscular performance in collegiate…
- Conditions
- Athletic Performance Enhancement, Neuromuscular Performance in Athletes, Physical Performance
- Trial name
- NAT-RT (NCT07782606)
- Testing
- Conventional Lower-Extremity Resistance Training, Neuroathletic Training-Integrated Resistance Training
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Spondylolisthesis, Lumbar Region, Spinal Trauma With Neurological Deficit
Adult Patient Outcomes After Spine Surgery With Fibergraft BG Putty/Viper Prime
The Viper Prime/Expedium spine systems are intended to provide immobilization and stabilization of spinal segments in skeletally mature patients as an adjunct to fusion in the treatment of acute and chronic instabilities or…
- Conditions
- Spondylolisthesis, Lumbar Region, Spinal Trauma With Neurological Deficit, Degeneration of Lumbar Intervertebral Disc
- Trial name
- NCT06704906
- Testing
- Use of Viper Prime/Expedium system with Fibergraft BG Putty
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nitin Agarwal
Pancreatic Ductal Adenocarcinoma
A Study to Evaluate ATP150/ATP152/ATP162, VSV-GP154 and Ezabenlimab in Patients With Pancreatic Ductal Adenocarcinoma
This study has stopped recruitment. Adults with advanced pancreatic cancer participate in this study. The study tests a type of immunotherapy.
- Trial name
- NCT05846516
- Testing
- VSV-GP154, ATP150, ATP152
- Where
- 21 sites in United States, Germany and 2 more
- Volunteers
- 59 people
- Sponsor
- Boehringer Ingelheim
Ovary Cyst, Fertility Issues
Dydrogesterone-Primed Ovarian Stimulation Protocol Versus Gonadotropin Releasing Hormone Antagonist Protocol in ICSI
GnRH antagonist protocol is currently a good strategy for controlled ovarian stimulation in women with PCOS undergoing IVF/ICSI cycles.
- Trial name
- NCT05751681
- Testing
- progestin primed ovarian stimulation protocol, dydrogesterone (Duphaston, Abbott), Cetrotide
- Where
- Egypt
- Volunteers
- 79 people
- Sponsor
- Zagazig University
Microcirculation
Evaluation of Different Priming Solutions Effects on Microcirculation, Oxidative Stress and Morbidity in Cardiovascular Surgery Patients
Single-centre prospective randomized study will be included the patients who undergo elective cardiovascular surgery. Preoperative fluid deficit will be calculated by the formula as starvation period X 4 X weight.
- Trial name
- Acibadem (NCT02501681)
- Testing
- priming solution during cardiovascular surgery
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Frisius Medisch Centrum
HIV Vaccine, HIV-1-infection
Safety and Immunogenicity of HIV-1 Vaccines C62-M4 or C1C62-M3M4 in Persons With HIV-1 Suppressed on ART
This is a double blind, randomized, placebo-controlled, parallel design study in which 18 in participants with HIV (PWH) on suppressive antiretroviral therapy will be randomly assigned to receive vaccination with C62 followed by…
- Trial name
- CM HIV-CORE008 (NCT05604209)
- Testing
- ChAdOx1.HIVconsv62, ChAdOx1.tHIVconsv1, MVA.tHIVconsv4
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- University of North Carolina, Chapel Hill
Non-small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck
Priming Immunotherapy in Advanced Disease With Radiation
This study proposes to treat metastatic non-small cell lung cancer (NSCLC) and head/neck squamous cell cancer (HNSCC) patients who are already initiating an immune checkpoint inhibitor (such as Nivolumab, Atezolizumab or…
- Trial name
- NCT03313804
- Testing
- Immune checkpoint inhibitor, Radiation Therapy
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- John L. Villano, MD, PhD
Malaria, Falciparum, Malaria
Safety and Immunogenicity Study of the Malaria Vaccines FP9 PP and MVA PP
This study examines two new malaria vaccines (FP9-PP and MVA-PP) in healthy human volunteers to determine their safety and ability to induce a measurable immune response against malaria.
- Trial name
- NCT00374998
- Testing
- FP9-PP (FP9 polyprotein), MVA-PP (Modified Virus Ankara polyprotein)
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- European Vaccine Initiative
Hypoxic-Ischemic Encephalopathy, Brain Injury
Prospective Research in Infants With Mild Encephalopathy
A multicenter observational pilot study will be conducted to determine the natural history of infants with early diagnosis (≤ 6 hrs of age) of mild neonatal encephalopathy (NE) who are not qualified for therapeutic hypothermia.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Brain Injury, Neonatal Seizure
- Trial name
- PRIME (NCT01747863)
- Testing
- Neurologic examination
- Where
- 7 sites in United States, Canada and 2 more
- Volunteers
- 63 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
HPV 16 Infection, HPV-Related Carcinoma
Clinical Trial Assessing the Safety and Immunologic Correlates of Heterologous Prime-Boost With pNGVL4a-Sig/E7(Detox)/HSP70 and TA-HPV in Healthy Donors Followed by Peripheral Blood Collection
This healthy related donor clinical trial is linked to a recipient clinical trial protocol for therapeutic purposes. In this healthy donor protocol, haploidentical relatives of a patient with recurrent or metastatic human…
- Conditions
- HPV 16 Infection, HPV-Related Carcinoma, Recurrence, Metastatic Cancer
- Trial name
- J21112LINKED (NCT06508138)
- Testing
- pNGVL4a-Sig/E7(detox)/HSP70 plasmid DNA; TA-HPV vaccinia virus
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Influenza A Virus, H7N9 Subtype
Safety and Immunogenicity of Priming With Live Attenuated A/H7N9 Influenza Virus Vaccine Followed By Inactivated A/H7N9 Influenza Virus Vaccine With AS03 Adjuvant
The purpose of this study is to evaluate the safety and immunogenicity of one dose of H7N9 pandemic live attenuated influenza vaccine (H7N9 pLAIV) followed by AS03-adjuvanted H7N9 pandemic inactivated influenza vaccine (H7N9…
- Trial name
- NCT02957656
- Testing
- H7N9 pLAIV, H7N9 pIIV, AS03 adjuvant
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Breast Cancer
PRospective Study to Measure the Impact of MammaPrint on Adjuvant Treatment in Hormone Receptor-positive HER2-negative Breast Cancer Patients (PRIMe)
PRIMe is a prospective, case-only trial designed to measure the impact of MammaPrint on physician chemotherapy intention in the two discordant groups (ET/POOR, CT/GOOD) in stage 1 and 2 HR-positive HER2-negative breast cancer…
- Trial name
- PRIMe (NCT02269813)
- Testing
- MammaPrint, BluePrint, TargetPrint
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 452 people
- Sponsor
- Women's Cancer Study Group GmbH